The time-varying autoregressive (TVAR) modeling of a non-stationary signal is studied. In the proposed method, time-varying parametric identification of a non-stationary signal can be translated into a linear time-i...The time-varying autoregressive (TVAR) modeling of a non-stationary signal is studied. In the proposed method, time-varying parametric identification of a non-stationary signal can be translated into a linear time-invariant problem by introducing a set of basic functions. Then, the parameters are estimated by using a recursive least square algorithm with a forgetting factor and an adaptive time-frequency distribution is achieved. The simulation results show that the proposed approach is superior to the short-time Fourier transform and Wigner distribution. And finally, the proposed method is applied to the fault diagnosis of a bearing , and the experiment result shows that the proposed method is effective in feature extraction.展开更多
Fast wavelet multi-resolution analysis (wavelet MRA) provides a effective tool for analyzing and canceling disturbing components in original signal. Because of its exponential frequency axis, this method isn't s...Fast wavelet multi-resolution analysis (wavelet MRA) provides a effective tool for analyzing and canceling disturbing components in original signal. Because of its exponential frequency axis, this method isn't suitable for extracting harmonic components. The modified exponential time-frequency distribution ( MED) overcomes the problems of Wigner distribution( WD) ,can suppress cross-terms and cancel noise further more. MED provides high resolution in both time and frequency domains, so it can make out weak period impulse components fmm signal with mighty harmonic components. According to the 'time' behavior, together with 'frequency' behavior in one figure,the essential structure of a signal is revealed clearly. According to the analysis of algorithm and fault diagnosis example, the joint of wavelet MRA and MED is a powerful tool for fault diagnosis.展开更多
This paper introduces the localized Radon transform (LRT) into time-frequency distributions and presents the localized Radon-Wigner transform (LRWT). The definition of LRWT and a fast algorithm is derived, the propert...This paper introduces the localized Radon transform (LRT) into time-frequency distributions and presents the localized Radon-Wigner transform (LRWT). The definition of LRWT and a fast algorithm is derived, the properties of LRWT and its relationship with Radon-Wigner transform, Wigner distribution (WD), ambiguity function (AF), and generalized-marginal time-frequency distributions are analyzed.展开更多
A new quadratic time-frequency distribution (TFD) with a compound kernel is proposed and a comparative study of several popular quadratic TFD is carried out. It is shown that the new TFD with compound kernel has stron...A new quadratic time-frequency distribution (TFD) with a compound kernel is proposed and a comparative study of several popular quadratic TFD is carried out. It is shown that the new TFD with compound kernel has stronger ability than the exponential distribution (ED) and the cone-shaped kernel distribution (CKD) in reducing cross terms, meanwhile almost not decreasing the time-frequency resolution of ED or CKD.展开更多
Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating method.In this work,we found these two pre-crystallization proces...Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating method.In this work,we found these two pre-crystallization processes lead to different order of crystallization dynamics within the perovskite thin film,resulting in the differences of additive distribution.We then tailor-designed an additive molecule named 1,3-bis(4-methoxyphenyl)thiourea to obtain films with fewer defects and holes at the buried interface,and prepared perovskite solar cells with a certified efficiency of 23.75%.Furthermore,this work also demonstrates an efficiency of 20.18%for the large-area perovskite solar module(PSM)with an aperture area of 60.84 cm^(2).The PSM possesses remarkable continuous operation stability for maximum power point tracking of T_(90)>1000 h in ambient air.展开更多
The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin a...The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin are expressed in mammalian brains.This has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small animals.Understanding this issue is critical for elucidating the in vivo roles of PINK1 and Parkin.Recently,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate brain.In the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate brain.We found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey brains.PINK1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable distribution.Immunofluorescent double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial stress.These findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.展开更多
BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various diseases.AIM To explore the association between pretreatment RDW and short-term outcomes after laparoscopi...BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various diseases.AIM To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively analyzed.Correlations between pretreatment RDW and clinicopathological characteristics and short-term outcomes were investigated.RESULTS Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal RDW.High pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,P<0.001)and severe POCs of grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,P<0.001)based on the Clavien-Dino classification system.Subgroup analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe hemorrhage.High pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional index.CONCLUSION Pretreatment RDW was a special parameter for patients who underwent LPD.It was associated with malnutrition,severe inflammatory status and poorer short-term outcomes.RDW could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.展开更多
Wigner-Ville distribution (WVD) is recognized as being a powerful tool and a nucleus in time-frequency representation (TFR) which gives an excellent time-frequency concentration, and more importantly, has many desirab...Wigner-Ville distribution (WVD) is recognized as being a powerful tool and a nucleus in time-frequency representation (TFR) which gives an excellent time-frequency concentration, and more importantly, has many desirable properties. A major shortcoming of WVD is the inherent cross-term (CT) interference. Although solutions to this problem from the bulk of contributions to the literature concerning TFR are currently available, none has been able to completely eliminate the CT’s in WVD. It is therefore a common belief that if there exists an auxiliary time-frequency distribution (TFD) which has the same auto-terms (AT’s) as that in WVD, but has CT’s with the opposite sign, then, by adding the auxiliary TFD to WVD, an ideal TFD, which preserves the concentration of WVD while annihilating the CT’s, is readily obtained. However, we prove that the auxiliary TFD does not exist. Moreover, it is found that in general, CT free joint distributions with their concentrations close to that of WVD do not exist either.展开更多
The striations of the reverberation spectrum in the time-frequency distribution were observed in a shallow water acoustic experiment in 2002. A model following the coherent reverberation model developed in 2002 is pre...The striations of the reverberation spectrum in the time-frequency distribution were observed in a shallow water acoustic experiment in 2002. A model following the coherent reverberation model developed in 2002 is presented to explain the observed striations. To examine the consistency between the measured data and numerical predictions, we have used a method based on Radon transform for determining the slope of the striations to the measured reverberation data and numerical predictions. The results indicate that the previously developed coherent reverberation model can predict the interference structure of the reverberation intensity in the time-frequency distribution.展开更多
This work demonstrates the use of the nonlinear time-frequency distribution (NLTFD) of a discrete time energy operator (DTEO) based on amplitude modulation-frequency modulation demodulation techniques as a feature i...This work demonstrates the use of the nonlinear time-frequency distribution (NLTFD) of a discrete time energy operator (DTEO) based on amplitude modulation-frequency modulation demodulation techniques as a feature in speech recognition. The duration distribution based hidden Markov module in a speaker independent large vocabulary mandarin speech recognition system was reconstructed from the feature vectors in the front-end detection stage. The goal was to improve the performance of the existing system by combining new features to the baseline feature vector. This paper also deals with errors associated with using a pre-emphasis filter in the front end processing of the present scheme, which causes an increase in the noise energy at high frequencies above 4 kHz and in some cases degrades the recognition accuracy. The experimental results show that eliminating the pre-emphasis filters from the pre-processing stage and using NLTFD with compensated DTEO combined with Mel frequency cepstrum components give a 21.95% reduction in the relative error rate compared to the conventional technique with 25 candidates used in the test.展开更多
An improved exponential time-frequency distribution is presented. Compared with those exponential time-frequency distributions represented by the Choi-Williams distribution, this distribution is designed to suit the p...An improved exponential time-frequency distribution is presented. Compared with those exponential time-frequency distributions represented by the Choi-Williams distribution, this distribution is designed to suit the properties of mechanical vibration signals, and is easier to be applied in the mechanical vibration signal processing. It has a strong cross-term suppression ability and is aliasing free.展开更多
In recent years, the coastal region of Southeast China has witnessed a significant increase in the frequency and intensity of extreme rainfall events associated with landfalling typhoons. The hilly and mountainous ter...In recent years, the coastal region of Southeast China has witnessed a significant increase in the frequency and intensity of extreme rainfall events associated with landfalling typhoons. The hilly and mountainous terrain of this area, combined with rapid rainfall accumulation, has led to a surge in flash floods and severe geological hazards. On August 10, 2019, Typhoon Lekima made landfall in Zhejiang Province, China, and its torrential rainfall triggered extensive landslides, resulting in substantial damage and economic losses. Utilizing high-resolution satellite images, we compiled a landslide inventory of the affected area, which comprises a total of 2,774 rainfallinduced landslides over an area of 2965 km2. The majority of these landslides were small to mediumsized and exhibited elongated, clustered patterns. Some landslides displayed characteristics of high-level initiation, obstructing or partially blocking rivers, leading to the formation of debris dams. We used the inventory to analyze the distribution pattern of the landslides and their relationship with topographical, geological, and hydrological factors. The results showed that landslide abundance was closely related to elevation, slope angle, faults, and road density. The landslides were predominantly located in hilly and low mountainous areas, with elevations ranging from 150 to 300 m, slopes of 20 to 30 degrees, and a NE-SE aspect. Notably, we observed the highest Landslide Number Density(LND) and Landslide Area Percentage(LAP) in the rhyolite region. Landslides were concentrated within approximately 4 km on either side of fault zones, with their size and frequency negatively correlated with distances to faults, roads, and river systems. Furthermore, under the influence of typhoons, regions with denser vegetation cover exhibited higher landslide density, reaching maximum values in shrubland areas. In areas experiencing significantly increased concentrated rainfall, landslide density also showed a corresponding rise. In terms of spatial distribution, the rainfall-triggered landslides primarily occurred in the northeastern part of the study area, particularly in regions characterized by complex topography such as Shanzao Village in Yantan Town, Xixia Township, and Shangzhang Township. The research findings offer crucial data on the rainfallinduced landslides triggered by Typhoon Lekima, shedding light on their spatial distribution patterns. These findings provide valuable references for mitigating risks and planning reconstruction in typhoon-affected area.展开更多
BACKGROUND For compensated advanced chronic liver disease(cACLD)patients,the first decompensation represents a dramatically worsening prognostic event.Based on the first decompensation event(DE),the transition to deco...BACKGROUND For compensated advanced chronic liver disease(cACLD)patients,the first decompensation represents a dramatically worsening prognostic event.Based on the first decompensation event(DE),the transition to decompensated advanced chronic liver disease(dACLD)can occur through two modalities referred to as acute decompensation(AD)and non-AD(NAD),respectively.Clinically Significant Portal Hypertension(CSPH)is considered the strongest predictor of decompensation in these patients.However,due to its invasiveness and costs,CSPH is almost never evaluated in clinical practice.Therefore,recognizing noninvasively predicting tools still have more appeal across healthcare systems.The red cell distribution width to platelet ratio(RPR)has been reported to be an indicator of hepatic fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD).However,its predictive role for the decompensation has never been explored.AIM In this observational study,we investigated the clinical usage of RPR in predicting DEs in MASLD-related cACLD patients.METHODS Fourty controls and 150 MASLD-cACLD patients were consecutively enrolled and followed up(FUP)semiannually for 3 years.At baseline,biochemical,clinical,and Liver Stiffness Measurement(LSM),Child-Pugh(CP),Model for End-Stage Liver Disease(MELD),aspartate aminotransferase/platelet count ratio index(APRI),Fibrosis-4(FIB-4),Albumin-Bilirubin(ALBI),ALBI-FIB-4,and RPR were collected.During FUP,DEs(timing and modaities)were recorded.CSPH was assessed at the baseline and on DE occurrence according to the available Clinical Practice Guidelines.RESULTS Of 150 MASLD-related cACLD patients,43(28.6%)progressed to dACLD at a median time of 28.9 months(29 NAD and 14 AD).Baseline RPR values were significantly higher in cACLD in comparison to controls,as well as MELD,CP,APRI,FIB-4,ALBI,ALBI-FIB-4,and LSM in dACLD-progressing compared to cACLD individuals[all P<0.0001,except for FIB-4(P:0.007)and ALBI(P:0.011)].Receiving operator curve analysis revealed RPR>0.472 and>0.894 as the best cut-offs in the prediction respectively of 3-year first DE,as well as its superiority compared to the other non-invasive tools examined.RPR(P:0.02)and the presence of baseline-CSPH(P:0.04)were significantly and independently associated with the DE.Patients presenting baseline-CSPH and RPR>0.472 showed higher risk of decompensation(P:0.0023).CONCLUSION Altogether these findings suggest the RPR as a valid and potentially applicable non-invasive tool in the prediction of timing and modalities of decompensation in MASLD-related cACLD patients.展开更多
Background: It is crucial to assess the severity of acute cholangitis(AC). There are currently several prognostic markers. However, the accuracies of these markers are not satisfied. The present study aimed to investi...Background: It is crucial to assess the severity of acute cholangitis(AC). There are currently several prognostic markers. However, the accuracies of these markers are not satisfied. The present study aimed to investigate the predictive value of the red cell distribution width(RDW)-to-albumin ratio(RAR) for the prognosis of AC. Methods: We retrospectively evaluated consecutive patients diagnosed with AC between May 2019 and March 2022. RAR was calculated, and its predictive ability for in-hospital mortality, intensive care unit(ICU) admission, bacteremia, and the length of hospitalization were analyzed. Results: Out of 438 patients, 34(7.8%) died. Multivariate analysis showed that malignant etiology [odds ratio(OR) = 4.816, 95% confidence interval(CI): 1.936-11.980], creatinine(OR = 1.649, 95% CI: 1.095-2.484), and RAR(OR = 2.064, 95% CI: 1.494-2.851) were independent risk factors for mortality. When adjusted for relevant covariates, including age, sex, malignant etiology, Tokyo severity grading(TSG), Charlson comorbidity index, and creatinine, RAR significantly predicted mortality(adjusted OR = 1.833, 95% CI: 1.280-2.624). When the cut-off of RAR was set to 3.8, its sensitivity and specificity for mortality were 94.1% and 56.7%, respectively. Patients with an RAR of > 3.8 had a 20.9-fold(OR = 20.9, 95% CI: 4.9-88.6) greater risk of mortality than the remaining patients. The area under the curve value of RAR for mortality was 0.835(95% CI: 0.770-0.901), which was significantly higher than that of TSG and the other prognostic markers, such as C-reactive protein-to-albumin ratio, and procalcitonin-to-albumin ratio. Lastly, RAR was not inferior to TSG in predicting ICU admission, bacteremia, and the length of hospitalization. Conclusions: RAR successfully predicted the in-hospital mortality, ICU admission, bacteremia, and the length of hospitalization of patients with AC, especially in-hospital mortality. RAR is a promising marker that is more convenient than TSG and other prognostic markers for predicting the prognosis of patients with AC.展开更多
A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long process...A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber principle.This method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined RAM.The performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data transmission.The experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 mm.The beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction method.The online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.展开更多
With the current integration of distributed energy resources into the grid,the structure of distribution networks is becoming more complex.This complexity significantly expands the solution space in the optimization p...With the current integration of distributed energy resources into the grid,the structure of distribution networks is becoming more complex.This complexity significantly expands the solution space in the optimization process for network reconstruction using intelligent algorithms.Consequently,traditional intelligent algorithms frequently encounter insufficient search accuracy and become trapped in local optima.To tackle this issue,a more advanced particle swarm optimization algorithm is proposed.To address the varying emphases at different stages of the optimization process,a dynamic strategy is implemented to regulate the social and self-learning factors.The Metropolis criterion is introduced into the simulated annealing algorithm to occasionally accept suboptimal solutions,thereby mitigating premature convergence in the population optimization process.The inertia weight is adjusted using the logistic mapping technique to maintain a balance between the algorithm’s global and local search abilities.The incorporation of the Pareto principle involves the consideration of network losses and voltage deviations as objective functions.A fuzzy membership function is employed for selecting the results.Simulation analysis is carried out on the restructuring of the distribution network,using the IEEE-33 node system and the IEEE-69 node system as examples,in conjunction with the integration of distributed energy resources.The findings demonstrate that,in comparison to other intelligent optimization algorithms,the proposed enhanced algorithm demonstrates a shorter convergence time and effectively reduces active power losses within the network.Furthermore,it enhances the amplitude of node voltages,thereby improving the stability of distribution network operations and power supply quality.Additionally,the algorithm exhibits a high level of generality and applicability.展开更多
Predicting the time-varying auto-spectral density of a spacecraft in high-altitude orbits requires an accurate model for the non-stationary random vibration signals with densely spaced modal frequency. The traditional...Predicting the time-varying auto-spectral density of a spacecraft in high-altitude orbits requires an accurate model for the non-stationary random vibration signals with densely spaced modal frequency. The traditional time-varying algorithm limits prediction accuracy, thus affecting a number of operational decisions. To solve this problem, a time-varying auto regressive (TVAR) model based on the process neural network (PNN) and the empirical mode decomposition (EMD) is proposed. The time-varying system is tracked on-line by establishing a time-varying parameter model, and then the relevant parameter spectrum is obtained. Firstly, the EMD method is utilized to decompose the signal into several intrinsic mode functions (IMFs). Then for each IMF, the PNN is established and the time-varying auto-spectral density is obtained. Finally, the time-frequency distribution of the signals can be reconstructed by linear superposition. The simulation and the analytical results from an example demonstrate that this approach possesses simplicity, effectiveness, and feasibility, as well as higher frequency resolution.展开更多
The conventional linear time-frequency analysis method cannot achieve high resolution and energy focusing in the time and frequency dimensions at the same time,especially in the low frequency region.In order to improv...The conventional linear time-frequency analysis method cannot achieve high resolution and energy focusing in the time and frequency dimensions at the same time,especially in the low frequency region.In order to improve the resolution of the linear time-frequency analysis method in the low-frequency region,we have proposed a W transform method,in which the instantaneous frequency is introduced as a parameter into the linear transformation,and the analysis time window is constructed which matches the instantaneous frequency of the seismic data.In this paper,the W transform method is compared with the Wigner-Ville distribution(WVD),a typical nonlinear time-frequency analysis method.The WVD method that shows the energy distribution in the time-frequency domain clearly indicates the gravitational center of time and the gravitational center of frequency of a wavelet,while the time-frequency spectrum of the W transform also has a clear gravitational center of energy focusing,because the instantaneous frequency corresponding to any time position is introduced as the transformation parameter.Therefore,the W transform can be benchmarked directly by the WVD method.We summarize the development of the W transform and three improved methods in recent years,and elaborate on the evolution of the standard W transform,the chirp-modulated W transform,the fractional-order W transform,and the linear canonical W transform.Through three application examples of W transform in fluvial sand body identification and reservoir prediction,it is verified that W transform can improve the resolution and energy focusing of time-frequency spectra.展开更多
BACKGROUND Previous studies have reported that low hematocrit levels indicate poor survival in patients with ovarian cancer and cervical cancer,the prognostic value of hematocrit for colorectal cancer(CRC)patients has...BACKGROUND Previous studies have reported that low hematocrit levels indicate poor survival in patients with ovarian cancer and cervical cancer,the prognostic value of hematocrit for colorectal cancer(CRC)patients has not been determined.The prognostic value of red blood cell distribution width(RDW)for CRC patients was controversial.AIM To investigate the impact of RDW and hematocrit on the short-term outcomes and long-term prognosis of CRC patients who underwent radical surgery.METHODS Patients who were diagnosed with CRC and underwent radical CRC resection between January 2011 and January 2020 at a single clinical center were included.The short-term outcomes,overall survival(OS)and disease-free survival(DFS)were compared among the different groups.Cox analysis was also conducted to identify independent risk factors for OS and DFS.RESULTS There were 4258 CRC patients who underwent radical surgery included in our study.A total of 1573 patients were in the lower RDW group and 2685 patients were in the higher RDW group.There were 2166 and 2092 patients in the higher hematocrit group and lower hematocrit group,respectively.Patients in the higher RDW group had more intraoperative blood loss(P<0.01)and more overall complications(P<0.01)than did those in the lower RDW group.Similarly,patients in the lower hematocrit group had more intraoperative blood loss(P=0.012),longer hospital stay(P=0.016)and overall complications(P<0.01)than did those in the higher hematocrit group.The higher RDW group had a worse OS and DFS than did the lower RDW group for tumor node metastasis(TNM)stage I(OS,P<0.05;DFS,P=0.001)and stage II(OS,P=0.004;DFS,P=0.01)than the lower RDW group;the lower hematocrit group had worse OS and DFS for TNM stage II(OS,P<0.05;DFS,P=0.001)and stage III(OS,P=0.001;DFS,P=0.001)than did the higher hematocrit group.Preoperative hematocrit was an independent risk factor for OS[P=0.017,hazard ratio(HR)=1.256,95%confidence interval(CI):1.041-1.515]and DFS(P=0.035,HR=1.194,95%CI:1.013-1.408).CONCLUSION A higher preoperative RDW and lower hematocrit were associated with more postoperative complications.However,only hematocrit was an independent risk factor for OS and DFS in CRC patients who underwent radical surgery,while RDW was not.展开更多
基金This paper is supported by National Natural Science Foundation of China under Grant No.50675209 InnovationFund for Outstanding Scholar of Henan Province under Grant No. 0621000500
文摘The time-varying autoregressive (TVAR) modeling of a non-stationary signal is studied. In the proposed method, time-varying parametric identification of a non-stationary signal can be translated into a linear time-invariant problem by introducing a set of basic functions. Then, the parameters are estimated by using a recursive least square algorithm with a forgetting factor and an adaptive time-frequency distribution is achieved. The simulation results show that the proposed approach is superior to the short-time Fourier transform and Wigner distribution. And finally, the proposed method is applied to the fault diagnosis of a bearing , and the experiment result shows that the proposed method is effective in feature extraction.
文摘Fast wavelet multi-resolution analysis (wavelet MRA) provides a effective tool for analyzing and canceling disturbing components in original signal. Because of its exponential frequency axis, this method isn't suitable for extracting harmonic components. The modified exponential time-frequency distribution ( MED) overcomes the problems of Wigner distribution( WD) ,can suppress cross-terms and cancel noise further more. MED provides high resolution in both time and frequency domains, so it can make out weak period impulse components fmm signal with mighty harmonic components. According to the 'time' behavior, together with 'frequency' behavior in one figure,the essential structure of a signal is revealed clearly. According to the analysis of algorithm and fault diagnosis example, the joint of wavelet MRA and MED is a powerful tool for fault diagnosis.
文摘This paper introduces the localized Radon transform (LRT) into time-frequency distributions and presents the localized Radon-Wigner transform (LRWT). The definition of LRWT and a fast algorithm is derived, the properties of LRWT and its relationship with Radon-Wigner transform, Wigner distribution (WD), ambiguity function (AF), and generalized-marginal time-frequency distributions are analyzed.
文摘A new quadratic time-frequency distribution (TFD) with a compound kernel is proposed and a comparative study of several popular quadratic TFD is carried out. It is shown that the new TFD with compound kernel has stronger ability than the exponential distribution (ED) and the cone-shaped kernel distribution (CKD) in reducing cross terms, meanwhile almost not decreasing the time-frequency resolution of ED or CKD.
基金supported by National Natural Science Foundation of China(62104082)Guangdong Basic and Applied Basic Research Foundation(2022A1515010746,2022A1515011228,and 2022B1515120006)the Science and Technology Program of Guangzhou(202201010458).
文摘Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating method.In this work,we found these two pre-crystallization processes lead to different order of crystallization dynamics within the perovskite thin film,resulting in the differences of additive distribution.We then tailor-designed an additive molecule named 1,3-bis(4-methoxyphenyl)thiourea to obtain films with fewer defects and holes at the buried interface,and prepared perovskite solar cells with a certified efficiency of 23.75%.Furthermore,this work also demonstrates an efficiency of 20.18%for the large-area perovskite solar module(PSM)with an aperture area of 60.84 cm^(2).The PSM possesses remarkable continuous operation stability for maximum power point tracking of T_(90)>1000 h in ambient air.
基金supported by the National Natural Science Foundation of China,Nos.32070534(to WY),32370567(to WY),82371874(to XL),81830032(to XL),82071421(to SL)Key Field Research and Development Program of Guangdong Province,No.2018B030337001(to XL)+2 种基金Guangzhou Key Research Program on Brain Science,No.202007030008(to XL)Department of Science and Technology of Guangdong Province,Nos.2021ZT09Y007,2020B121201006(to XL)Guangdong Basic and Applied Basic Research Foundation,Nos.2022A1515012301(to WY),2023B1515020031(to WY).
文摘The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin are expressed in mammalian brains.This has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small animals.Understanding this issue is critical for elucidating the in vivo roles of PINK1 and Parkin.Recently,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate brain.In the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate brain.We found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey brains.PINK1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable distribution.Immunofluorescent double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial stress.These findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.
基金Supported by the National Natural Science Foundation of China,No.81302124.
文摘BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various diseases.AIM To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively analyzed.Correlations between pretreatment RDW and clinicopathological characteristics and short-term outcomes were investigated.RESULTS Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal RDW.High pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,P<0.001)and severe POCs of grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,P<0.001)based on the Clavien-Dino classification system.Subgroup analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe hemorrhage.High pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional index.CONCLUSION Pretreatment RDW was a special parameter for patients who underwent LPD.It was associated with malnutrition,severe inflammatory status and poorer short-term outcomes.RDW could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.
基金This work was supported by the National Natural Science Foundation of China (Grant No. 60172026)the Basic Research Foundation of Tsinghua University (Grant No. JC2001028) and the Scientific Innovation Foundation of Ph. D. Candidates of Tsinghua Uni
文摘Wigner-Ville distribution (WVD) is recognized as being a powerful tool and a nucleus in time-frequency representation (TFR) which gives an excellent time-frequency concentration, and more importantly, has many desirable properties. A major shortcoming of WVD is the inherent cross-term (CT) interference. Although solutions to this problem from the bulk of contributions to the literature concerning TFR are currently available, none has been able to completely eliminate the CT’s in WVD. It is therefore a common belief that if there exists an auxiliary time-frequency distribution (TFD) which has the same auto-terms (AT’s) as that in WVD, but has CT’s with the opposite sign, then, by adding the auxiliary TFD to WVD, an ideal TFD, which preserves the concentration of WVD while annihilating the CT’s, is readily obtained. However, we prove that the auxiliary TFD does not exist. Moreover, it is found that in general, CT free joint distributions with their concentrations close to that of WVD do not exist either.
基金supported by the National Natural Science Foundation of China (Grant No. 10734100)
文摘The striations of the reverberation spectrum in the time-frequency distribution were observed in a shallow water acoustic experiment in 2002. A model following the coherent reverberation model developed in 2002 is presented to explain the observed striations. To examine the consistency between the measured data and numerical predictions, we have used a method based on Radon transform for determining the slope of the striations to the measured reverberation data and numerical predictions. The results indicate that the previously developed coherent reverberation model can predict the interference structure of the reverberation intensity in the time-frequency distribution.
基金the National High- Tech Research andDevelopm ent Program of China(No. 2 0 0 1AA114 0 71)
文摘This work demonstrates the use of the nonlinear time-frequency distribution (NLTFD) of a discrete time energy operator (DTEO) based on amplitude modulation-frequency modulation demodulation techniques as a feature in speech recognition. The duration distribution based hidden Markov module in a speaker independent large vocabulary mandarin speech recognition system was reconstructed from the feature vectors in the front-end detection stage. The goal was to improve the performance of the existing system by combining new features to the baseline feature vector. This paper also deals with errors associated with using a pre-emphasis filter in the front end processing of the present scheme, which causes an increase in the noise energy at high frequencies above 4 kHz and in some cases degrades the recognition accuracy. The experimental results show that eliminating the pre-emphasis filters from the pre-processing stage and using NLTFD with compensated DTEO combined with Mel frequency cepstrum components give a 21.95% reduction in the relative error rate compared to the conventional technique with 25 candidates used in the test.
文摘An improved exponential time-frequency distribution is presented. Compared with those exponential time-frequency distributions represented by the Choi-Williams distribution, this distribution is designed to suit the properties of mechanical vibration signals, and is easier to be applied in the mechanical vibration signal processing. It has a strong cross-term suppression ability and is aliasing free.
基金supported by National Natural Science Foundation of China (42277136)Natural Science Research Project of Anhui Educational Committee (2023AH030041)National Key Research and Development Program of China (2021YFB3901205)。
文摘In recent years, the coastal region of Southeast China has witnessed a significant increase in the frequency and intensity of extreme rainfall events associated with landfalling typhoons. The hilly and mountainous terrain of this area, combined with rapid rainfall accumulation, has led to a surge in flash floods and severe geological hazards. On August 10, 2019, Typhoon Lekima made landfall in Zhejiang Province, China, and its torrential rainfall triggered extensive landslides, resulting in substantial damage and economic losses. Utilizing high-resolution satellite images, we compiled a landslide inventory of the affected area, which comprises a total of 2,774 rainfallinduced landslides over an area of 2965 km2. The majority of these landslides were small to mediumsized and exhibited elongated, clustered patterns. Some landslides displayed characteristics of high-level initiation, obstructing or partially blocking rivers, leading to the formation of debris dams. We used the inventory to analyze the distribution pattern of the landslides and their relationship with topographical, geological, and hydrological factors. The results showed that landslide abundance was closely related to elevation, slope angle, faults, and road density. The landslides were predominantly located in hilly and low mountainous areas, with elevations ranging from 150 to 300 m, slopes of 20 to 30 degrees, and a NE-SE aspect. Notably, we observed the highest Landslide Number Density(LND) and Landslide Area Percentage(LAP) in the rhyolite region. Landslides were concentrated within approximately 4 km on either side of fault zones, with their size and frequency negatively correlated with distances to faults, roads, and river systems. Furthermore, under the influence of typhoons, regions with denser vegetation cover exhibited higher landslide density, reaching maximum values in shrubland areas. In areas experiencing significantly increased concentrated rainfall, landslide density also showed a corresponding rise. In terms of spatial distribution, the rainfall-triggered landslides primarily occurred in the northeastern part of the study area, particularly in regions characterized by complex topography such as Shanzao Village in Yantan Town, Xixia Township, and Shangzhang Township. The research findings offer crucial data on the rainfallinduced landslides triggered by Typhoon Lekima, shedding light on their spatial distribution patterns. These findings provide valuable references for mitigating risks and planning reconstruction in typhoon-affected area.
文摘BACKGROUND For compensated advanced chronic liver disease(cACLD)patients,the first decompensation represents a dramatically worsening prognostic event.Based on the first decompensation event(DE),the transition to decompensated advanced chronic liver disease(dACLD)can occur through two modalities referred to as acute decompensation(AD)and non-AD(NAD),respectively.Clinically Significant Portal Hypertension(CSPH)is considered the strongest predictor of decompensation in these patients.However,due to its invasiveness and costs,CSPH is almost never evaluated in clinical practice.Therefore,recognizing noninvasively predicting tools still have more appeal across healthcare systems.The red cell distribution width to platelet ratio(RPR)has been reported to be an indicator of hepatic fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD).However,its predictive role for the decompensation has never been explored.AIM In this observational study,we investigated the clinical usage of RPR in predicting DEs in MASLD-related cACLD patients.METHODS Fourty controls and 150 MASLD-cACLD patients were consecutively enrolled and followed up(FUP)semiannually for 3 years.At baseline,biochemical,clinical,and Liver Stiffness Measurement(LSM),Child-Pugh(CP),Model for End-Stage Liver Disease(MELD),aspartate aminotransferase/platelet count ratio index(APRI),Fibrosis-4(FIB-4),Albumin-Bilirubin(ALBI),ALBI-FIB-4,and RPR were collected.During FUP,DEs(timing and modaities)were recorded.CSPH was assessed at the baseline and on DE occurrence according to the available Clinical Practice Guidelines.RESULTS Of 150 MASLD-related cACLD patients,43(28.6%)progressed to dACLD at a median time of 28.9 months(29 NAD and 14 AD).Baseline RPR values were significantly higher in cACLD in comparison to controls,as well as MELD,CP,APRI,FIB-4,ALBI,ALBI-FIB-4,and LSM in dACLD-progressing compared to cACLD individuals[all P<0.0001,except for FIB-4(P:0.007)and ALBI(P:0.011)].Receiving operator curve analysis revealed RPR>0.472 and>0.894 as the best cut-offs in the prediction respectively of 3-year first DE,as well as its superiority compared to the other non-invasive tools examined.RPR(P:0.02)and the presence of baseline-CSPH(P:0.04)were significantly and independently associated with the DE.Patients presenting baseline-CSPH and RPR>0.472 showed higher risk of decompensation(P:0.0023).CONCLUSION Altogether these findings suggest the RPR as a valid and potentially applicable non-invasive tool in the prediction of timing and modalities of decompensation in MASLD-related cACLD patients.
文摘Background: It is crucial to assess the severity of acute cholangitis(AC). There are currently several prognostic markers. However, the accuracies of these markers are not satisfied. The present study aimed to investigate the predictive value of the red cell distribution width(RDW)-to-albumin ratio(RAR) for the prognosis of AC. Methods: We retrospectively evaluated consecutive patients diagnosed with AC between May 2019 and March 2022. RAR was calculated, and its predictive ability for in-hospital mortality, intensive care unit(ICU) admission, bacteremia, and the length of hospitalization were analyzed. Results: Out of 438 patients, 34(7.8%) died. Multivariate analysis showed that malignant etiology [odds ratio(OR) = 4.816, 95% confidence interval(CI): 1.936-11.980], creatinine(OR = 1.649, 95% CI: 1.095-2.484), and RAR(OR = 2.064, 95% CI: 1.494-2.851) were independent risk factors for mortality. When adjusted for relevant covariates, including age, sex, malignant etiology, Tokyo severity grading(TSG), Charlson comorbidity index, and creatinine, RAR significantly predicted mortality(adjusted OR = 1.833, 95% CI: 1.280-2.624). When the cut-off of RAR was set to 3.8, its sensitivity and specificity for mortality were 94.1% and 56.7%, respectively. Patients with an RAR of > 3.8 had a 20.9-fold(OR = 20.9, 95% CI: 4.9-88.6) greater risk of mortality than the remaining patients. The area under the curve value of RAR for mortality was 0.835(95% CI: 0.770-0.901), which was significantly higher than that of TSG and the other prognostic markers, such as C-reactive protein-to-albumin ratio, and procalcitonin-to-albumin ratio. Lastly, RAR was not inferior to TSG in predicting ICU admission, bacteremia, and the length of hospitalization. Conclusions: RAR successfully predicted the in-hospital mortality, ICU admission, bacteremia, and the length of hospitalization of patients with AC, especially in-hospital mortality. RAR is a promising marker that is more convenient than TSG and other prognostic markers for predicting the prognosis of patients with AC.
基金supported by the National Natural Science Foundation of China(No.12075237)。
文摘A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber principle.This method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined RAM.The performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data transmission.The experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 mm.The beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction method.The online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.
基金This research is supported by the Science and Technology Program of Gansu Province(No.23JRRA880).
文摘With the current integration of distributed energy resources into the grid,the structure of distribution networks is becoming more complex.This complexity significantly expands the solution space in the optimization process for network reconstruction using intelligent algorithms.Consequently,traditional intelligent algorithms frequently encounter insufficient search accuracy and become trapped in local optima.To tackle this issue,a more advanced particle swarm optimization algorithm is proposed.To address the varying emphases at different stages of the optimization process,a dynamic strategy is implemented to regulate the social and self-learning factors.The Metropolis criterion is introduced into the simulated annealing algorithm to occasionally accept suboptimal solutions,thereby mitigating premature convergence in the population optimization process.The inertia weight is adjusted using the logistic mapping technique to maintain a balance between the algorithm’s global and local search abilities.The incorporation of the Pareto principle involves the consideration of network losses and voltage deviations as objective functions.A fuzzy membership function is employed for selecting the results.Simulation analysis is carried out on the restructuring of the distribution network,using the IEEE-33 node system and the IEEE-69 node system as examples,in conjunction with the integration of distributed energy resources.The findings demonstrate that,in comparison to other intelligent optimization algorithms,the proposed enhanced algorithm demonstrates a shorter convergence time and effectively reduces active power losses within the network.Furthermore,it enhances the amplitude of node voltages,thereby improving the stability of distribution network operations and power supply quality.Additionally,the algorithm exhibits a high level of generality and applicability.
基金Aeronautical Science Foundation of China (20071551016)
文摘Predicting the time-varying auto-spectral density of a spacecraft in high-altitude orbits requires an accurate model for the non-stationary random vibration signals with densely spaced modal frequency. The traditional time-varying algorithm limits prediction accuracy, thus affecting a number of operational decisions. To solve this problem, a time-varying auto regressive (TVAR) model based on the process neural network (PNN) and the empirical mode decomposition (EMD) is proposed. The time-varying system is tracked on-line by establishing a time-varying parameter model, and then the relevant parameter spectrum is obtained. Firstly, the EMD method is utilized to decompose the signal into several intrinsic mode functions (IMFs). Then for each IMF, the PNN is established and the time-varying auto-spectral density is obtained. Finally, the time-frequency distribution of the signals can be reconstructed by linear superposition. The simulation and the analytical results from an example demonstrate that this approach possesses simplicity, effectiveness, and feasibility, as well as higher frequency resolution.
基金Supported by the National Science Foundation of China(42055402)。
文摘The conventional linear time-frequency analysis method cannot achieve high resolution and energy focusing in the time and frequency dimensions at the same time,especially in the low frequency region.In order to improve the resolution of the linear time-frequency analysis method in the low-frequency region,we have proposed a W transform method,in which the instantaneous frequency is introduced as a parameter into the linear transformation,and the analysis time window is constructed which matches the instantaneous frequency of the seismic data.In this paper,the W transform method is compared with the Wigner-Ville distribution(WVD),a typical nonlinear time-frequency analysis method.The WVD method that shows the energy distribution in the time-frequency domain clearly indicates the gravitational center of time and the gravitational center of frequency of a wavelet,while the time-frequency spectrum of the W transform also has a clear gravitational center of energy focusing,because the instantaneous frequency corresponding to any time position is introduced as the transformation parameter.Therefore,the W transform can be benchmarked directly by the WVD method.We summarize the development of the W transform and three improved methods in recent years,and elaborate on the evolution of the standard W transform,the chirp-modulated W transform,the fractional-order W transform,and the linear canonical W transform.Through three application examples of W transform in fluvial sand body identification and reservoir prediction,it is verified that W transform can improve the resolution and energy focusing of time-frequency spectra.
基金The study was approved by the ethics committee of the First Affiliated Hospital of Chongqing Medical University(2022-K205),this study was conducted in accordance with the World Medical Association Declaration of Helsinki as well。
文摘BACKGROUND Previous studies have reported that low hematocrit levels indicate poor survival in patients with ovarian cancer and cervical cancer,the prognostic value of hematocrit for colorectal cancer(CRC)patients has not been determined.The prognostic value of red blood cell distribution width(RDW)for CRC patients was controversial.AIM To investigate the impact of RDW and hematocrit on the short-term outcomes and long-term prognosis of CRC patients who underwent radical surgery.METHODS Patients who were diagnosed with CRC and underwent radical CRC resection between January 2011 and January 2020 at a single clinical center were included.The short-term outcomes,overall survival(OS)and disease-free survival(DFS)were compared among the different groups.Cox analysis was also conducted to identify independent risk factors for OS and DFS.RESULTS There were 4258 CRC patients who underwent radical surgery included in our study.A total of 1573 patients were in the lower RDW group and 2685 patients were in the higher RDW group.There were 2166 and 2092 patients in the higher hematocrit group and lower hematocrit group,respectively.Patients in the higher RDW group had more intraoperative blood loss(P<0.01)and more overall complications(P<0.01)than did those in the lower RDW group.Similarly,patients in the lower hematocrit group had more intraoperative blood loss(P=0.012),longer hospital stay(P=0.016)and overall complications(P<0.01)than did those in the higher hematocrit group.The higher RDW group had a worse OS and DFS than did the lower RDW group for tumor node metastasis(TNM)stage I(OS,P<0.05;DFS,P=0.001)and stage II(OS,P=0.004;DFS,P=0.01)than the lower RDW group;the lower hematocrit group had worse OS and DFS for TNM stage II(OS,P<0.05;DFS,P=0.001)and stage III(OS,P=0.001;DFS,P=0.001)than did the higher hematocrit group.Preoperative hematocrit was an independent risk factor for OS[P=0.017,hazard ratio(HR)=1.256,95%confidence interval(CI):1.041-1.515]and DFS(P=0.035,HR=1.194,95%CI:1.013-1.408).CONCLUSION A higher preoperative RDW and lower hematocrit were associated with more postoperative complications.However,only hematocrit was an independent risk factor for OS and DFS in CRC patients who underwent radical surgery,while RDW was not.