Compartmentalized regulation of organelle integrity in neurodegenerative diseases:lessons from the Drosophila motor neuron

Neurons are highly polarized,morphologically asymmetric,and functionally compartmentalized cells that contain long axons extending from the cell body.For this reason,their maintenance relies on spatiotemporal regulation of organelle distribution between the somatodendritic and axonal domains.Although some organelles,such as mitochondria and smooth endoplasmic reticulum,are widely distributed throughout the neuron,others are segregated to either the somatodendritic or axonal compartment.For example,Golgi outposts and acidified lysosomes are predominantly present in the somatodendritic domain and rarely distributed along the axon,whereas newly formed autophagosomes and synaptic vesicles are mainly distributed in the distal axon(Britt et al.,2016).

Coordinated voltage regulation strategy of OLTC and BESS considering switching delay

When large-scale distributed renewable energy power generation systems are connected to the power grid,the risk of grid voltage fluctuations and exceeding the limit increases greatly.Fortunately,the on-load tap changer(OLTC)can adjust the transformer winding tap to maintain the secondary side voltage within the normal range.However,the inevitable delay in switching transformer taps makes it difficult to respond quickly to voltage fluctuations.Moreover,switching the transformer taps frequently will decrease the service life of OLTC.In order to solve this critical issue,a cooperative voltage regulation strategy applied between the battery energy storage systems(BESSs)and OLTSs.is proposed By adjusting the charge and discharge power of BESSs,the OLTC can frequently switch the transformer taps to achieve rapid voltage regulation.The effectiveness of the proposed coordinated regulation strategy is verified in the IEEE 33 node distribution systems.The simulation results show that the proposed coordinated regulation strategy can stabilize the voltage of the distribution network within a normal range and reduce the frequency of tap switching,as such elongating the service life of the equipment.

Distributed ledger technology for securities clearing and settlement: benefits, risks, and regulatory implications

This article outlines the benefits and risks of the distributed ledger technology(DLT)for the clearing and settlement of exchange-traded and OTC securities,followed by a description of the technology’s potential role for central counterparties and central securities depositories.Although the industry and scholars are attempting to solve the technological and operational issues that DLT systems still face,outstanding legal risks are such that the financial industry is asking for more regulatory guidance and intervention.This article wants to contribute to the public policy debate by presenting potential regulatory barriers that may have to be removed for DLT to be fully adopted.In addition,it identifies areas requiring an update of the legal framework in order to address certain prudential and conduct risks that this technology could introduce.

Power Distribution System Regulation (A Review)

This article presents a framework and a comprehensive model to optimize the regulation of the electricity distribution system.The regulatory requirements of the electricity distribution system and research gaps in this field are among the important outputs of this review article.In each of the presented parts of the framework,it has reviewed,introduced and listed the regulatory studies of the electricity distribution system.In order to calculate the PDSR(regulation of power distribution system)framework,governance first presents,its goals,and its development plan in the distribution sector,and discusses the regulatory position in it.After that,in the electricity distribution system,it describes the role of the regulator in the goals and plans of the electricity distribution system,and introduces the types of regulation of the electricity distribution system,and finally,discusses about the place of data in the regulation and its requirements,and the effects of regulation in the evolution and stability of the electricity distribution system.

Cognitive-affective regulation process for micro-expressions based on Gaussian cloud distribution

In this paper, we explore the process of emotional state transition. And the process is impacted by emotional state of interaction objects. First of all, the cognitive reasoning process and the micro-expressions recognition is the basis of affective computing adjustment process. Secondly, the threshold function and attenuation function are proposed to quantify the emotional changes. In the actual environment, the emotional state of the robot and external stimulus are also quantified as the transferring probability. Finally, the Gaussian cloud distribution is introduced to the Gross model to calculate the emotional transitional probabilities. The experimental results show that the model in human-computer interaction can effectively regulate the emotional states, and can significantly improve the humanoid and intelligent ability of the robot. This model is consistent with experimental and emulational significance of the psychology, and allows the robot to get rid of the mechanical emotional transfer process.

Distributed Periodic Event-Triggered Optimal Control of DC Microgrids Based on Virtual Incremental Cost

This article presents a distributed periodic eventtriggered(PET)optimal control scheme to achieve generation cost minimization and average bus voltage regulation in DC microgrids.In order to accommodate the generation constraints of the distributed generators(DGs),a virtual incremental cost is firstly designed,based on which an optimality condition is derived to facilitate the control design.To meet the discrete-time(DT)nature of modern control systems,the optimal controller is directly developed in the DT domain.Afterward,to reduce the communication requirement among the controllers,a distributed event-triggered mechanism is introduced for the DT optimal controller.The event-triggered condition is detected periodically and therefore naturally avoids the Zeno phenomenon.The closed-loop system stability is proved by the Lyapunov synthesis for switched systems.The generation cost minimization and average bus voltage regulation are obtained at the equilibrium point.Finally,switch-level microgrid simulations validate the performance of the proposed optimal controller.

A fault-tolerant control method for distributed flight control system facing wing damage

With the strong battlefield application environment of the next generation fighter,based on the design of distributed vehicle management system,a fault diagnosis and fault-tolerant control(FTC)method for wing surface damage is proposed in this paper.Aiming at three kinds of wing damage modes,this paper proposes a diagnosis method based on the fault decision tree and forms a fault decision tree for wing damage from the aspects of sample database construction,feature parameter extraction,and fault decision tree construction.Based on the fault diagnosis results,the longitudinal control law based on dynamic inverse and the lateral-directional robust control laws based on linear quadratic regulator(LQR)are proposed.From the simulation examples,the fault diagnosis algorithm based on the decision tree can complete the judgment of three wing surface damage modes within 2 ms,and the FTC law can make the fighter quickly return to a stable flight state after a short transient of 1 s,which achieves the fault-tolerant goal.

Optimization of Minimum Power Output for Combined Heat and Power Units Considering Peak Load Regulation Ability

Northern China has rich wind power and photovoltaic renewable resources. Combined Heat and Power (CHP) Units to meet the load demand and limit its peaking capacity in winter, to a certain extent, it results in structural problems of wind-solar power and thermoelectric. To solve these problems, this paper proposes a plurality of units together to ensure supply of heat load on the premise, by building a thermoelectric power peaking considering thermal load unit group dynamic scheduling model, to achieve the potential of different thermoelectric properties peaking units of the excavation. Simulation examples show, if the unit group exists obvious relationship thermoelectric individual differences, the thermal load dynamic scheduling can be more significantly improved overall performance peaking unit group, effectively increase clean energy consumptive.

Evaluation of intermittent-distributed-generation hosting capability of a distribution system with integrated energy-storage systems

The penetration rate of distributed generation is gradually increasing in the distribution system concerned.This is creating new problems and challenges in the planning and operation of the system.The intermittency and variability of power outputs from numerous distributed renewable generators could significantly jeopardize the secure operation of the distribution system.Therefore,it is necessary to assess the hosting capability for intermittent distributed generation by a distribution system considering operational constraints.This is the subject of this study.An assessment model considering the uncertainty of generation outputs from distributed generators is presented for this purpose.It involves different types of regulation or control functions using on-load tap-changers(OLTCs),reactive power compensation devices,energy storage systems,and the reactive power support of the distributed generators employed.A robust optimization model is then attained It is solved by Bertsimas robust counterpart through GUROBI solver.Finally,the feasibility and efficiency of the proposed method are demonstrated by a modified IEEE 33-bus distribution system.In addition,the effects of the aforementioned regulation or control functions on the enhancement of the hosting capability for intermittent distributed generation are examined.

Discussion on IAEA and China Safety Regulation for NPP Coastal Defense Infrastructures against Typhoon/Hurricane Attacks

The World Meteorological Organization estimates that about 90 percent of all natural disasters is extreme meteorological hazards like typhoon/hurricane and tropical cyclone triggered disasters. With the increasing tendency of natural hazards, the typhoon induced surge, wave, precipitation, flood and wind as extreme external loads menacing Nuclear Power Plants (NPP) in coastal and inland provinces of China. For all of the planned, designed and constructed NPP in China the National Nuclear Safety Administration of China and IAEA recommended Probable Maximum Hurricane/ Typhoon/(PMH/T), Probable Maximum Storm Surge (PMSS), Probable Maximum Flood (PMF), Design Basis Flood (DBF) as safety regulations recommended for NPP defense infrastructures. This paper discusses the joint probability analysis of simultaneous occurrence typhoon induced extreme external hazards and compared with IAEA 2003-2011 recommended safety regulations for some NPP along China coast to make safety assessment based on the “As Low As Reasonable Practice” (ALARP) principle.

Localization of Voltage Regulators in Distribution Systems by a Mixed Genetic–Tabu Search Algorithm

The optimal allocation of regulators banks in distribution systems is a merely combinatorial problem in which the best points of installation correspond to the best benefit, considering the admitted objective function, without violating and operating limits. The objective function must be chosen so that its value represents the operation state of the system. As the problem possesses combinatorial nature, its complexity will increase exponentially with the number of possibilities. Systems with large numbers of nodes and / or with the possibility of installing more than one bank require a large number of calculations to find the solution. An additional issue is the fact that the problem does not have a continuous nature, presenting discontinuity points in the objective function, limiting the application of optimization methods based on gradients. Based on the nature of the problem two optimization methods were used to solve the problem: Genetic Algorithm (GA) and modified Tabu Search (TS). The GA function will scour the search space and find regions with local minima that are candidates to be the solution. On the other hand the TS provides local search in the regions defined by GA so that the overall optimum is achieved.

Containment-Based Multiple PCC Voltage Regulation Strategy for Communication Link and Sensor Faults

The distributed AC microgrid(MG) voltage restoration problem has been extensively studied. Still, many existing secondary voltage control strategies neglect the co-regulation of the voltage at the point of common coupling(PCC) in the AC multi-MG system(MMS). When an MMS consists of sub-MGs connected in series, power flow between the sub-MGs is not possible if the PCC voltage regulation relies on traditional consensus control objectives. In addition, communication faults and sensor faults are inevitable in the MMS. Therefore, a resilient voltage regulation strategy based on containment control is proposed.First, the feedback linearization technique allows us to deal with the nonlinear distributed generation(DG) dynamics, where the PCC regulation problem of an AC MG is transformed into an output feedback tracking problem for a linear multi-agent system(MAS) containing nonlinear dynamics. This process is an indispensable pre-processing in control algorithm design. Moreover, considering the unavailability of full-state measurements and the potential faults present in the sensors, a novel follower observer is designed to handle communication faults. Based on this, a controller based on containment control is designed to achieve voltage regulation. In regulating multiple PCC voltages to a reasonable upper and lower limit, a voltage difference exists between sub-MGs to achieve power flow. In addition, the secondary control algorithm avoids using global information of directed communication network and fault boundaries for communication link and sensor faults. Finally, the simulation results verify the performance of the proposed strategy.

Markets in crypto‑assets regulation:Does it provide legal certainty and increase adoption of crypto‑assets?

This study discusses the European Union’s proposal for a Regulation on Markets in Crypto-Assets,now subject to formal approval by the European Parliament.The objective is to explore whether it will positively impact the adoption of crypto-assets in the financial sector.The use of crypto-assets is growing.However,some stakeholders in the financial service sector remain skeptical and hesitant to adopt assets that are yet to be defined and have an unclear legal status.This regulatory uncertainty has been identified as the primary reason for the reluctant adoption.The proposed regulation(part of the EU’s Digital Finance Strategy)aims to provide this legal certainty for currently unregulated crypto-assets.This study investigates whether or not the proposed regulation can be expected to have the intended effect by reviewing the proposed regulation itself,the opinions and reactions of the various stakeholders,and secondary literature.Findings reveal that such regulation will most likely not accelerate the adoption of crypto-assets in the EU financial services sector,at least not sufficiently or as intended.Some suggestions are made to improve the proposal.

Output Feedback Regulation for 1-D Anti-Stable Wave Equation with External System Disturbance

This paper has studied the output feedback regulation problem for 1-D anti-stable wave equation with distributed disturbance and a given reference signal generated by a finite-dimensional exosystem. We first design an observer for both exosystem and auxiliary PDE system to recover the state. Then we show the well-posedness of the regulator equations and propose an observer-based feedback control law to regulate the tracking error to zero exponentially and keep all the states bounded.

Illustrations with Real Examples of Using Ecological Regulation Strategies Against Crop Pests in China

In this paper, a series of examples from China, including those using ecological regulation strategies successfully to keep crop pests under control and those making more damages of crop pests caused by wrong cropping systems, crop distributions or extensive cultivation, were given and analyzed. From these, two pieces of experience were enlightened as follows: the first, the reforms of cropping systems and crop distributions must be beneficial to pest control or at least not increase the damage of crop pests; the second, we should further clarify the relationship between population dynamics of pests and cropping system/crop distribution, the basis for correctly laying down the ecological regulation systems.

Component content distribution profile control in rare earth countercurrent extraction process

Considering that the on-line measurement and automatic control of element component content(ECC) are difficult to perform in rare earth cascade extraction process, the ECC distribution profile is dynamically regulated at all stages to assess the effect of product purity control. Focusing on the theory of countercurrent extraction, the technology parameters and pre-setting flow-rates during the extract process are designed. Under varying process parameters, a novel step by step model is also proposed for each stage to analyze the impact on the distribution profile change. Combining the mass balance model and ECC changing trend at the monitoring stage, the ECC distribution profile can be automatically regulated by dynamically compensating the related extract or scrubbing liquid flow-rate. To this end, the required product purity at the two outlets is achieved. Based on Wincc and Matlab dynamic simulators, a specific Pr/Nd cascade extraction process is used to illustrate and demonstrate the application of the present approach.

An output-based distributed observer and its application to the cooperative linear output regulation problem

In this paper, we first extend an existing stability result for a class of linear switched systems. This extended result will relax the existenceconditions of the output-based distributed observer for a leader system subject to jointly connected switching communication networks in the literature. As an application of this output-based distributed observer, we solve the cooperative output regulati on problem of a linear multi-age nt system subject to jointly connected switching communicatio n n etworks by composing a purely decentralized control law and the output-based distributed observer based on the certainty equivalence principle.

Coordinated control for voltage regulation of distribution network voltage regulation by distributed energy storage systems

With more and more distributed photovoltaic(PV)plants access to the distribution system,whose structure is changing and becoming an active network.The traditional methods of voltage regulation may hardly adapt to this new situation.To address this problem,this paper presents a coordinated control method of distributed energy storage systems(DESSs)for voltage regulation in a distribution network.The influence of the voltage caused by the PV plant is analyzed in a simple distribution feeder at first.The voltage regulation areas corresponding to DESSs are divided by calculating and comparing the voltage sensitivity matrix.Then,a coordinated voltage control strategy is proposed for the DESSs.Finally,the simulation results of the IEEE 33-bus radial distribution network verify the effectiveness of the proposed coordinated control method.

Experimental and Numerical Study on the Gas Explosion in Urban Regulator Station

Regulator station is an important part in the urban gas transmission and distribution system.Once gas explosion occurs,the real explosion process and consequences of methane gas explosion in the regulator station were not revealed systematically.In this study,a full-scale experiment was carried out to simulate the regulator station explosion process,and some numerical simulations with a commercial CFD software called FLACS were conducted to analyze the effect of ignition and vent conditions on the blast overpressure and flame propagation.The experimental results demonstrated that the peak overpressure increased as the distance from the vent increased within a certain distance.And the maximum overpressure appeared 3 m away from the door,which was about 36.6 kPa.It was found that the pressure-time rising curves obtained from the simulation are basically the same as the ones from the experiment,however,the time of reaching the peak pressure was much shorter.The numerical simulation results show that the peak overpressures show an increase trend as the ignition height decreased and the vent relief pressure increased.It indicates that the damage and peak overpressure of gas explosion could be well predicted by FLACS in different styles of regulator station.In addition,the results help us to understand the internal mechanism and development process of gas explosion better.It also offers technical support for the safety protection of the urban regulator station.

Root distribution and influencing factors of dry-sowing and wet-growing cotton plants under different water conditions

To study the effect of soil water and salt environment factors on the root growth of cotton under different moisture control,three different emergence water volumes(60,105,and 150 m^(3)/hm^(2)),two different frequencies(high frequency and low frequency)and one double film cover winter irrigation control treatment(CK:2250 m^(3)/hm^(2))were set up to analyze the spatial distribution patterns of soil water and salt environment and root density in dry sown and wet emerged cotton fields under diffe-rent moisture control conditions.The results show that the soil water content and water infiltration range gradually become larger with the increase of seedling water quantity,and the larger the seedling water quantity,the higher the soil water content.With the same seedling water quantity,the soil water content of the high-frequency(HF)treatment becomes obviously larger.The soil conductivity of each treatment tends to decrease gradually with the increase of seedling water and drip frequency,among which the distribution of soil conductivity of S6 treatment is closest to that of CK.With the increase in soil depth,the soil conductivity tends to increase first and then decrease.Compared with the low-frequency(LF)treatment,the high-frequency treatment shows a significantly deeper soil salt accumulation layer.The root length density(RLD)of cotton gradually increases with the amount of seedling water and the frequency of dripping.The soil layer of root distribution gradually deepens with the amount of seedling water in the vertical direction,and the RLD value in the horizontal direction is significantly greater in the mulched area than that in the bare area between films.This research can serve as a solid scientific foundation for the use of dry sowing and wet emergence techniques in cotton fields in southern Xinjiang.