Comparative study on the efficacy of transoral robotic surgery and non-robotic surgery for tongue base tumors

Objective:To compare the efficacy of transoral robotic surgery(TORS)and non-robotic surgery(NRS)in the treatment of tongue base tumors.Methods:A total of 45 patients with tongue base tumors treated in our hospital were selected,and they were divided into the TORS group and NRS group according to different surgical methods.The surgical indicators and postoperative complications of patients in the two groups were compared and analyzed.Results:Compared with the NRS group,the operative time,bleeding volume and length of hospital stay were less in the TORS group,and the postoperative recurrence rate was less in the TORS group than that in the NRS group.The incidence rate of dysphagia and restricted mouth opening in the TORS group was lower than that in the NRS group within 30 d after surgery,and the difference was statistically significant(P<0.05).Conclusion:TORS has better minimally invasive advantages in the treatment of tongue base tumors,including less intraoperative bleeding,smaller trauma,shorter length of hospital stay and faster recovery.

Pre-mental foramen mandibulotomy for resecting tumors of tongue base and parapharyngeal space

Background Resection of tumors arising from the tongue base and the parapharyngeal space is difficult for exposure and manipulation because of their obscure location. The aim of this study was to evaluate the surgical approach of the pre-mental foramen mandibulotomy for resecting the tumors of tongue base and parapharyngeal space. Methods Fifty-one patients with tumors of tongue base and parapharyngeal space were treated using the mandibulotomy approach on the pre-mental foramen. In the present study, this technique was described in detail. The patients were followed up for three months to six years with a mean of 26 months. Results The tumors of tongue base and parapharyngeal space could be exposed clearly and be resected radically by surgical approach of pre-mental foramen mandibulotomy. The surgical complications were reduced. Conclusions Compared to other surgical approaches, such as lateral mandibulotomy, midline mandibulotomy, the suprahyoid parapharyngeal approach, and paramedian mandibulotomy, we found that the pre-mental foramen mandibulotomy is the ideal choice for resecting the tumors of tongue base and parapharyngeal space.

Therapeutic effect of AdCMVCD/5-FC system and metabolism of 5-FC in the treatment of human tongue squamous cell carcinoma

To investigate the therapeutic effect and metabolism of 5 fluorocytosine (5 FC ) in human tongue squamous carcinoma cells after treatment with adenovirus medi ated cytosine deaminase (AdCMVCD)/5 FC system Methods Human tongue squamous carcinoma cells (Tca8113 cell line) and its xenografts in BALB/c nude mice were treated with AdCMVCD/5 FC system The killing effect in vitro and bystander effect were detected by microculture tetrazolium (MTT) assay Tumor inhibition effect and histopathological changes were observed in vivo High performance liquid chromatography (HPLC) was performed to determine the m etabolism of 5 FC in vitro and in vivo Results AdCMVCD/5 FC system had strong killing effect and bystander effect on Tca8113 c ells Both condition media and cell extracts showed two peaks identified as 5 FC and 5 fluorouracil (5 FU) by HPLC and a time dependent generation of 5 FU and concomitant time dependent decreases of 5 FC Compared to the control gr oups, mice treated with AdCMVCD/5 FC system demonstrated significant tumor regr ession ( P <0 001); the tumor doubling time prolonged and inhibition rate was 92 62% There were substantial tumor necrotic areas and infiltrative lymphocy tes around necrotic areas in the AdCMVCD/5 FC treated group under light microsc ope There was a significantly low concentration of 5 FC and high concentratio n of 5 FU in tumor tissue, but only 5 FC was found in blood Conclusion AdCMVCD/5 FC suicide gene system had significant in vitro and in vivo anti tum or effect on human tongue squamous cell carcinoma due to convert 5 FC into 5 F U