The forward flight of a model butterfly was stud- ied by simulation using the equations of motion coupled with the Navier-Stokes equations. The model butterfly moved under the action of aerodynamic and gravitational f...The forward flight of a model butterfly was stud- ied by simulation using the equations of motion coupled with the Navier-Stokes equations. The model butterfly moved under the action of aerodynamic and gravitational forces, where the aerodynamic forces were generated by flapping wings which moved with the body, allowing the body os- cillations of the model butterfly to be simulated. The main results are as follows: (1) The aerodynamic force produced by the wings is approximately perpendicular to the long-axis of body and is much larger in the downstroke than in the up- stroke. In the downstroke the body pitch angle is small and the large aerodynamic force points up and slightly backward, giving the weight-supporting vertical force and a small neg- ative horizontal force, whilst in the upstroke, the body an- gle is large and the relatively small aerodynamic force points forward and slightly downward, giving a positive horizon- tal force which overcomes the body drag and the negative horizontal force generated in the downstroke. (2) Pitching oscillation of the butterfly body plays an equivalent role of the wing-rotation of many other insects. (3) The body-mass- specific power of the model butterfly is 33.3 W/kg, not very different from that of many other insects, e.g., fruitflies and dragonflies.展开更多
Recently, canopy transpiration (Ec) has been often estimated by xylem sap-flow measurements. However, there is a significant time lag between sap flow measured at the base of the stem and canopy transpiration due to...Recently, canopy transpiration (Ec) has been often estimated by xylem sap-flow measurements. However, there is a significant time lag between sap flow measured at the base of the stem and canopy transpiration due to the capacitive exchange between the transpiration stream and stem water storage. Significant errors will be introduced in canopy conductance (gc) and canopy transpiration estimation if the time lag is neglected. In this study, a cross-correlation analysis was used to quantify the time lag, and the sap flowbased transpiration was measured to pararneterize Jarvistype models of gc and thus to simulate Ec of Populus cathayana using the Penman-Monteith equation. The results indicate that solar radiation (Rs) and vapor pressure deficit (VPD) are not fully coincident with sap flow and have an obvious lag effect; the sap flow lags behind Rs and precedes VPD, and there is a 1-h time shift between Eo and sap flow in the 30-min interval data set. A parameterized Jarvis-type gc model is suitable to predict P. cathayana transpiration and explains more than 80% of the variation observed in go, and the relative error was less than 25%, which shows a preferable simulation effect. The root mean square error (RMSEs) between the predicted and measured Ec were 1.91×10^-3 (with the time lag) and 3.12×10^-3cm h^-1 (without the time lag). More importantly, Ec simulation precision that incorporates time lag is improved by 6% compared to the results without the time lag, with the mean relative error (MRE) of only 8.32% and the mean absolute error (MAE) of 1.48 × 10^-3 cm h^-1.展开更多
Recent advances in intelligent transportation system allow traffic safety studies to extend from historic data-based analyses to real-time applications. The study presents a new method to predict crash likelihood with...Recent advances in intelligent transportation system allow traffic safety studies to extend from historic data-based analyses to real-time applications. The study presents a new method to predict crash likelihood with traffic data collected by discrete loop detectors as well as the web-crawl weather data. Matched case-control method and support vector machines (SVMs) technique were employed to identify the risk status. The adaptive synthetic over-sampling technique was applied to solve the imbalanced dataset issues. Random forest technique was applied to select the contributing factors and avoid the over-fitting issues. The results indicate that the SVMs classifier could successfully classify 76.32% of the crashes on the test dataset and 87.52% of the crashes on the overall dataset, which were relatively satisfactory compared with the results of the previous studies. Compared with the SVMs classifier without the data, the SVMs classifier with the web-crawl weather data increased the crash prediction accuracy by 1.32% and decreased the false alarm rate by 1.72%, showing the potential value of the massive web weather data. Mean impact value method was employed to evaluate the variable effects, and the results are identical with the results of most of previous studies. The emerging technique based on the discrete traffic data and web weather data proves to be more applicable on real- time safety management on freeways.展开更多
In this article,a high-order scheme,which is formulated by combining the quadratic finite element method in space with a second-order time discrete scheme,is developed for looking for the numerical solution of a two-d...In this article,a high-order scheme,which is formulated by combining the quadratic finite element method in space with a second-order time discrete scheme,is developed for looking for the numerical solution of a two-dimensional nonlinear time fractional thermal diffusion model.The time Caputo fractional derivative is approximated by using the L2-1formula,the first-order derivative and nonlinear term are discretized by some second-order approximation formulas,and the quadratic finite element is used to approximate the spatial direction.The error accuracy O(h3+t2)is obtained,which is verified by the numerical results.展开更多
Forest losses or gains have long been recognized as critical processes modulating the carbon flux between the biosphere and the atmosphere. Timely, accurate and spatially explicit information on forest disturbance and...Forest losses or gains have long been recognized as critical processes modulating the carbon flux between the biosphere and the atmosphere. Timely, accurate and spatially explicit information on forest disturbance and recovery history is required for assessing the effectiveness of existing forest management. The major objectives of our research focused on testing the mapping efficacy of the vegetation change tracker (VCT) model over a forested area in China. We used a new version of VCT algorithm built upon the Landsat time series stacks (LTSS). The LTSS consisted of yearly image acquisitions to map forest disturbance history from 1987 to 2011 over the Ning-Zhen Mountains, Jiangsu Province of east China. The LTSS consisted of TM and ETM+ scenes with different projec- tions due to distinct data sources (Beijing remote sensing ground station and the USGS EROS Center). The valida- tion results of the disturbance year maps showed that most spatial agreement measures ranged from 70 to 86 %, comparable with the VCT accuracies reported for many places in USA. Very low accuracies were identified in 1995 (38.3 %) and 1992 (56.2 %) in the current analysis. These resulted from the insensitivity of the VCT algorithm to detect low intensity disturbances and also from the mis- registration errors of the image pairs. Major forest distur- bance types existing in our study area were identified as agricultural expansion (39.8 %), urbanization (24.9 %), forest management practice (19.3 %), and mining (12.8 %). In general, there was a gradual decreasing trend in forest cover throughout this region, caused principally by China's economic, demographic, environmental and political policies and decisions, as well as some weather events. While VCT has largely been used to assess long term changes and trends in the USA, it has great potential for assessing landscape level change elsewhere throughout the world.展开更多
We previously demonstrated that administering 2-(2-benzofuranyl)-2-imidazolin(2-BFI), an imidazoline I2 receptor agonist, immediately after ischemia onset can protect the brain from ischemic insult. However, immed...We previously demonstrated that administering 2-(2-benzofuranyl)-2-imidazolin(2-BFI), an imidazoline I2 receptor agonist, immediately after ischemia onset can protect the brain from ischemic insult. However, immediate administration after stroke is difficult to realize in the clinic. Thus, the therapeutic time window of 2-BFI should be determined. Sprague-Dawley rats provided by Wenzhou Medical University in China received right middle cerebral artery occlusion for 120 minutes, and were treated with 2-BFI(3 mg/kg) through the caudal vein at 0, 1, 3, 5, 7, and 9 hours after reperfusion. Neurological function was assessed using the Longa's method. Infarct volume was measured by 2,3,5-triphenyltetrazolium chloride assay. Morphological changes in the cortical penumbra were observed by hematoxylin-eosin staining under transmission electron microscopy. The apoptosis levels in the ipsilateral cortex were examined with terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling(TUNEL) assay. The protein expression of Bcl-2 and BAX was detected using immunohistochemistry. We found the following: Treatment with 2-BFI within 5 hours after reperfusion obviously improved neurological function. Administering 2-BFI within 9 hours after ischemia/reperfusion decreased infarct volume and alleviated apoptosis. 2-BFI administration at different time points after reperfusion alleviated the pathological damage of the ischemic penumbra and reduced the number of apoptotic neurons, but the protective effect was more obvious when administered within 5 hours. Administration of 2-BFI within 5 hours after reperfusion remarkably increased Bcl-2 expression and decreased BAX expression. To conclude, 2-BFI shows potent neuroprotective effects when administered within 5 hours after reperfusion, seemingly by up-regulating Bcl-2 and down-regulating BAX expression. The time window provided clinical potential for ischemic stroke by 2-BFI.展开更多
This paper deals with the problem of decentralized robustcontrol for a class of interconnected uncertain systemswith state delays.The parameter uncertainties are un-known but norm-bounded.A new sufficient condition is...This paper deals with the problem of decentralized robustcontrol for a class of interconnected uncertain systemswith state delays.The parameter uncertainties are un-known but norm-bounded.A new sufficient condition isobtained for each subsystem and overall system to be sta-bilizable via linear memoryless state feedback robust de-centralized controllers.The results depend on the size of the delays and are given in terms of linear matrix ine-qualities,so they are less conservative than those of delay-independent.Moreover,matching condition is not a necessary condition.Finally,an example is presented to illustrative the effectiveness of the proposed method.展开更多
March is a right party time for friends to get together to enjoy the smell of early spring. Moreover, people would like to take off the thick winter coat to showcase their colorful attitude towards the warm spring sun...March is a right party time for friends to get together to enjoy the smell of early spring. Moreover, people would like to take off the thick winter coat to showcase their colorful attitude towards the warm spring sunshine. Here, an annual fashion feast in Beijing not only could provide you a visual inspiration of trend, but also would tell you what’s the most "in" factors in the coming season.展开更多
Shaw's method used to correlate 40 sections across the Permo-Triassic boundary in South China is applied in the paper. Two steps are adopted to get an Integral Composite Section (ICS) by synthesizing these data : ...Shaw's method used to correlate 40 sections across the Permo-Triassic boundary in South China is applied in the paper. Two steps are adopted to get an Integral Composite Section (ICS) by synthesizing these data : First , South China is divided into five areas and composite section developed for each area . Then the second step . the Changxing composite section is regarded as a composite standard (CSRS) while the ICS is produced by matching the CSRS with composite sections of the other areas. Three biozones in the Changxingian and two biozones in the Griesbachian can be discerned on the basis of computing Z values in the ICS. These biozones are marked by the Z values which quantitatively represent their time ranges ; therefore , they may increase accuracy of stratigraphic time correlation . The mass extinction at the end of the Permian is an abrupt event that is supported by the relative rate of extinction near the P/T boundary . About 90% of invertebrate species died out by the end of the Permian . The duration of the mass extinction is rather short ,approximately 0.018Ma .展开更多
In view of engineering application, it is practicable to decompose the aerodynamics into three components: the static aerodynamics, the aerodynamic increment due to steady rotations, and the aerodynamic increment due...In view of engineering application, it is practicable to decompose the aerodynamics into three components: the static aerodynamics, the aerodynamic increment due to steady rotations, and the aerodynamic increment due to unsteady separated and vortical flow. The first and the second components can be presented in conventional forms, while the third is described using a one-order differential equation and a radial-basis-function (RBF) network. For an aircraft configuration, the mathematical models of 6- component aerodynamic coefficients are set up from the wind tunnel test data of pitch, yaw, roll, and coupled yawroll large-amplitude oscillations. The flight dynamics of an aircraft is studied by the bifurcation analysis technique in the case of quasi-steady aerodynamics and unsteady aerodynam- ics, respectively. The results show that: (1) unsteady aerodynamics has no effect upon the existence of trim points, but affects their stability; (2) unsteady aerodynamics has great effects upon the existence, stability, and amplitudes of periodic solutions; and (3) unsteady aerodynamics changes the stable regions of trim points obviously. Furthermore, the dynamic responses of the aircraft to elevator deflections are inspected. It is shown that the unsteady aerodynamics is beneficial to dynamic stability for the present aircraft. Finally, the effects of unsteady aerodynamics on the post-stall maneuverability展开更多
Our previous study shows that the hovering and forward flight of a bumblebee do not have inherent stability (passive stability). But the bumblebees are observed to fly stably. Stabilization control must have been ap...Our previous study shows that the hovering and forward flight of a bumblebee do not have inherent stability (passive stability). But the bumblebees are observed to fly stably. Stabilization control must have been applied. In this study, we investigate the longitudinal stabilization control of the bumblebee. The method of computational fluid dynamics is used to compute the control derivatives and the techniques of eigenvalue and eigenvector analysis and modal decomposition are used for solving the equations of motion. Controllability analysis shows that at all flight speeds considered, although inherently unstable, the flight is controllable. By feedbacking the state variables, i.e. vertical and horizontal velocities, pitching rate and pitch angle (which can be measured by the sensory system of the insect), to produce changes in stroke angle and angle of attack of the wings, the flight can be stabilized, explaining why the bumblebees can fly stably even if they are passively unstable.展开更多
In the present paper, the lateral dynamic flight stability properties of two hovering model insects are predicted by an approximate theory based on the averaged model, and computed by numerical simulation that solves ...In the present paper, the lateral dynamic flight stability properties of two hovering model insects are predicted by an approximate theory based on the averaged model, and computed by numerical simulation that solves the complete equations of motion coupled with the Naviertokes equations. Comparison between the theoretical and simulational results provides a test to the validity of the assumptions made in the theory. One of the insects is a model dronefly which has relatively high wingbeat frequency (164Hz) and the other is a model hawkmoth which has relatively low wingbeat frequency (26 Hz). The following conclusion has been drawn. The theory based on the averaged model works well for the lateral motion of the dronefly. For the hawkmoth, relatively large quantitative differences exist between theory and simulation. This is because the lateral non-dimensional eigenvalues of the hawkmoth are not very small compared with the non-dimensional flapping frequency (the largest lateral non-dimensional eigenvalue is only about 10% smaller than the non-dimensional flapping frequency). Nevertheless, the theory can still correctly predict variational trends of the dynamic properties of the hawkmoth's lateral motion.展开更多
In order to further optimize welding process of Nb-Ti-Mo microalloyed steel, welding thermal cycles on coarse-grained heat-affected zone (CGHAZ) of welded joints were simulated using Gleeble 1500. The microstructure...In order to further optimize welding process of Nb-Ti-Mo microalloyed steel, welding thermal cycles on coarse-grained heat-affected zone (CGHAZ) of welded joints were simulated using Gleeble 1500. The microstructure and low-temperature impact fracture were investigated using a scanning electron microscope and a pendulum impact machine, respectively. Moreover, the relationship between cooling time ts/5 and the microstructure of CGHAZ was discussed, and the effect of microstructure on impact toughness was also studied. As cooling time increased, martensite fraction decreased from 97.8% (3 s) to 3.0% (60 s). The fraction of martensite/austenite (M/A) constituent increased from 2.2% (3 s) to 39.0% (60 s), its shape changed from granular to strip, and the maximum length increased from 2.4 μm (3 s) to 7.0 μm (60 s). As cooling time increased, the prior austenite grain size increased from 34.0 μm (3 s) to 49.0 gm (60 s), the impact absorption energy reduced from 101.8 J (5 s) to 7.2 J (60 s), and the fracture mechanism changed from quasi-cleavage fracture to cleavage fracture. The decreased toughness of CGHAZ was due to the reduction of lath martensite-content, coarsening of original austenite grain, and increase and coarsening of M/A constituent. The heat input was controlled under 7 kJ cm-1 during actual welding for these steels.展开更多
Background:With the emergence of the COVID-19 pandemic,all existing health protocols were tested under the worst health crisis humanity has experienced since the Black Death in the 14th century.Countries in Latin Amer...Background:With the emergence of the COVID-19 pandemic,all existing health protocols were tested under the worst health crisis humanity has experienced since the Black Death in the 14th century.Countries in Latin America have been the epicenter of the COVID-19 pandemic,with more than 1.5 million people killed.Worldwide health measures have included quarantines,border closures,social distancing,and mask use,among others.In particular,Chile implemented total or partial quarantine measures depending on the number of infections in each region of the country.Therefore,it is necessary to study the effectiveness of these quarantines in relation to the public health measures implemented by government entities at the national level.Objective:The main objective of this study is to analyze the effectiveness of national-and region-level quarantines in Chile during the pandemic based on information published by the Chilean Ministry of Health,and answers to the following question are sought:Were quarantine measures in Chile effective during the COVID-19 pandemic?Methods:The causal effect between the rates of COVID-19 infections and the population rates in Phase 1 and Phase 2 quarantines in the period from March 2020 to March 2021 in different regions of Chile were evaluated using intervention analyses obtained through Bayesian structural time series models.In addition,the Kendall correlation coefficient obtained through the copula approach was used to evaluate the comovement between these rates.Results:In 75%of the Chilean regions under study(12 regions out of a total of 16),an effective Phase 1 quarantine,which was implemented to control and reduce the number of cases of COVID-19 infection,was observed.The main regions that experienced a decrease in cases were those located in the north and center of Chile.Regarding Phase 2,the COVID-19 pandemic was effectively managed in 31%(5 out of 16)of the regions.In the southcentral and extreme southern regions of Chile,the effectiveness of these phases was null.Conclusion:The findings indicate that in the northern and central regions of Chile,the Phase 1 quarantine application period was an effective strategy to prevent an increase in COVID-19 infections.The same observation was made with respect to Phase 2,which was effective in five regions of northern Chile;in the rest of the regions,the effectiveness of these phases was weak or null.展开更多
基金supported by the National Natural Science Foundation of China(11232002)the Ph.D.Student Foundation of Chinese Ministry of Education(30400002011105001)
文摘The forward flight of a model butterfly was stud- ied by simulation using the equations of motion coupled with the Navier-Stokes equations. The model butterfly moved under the action of aerodynamic and gravitational forces, where the aerodynamic forces were generated by flapping wings which moved with the body, allowing the body os- cillations of the model butterfly to be simulated. The main results are as follows: (1) The aerodynamic force produced by the wings is approximately perpendicular to the long-axis of body and is much larger in the downstroke than in the up- stroke. In the downstroke the body pitch angle is small and the large aerodynamic force points up and slightly backward, giving the weight-supporting vertical force and a small neg- ative horizontal force, whilst in the upstroke, the body an- gle is large and the relatively small aerodynamic force points forward and slightly downward, giving a positive horizon- tal force which overcomes the body drag and the negative horizontal force generated in the downstroke. (2) Pitching oscillation of the butterfly body plays an equivalent role of the wing-rotation of many other insects. (3) The body-mass- specific power of the model butterfly is 33.3 W/kg, not very different from that of many other insects, e.g., fruitflies and dragonflies.
基金supported by the Qinghai province natural science foundation project(2015-ZJ-902)the Qinghai province science and technology plan program(2014-NK-A4-4)
文摘Recently, canopy transpiration (Ec) has been often estimated by xylem sap-flow measurements. However, there is a significant time lag between sap flow measured at the base of the stem and canopy transpiration due to the capacitive exchange between the transpiration stream and stem water storage. Significant errors will be introduced in canopy conductance (gc) and canopy transpiration estimation if the time lag is neglected. In this study, a cross-correlation analysis was used to quantify the time lag, and the sap flowbased transpiration was measured to pararneterize Jarvistype models of gc and thus to simulate Ec of Populus cathayana using the Penman-Monteith equation. The results indicate that solar radiation (Rs) and vapor pressure deficit (VPD) are not fully coincident with sap flow and have an obvious lag effect; the sap flow lags behind Rs and precedes VPD, and there is a 1-h time shift between Eo and sap flow in the 30-min interval data set. A parameterized Jarvis-type gc model is suitable to predict P. cathayana transpiration and explains more than 80% of the variation observed in go, and the relative error was less than 25%, which shows a preferable simulation effect. The root mean square error (RMSEs) between the predicted and measured Ec were 1.91×10^-3 (with the time lag) and 3.12×10^-3cm h^-1 (without the time lag). More importantly, Ec simulation precision that incorporates time lag is improved by 6% compared to the results without the time lag, with the mean relative error (MRE) of only 8.32% and the mean absolute error (MAE) of 1.48 × 10^-3 cm h^-1.
基金supported by the National Natural Science Foundation (71301119)the Shanghai Natural Science Foundation (12ZR1434100)
文摘Recent advances in intelligent transportation system allow traffic safety studies to extend from historic data-based analyses to real-time applications. The study presents a new method to predict crash likelihood with traffic data collected by discrete loop detectors as well as the web-crawl weather data. Matched case-control method and support vector machines (SVMs) technique were employed to identify the risk status. The adaptive synthetic over-sampling technique was applied to solve the imbalanced dataset issues. Random forest technique was applied to select the contributing factors and avoid the over-fitting issues. The results indicate that the SVMs classifier could successfully classify 76.32% of the crashes on the test dataset and 87.52% of the crashes on the overall dataset, which were relatively satisfactory compared with the results of the previous studies. Compared with the SVMs classifier without the data, the SVMs classifier with the web-crawl weather data increased the crash prediction accuracy by 1.32% and decreased the false alarm rate by 1.72%, showing the potential value of the massive web weather data. Mean impact value method was employed to evaluate the variable effects, and the results are identical with the results of most of previous studies. The emerging technique based on the discrete traffic data and web weather data proves to be more applicable on real- time safety management on freeways.
基金the National Natural Science Fund(11661058,11761053)Natural Science Fund of Inner Mongolia Autonomous Region(2016MS0102,2017MS0107)+1 种基金Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(NJYT-17-A07)National Undergraduate Innovative Training Project of Inner Mongolia University(201710126026).
文摘In this article,a high-order scheme,which is formulated by combining the quadratic finite element method in space with a second-order time discrete scheme,is developed for looking for the numerical solution of a two-dimensional nonlinear time fractional thermal diffusion model.The time Caputo fractional derivative is approximated by using the L2-1formula,the first-order derivative and nonlinear term are discretized by some second-order approximation formulas,and the quadratic finite element is used to approximate the spatial direction.The error accuracy O(h3+t2)is obtained,which is verified by the numerical results.
基金funded by the following grants:the Forestry Public Welfare Project(201304208)the‘‘948’’Project sponsored by the State Forestry Administration(SFA)of China(2014-4-25)+4 种基金the National Natural Science Foundation of China(31270587,31100414)the PAPD(Priority Academic Program Development)of Jiangsu provincial universitiesperformed while the lead author held a scholarship sponsored the CSC(China Scholarship Council)(201208320553)at the department of Geographical Sciences,University of Marylandawardee of the 2012 Youth Backbone Teachers Support Plan of Jiangsu Provincethe 2012 Youth Talents Support Plan of Nanjing Forestry University
文摘Forest losses or gains have long been recognized as critical processes modulating the carbon flux between the biosphere and the atmosphere. Timely, accurate and spatially explicit information on forest disturbance and recovery history is required for assessing the effectiveness of existing forest management. The major objectives of our research focused on testing the mapping efficacy of the vegetation change tracker (VCT) model over a forested area in China. We used a new version of VCT algorithm built upon the Landsat time series stacks (LTSS). The LTSS consisted of yearly image acquisitions to map forest disturbance history from 1987 to 2011 over the Ning-Zhen Mountains, Jiangsu Province of east China. The LTSS consisted of TM and ETM+ scenes with different projec- tions due to distinct data sources (Beijing remote sensing ground station and the USGS EROS Center). The valida- tion results of the disturbance year maps showed that most spatial agreement measures ranged from 70 to 86 %, comparable with the VCT accuracies reported for many places in USA. Very low accuracies were identified in 1995 (38.3 %) and 1992 (56.2 %) in the current analysis. These resulted from the insensitivity of the VCT algorithm to detect low intensity disturbances and also from the mis- registration errors of the image pairs. Major forest distur- bance types existing in our study area were identified as agricultural expansion (39.8 %), urbanization (24.9 %), forest management practice (19.3 %), and mining (12.8 %). In general, there was a gradual decreasing trend in forest cover throughout this region, caused principally by China's economic, demographic, environmental and political policies and decisions, as well as some weather events. While VCT has largely been used to assess long term changes and trends in the USA, it has great potential for assessing landscape level change elsewhere throughout the world.
基金supported by the National Natural Science Foundation of China,No.81571114 and 81771267(to ZH)the National Science Funds for Distinguished Youth Scholars of China,No.81325007(to XMJ)+2 种基金the Distinguished Professor of Cheung Kong Scholars Program in China,No.T2014251(to XMJ)the Wenzhou Municipal Sci-Tec Bureau Programs in China,No.Y20120154(to ZZ) and Y20140686(to ZH)the Projects of International Cooperation and Exchanges National Natural Science Foundation of China,No.81620108011(to XMJ)
文摘We previously demonstrated that administering 2-(2-benzofuranyl)-2-imidazolin(2-BFI), an imidazoline I2 receptor agonist, immediately after ischemia onset can protect the brain from ischemic insult. However, immediate administration after stroke is difficult to realize in the clinic. Thus, the therapeutic time window of 2-BFI should be determined. Sprague-Dawley rats provided by Wenzhou Medical University in China received right middle cerebral artery occlusion for 120 minutes, and were treated with 2-BFI(3 mg/kg) through the caudal vein at 0, 1, 3, 5, 7, and 9 hours after reperfusion. Neurological function was assessed using the Longa's method. Infarct volume was measured by 2,3,5-triphenyltetrazolium chloride assay. Morphological changes in the cortical penumbra were observed by hematoxylin-eosin staining under transmission electron microscopy. The apoptosis levels in the ipsilateral cortex were examined with terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling(TUNEL) assay. The protein expression of Bcl-2 and BAX was detected using immunohistochemistry. We found the following: Treatment with 2-BFI within 5 hours after reperfusion obviously improved neurological function. Administering 2-BFI within 9 hours after ischemia/reperfusion decreased infarct volume and alleviated apoptosis. 2-BFI administration at different time points after reperfusion alleviated the pathological damage of the ischemic penumbra and reduced the number of apoptotic neurons, but the protective effect was more obvious when administered within 5 hours. Administration of 2-BFI within 5 hours after reperfusion remarkably increased Bcl-2 expression and decreased BAX expression. To conclude, 2-BFI shows potent neuroprotective effects when administered within 5 hours after reperfusion, seemingly by up-regulating Bcl-2 and down-regulating BAX expression. The time window provided clinical potential for ischemic stroke by 2-BFI.
基金China Postdoctotral Foundation and Shanghai Postdoctoral Foundation
文摘This paper deals with the problem of decentralized robustcontrol for a class of interconnected uncertain systemswith state delays.The parameter uncertainties are un-known but norm-bounded.A new sufficient condition isobtained for each subsystem and overall system to be sta-bilizable via linear memoryless state feedback robust de-centralized controllers.The results depend on the size of the delays and are given in terms of linear matrix ine-qualities,so they are less conservative than those of delay-independent.Moreover,matching condition is not a necessary condition.Finally,an example is presented to illustrative the effectiveness of the proposed method.
文摘March is a right party time for friends to get together to enjoy the smell of early spring. Moreover, people would like to take off the thick winter coat to showcase their colorful attitude towards the warm spring sunshine. Here, an annual fashion feast in Beijing not only could provide you a visual inspiration of trend, but also would tell you what’s the most "in" factors in the coming season.
文摘Shaw's method used to correlate 40 sections across the Permo-Triassic boundary in South China is applied in the paper. Two steps are adopted to get an Integral Composite Section (ICS) by synthesizing these data : First , South China is divided into five areas and composite section developed for each area . Then the second step . the Changxing composite section is regarded as a composite standard (CSRS) while the ICS is produced by matching the CSRS with composite sections of the other areas. Three biozones in the Changxingian and two biozones in the Griesbachian can be discerned on the basis of computing Z values in the ICS. These biozones are marked by the Z values which quantitatively represent their time ranges ; therefore , they may increase accuracy of stratigraphic time correlation . The mass extinction at the end of the Permian is an abrupt event that is supported by the relative rate of extinction near the P/T boundary . About 90% of invertebrate species died out by the end of the Permian . The duration of the mass extinction is rather short ,approximately 0.018Ma .
文摘In view of engineering application, it is practicable to decompose the aerodynamics into three components: the static aerodynamics, the aerodynamic increment due to steady rotations, and the aerodynamic increment due to unsteady separated and vortical flow. The first and the second components can be presented in conventional forms, while the third is described using a one-order differential equation and a radial-basis-function (RBF) network. For an aircraft configuration, the mathematical models of 6- component aerodynamic coefficients are set up from the wind tunnel test data of pitch, yaw, roll, and coupled yawroll large-amplitude oscillations. The flight dynamics of an aircraft is studied by the bifurcation analysis technique in the case of quasi-steady aerodynamics and unsteady aerodynam- ics, respectively. The results show that: (1) unsteady aerodynamics has no effect upon the existence of trim points, but affects their stability; (2) unsteady aerodynamics has great effects upon the existence, stability, and amplitudes of periodic solutions; and (3) unsteady aerodynamics changes the stable regions of trim points obviously. Furthermore, the dynamic responses of the aircraft to elevator deflections are inspected. It is shown that the unsteady aerodynamics is beneficial to dynamic stability for the present aircraft. Finally, the effects of unsteady aerodynamics on the post-stall maneuverability
基金the National Natural Science Foundation of China (10732030)
文摘Our previous study shows that the hovering and forward flight of a bumblebee do not have inherent stability (passive stability). But the bumblebees are observed to fly stably. Stabilization control must have been applied. In this study, we investigate the longitudinal stabilization control of the bumblebee. The method of computational fluid dynamics is used to compute the control derivatives and the techniques of eigenvalue and eigenvector analysis and modal decomposition are used for solving the equations of motion. Controllability analysis shows that at all flight speeds considered, although inherently unstable, the flight is controllable. By feedbacking the state variables, i.e. vertical and horizontal velocities, pitching rate and pitch angle (which can be measured by the sensory system of the insect), to produce changes in stroke angle and angle of attack of the wings, the flight can be stabilized, explaining why the bumblebees can fly stably even if they are passively unstable.
基金supported by the National Natural Science Foundation of China (10732030)the Foundation for the Author of National Excellent Doctoral Dissertation (2007B31)
文摘In the present paper, the lateral dynamic flight stability properties of two hovering model insects are predicted by an approximate theory based on the averaged model, and computed by numerical simulation that solves the complete equations of motion coupled with the Naviertokes equations. Comparison between the theoretical and simulational results provides a test to the validity of the assumptions made in the theory. One of the insects is a model dronefly which has relatively high wingbeat frequency (164Hz) and the other is a model hawkmoth which has relatively low wingbeat frequency (26 Hz). The following conclusion has been drawn. The theory based on the averaged model works well for the lateral motion of the dronefly. For the hawkmoth, relatively large quantitative differences exist between theory and simulation. This is because the lateral non-dimensional eigenvalues of the hawkmoth are not very small compared with the non-dimensional flapping frequency (the largest lateral non-dimensional eigenvalue is only about 10% smaller than the non-dimensional flapping frequency). Nevertheless, the theory can still correctly predict variational trends of the dynamic properties of the hawkmoth's lateral motion.
基金This work was financially supported by the National Natural Science Foundation of China (No. 51775102), Open Research Fund from the State Key Laboratory of Roiling and Automation, Northeastern University (No. 2016005) and Project Funded by China Postdoctoral Science Foundation (No. 2016M601877).
文摘In order to further optimize welding process of Nb-Ti-Mo microalloyed steel, welding thermal cycles on coarse-grained heat-affected zone (CGHAZ) of welded joints were simulated using Gleeble 1500. The microstructure and low-temperature impact fracture were investigated using a scanning electron microscope and a pendulum impact machine, respectively. Moreover, the relationship between cooling time ts/5 and the microstructure of CGHAZ was discussed, and the effect of microstructure on impact toughness was also studied. As cooling time increased, martensite fraction decreased from 97.8% (3 s) to 3.0% (60 s). The fraction of martensite/austenite (M/A) constituent increased from 2.2% (3 s) to 39.0% (60 s), its shape changed from granular to strip, and the maximum length increased from 2.4 μm (3 s) to 7.0 μm (60 s). As cooling time increased, the prior austenite grain size increased from 34.0 μm (3 s) to 49.0 gm (60 s), the impact absorption energy reduced from 101.8 J (5 s) to 7.2 J (60 s), and the fracture mechanism changed from quasi-cleavage fracture to cleavage fracture. The decreased toughness of CGHAZ was due to the reduction of lath martensite-content, coarsening of original austenite grain, and increase and coarsening of M/A constituent. The heat input was controlled under 7 kJ cm-1 during actual welding for these steels.
文摘Background:With the emergence of the COVID-19 pandemic,all existing health protocols were tested under the worst health crisis humanity has experienced since the Black Death in the 14th century.Countries in Latin America have been the epicenter of the COVID-19 pandemic,with more than 1.5 million people killed.Worldwide health measures have included quarantines,border closures,social distancing,and mask use,among others.In particular,Chile implemented total or partial quarantine measures depending on the number of infections in each region of the country.Therefore,it is necessary to study the effectiveness of these quarantines in relation to the public health measures implemented by government entities at the national level.Objective:The main objective of this study is to analyze the effectiveness of national-and region-level quarantines in Chile during the pandemic based on information published by the Chilean Ministry of Health,and answers to the following question are sought:Were quarantine measures in Chile effective during the COVID-19 pandemic?Methods:The causal effect between the rates of COVID-19 infections and the population rates in Phase 1 and Phase 2 quarantines in the period from March 2020 to March 2021 in different regions of Chile were evaluated using intervention analyses obtained through Bayesian structural time series models.In addition,the Kendall correlation coefficient obtained through the copula approach was used to evaluate the comovement between these rates.Results:In 75%of the Chilean regions under study(12 regions out of a total of 16),an effective Phase 1 quarantine,which was implemented to control and reduce the number of cases of COVID-19 infection,was observed.The main regions that experienced a decrease in cases were those located in the north and center of Chile.Regarding Phase 2,the COVID-19 pandemic was effectively managed in 31%(5 out of 16)of the regions.In the southcentral and extreme southern regions of Chile,the effectiveness of these phases was null.Conclusion:The findings indicate that in the northern and central regions of Chile,the Phase 1 quarantine application period was an effective strategy to prevent an increase in COVID-19 infections.The same observation was made with respect to Phase 2,which was effective in five regions of northern Chile;in the rest of the regions,the effectiveness of these phases was weak or null.