In this study, several advanced analysis methods are applied to understand the relationships between the Nino-3.4 sea surface temperatures （SST） and the SSTs related to the tropical Indian Ocean Dipole （IOD）. By a...In this study, several advanced analysis methods are applied to understand the relationships between the Nino-3.4 sea surface temperatures （SST） and the SSTs related to the tropical Indian Ocean Dipole （IOD）. By analyzing a long data record, the authors focus on the time-frequency characteristics of these relationships, and of the structure of IOD. They also focus on the seasonal dependence of those characteristics in both time and frequency domains. Among the Nino-3.4 SST, IOD, and SSTs over the tropical western Indian Ocean （WIO） and eastern Indian Ocean （EIO）, the WIO SST has the strongest annual and semiannual oscillations. While the Nino-3.4 SST has large inter-annual variability that is only second to its annual variability, the IOD is characterized by the largest semiannual oscillation, which is even stronger than its annual oscillation. The IOD is strongly and stably related to the EIO SST in a wide range of frequency bands and in all seasons. However, it is less significantly related to the WIO SST in the boreal winter and spring. There exists a generally weak and unstable relationship between the WIO and EIO SSTs, especially in the biennial and higher frequency bands. The relationship is especially weak in summer and fall, when IOD is apparent, but appears highly positive in winter and spring, when the IOD is unimportantly weak and even disappears. This feature reflects a caution in the definition and application of IOD. The Nino-3.4 SST has a strong positive relationship with the WIO SST in all seasons, mainly in the biennial and longer frequency bands. However, it shows no significant relationship with the EIO SST in summer and fall, and with IOD in winter and spring.展开更多
背景:活性氧可能与肌腱病发生、发展密切相关,但其确切作用及相关信号转导机制尚未进行全面总结。目的:综述目前临床或临床前原始研究,对活性氧在肌腱病中的作用及相关信号转导通路进行归纳总结,探究其作用特点以及是否存在统一的下游...背景:活性氧可能与肌腱病发生、发展密切相关,但其确切作用及相关信号转导机制尚未进行全面总结。目的:综述目前临床或临床前原始研究,对活性氧在肌腱病中的作用及相关信号转导通路进行归纳总结,探究其作用特点以及是否存在统一的下游通路。方法:通过计算机对PubMed、Embase、Web of Science以及中国知网、万方、维普数据库中的相关原始研究进行检索,依据入选标准对检索结果进行筛选、排除,最终纳入90篇文献进行综述分析。结果与结论:①活性氧可通过同时作用于肌腱细胞和细胞外基质来影响肌腱愈合方向,其作用方式呈双面作用特点,浓度可能是决定其作用方向的关键,低剂量活性氧可以参与肌腱正常生理愈合活动或肌腱组织具有刺激自适应性可能是产生这种作用特点的内在机制。②活性氧主要是通过基质金属蛋白酶、丝裂原活化蛋白激酶、线粒体凋亡、叉头转录因子O家族、自噬、炎症以及抗氧化信号转导通路,来改变肌腱细胞外基质的组成和结构,影响肌腱细胞正常修复、应对外界和维持生存能力,对肌腱状态造成影响。③不同的活性氧刺激强度、时间以及外在环境可能会造成下游分子通路的不同改变,从而对肌腱产生不同影响。④由于目前纳入的活性氧正、负面作用的考察文献数量差距较大,可能对寻找活性氧在肌腱中作用特点的背后因素造成一定的分析误差;另外由于大多数实验干预条件和关注结果比较单一,具体活性氧的时效、量效机制以及与其他干预因素的协同作用未能明确,也未能构建活性氧在肌腱病中的分子作用整体体系。⑤文章结果表明,活性氧未来或许可以作为一种有利因素参与肌腱病的治疗和预防,并促进之后肌腱病中氧化应激信号转导通路和整体分子作用体系的探索,也为不同抗氧化剂在肌腱病中的治疗策略打下研究基础,以更好地达到防治肌腱损伤变性的目的。展开更多
文摘In this study, several advanced analysis methods are applied to understand the relationships between the Nino-3.4 sea surface temperatures （SST） and the SSTs related to the tropical Indian Ocean Dipole （IOD）. By analyzing a long data record, the authors focus on the time-frequency characteristics of these relationships, and of the structure of IOD. They also focus on the seasonal dependence of those characteristics in both time and frequency domains. Among the Nino-3.4 SST, IOD, and SSTs over the tropical western Indian Ocean （WIO） and eastern Indian Ocean （EIO）, the WIO SST has the strongest annual and semiannual oscillations. While the Nino-3.4 SST has large inter-annual variability that is only second to its annual variability, the IOD is characterized by the largest semiannual oscillation, which is even stronger than its annual oscillation. The IOD is strongly and stably related to the EIO SST in a wide range of frequency bands and in all seasons. However, it is less significantly related to the WIO SST in the boreal winter and spring. There exists a generally weak and unstable relationship between the WIO and EIO SSTs, especially in the biennial and higher frequency bands. The relationship is especially weak in summer and fall, when IOD is apparent, but appears highly positive in winter and spring, when the IOD is unimportantly weak and even disappears. This feature reflects a caution in the definition and application of IOD. The Nino-3.4 SST has a strong positive relationship with the WIO SST in all seasons, mainly in the biennial and longer frequency bands. However, it shows no significant relationship with the EIO SST in summer and fall, and with IOD in winter and spring.
文摘背景:活性氧可能与肌腱病发生、发展密切相关,但其确切作用及相关信号转导机制尚未进行全面总结。目的:综述目前临床或临床前原始研究,对活性氧在肌腱病中的作用及相关信号转导通路进行归纳总结,探究其作用特点以及是否存在统一的下游通路。方法:通过计算机对PubMed、Embase、Web of Science以及中国知网、万方、维普数据库中的相关原始研究进行检索,依据入选标准对检索结果进行筛选、排除,最终纳入90篇文献进行综述分析。结果与结论:①活性氧可通过同时作用于肌腱细胞和细胞外基质来影响肌腱愈合方向,其作用方式呈双面作用特点,浓度可能是决定其作用方向的关键,低剂量活性氧可以参与肌腱正常生理愈合活动或肌腱组织具有刺激自适应性可能是产生这种作用特点的内在机制。②活性氧主要是通过基质金属蛋白酶、丝裂原活化蛋白激酶、线粒体凋亡、叉头转录因子O家族、自噬、炎症以及抗氧化信号转导通路,来改变肌腱细胞外基质的组成和结构,影响肌腱细胞正常修复、应对外界和维持生存能力,对肌腱状态造成影响。③不同的活性氧刺激强度、时间以及外在环境可能会造成下游分子通路的不同改变,从而对肌腱产生不同影响。④由于目前纳入的活性氧正、负面作用的考察文献数量差距较大,可能对寻找活性氧在肌腱中作用特点的背后因素造成一定的分析误差;另外由于大多数实验干预条件和关注结果比较单一,具体活性氧的时效、量效机制以及与其他干预因素的协同作用未能明确,也未能构建活性氧在肌腱病中的分子作用整体体系。⑤文章结果表明,活性氧未来或许可以作为一种有利因素参与肌腱病的治疗和预防,并促进之后肌腱病中氧化应激信号转导通路和整体分子作用体系的探索,也为不同抗氧化剂在肌腱病中的治疗策略打下研究基础,以更好地达到防治肌腱损伤变性的目的。
文摘目的:探讨“冬病夏治”全方配伍和无白芥子配伍延胡索乙素在模型家兔“肺俞”穴皮下药代动力学特征及药代动力学-药效动力学(PK-PD)模型的相关性。方法:支气管哮喘模型家兔随机分成延胡索单方组、缺白芥子组、全方组,微透析技术收集14 h穴位皮下透析液,液相色谱-质谱法(Liquid Chromatography Mass Spectrometry,LCMS)法检测方中君药延胡索主要成分延胡索乙素浓度,获得药代动力学参数;酶联免疫吸附试验(ELISA)法检测对应时间点模型动物血清中IgE水平,获得药效学参数;对药动学、药效学参数进行PK-PD模型拟合。结果:白芥子配伍后的药峰浓度(C_(max))、药时曲线下面积(AUC_(0-t))、平均滞留时间(MRT_(0-t))均显著增加(P<0.01,P<0.01,P<0.05),达峰时间(T_(max))提前(P<0.01);“浓度-时间-效应”三维曲线表明,方中有白芥子配伍时,药效出现更快、消退更慢,起效时间晚于峰浓度,具有一定滞后性。结论:动力学参数、PK-PD模型结果表明,白芥子配伍能够改变“方中君药”——延胡索的主要成分延胡索乙素穴位局部的皮下分布,促进方中君药有效成分快速吸收,延长滞留时间,在方剂中起到主药、改善其他药物分布的“双重”作用。
