To clarify the role of TAFI in hypertensive disorders in pregnancy, 22 subjects, including 10 with pre-eclampsia （PE） and 12 with gestational hypertension were examined for the levels of TAFI and thrombin-antithromb...To clarify the role of TAFI in hypertensive disorders in pregnancy, 22 subjects, including 10 with pre-eclampsia （PE） and 12 with gestational hypertension were examined for the levels of TAFI and thrombin-antithrombin （TAT） complex. Thirty normal pregnant women served as controls. ELISA was employed for the detection. The results showed that the TAFI antigen levels in normal pregnancy group, gestational hypertension group and PE group were （85.35±24.69）%, （99.65±18.27）%, （110.12±23.36）%; （97.06±21.40）%, （114.08±27.76）%, （125.49±24.70）%; （106.6±19.21）%, （129.2±25.07）%, （139.1±30.12）%, in the 1st, 2nd and 3rd trimester respectively. No significant differences were found between the normal pregnancy group and gestational hypertension group but significant difference existed between normal pregnancy group and PE group in each trimester （P〈0.05）. TAT complexes were significantly higher in patients with PE than that in controls （P〈0.05）, but no correlation was found between TAT and TAFI. It is concluded that TAFI may contributed to the impairment of fibrinolysis in the patients with PE and may serves as a sensitive indicator for PE, but it may not help in the diagnosis of the gestational hypertension.展开更多
目的探讨凝血酶激活的纤溶抑制物(TAFI)编码区基因单核苷酸多态性与心肌梗死的相关性。方法应用聚合酶链反应-限制性内切酶片段长度多态性(Restriction fragment length polymorphism,PCR-RFLP)分析技术检测了100例心肌梗死(MI)患者和9...目的探讨凝血酶激活的纤溶抑制物(TAFI)编码区基因单核苷酸多态性与心肌梗死的相关性。方法应用聚合酶链反应-限制性内切酶片段长度多态性(Restriction fragment length polymorphism,PCR-RFLP)分析技术检测了100例心肌梗死(MI)患者和90例正常对照者的CPB2基因的基因型。结果CPB2基因的3种基因型(Thr325Thr、Thr325Ile、Ile325Ile)频率在MI组和对照组分别为32%、53%、15%和34.4%、54.4%、11.2%,等位基因C、T频率在MI组和对照组分别为58.5%、41.5%和61.7%、38.3%,两组之间基因型和等位基因频率分布差异无统计学意义(P>0.05),且均符合Hardy-Weinberg平衡定律。结论CPB2基因的基因多态性(Thr325Ile)与心肌梗死没有明显关系。展开更多
基金a grant from the Key Program of Clinical Sciences of Ministry of Health of China (No. WGCF468)
文摘To clarify the role of TAFI in hypertensive disorders in pregnancy, 22 subjects, including 10 with pre-eclampsia （PE） and 12 with gestational hypertension were examined for the levels of TAFI and thrombin-antithrombin （TAT） complex. Thirty normal pregnant women served as controls. ELISA was employed for the detection. The results showed that the TAFI antigen levels in normal pregnancy group, gestational hypertension group and PE group were （85.35±24.69）%, （99.65±18.27）%, （110.12±23.36）%; （97.06±21.40）%, （114.08±27.76）%, （125.49±24.70）%; （106.6±19.21）%, （129.2±25.07）%, （139.1±30.12）%, in the 1st, 2nd and 3rd trimester respectively. No significant differences were found between the normal pregnancy group and gestational hypertension group but significant difference existed between normal pregnancy group and PE group in each trimester （P〈0.05）. TAT complexes were significantly higher in patients with PE than that in controls （P〈0.05）, but no correlation was found between TAT and TAFI. It is concluded that TAFI may contributed to the impairment of fibrinolysis in the patients with PE and may serves as a sensitive indicator for PE, but it may not help in the diagnosis of the gestational hypertension.
文摘目的探讨凝血酶激活的纤溶抑制物(TAFI)编码区基因单核苷酸多态性与心肌梗死的相关性。方法应用聚合酶链反应-限制性内切酶片段长度多态性(Restriction fragment length polymorphism,PCR-RFLP)分析技术检测了100例心肌梗死(MI)患者和90例正常对照者的CPB2基因的基因型。结果CPB2基因的3种基因型(Thr325Thr、Thr325Ile、Ile325Ile)频率在MI组和对照组分别为32%、53%、15%和34.4%、54.4%、11.2%,等位基因C、T频率在MI组和对照组分别为58.5%、41.5%和61.7%、38.3%,两组之间基因型和等位基因频率分布差异无统计学意义(P>0.05),且均符合Hardy-Weinberg平衡定律。结论CPB2基因的基因多态性(Thr325Ile)与心肌梗死没有明显关系。
