Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury

Traumatic spinal cord injury （SCI） causes motor paralysis, sensory anesthesia and autonomic dysfunction below the le- sion site and additionally some SCI patients refer neuropathic pain together with these signs and symptoms. Clinical and experimental studies have revealed the main pathological changes of injured spinal cord implicated in all these signs and symptoms, including neuropathic pain. After few hours of traumatic SCI, it is usual to observe broken blood brain barrier with plasma and blood cells extravasation, cell necrosis, disruption of ascending and descending spinal cord pathways and increased potassium and glutamate. Glutamate contributes to excitotoxicity of neurons whereas potassium facilitates ectopic depolarization of survival neurons and activation of resident microglia.

Reducing intrathecal pressure after traumatic spinal cord injury: a potential clinical target to promote tissue survival

Spinal cord injury （SCI） is an unexpected event that is both devastating and debilitating, resulting in not just motor and sensory loss, but also autonomic dysfunction of the bladder, bowel and sexual organs. Currently, there are no treatments available to improve outcome follow- ing SCI, leaving individuals with permanent and lifelong physical disability. Worldwide it is estimated that more than 500,000 people sustain a SCI each year, with average lifetime cost of paraplegia and quadriplegia estimated at $5 million and $9.5 million respectively. We therefore urgently need effective therapies to improve quality of life following SCI, and this requires a greater understanding of how cell and axonal injury develops after the traumatic event.

Valproic acid as a micro RNA modulator to promote neurite outgrowth

Valproic acid （VPA） has been a first-choice drug for clinical treatment of epilepsy and manic disorder. For decades, its phar- macological action was believed to act on inhibition of gam- ma-aminobutyric acid （GABA） transaminase, in turn, increas- ing GABA in inhibitory synapses. However, in recent years, VPA has been investigated on other therapeutic actions. Those investigations demonstrate that VPA shows neuroprotective ef- fects by promoting neurogenesis, neuronal differentiation, and neuroregeneration （Foti et al., 2013）.

The choline pathway as a strategy to promote central nervous system(CNS) remyelination

Multiple sclerosis is a chronic companied by demyelination inflammatory disease that is ac- and axonal damage resulting in neurological deficits. Remyelination is the natural endogenous repair mechanism of demyelinated axons and it is supposed to protect axons/neurons from degeneration and thus the patient from progressive disability （Franklin and Ffrench-Constant, 2008）. Current therapeutics for patients with multiple sclerosis are to some extent very effective in inhibiting neuroinflamma- tion and demyelination. However, to date there are no substanc- es available that can enhance remyelination. Remyelination is the result of recruitment/proliferation of new oligodendrocyte precursor cells （OPC） and differentiation into mature myelin producing oligodendrocytes （Franklin and Ffrench-Constant, 2008）. These processes are supported by many factors and signals and failure at any stage might lead to repair failure. Strategies to enhance myelin repair are either the promotion of endogenous repair mechanisms via modulation of OPC prolif- eration and oligodendrocyte differentiation or the transplantion of myelinating cells into lesions. Due to the multiloculated pro- cess in multiple sclerosis and the ethical problems with the cell source, the latter is less favoured. The endogenous promotion of remvelination could be achieved by several approaches such as：

Neuregulin 1 isoforms could be an effective therapeutic candidate to promote peripheral nerve regeneration

Traumatic injuries of peripheral nerves represent common casualties and their social impact is considerably high. Although peripheral nerves retain a good regeneration potential, the clinical outcome after nerve lesion is far from being satisfactory and functional recovery is almost never complete, especially in the case of large nerve defects, that result in loss or diminished sensitivity and/or motor activity of the innervated target organs. Therefore, to improve the outcome after nerve damage, or in peripheral neuropathies, there is a need for further research in nerve repair and regeneration to identify factors that promote axonal regrowth, remvelination and target reinnervation.

Releasing Nrf2 to promote neurite outgrowth

Roles of Keap1-Nrf2 pathway in brain：Neuronal survival and neurogenesis are impaired in neurodegenerative diseases such as Parkinson＇s disease and Alzheimer＇s disease（Winner et al.,2011）.Genetic up-regulation of growth factors enhanced neuronal survival and neurogenesis.

To Promote Scientific and Technological Innovation from Higher Starting Point

The year of 2008 has been a time of achieving major victory besides withstanding enormous challenges for the economic and social development of China. Under the correct leadership of the Party Central

Anatomical changes in the somatosensory system after large sensory loss predict strategies to promote functional recovery after spinal cord injury

Among cases of spinal cord injury are injuries involving the dorsal column in the cervical spinal cord that interrupt the major cutaneous afferents from the hand to the cuneate nucleus（Cu）in the brainstem.Deprivation of touch and proprioceptive inputs consequently impair skilled hand use.

Modern Electronic Information Industry to Promote Economic and Social Information—An Interview with Electronics Industry Minister Hu Qili

Spurred by the world information tide, China has organized a series of information projects, called the "Three Gold" projects. Recently I had an interview with Mr. Hu Qili, Minister of Electronics Industry, about the establishment of China’s modern Electronic Information Industry. Mr. Hu told me that information is the mark of development of a modern society and electronics is the major means of carrying information. Establishing

Polish Embassy Ready to Promote Economic Cooperations with China Interview with Krzysztof Szumski, Ambassador of Poland to China

Ql: Would you give us your comments on China 's job in 2005 in promoting the economic and trade relations with vour Country ?……

Potential of the use of an antioxidant compound to promote peripheral nerve regeneration after injury

The peripheral nervous system is a vital part of the body because it transfers information to coordinate all actions.Peripheral nerve injuries are detrimental to the proper function of this system and can cause loss of sense and movement.It is of utmost importance to research approaches to the treatment of peripheral nerve damage because such injuries can drastically change a person’s life,

Revolutionary Technologies to Promote Employment

Artificial intelligence will transform the faces of many industry sectors,and also creates a large amount of opportunities.We have witnessed,in the past 10 to 20years,a change within the network industry.I also belive that something big will happen in the next 10 to 20years.We hold great expectations to the

Implementing Brandname Strategy to Promote the Development of Light Industry

China’s light industry hasdeveloped rapidly since thereform and opening drivebegan.In 1994,the total outputvalue of light industry wasRMB490.2 billion,and theexport volume of lightindustrial products wasUS＄35.6 billion,one third ofChina’s total export volume.In the first half of 1995,thetotal output value of lightindustry increased 14.7%,andthe export volume of lightindustrial products wasUS＄18.9 billion,43% over thesame period of 1994.

Standization Trends in Local Regions Ningxia Hui Autonomous Region Utilizes Standardization to Promote Economic Development

In China, 10 ethnic minorities with a combined population of over 20 million people are followers of Islam. In Ningxia Hui Autonomous Region, the population is nearly 6 million, among which the Islamic population is about 2 million.……

Developing Advanced Technologies to Promote Implementation of Smart Grid in China

In recent years, "Smart Grid" has become a hot topic and its related technologies are believed to be the best solutions for future power grid development to meet the 21st century’s challenges across the world, especially

Suggestions to Promote Sino-Japanese Relations

It is obvious that Sino-Japanese relations are importantly both to China and to Japan. Nevertheless, the reality of "hot economic relations vs. cold political relations" between the two countries puzzles people who show deep concern for Sino-Japanese relations: Are the inherent features of Sino-Japanese relations the cause of the phenomenon? Is the gap between aspiration and action the cause of it? Or both are the causes? The answer is there, but exploration needs to be made. In October 2003, the Export Forum of Contemporary Internation- al Relations held a discussion on "the Future of Sino-Japanese Relations. " On June 5, 2004, the forum further sponsored a symposium, inviting four members of the 21st Century Committee for Sino-Japanese Friendship to have a discussion on "Suggestions to Promote Sino-Japanese Relations" in Wanshou Housing Estate. Based on the current situation of Sino- Japanese relations and on "pulse-feeling" and "group consultation," the four members of the 21st Century Committee for Sino-Japanese Friendship in Beijing tried to write out a "prescription" for the development of Sino-Japanese relations. Though the speeches of the four members vary in length and even differ in views, we sincerely hope the discussion could attract your high attention to Sino-Japanese relations so as to make joint effort to bring Sino-Japanese relations to step onto the right track for healthy development.

To promote new energy development by top experimental research

Mr.Liu Zhenya,general manager of the State Grid and Mr.Fu Zhifang,executive vice governor of Hebei Province together with their colleagues jointly inspected the development of new energy project in Zhangbei County,Zhangjiakou City,Hebei Province.