The SHRIMP U-Pb zircon dating result of the Tongshi magmatic complex in western Shandong is presented in this paper. The Tongshi magmatic complex comprises fine-grained porphyritic diorite and syenitic porphyry. Eight...The SHRIMP U-Pb zircon dating result of the Tongshi magmatic complex in western Shandong is presented in this paper. The Tongshi magmatic complex comprises fine-grained porphyritic diorite and syenitic porphyry. Eighteen analyses for fine-grained porphyritic diorite gave two concordia ages, in which ten analyses constitute the young age group, giving ^206Pb/^238U ages ranging from 167.9 Ma to 183 Ma with a weighted mean age of 175.7±3.8 Ma, and the other eight yielded ^207Pb/^206Pb ages of 2502 Ma to 2554 Ma with a weighted mean 2518±11 Ma. Two analyses for syenitic porphyry gave ages of 2485 Ma and 2512 Ma, respectively. The age of 175.7±3.8 Ma indicates that the crystallization of the Tongshi magmatic complex occurred in the Middle Jurassic, whereas that of 2518±11 Ma is interpreted as the age of inherited magmatic zircons in the Neoarchean Wutai period.展开更多
Because of the complication of geological procedures,the recorded data have the feature of nonlinear.The multi-fractal singularity value decomposition (MSVD) was used to decomposed the gravity data.In this paper,the M...Because of the complication of geological procedures,the recorded data have the feature of nonlinear.The multi-fractal singularity value decomposition (MSVD) was used to decomposed the gravity data.In this paper,the MSVD was utilized to extract the gravity anomaly associated with the gold mineralization in Tongshi gold field in the southwest of Shandong province.The results showed that the Tongshi complex with negative circular gravity anomaly is an important ore-controlling factor.And the positive ring gravity anomaly distributed展开更多
THE alkali-rich subvolcanic complex of Tongshi and the associated gold mineralization are located at thesouth boundary of Pinyi Mesozoic volcanic depression in western Shandong Province. There are morethan 30 gold dep...THE alkali-rich subvolcanic complex of Tongshi and the associated gold mineralization are located at thesouth boundary of Pinyi Mesozoic volcanic depression in western Shandong Province. There are morethan 30 gold deposits and mineralization locations around the complex, in which Guilaizhuang gold deposit and Zhuojiazhuang bonanza gold deposit with important economic value are included. This area isbecoming a perspective target of superlarge gold deposit. In the mine area, there crop out Archeangranitic gneisses, Paleozoic carbonates and Jurassic clastic rocks, which was intruded by Tongshi complexwith 30 km. The complex consists of K-high igneous rocks formed by two stages of magmatism. In thefirst stage, the monzonitic dioritic porphyrys, which belong to K-high calc-alkalic rocks, were formed andin the second stage, monzonitic-syenitic porphyrys, which belong to K-high alkalic rocks, were formed.Their Ar-Ar ages are 189 Ma and 188 Ma, respectively. At the end of the second stage, a lot of theexplosive breccias were formed. The gold mineralization in this area is closely associated in time andspace with the second stage monzonitic-syenitic porphyrys. Based on the characteristics of展开更多
目的:通过网络药理学联合基因测序技术探讨补肾通蚀丸治疗酒精性股骨头坏死的潜在分子作用机制。方法:从中药系统药理数据库和分析平台(TCMSP)与BATMAN数据库中寻找补肾通蚀丸组成中药的活性有效成分和作用靶点。提取3名酒精性股骨头坏...目的:通过网络药理学联合基因测序技术探讨补肾通蚀丸治疗酒精性股骨头坏死的潜在分子作用机制。方法:从中药系统药理数据库和分析平台(TCMSP)与BATMAN数据库中寻找补肾通蚀丸组成中药的活性有效成分和作用靶点。提取3名酒精性股骨头坏死患者和3名健康志愿者外周血进行基因测序,利用R语言软件中的“DESeq2”包筛选具有差异表达的信使核糖核酸(Msessenger RNA,mRNA)。通过perl软件将基因测序获得的差异基因与药物靶基因取交集,剔除重复有效成分,获得本研究的关键基因及其对应的有效成分。将关键基因及其对应的有效成分导入Cytoscape3.8.0软件中构建成分-靶点网络。利用STRING在线数据库和R语言软件筛选出度(Degree)值得分前10的关键基因。对获得的关键基因进行基因本体论(GO)功能富集和京都基因与基因组百科全书(KEGG)通路富集分析。Degree值前2的目标基因与其对应的有效成分进行分子对接验证。结果:基因测序共获得921个差异表达基因。补肾通蚀丸共获得483个药物靶基因,74个不重复有效成分,两者交集共获得27个关键基因。半胱氨酸蛋白酶(Caspase,CASP)9和胰岛素样生长因子结合蛋白3(Insulin Like Growth Factor Binding Protein 3,IGFBP3)是本次实验获得的目标基因,β-谷甾醇、槲皮素、β-胡萝卜素、木犀草素和川陈皮素是其对应的有效成分。GO结果表明关键基因生物学过程涉及白细胞凋亡过程、血小板活化和对皮质类固醇的反应;KEGG结果表明关键基因富集在卵巢类固醇生成信号通路。分子对接显示CASP9和IGFBP3与其对应的有效成分结合良好。结论:补肾通蚀丸是通过β-谷甾醇、槲皮素、木犀草素和川陈皮素等有效成分,抑制CASP9和IGFBP3靶点蛋白的表达,调控卵巢类固醇生成通路,参与骨代谢,调节骨稳态,促进血管生成和抑制炎症因子表达,发挥治疗酒精性股骨头坏死的作用。展开更多
The geological anomaly unit method (GAUM) is a new way to delineate and evaluate ore finding targets in line with the “geological anomaly ore finding theory”. Comprehensive ore finding information from geological, g...The geological anomaly unit method (GAUM) is a new way to delineate and evaluate ore finding targets in line with the “geological anomaly ore finding theory”. Comprehensive ore finding information from geological, geochemical and geophysical data is used for quantitative measurement of the “ore forming geological anomaly unit” in this paper. The main procedures are shown as follows: (1) The geo anomalous events associated with gold mineralization are analyzed in Tongshi gold field; (2) The zonation in the concentrated heavy minerals and the stream sediment elements of ore forming geo anomaly are studied in detail; (3) The deep geological structural framework is deduced by means of the synthetic geological interpretation of gravity and magnetic information; (4) The ore controlling geo anomalies and ore anomalies are chosen as the variables of the favorable ore forming indexes that can be used for the quantitative delineation and evaluation of the potential ore forming regions.展开更多
基金This study was supported by the Major State Basic Rsearch Program of China(grant G1999043211)National Natural Science Foundation of China(grant 40272088).
文摘The SHRIMP U-Pb zircon dating result of the Tongshi magmatic complex in western Shandong is presented in this paper. The Tongshi magmatic complex comprises fine-grained porphyritic diorite and syenitic porphyry. Eighteen analyses for fine-grained porphyritic diorite gave two concordia ages, in which ten analyses constitute the young age group, giving ^206Pb/^238U ages ranging from 167.9 Ma to 183 Ma with a weighted mean age of 175.7±3.8 Ma, and the other eight yielded ^207Pb/^206Pb ages of 2502 Ma to 2554 Ma with a weighted mean 2518±11 Ma. Two analyses for syenitic porphyry gave ages of 2485 Ma and 2512 Ma, respectively. The age of 175.7±3.8 Ma indicates that the crystallization of the Tongshi magmatic complex occurred in the Middle Jurassic, whereas that of 2518±11 Ma is interpreted as the age of inherited magmatic zircons in the Neoarchean Wutai period.
文摘Because of the complication of geological procedures,the recorded data have the feature of nonlinear.The multi-fractal singularity value decomposition (MSVD) was used to decomposed the gravity data.In this paper,the MSVD was utilized to extract the gravity anomaly associated with the gold mineralization in Tongshi gold field in the southwest of Shandong province.The results showed that the Tongshi complex with negative circular gravity anomaly is an important ore-controlling factor.And the positive ring gravity anomaly distributed
文摘THE alkali-rich subvolcanic complex of Tongshi and the associated gold mineralization are located at thesouth boundary of Pinyi Mesozoic volcanic depression in western Shandong Province. There are morethan 30 gold deposits and mineralization locations around the complex, in which Guilaizhuang gold deposit and Zhuojiazhuang bonanza gold deposit with important economic value are included. This area isbecoming a perspective target of superlarge gold deposit. In the mine area, there crop out Archeangranitic gneisses, Paleozoic carbonates and Jurassic clastic rocks, which was intruded by Tongshi complexwith 30 km. The complex consists of K-high igneous rocks formed by two stages of magmatism. In thefirst stage, the monzonitic dioritic porphyrys, which belong to K-high calc-alkalic rocks, were formed andin the second stage, monzonitic-syenitic porphyrys, which belong to K-high alkalic rocks, were formed.Their Ar-Ar ages are 189 Ma and 188 Ma, respectively. At the end of the second stage, a lot of theexplosive breccias were formed. The gold mineralization in this area is closely associated in time andspace with the second stage monzonitic-syenitic porphyrys. Based on the characteristics of
文摘目的:通过网络药理学联合基因测序技术探讨补肾通蚀丸治疗酒精性股骨头坏死的潜在分子作用机制。方法:从中药系统药理数据库和分析平台(TCMSP)与BATMAN数据库中寻找补肾通蚀丸组成中药的活性有效成分和作用靶点。提取3名酒精性股骨头坏死患者和3名健康志愿者外周血进行基因测序,利用R语言软件中的“DESeq2”包筛选具有差异表达的信使核糖核酸(Msessenger RNA,mRNA)。通过perl软件将基因测序获得的差异基因与药物靶基因取交集,剔除重复有效成分,获得本研究的关键基因及其对应的有效成分。将关键基因及其对应的有效成分导入Cytoscape3.8.0软件中构建成分-靶点网络。利用STRING在线数据库和R语言软件筛选出度(Degree)值得分前10的关键基因。对获得的关键基因进行基因本体论(GO)功能富集和京都基因与基因组百科全书(KEGG)通路富集分析。Degree值前2的目标基因与其对应的有效成分进行分子对接验证。结果:基因测序共获得921个差异表达基因。补肾通蚀丸共获得483个药物靶基因,74个不重复有效成分,两者交集共获得27个关键基因。半胱氨酸蛋白酶(Caspase,CASP)9和胰岛素样生长因子结合蛋白3(Insulin Like Growth Factor Binding Protein 3,IGFBP3)是本次实验获得的目标基因,β-谷甾醇、槲皮素、β-胡萝卜素、木犀草素和川陈皮素是其对应的有效成分。GO结果表明关键基因生物学过程涉及白细胞凋亡过程、血小板活化和对皮质类固醇的反应;KEGG结果表明关键基因富集在卵巢类固醇生成信号通路。分子对接显示CASP9和IGFBP3与其对应的有效成分结合良好。结论:补肾通蚀丸是通过β-谷甾醇、槲皮素、木犀草素和川陈皮素等有效成分,抑制CASP9和IGFBP3靶点蛋白的表达,调控卵巢类固醇生成通路,参与骨代谢,调节骨稳态,促进血管生成和抑制炎症因子表达,发挥治疗酒精性股骨头坏死的作用。
文摘The geological anomaly unit method (GAUM) is a new way to delineate and evaluate ore finding targets in line with the “geological anomaly ore finding theory”. Comprehensive ore finding information from geological, geochemical and geophysical data is used for quantitative measurement of the “ore forming geological anomaly unit” in this paper. The main procedures are shown as follows: (1) The geo anomalous events associated with gold mineralization are analyzed in Tongshi gold field; (2) The zonation in the concentrated heavy minerals and the stream sediment elements of ore forming geo anomaly are studied in detail; (3) The deep geological structural framework is deduced by means of the synthetic geological interpretation of gravity and magnetic information; (4) The ore controlling geo anomalies and ore anomalies are chosen as the variables of the favorable ore forming indexes that can be used for the quantitative delineation and evaluation of the potential ore forming regions.
