Research on the Development of Kindergarten-Based Curriculum with Tongyu New Year’s Paintings as Curriculum Resource

With the rapid development of modern society,the protection and inheritance of traditional culture are becoming increasingly important.As a part of Chinese traditional culture,Tongyu New Year’s Paintings,with their unique artistic style and rich cultural connotation,have become an excellent resource for exploring the beauty of tradition and inspiring creativity.Based on this,LH Kindergarten in Baicheng City,Jilin Province,has utilized Tongyu New Year’s Paintings as a curriculum resource to develop a school-based curriculum,“The Beauty of Tongyu New Year’s Paintings:Artistic Exploration for Teachers and Children.”Through diversified learning styles,teachers and children will learn about the history of New Year’s paintings,incorporate certain features of the paintings into their art activities,and cultivate creativity and the spirit of teamwork,so as to pass on the precious essence of traditional culture to children and carry forward the spirit of teamwork in their hearts.This program will lead children to experience the treasures of traditional culture and the rich connotations behind Chinese New Year’s paintings,laying a solid foundation for their growth and lifelong learning.

Use of a Land Surface Model to Evaluate the Observed Soil Moisture of Grassland at the Tongyu Reference Site

A land surface model driven by the continuous three-year observed meteorological data with a time interval of 30 minutes at the Tongyu station, a reference site of the Coordinated Enhanced Observing Period （CEOP）, was used to evaluate the observation bias of soil moisture （SM） data and analyze the variation of SM at different time scales. The saline-alkaline soil of the grassland at the Tongyu site makes the measured SM too high, especially in boreal summer of 2003-05. The simulated annual mean SM has the lowest value in 2004 and its three-year variation corresponds to the change of precipitation, whereas the observation shows the increasing trend from 2003 to 2005. Compared to the variation range between -60% and 40% for the anomaly percentage of the simulated daily mean SM during May-October of 2004, the measured data show the higher values more than 40%. The magnitude of the variation trend of the observed daily mean SM in 2003 and 2005 is generally consistent with the simulation. The largest deficiency for the soil moisture observation of the grassland is the overestimated value in the drought year with less precipitation. The simulated monthly mean SM has the lowest value in March due to the large contribution of evaporation relative to precipitation and this phenomenon can not be reproduced in the observation.

Study on Eco-environmental Stress Based on the Method of Entropy-GM(1,1) ——A Case Study in Tongyu County of Jilin Province

This paper takes the Tongyu County as an example, based on the evaluation indicator system of eco-environmental stress, using the method of the entropy- GM（1,1 ）, the eco-environmental stress is evaluated and forecasted, Results show that the shortage of water resources, the desertification, the salinization, the grassland degeneration and the population increase are major stress factors of eco-environment worsening in the Tongyu County; eco-environmental stress coefficient from 1994 to 2013 in the region was increasing year by year, and the stress degree jumped from level-Ⅲ to level-Ⅳ. The forecast results show that if the measures don＇t be taken to protect eco-environment, the stress coefficient still grows, and the stress degree aggravates. In view of the above situation, we take the measures to lighten eco-environment stress, and promote the coordi- nated development of resources, environment and social economy, which is linking rivers and lakes, water resources optimization, preventing and controlling the desertification and the salinization, improving the degenerated grassland.

Formation Mechanism of the Tongyu Gold Deposit,Shaanxi——A Discussion of a Model for the Formation of Syntectonic Gold Deposits

The formation of the Tongyu gold deposit, controlled by regional polyphase deformation-metamorphism.is closely related to the regional composite antiform-shear slip fracture zone. Late-stage reworking of theTaihua Group accounts for the enrichment of ore substances. It is a typical syntectonic gold deposit. The formation and evolution of the deposit involved four stages: (Ⅰ) the state of preparation of ore sub-stances, in which primary source beds originated: (Ⅱ) the stage of remobilization of ore substances, in whichregional progressive metamorphism and migmatization and thermodynamic-chemical differentiation led toremobilization of gold and its initial local concentration: (Ⅲ) the stage of gold deposit formation, in which re-gional folding produced concordant and cross shear-slip fractures and under the dynamic action gold was sepa-rated and migrated in a certain direction and concentrated to form a gold deposit: (Ⅳ) the stage ofsuperpositon, reworking and exposure of orebodies, in which the block uplifted and the deposit againunderwent reworking through faulting and mechanical differentiation.Thermodynamic mineralization played adominant role in the formation of the deposit.

艳丽登场 JAC TONGYUE RS

不到半年的时间,继同悦之后同悦RS艳丽登场,三厢和两厢的搭配大大加强了江淮打拼A级轿车市场的实力。

Buxu Tongyu Granule Alleviates Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble Guanylate Cyclase to Inhibit Abnormal Vasomotion

Myocardial ischemia is a serious threat to human health,and vascular dysfunction is its main cause.Buxu Tongyu(BXTY)Granule is an effective traditional Chinese medicine(TCM)for treating myocardial ischemia.However,the underlying mechanism of BXTY is still unclear.In this study,we demonstrate that BXTY ameliorates myocardial ischemia by activating the soluble guanylate cyclase(sGC)-30,50-cyclic guanosine monophosphate(cGMP)-protein kinase G(PKG)signaling pathway in vascular smooth muscle cells(VSMCs)to dilate the arteries.BXTY was given by gavage for ten consecutive days before establishing an animal model of acute myocardial ischemia in mice via the intraperitoneal injection of pituitrin.The results showed that BXTY alleviated the symptoms of myocardial ischemia induced by pituitrin in mice,including electrocardiogram abnormalities and changes in plasma enzymes.In addition,BXTY dilated pre-constricted blood vessels and inhibited the vasoconstriction of the superior mesenteric artery in a dose-dependent but endothelial-independent manner.These effects were eliminated by preincubating vascular rings with the sGC inhibitors NS 2028 or ODQ,or with the PKG inhibitor KT 5823.Moreover,BXTY increased the protein expression of sGC-b1 and the intracellular second messenger cGMP level in mouse aortic vascular smooth muscle cells(MOVAs).NS 2028 or ODQ reversed these effects of BXTY.The expression level of the cGMP downstream effector protein PKG-1 increased after treating MOVAs with BXTY.NS 2028,ODQ,or KT 5823 also reversed this effect of BXTY.In conclusion,BXTY can improve the symptoms of acute myocardial ischemia in mice,and activating the sGC-cGMP-PKG pathway in VSMCs to induce vasodilation is its key pharmacodynamic mechanism.

Ningxin Tongyu Zishen Tang in Treatment of Premature Ovarian Insufficiency:A Retrospective Control Study

Background:Premature ovarian insufficiency(POI)is a common refractory disease in gynecology,and its etiology and pathogenesis are complex.Psychological stress exerts an impact on women’s physical and mental health,and in turn affects the ovarian reserve function,which is one of the important etiologies and pathogenesis of POI.The compound formula Ningxin Tongyu Zishen Tang(NTZT)is composed of Chinese herbal medicines which can nourish heart and tranquilize mind,tonify kidney and supplement essence.By comparing the menstrual symptoms,traditional Chinese medicine(TCM)symptoms and the levels of serum sex hormone before and after treatment,the NTZT is clarified for its curative effect and advantages in patients with POI.Objective:The study aimed to observe the effects of NTZT on menstrual symptoms,TCM symptoms and the levels of serum sex hormone in POI patients.Methods:60 POI patients were divided into two groups,namely observation group and control group,with 30 patients in each group.The patients in both groups were treated by hormone replacement therapy(HRT).The observation and control groups received treatment with NTZT and or Liuwei Dihuang Wan(LDW),respectively.All of the patients were treated for 3 months continuously.The menstrual symptoms,TCM symptoms and the levels of serum sex hormone of the two groups were investigated before and after treatment.Results:It was found that the menstrual symptoms,TCM symptoms and the levels of serum sex hormone improved dramatically after treatment in the observation group(P<0.01).By comparison,the menstrual symptoms and the levels of serum sex hormone improved significantly(P<0.01),but no obvious improvement in TCM symptoms(P>0.05)in the control group was observed.Compared with the control group,the observation group showed significant improvement in TCM symptoms and the levels of serum sex hormone(P<0.01),but no significant difference was observed in the menstrual symptoms(P>0.05).In addition,there was no any adverse events such as gastrointestinal dysfunction and drug allergyobserved in both groups,indicating the safety of the two TCM formulas.Conclusion:The study found that NTZT could restore menstruation and improve the levels of sex hormone in patients with POI.It was also found that NTZT could eliminate the feelings of vexation,insomnia and dream-fulness,as well as tidal fever and sweating,aching pain of loins,and vaginal dryness significantly.It can be proved that NTZT is effective in treating patients with POI owing to its effects of nourishing heart and tranquil-izing mind,tonifying kidney and supplementing essence together,leading to elimination of psychological stress,which further promotes the development of the ovaries.

丹黄化浊通瘀丸治疗痛风性肾病的临床研究

目的:观察丹黄化浊通瘀丸治疗痛风性肾病的疗效及安全性。方法:选取痛风性肾病患者100例,随机分为观察组和对照组,每组50例。对照组予以调节血脂、止痛等对症处理,并口服别嘌呤醇及坎地沙坦,观察组在此基础上口服丹黄化浊通瘀丸。两组均于治疗12周后评定疗效,并测定治疗前后血尿酸、24 h尿蛋白定量、尿微量白蛋白/肌酐、β_(2)微球蛋白及不良反应发生情况。结果:观察组总有效率[94.0%(47/50)]高于对照组[78.0%(39/50)](P<0.05)。两组血尿酸、24 h尿蛋白、尿微量白蛋白/肌酐、β_(2)微球蛋白均较治疗前下降(P<0.05);其中血尿酸、β_(2)微球蛋白观察组较对照组下降更明显(P<0.05)。两组用药前后血常规、肝肾功能未见明显变化,无明显不良反应发生。结论:在常规应用西药治疗的基础上,以丹黄化浊通瘀丸治疗痛风性肾病可明显降低尿酸、减少蛋白尿,改善临床症状,且安全可靠。

愈梗通瘀汤治疗急性心肌梗死患者的疗效及对其血流动力学、心肌损伤标志物水平的影响

目的观察愈梗通瘀汤对急性心肌梗死(Acute myocardial infarction,AMI)患者的疗效及对其血流动力学、心肌损伤标志物水平的影响。方法选取2021年5月—2022年5月期间焦作市人民医院收治的AMI患者108例,根据简单随机化法分为对照组和联合组,每组各54例。对照组予常规对症治疗,联合组在常规对症治疗基础上给予愈梗通瘀汤治疗,均治疗14 d。观察比较两组患者治疗效果及治疗前、治疗14 d后炎症因子[肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-1β(Interleukin-1β,IL-1β)-1β、白细胞介素-6(Interleukin-6,IL-6)]、血流动力学指标[心输出量(Cardiac output,CO)、每博输出量(Stroke volume,SV)和心脏指数(Cardiac index,CI)]、心肌损伤标志物[心肌肌钙蛋白I(Cardiac troponin I,cTnI)、心型脂肪酸结合蛋白(Heart type fatty acid binding protein,H-FABP)和肌酸激酶同工酶(Creatine kinase isoenzyme,CK-MB)],分析两组患者随访6个月终点事件发生情况。结果治疗后联合组总有效率92.59%(50/54)明显高于对照组77.78%(42/54),差异有统计学意义(P<0.05)。治疗后两组患者炎症因子TNF-α、IL-1β、IL-6水平均较治疗前降低,差异有统计学意义(P<0.05);且联合组炎症因子TNF-α、IL-1β、IL-6水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血流动力学CO、SV、CI指标均较治疗前升高,差异有统计学意义(P<0.05);且联合组血流动力学CO、SV、CI指标均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者心肌损伤标志物cTnI、H-FABP、CK-MB水平均较治疗前降低,差异有统计学意义(P<0.05);且联合组心肌损伤标志物cTnI、H-FABP、CK-MB水平均明显低于对照组,差异有统计学意义(P<0.05)。随访6个月期间,联合组脑卒中和再住院发生率低于对照组,差异有统计学意义(P<0.05);两组患者非致死性心肌梗死、心血管死亡、再次血运重建发生率比较,差异无统计学意义(P>0.05)。结论愈梗通瘀汤治疗AMI疗效确切,能有效抑制炎症反应,调节血流动力学,降低心肌损伤标志物水平,改善短期预后。

活血通瘀法联合热敷方加针刺治疗输卵管阻塞性不孕的临床研究

目的观察活血通瘀法联合热敷方加针刺对输卵管阻塞性不孕患者输卵管形态、子宫微循环、复通率和预后的影响。方法选取2021年1月至2022年1月于南通大学附属南京江北医院治疗的98例输卵管阻塞性不孕患者作为研究对象。按照随机数字表法分组,49例为对照组,给予活血通瘀法联合热敷方治疗;49例为针刺联合组,给予活血通瘀法联合热敷方加针刺治疗。治疗前、后检测两组卵巢动脉的阻力指数(RI)、血管化血流指数(VFI)、搏动指数(PI),治疗前、后观察两组输卵管迂曲、僵直、似串珠样改变情况,治疗后比较两组输卵管阻塞率、输卵管通而不畅率、输卵管通畅率。随访12个月,记录两组受孕成功率。结果治疗后,针刺联合组VFI较对照组高(P<0.05),PI、RI较对照组低(P<0.05);针刺联合组输卵管迂曲、僵直、似串珠样改变发生率低于对照组(P<0.05);针刺联合组输卵管通畅率、受孕成功率高于对照组(P<0.05)。结论活血通瘀法联合热敷方加针刺治疗输卵管阻塞性不孕患者,可改善其输卵管形态及子宫微循环,提高复通率及受孕成功率,改善预后结局。

水稻新品种通育8802的选育及栽培技术

通育8802是利用远缘杂交方法选育而成。运用复态导入法将马唐基因转入到水稻中,从而获得新的品种后代。通育8802在米质、产量比较、抗性等方面均表现突出,该文从育种经过、栽培技术要点、产量表现、抗病抗逆、米质分析、主要特征特性等方面对其进行了详细介绍。

疏肝益肾通瘀方联合疏肝补肾针刺法治疗肝郁肾虚型月经后期临床研究

目的:观察疏肝益肾通瘀方联合疏肝补肾针刺法治疗肝郁肾虚型月经后期临床疗效及其安全性。方法:选取98例月经后期肝郁肾虚型患者,按随机数字表法分为对照组47例及观察组51例。对照组进行现代医学常规治疗(戊酸雌二醇片、地屈孕酮片),观察组在常规治疗基础上加用疏肝益肾通瘀方联合疏肝补肾针刺法治疗。比较2组临床疗效、排卵率及不良反应发生情况,比较2组治疗前后中医证候积分、性激素水平[雌二醇(E2)、黄体生成素(LH)、血清促卵泡生成素(FSH)]、子宫内膜厚度的变化。结果:观察组临床疗效总有效率为96.08%,对照组总有效率为82.98%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组经期错后、经量少、小腹胀痛、乳房胀痛中医证候积分均较治疗前下降(P<0.05),观察组上述4项中医证候积分均低于对照组(P<0.05)。治疗后,对照组排卵率为72.34%,观察组排卵率为92.16%,2组排卵率比较,差异有统计学意义(P<0.05)。治疗后,2组性激素E2、LH、FSH水平均较治疗前上升(P<0.05),观察组上述3项水平均高于对照组(P<0.05)。治疗后,2组子宫内膜厚度均较治疗前增加(P<0.05),观察组子宫内膜厚度大于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:疏肝益肾通瘀方联合疏肝补肾针刺法治疗肝郁肾虚型月经后期临床疗效显著,可缓解患者症状,改善性激素水平,提升排卵率,安全性高。

水下机器人在入海水道通榆河立交工程涵洞的探查应用

入海水道通榆河立交工程经多年运行,需对难以精确检查的水下部分进行详实探查。结合历年水下检查成果报告、工程现状调查分析报告等资料,以20#涵洞为典型场景,选择搭载水下光学摄像设备、二维图像声呐传感器、全向成像声呐等设备的水下机器人进行水下探查,为工程运行管理和安全评估提供参考。

蛭龙活血通瘀胶囊对糖尿病心肌病小鼠心功能的影响

目的探讨蛭龙活血通瘀胶囊(Zhilong Huoxue Tongyu capsule,ZL)对糖尿病心肌病(Diabetic cardiomy-opathy,DCM)小鼠心功能的影响。方法本研究选取2023年2月1日开始于西南医科大学动物实验中心进行实验的27只C57BL/6J小鼠作为研究对象,按随机数表法分为对照组(n=9),实验组(n=18)。实验组小鼠采用链脲佐菌素(Streptozocin,STZ)结合高脂饮食喂养,建立DCM小鼠模型。建模成功后,实验组分为模型组,蛭龙活血通瘀胶囊组,每组8只。蛭龙活血通瘀胶囊组给予ZL 6.24 g/(kg·d)灌胃,其余组给予等体积生理盐水,连续6周。观察3组小鼠心脏质量指数、血脂、心肌组织病理、心脏彩超。结果给药6周后,蛭龙活血通瘀胶囊组小鼠心脏质量指数低于模型组,各项血脂指标及心功能指标优于模型组,差异有统计学意义(P均<0.05)。H&E染色结果显示,蛭龙活血通瘀胶囊组小鼠心肌间质胶原纤维数量较模型组显著减少。结论ZL具有抑制DCM小鼠心肌纤维化的作用,从而发挥心脏保护作用。

基于Nrf-2通路探讨蛭龙活血通瘀胶囊对脑出血大鼠氧化应激损伤的机制

目的探究蛭龙活血通瘀胶囊治疗脑出血氧化应激损伤的机制。方法将45只清洁级SD大鼠随机均分为假手术组(Sham组),脑出血模型组(ICH组),蛭龙活血通瘀胶囊组(ZL组)。ICH组及ZL组以自体血注入法造模,造模成功后,ZL组以蛭龙活血通瘀胶囊(1g∙kg-1∙d-1)灌胃,ICH组及Sham组以等剂量生理盐水灌胃,喂养7 d后,观察各组大鼠神经功能缺损程度,检测脑组织及血清内氧化因子与抗氧化因子的表达,检测脑海马组织中抗氧化应激相关蛋白表达情况。结果与Sham组相比,ICH、ZL组有明显神经功能缺损,脑组织及血清中抗氧化因子含量降低,氧化因子含量增加,脑组织中核因子E2相关因子2(nuclear factor E2-related factor 2,Nrf-2)相关通路蛋白表达程度升高;与ICH组相比,ZL的神经功能缺损程度减轻,脑组织及血清中抗氧化因子含量增加,氧化因子含量减少,脑组织中Nrf-2相关通路蛋白表达程度更高。结论蛭龙活血通瘀胶囊能减轻脑出血大鼠的神经功能损伤,缓解脑组织病变,提高大鼠脑出血后Nrf-2相关蛋白表达及脑组织抗氧化能力,减轻脑出血后的氧化应激损伤。

陕西潼关桐峪金矿区深部地层岩石Au背景值变化特征及其成矿作用研究

以陕西小秦岭金矿田桐峪金矿区的两个深部探矿钻孔岩芯为研究对象,对矿田深部地层岩性构成、规模及各类岩石的Au含量进行系统研究、测试分析和规律总结,弥补矿田以往研究成果中在矿田深部地层岩性组合、各类岩石Au含量资料的欠缺,进而探讨Au元素丰度值的变化特征,为进一步完善金矿田成矿模式,助力找矿新突破,提供具有价值依据的深部地球化学背景资料。

自拟益肾养肝化痰通瘀方联合瑞舒伐他汀对颈动脉粥样硬化患者颈动脉血流参数及血脂水平的影响

目的探讨自拟益肾养肝化痰通瘀方联合瑞舒伐他汀对颈动脉粥样硬化患者颈动脉血流参数及血脂水平的影响。方法选取2020年1月—2021年6月在该院收治的颈动脉粥样硬化患者130例,采用简单随机数表法将其分组为观察组与对照组,每组65例。对照组予以瑞舒伐他汀口服,观察组在其基础上行自拟益肾养肝化痰通瘀方口服,两组均持续用药24周。比较两组临床疗效、中医证候评分、血脂水平、彩色多普勒超声结果和不良反应。结果观察组治疗后总有效率为95.38%(62/65)与对照组92.31%(60/65),差异比较无统计学意义(P>0.05);治疗后两组腰膝酸软、胸闷气短、体胖痰多中医证候评分、总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)均低于治疗前,观察组低于对照组(P<0.05),治疗后两组高密度脂蛋白胆固醇(HDL-C)、颈总动脉平均血流速度(Vm)和收缩期峰值血流速度(Vp)高于治疗前,且观察组高于对照组(P<0.05);治疗后两组搏动指数(PI)、斑块面积和颈部总动脉内膜中膜厚度(IMT)均低于治疗前,且观察组低于对照组(P<0.05);观察组治疗期间恶心、呕吐、头痛与皮肤瘙痒不良反应发生率与对照组7.69%(5/65)比较差异无统计学意义(P>0.05)。结论自拟益肾养肝化痰通瘀方联合瑞舒伐他汀可显著降低颈动脉粥样硬化患者中医证候评分,显著改善患者颈动脉血流参数和血脂水平。

早熟优质多抗玉米新品种通玉1701特征特性及其全程机械化栽培技术

通玉1701是江苏沿江地区农业科学研究所用自育自交系“SSG-1”为母本、“DK516”为父本配制杂交玉米新组合,通过2017—2018年国家东南普通玉米区域试验,2019年生产试验,2021年国家农作物品种审定委员会审定,定名为通玉1701,审定编号为国审玉20210682。该品种丰产性好,2017—2018年在国家东南普通玉米区域试验中,2年平均产量584.60 kg/667 m^(2),比对照苏玉29增产5.94%,全生育期101 d,株高254 cm,穗位高96.4 cm,倒伏率2.5%,倒折率1.1%,穗长18.6 cm,穗行数14~16行,秃尖长0.9 cm,百粒质量30.4 g,抗逆性好,适宜全程机械化生产。本文详细介绍了通玉1701的亲本来源、选育过程、产量抗性表现、特征特性、主要栽培技术、适宜种植的区域及其推广应用前景。