Jean Jacques Rousseau was one of the famous French Enlightenment thinkers,and Emile was one of his great masterpieces,in which he emphasized his objection to the medieval religious and feudal education that was a hind...Jean Jacques Rousseau was one of the famous French Enlightenment thinkers,and Emile was one of his great masterpieces,in which he emphasized his objection to the medieval religious and feudal education that was a hindrance for the development of children's natural individuality,and he advocated implementing the natural education that was conformity to the children's nature,and fostered the harmonious development of children's body and mind.Rousseau's natural education theory was an education rationale for human innovation of its education posterior to his time,which thus was called "Copernican revolution" in human education history.From Rousseau onwards,the human education theory has begun to enter a new period of emphasis on research of children.展开更多
Fifteen new meroterpenoids, littoreanoids A—O (1—15), including three rearranged skeleton meroterpenoids (1—3), were isolated from the mangrove-derived fungus Penicillium sp. HLLG-122. Compound 1 was a novel berkel...Fifteen new meroterpenoids, littoreanoids A—O (1—15), including three rearranged skeleton meroterpenoids (1—3), were isolated from the mangrove-derived fungus Penicillium sp. HLLG-122. Compound 1 was a novel berkeleyacetal-derived meroterpenoid featuring an unusual spirocyclic 2-oxaspiro[5.5]undeca-4,7-dien-3-one moiety. Compound 2 possessed an unusual 6/6/6/6/6 pentacyclic system with a novel 1-hydroxy-7,7-dimethyl-2-oxabicyclo[2.2.2]octan-5-yl acetate moiety. Compound 3 was an unusual 6/7/6/5/6/5/4 polycyclic systems containing a β-lactone ring. The structures and absolute configurations of new compounds were elucidated by HRESIMS, NMR spectroscopy, single crystal X-ray diffraction analysis, and electronic circular dichroism calculations. The plausible biosynthetic pathways of 1—3 were also proposed. Compounds 6 and 11 exhibited anti-inflammatory effects with IC_(50) values of 30.41 and 19.02 μmol/L, respectively. The bioactive compound 11 was selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments. Compound 11 could suppress the levels of TNF-α and IL-6, and down-regulate the protein expression of iNOS and COX-2 in RAW 264.7 cells.展开更多
In this investigation,we have shown that the combination of deep learning,including natural language processing,and conformal prediction results in highly predictive and efficient temporal test set sentiment estimates...In this investigation,we have shown that the combination of deep learning,including natural language processing,and conformal prediction results in highly predictive and efficient temporal test set sentiment estimates for 12 categories of Amazon product reviews using either in-category predictions,i.e.the model and the test set are from the same review category or cross-category predictions,i.e.using a model of another review category for predicting the test set.The similar results from in-and cross-category predictions indicate high degree of generalizability across product review categories.The investigation also shows that the combination of deep learning and conformal prediction gracefully handles class imbalances without explicit class balancing measures.展开更多
Natural disasters usually involve a phenomenon with consequences that exceed the response capabilities of local communities and have a significant impact on the region’s socioeconomic development. Droughts, floods, a...Natural disasters usually involve a phenomenon with consequences that exceed the response capabilities of local communities and have a significant impact on the region’s socioeconomic development. Droughts, floods, and hurricanes are all natural disasters that jeopardize the environment and the lives of Somalis. Severe floods have devastated the south and central parts of the country multiple times, destroying infrastructure and homes and killing many vulnerable people. Droughts in the south and central parts of the country, particularly in the Middle Shebelle region, have killed a number of children and mothers. It also had a negative influence on crops and cattle. Objective of this study is to know the recurrence of Natural Disasters in Jowhar, Middle Shabelle region, Somalia: The Causes and Impacts. The Somali people are completely aware of natural disasters such as droughts and floods, and they are self-sufficient in dealing with the consequences of these disasters. Furthermore, the Somali government has not fully created environmental laws to protect and conserve the environment, and the majority of laws, rules, acts, and regulations are not used or administered effectively. We also found that the Somali government is not yet financially prepared to deal with these crises, and that there are no strategic plans in the central government or even state administrations to prevent or at least control these disasters from causing extreme harm to the community and the environment.展开更多
Conformation analysis of the model compounds for tunicamycin V and its natural donor substrate, UDP-N-acetylglucose, is performed to reveal the detail of the inhibition process.
Why are some of us easily affected by the majority's action whereas others frequently make unique choices? In this behavioral genetic study on conformity,we designed a social episode to investigate the genetic and...Why are some of us easily affected by the majority's action whereas others frequently make unique choices? In this behavioral genetic study on conformity,we designed a social episode to investigate the genetic and environmental origin of individual differences in conforming behavior during psychosocial development.Specifically,107 monozygotic(MZ) and 74 dizygotic(DZ) twin pairs(age 7-19) were asked to choose a pen from a group of pens either with the majority color or with the minority color.We found that the resemblance between MZ twins in selecting the pen with the majority color was not significantly higher than that between DZ twins,suggesting that individual differences in conformity are due almost exclusively to the environment.Moreover,biometric model fitting revealed that the shared environmental component played a sizable role in shaping individuals' conforming behavior,and the influence increased with age(from 16% to 26%).Taken together,our study suggests that the common family and cultural environment has important ramifications for conformity.展开更多
文摘Jean Jacques Rousseau was one of the famous French Enlightenment thinkers,and Emile was one of his great masterpieces,in which he emphasized his objection to the medieval religious and feudal education that was a hindrance for the development of children's natural individuality,and he advocated implementing the natural education that was conformity to the children's nature,and fostered the harmonious development of children's body and mind.Rousseau's natural education theory was an education rationale for human innovation of its education posterior to his time,which thus was called "Copernican revolution" in human education history.From Rousseau onwards,the human education theory has begun to enter a new period of emphasis on research of children.
基金supported by the National Natural Science Foundation of China(Nos.22177023 and 41866005)the Key Sci-ence and Technology Program of Hainan Province(No.ZDKJ202008)+3 种基金the Hainan Provincial Natural Science Foundation of China(221RC1054)the Specific Research Fund of the Innovation Platform for Academicians of Hainan Province(YSPTZX202030)the Innovation Platform for Academicians of Hainan Province,the Central Government Guides Local Science and Technology Devel-opment(ZY2022HN08)the research was also supported by the Innovative Research Project of Hainan Graduate Students(Qhyb2022-105).
文摘Fifteen new meroterpenoids, littoreanoids A—O (1—15), including three rearranged skeleton meroterpenoids (1—3), were isolated from the mangrove-derived fungus Penicillium sp. HLLG-122. Compound 1 was a novel berkeleyacetal-derived meroterpenoid featuring an unusual spirocyclic 2-oxaspiro[5.5]undeca-4,7-dien-3-one moiety. Compound 2 possessed an unusual 6/6/6/6/6 pentacyclic system with a novel 1-hydroxy-7,7-dimethyl-2-oxabicyclo[2.2.2]octan-5-yl acetate moiety. Compound 3 was an unusual 6/7/6/5/6/5/4 polycyclic systems containing a β-lactone ring. The structures and absolute configurations of new compounds were elucidated by HRESIMS, NMR spectroscopy, single crystal X-ray diffraction analysis, and electronic circular dichroism calculations. The plausible biosynthetic pathways of 1—3 were also proposed. Compounds 6 and 11 exhibited anti-inflammatory effects with IC_(50) values of 30.41 and 19.02 μmol/L, respectively. The bioactive compound 11 was selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments. Compound 11 could suppress the levels of TNF-α and IL-6, and down-regulate the protein expression of iNOS and COX-2 in RAW 264.7 cells.
文摘In this investigation,we have shown that the combination of deep learning,including natural language processing,and conformal prediction results in highly predictive and efficient temporal test set sentiment estimates for 12 categories of Amazon product reviews using either in-category predictions,i.e.the model and the test set are from the same review category or cross-category predictions,i.e.using a model of another review category for predicting the test set.The similar results from in-and cross-category predictions indicate high degree of generalizability across product review categories.The investigation also shows that the combination of deep learning and conformal prediction gracefully handles class imbalances without explicit class balancing measures.
文摘Natural disasters usually involve a phenomenon with consequences that exceed the response capabilities of local communities and have a significant impact on the region’s socioeconomic development. Droughts, floods, and hurricanes are all natural disasters that jeopardize the environment and the lives of Somalis. Severe floods have devastated the south and central parts of the country multiple times, destroying infrastructure and homes and killing many vulnerable people. Droughts in the south and central parts of the country, particularly in the Middle Shebelle region, have killed a number of children and mothers. It also had a negative influence on crops and cattle. Objective of this study is to know the recurrence of Natural Disasters in Jowhar, Middle Shabelle region, Somalia: The Causes and Impacts. The Somali people are completely aware of natural disasters such as droughts and floods, and they are self-sufficient in dealing with the consequences of these disasters. Furthermore, the Somali government has not fully created environmental laws to protect and conserve the environment, and the majority of laws, rules, acts, and regulations are not used or administered effectively. We also found that the Somali government is not yet financially prepared to deal with these crises, and that there are no strategic plans in the central government or even state administrations to prevent or at least control these disasters from causing extreme harm to the community and the environment.
文摘Conformation analysis of the model compounds for tunicamycin V and its natural donor substrate, UDP-N-acetylglucose, is performed to reveal the detail of the inhibition process.
基金supported by the National Natural Science Foundation of China (31230031,91132703)the National Basic Research Program of China (2010CB833903)
文摘Why are some of us easily affected by the majority's action whereas others frequently make unique choices? In this behavioral genetic study on conformity,we designed a social episode to investigate the genetic and environmental origin of individual differences in conforming behavior during psychosocial development.Specifically,107 monozygotic(MZ) and 74 dizygotic(DZ) twin pairs(age 7-19) were asked to choose a pen from a group of pens either with the majority color or with the minority color.We found that the resemblance between MZ twins in selecting the pen with the majority color was not significantly higher than that between DZ twins,suggesting that individual differences in conformity are due almost exclusively to the environment.Moreover,biometric model fitting revealed that the shared environmental component played a sizable role in shaping individuals' conforming behavior,and the influence increased with age(from 16% to 26%).Taken together,our study suggests that the common family and cultural environment has important ramifications for conformity.
