To find out the relationship between the oil-based mud,the formation fluid and the extracted gas,we use a thermodynamic approach based on static headspace gas chromatography technique to calculate the partition coeffi...To find out the relationship between the oil-based mud,the formation fluid and the extracted gas,we use a thermodynamic approach based on static headspace gas chromatography technique to calculate the partition coefficients of 47 kinds of light hydrocarbons compounds between nC5 and nC8 in two kinds of oil-based mud-air systems,and reconstruct the original formation fluid composition under thermodynamic equilibrium.The oil-based drilling mud has little effect on the formation fluid compositions in the range of nC5-nC8(less than 1%for low-toxicity oil-based mud and less than 10%for oil-based mud).For most light hydrocarbon compositions,the partition coefficients obtained by vapor phase calibration and the direct quantitative methods have errors of less than 10%,and the partition coefficients obtained by direct quantitative method are more accurate.The reconstructed compositions of the two kinds of crude oil have match degrees of 91%and 89%with their real compositions,proving the feasibility and accuracy of reconstructing the composition of original formation fluid by using partition coefficients of light hydrocarbon compositions between nC5 and nC8.展开更多
Three types of mine gas samples were used in the solutions of tetrahydrofuran(THF),sodium dodecyl sulfate(SDS)and THF-SDS with/without MMT respectively to investigate the effect of montmorillonite(MMT)on separation ch...Three types of mine gas samples were used in the solutions of tetrahydrofuran(THF),sodium dodecyl sulfate(SDS)and THF-SDS with/without MMT respectively to investigate the effect of montmorillonite(MMT)on separation characteristics of methane recovered from mine gas based on hydrate method.The partition coefficient,separation factor and recovery rate were used to evaluate the effects of MMT,and the selection factor was primarily proposed to define the selectivity of mine gas hydrate in the relative target gases.The experimental results indicate that MMT could improve the following factors including hydration separation factor,the selection factor,the partition coefficient,and the recovery rate.Furthermore,the effect of SDS on the function of MMT is analyzed in the process of hydration separation.Finally,due to the results of the experiment,it is concluded that MMT hydration mechanism explores the effect of MMT enrichment methane from mine gas.展开更多
A rapid, sensitive, and robust reversed-phase liquid chromatography with tandem mass spectrometry method was developed and validated for the determination of total and unbound ceritinib, a secondgeneration ALK inhibit...A rapid, sensitive, and robust reversed-phase liquid chromatography with tandem mass spectrometry method was developed and validated for the determination of total and unbound ceritinib, a secondgeneration ALK inhibitor, in patient plasma and brain tumor tissue samples. Sample preparation involved simple protein precipitation with acetonitrile. Chromatographic separation was achieved on a Waters ACQUITY UPLC BEH C_(18) column using a 4-min gradient elution consisting of mobile phase A(0.1% formic acid in water) and mobile phase B(0.1% formic acid in acetonitrile), at a flow rate of 0.4 m L/min. Ceritinib and the internal standard([^(13)C_6]ceritinib) were monitored using multiple reaction monitoring mode under positive electrospray ionization. The lower limit of quantitation(LLOQ) was 1 n M of ceritinib in plasma. The calibration curve was linear over ceritinib concentration range of 1–2000 n M in plasma. The intra-and interday precision and accuracy were within the generally accepted criteria for bioanalytical method( o15%).The method was successfully applied to assess ceritinib brain tumor penetration, as assessed by the unbound drug brain concentration to unbound drug plasma concentration ratio, in patients with brain tumors.展开更多
文摘To find out the relationship between the oil-based mud,the formation fluid and the extracted gas,we use a thermodynamic approach based on static headspace gas chromatography technique to calculate the partition coefficients of 47 kinds of light hydrocarbons compounds between nC5 and nC8 in two kinds of oil-based mud-air systems,and reconstruct the original formation fluid composition under thermodynamic equilibrium.The oil-based drilling mud has little effect on the formation fluid compositions in the range of nC5-nC8(less than 1%for low-toxicity oil-based mud and less than 10%for oil-based mud).For most light hydrocarbon compositions,the partition coefficients obtained by vapor phase calibration and the direct quantitative methods have errors of less than 10%,and the partition coefficients obtained by direct quantitative method are more accurate.The reconstructed compositions of the two kinds of crude oil have match degrees of 91%and 89%with their real compositions,proving the feasibility and accuracy of reconstructing the composition of original formation fluid by using partition coefficients of light hydrocarbon compositions between nC5 and nC8.
基金Projects(51404102,51334005,51274267)supported by the National Natural Science Foundation of ChinaProject(UNPYSCT-2017140)supported by the Youth Innovation Personnel Training in University and College of Heilongjiang Province,China
文摘Three types of mine gas samples were used in the solutions of tetrahydrofuran(THF),sodium dodecyl sulfate(SDS)and THF-SDS with/without MMT respectively to investigate the effect of montmorillonite(MMT)on separation characteristics of methane recovered from mine gas based on hydrate method.The partition coefficient,separation factor and recovery rate were used to evaluate the effects of MMT,and the selection factor was primarily proposed to define the selectivity of mine gas hydrate in the relative target gases.The experimental results indicate that MMT could improve the following factors including hydration separation factor,the selection factor,the partition coefficient,and the recovery rate.Furthermore,the effect of SDS on the function of MMT is analyzed in the process of hydration separation.Finally,due to the results of the experiment,it is concluded that MMT hydration mechanism explores the effect of MMT enrichment methane from mine gas.
基金supported by the United States Public Health Service Cancer Center Support Grant P30 CA022453Novartis for providing the study drug and isotope-labeled internal standard and providing financial support for the clinical study
文摘A rapid, sensitive, and robust reversed-phase liquid chromatography with tandem mass spectrometry method was developed and validated for the determination of total and unbound ceritinib, a secondgeneration ALK inhibitor, in patient plasma and brain tumor tissue samples. Sample preparation involved simple protein precipitation with acetonitrile. Chromatographic separation was achieved on a Waters ACQUITY UPLC BEH C_(18) column using a 4-min gradient elution consisting of mobile phase A(0.1% formic acid in water) and mobile phase B(0.1% formic acid in acetonitrile), at a flow rate of 0.4 m L/min. Ceritinib and the internal standard([^(13)C_6]ceritinib) were monitored using multiple reaction monitoring mode under positive electrospray ionization. The lower limit of quantitation(LLOQ) was 1 n M of ceritinib in plasma. The calibration curve was linear over ceritinib concentration range of 1–2000 n M in plasma. The intra-and interday precision and accuracy were within the generally accepted criteria for bioanalytical method( o15%).The method was successfully applied to assess ceritinib brain tumor penetration, as assessed by the unbound drug brain concentration to unbound drug plasma concentration ratio, in patients with brain tumors.
