Experimental Study on Tissue Ablation with Novel Microwave Probe

Objective: To validate a newly designed microwave probe capable of producing larger volume of ablated lesions in ex vivo swine livers. Methods: A novel microwave probe was developed and tested in ex vivo specimens of swine liver. Group A was not given saline infusion under power output 50 W. Group B, C, D under power output 90 W were tested respectively according to the condition of no saline infusion (group B), 5 min preinfusion (5 ml saline, group C), preinfusion and continuous infusion (at the rate of 1 ml/min, group D) using the novel probe. The sizes of the microwave-induced lesions were evaluated and the volume of the tissue destruction qualified. Results: The approximate volumes of the microwave-induced lesions were (16.48±3.86) cm3, (28.86±6.15) cm3, (34.11±5.86) cm3, (40.50±10.88) cm3, respectively (P<0.01). Preinfusion and continuous infusion (group D) created more spherical lesions than only preinfusion (group C). Conclusion: The newly-developed microwave probe increased the volume of coagulation necrosis, created a more spherical lesion under the power output of 90 W, and might achieve the effective treatment of larger neoplasm with a single application of microwave energy.

High-intensity focused ultrasound with large scale spherical phased array for the ablation of deep tumors

Under some circumstances surgical resection is feasible in a low percentage for the treatment of deep tumors. Nevertheless, high-intensity focused ultrasound （HIFU） is beginning to offer a potential noninvasive alternative to conventional therapies for the treatment of deep tumors. In our previous study, a large scale spherical HIFU-phased array was developed to ablate deep tumors. In the current study, taking into account the required focal depth and maximum acoustic power output, 90 identical circular PZT-8 elements （diameter=1.4 cm and frequency=l MHz） were mounted on a spherical shell with a radius of curvature of 18 cm and a diameter of 21 cm. With the developed array, computer simulations and ex vivo experiments were carried out. The simulation results theoretically demonstrate the ability of the array to focus and steer in the specified volume （a 2 cm×2 cm×3 cm volume） at the focal depth of 15 to 18 cm. Ex vivo experiment results also verify the capability of the developed array to ablate deep target tissue by either moving single focal point or generating multiple foci simultaneously.

Development of a high-power blue diode laser for precision vaporization of prostate tissue for the surgical management of benign prostatic hyperplasia

This paper explores the advancement and application of high-power blue diode lasers in treating benign prostatic hyperplasia(BPH).Addressing the challenges posed by existing techniques,the study focuses on optimizing tissue removal methods.Energy platform for BPH should balance a range of factors,such as operative time,patient conditions,urinary functions,complications,durability,accessibility,and cost,all while prioritizing patient care.Blueray Medical's innovation of high-power blue diode laser systems for BPH surgery is explored,with emphasis on achieving a balance among these considerations.By illustrating the biomedical effects of lasers and their interaction with soft tissues,particularly emphasizing the role of photon absorption by biomolecules and proteins in tissue behavior,this study outlines the advantages of the highpower blue diode laser system.The initial laboratory experiments and clinical results consistently align with our theoretical predictions,especially in terms of tissue vaporization efficiency,tissue coagulation,and bleeding control.In conclusion,blue diode lasers hold potential to enhance surgical outcomes for BPH.Their unique properties offer benefits like improved tissue removal rate and reduced thermal damages.Integrating blue laser technology into BPH protocols could lead to shorter hospital stays,cost savings,and expanded patient eligibility,although rigorous clinical studies are needed to fully understand their benefits and limitations.