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Factor Ⅺ as A Novel Target for Treatment of Thrombotic Disease
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作者 贺蓉 贺石林 《血栓与止血学》 2011年第6期243-246,共4页
Introduction Thrombosis is a major pathological process that threatens human health.It underlies the pathogenesis of the leading causes of death myocardial infarction (MI)and ischemic stroke (IS),as well as life-threa... Introduction Thrombosis is a major pathological process that threatens human health.It underlies the pathogenesis of the leading causes of death myocardial infarction (MI)and ischemic stroke (IS),as well as life-threatening disseminated intravascular coagulation ( DIC),and deep venous thromboembolism (DVT) and pulmonary embolism.Antithrombosis encompasses several aspects:coagulation,platelets,fibrinolysis,vascular endothelial cells,hemodynamics and hemorheology.Among them,anticoagulation is a fundamental step in antithrombotic therapy.Existing anticoagulants inhibit coagulation factors effectively,and are countered by substantial limitations with severe bleeding risk.For newer generation anticoagulant development,it is important to achieve a low ratio of hemorrhagic risk/antithrombotic benefit. 展开更多
关键词 Factor XI TREATMENT thrombotic Disease
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In silico Discovery of Novel FXa Inhibitors by Pharmacophore Modeling and Molecular Docking
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作者 Yinglan Pu Hui Liu +6 位作者 Yeheng Zhou Jiale Peng Yaping Li Penghua Li Yingying Li Xingyong Liu Li Zhang 《Natural Products and Bioprospecting》 CAS 2017年第3期249-256,共8页
Coagulation Factor Xa(FXa)is the crucial enzyme at the convergent point of the intrinsic and extrinsic coagulation pathways.The inhibition of FXa is an effective approach against thrombotic diseases.In the present stu... Coagulation Factor Xa(FXa)is the crucial enzyme at the convergent point of the intrinsic and extrinsic coagulation pathways.The inhibition of FXa is an effective approach against thrombotic diseases.In the present study,a specific strategy is reported to discover 10 novel FXa inhibitors based on ligand-based(pharmacophore)virtual screening and molecular docking analysis from a dataset of specs(containing 220000 molecules).The binding modes analysis provide insights into the contribution of particular structural moieties of the compounds towards their activity against FXa,and 10 novel structural compounds were discovered as potent candidate molecules.This work could be helpful in further design and development of FXa inhibitors. 展开更多
关键词 FXa thrombotic diseases PHARMACOPHORE DOCKING
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Polymorphism of human platelet alloantigen in Chinese patinets with acute myocardial infarction and acute ischemic stroke
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作者 陈方平 蹇在伏 +3 位作者 解勤之 蒲晓群 肖波 韩玲 《Chinese Medical Journal》 SCIE CAS CSCD 2000年第8期30-33,共4页
关键词 human platelet alloantigen POLYMORPHISM arterial thrombotic diseases
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