Objective: To observe the effects of S-adenosylmethio-nine (SAMe) in the treatment of cholestasis after totalparenteral nutrition (TPN).Methods: Thirty SD rats were randomly divided intocontrol group, hypercalorie gro...Objective: To observe the effects of S-adenosylmethio-nine (SAMe) in the treatment of cholestasis after totalparenteral nutrition (TPN).Methods: Thirty SD rats were randomly divided intocontrol group, hypercalorie group, hypercalorie+SAMegroup, sepsis group and sepsis+SAMe group to com-pare their states of cholestasis. Sixteen patients re-ceived SAMe because of cholestasis after prolongedTPN, and the therapeutic efficacy was observed.Results: Bile flow was obviously decreased and theserum levels of total bile acid and gamma-glutamyltranspeptidase(γ-GT) were markedly increased in thehypercalorie and sepsis groups. Meanwhile, hepatocytefatty degeneration, dilatation of cholangioles, and bilesludge could be seen microscopically. SAMe adminis-tration in the hypercalorie+SAMe and sepsis+SAMegroups could increase the bile flow, decrease theserum levels of total bile acid and γ-GT, reduce thepathological damage to the liver, and clear the bilesludge in the cholangioles. Cholestasis and abnormalliver function were the main manifestations of the 16patients before SAMe administration. After SAMe treat-ment for 3 weeks, serum levels of total bilirubin, al-kaline phosphatase(AKP), γ-GT, alanine aminotrans-ferase(ALT), and aspartate aminotransferase(AST)were obviously decreased, and normalized in the 4thweek.Conclusion: SAMe could prevent and treat cholestasiswithout discontinuation of TPN.展开更多
Based on Hencky＇s total strain theory of plasticity,ultimate bending capacity of steel pipes can be determined analytically assuming an elastic-linear strain hardening material,the simplified analytical solution is p...Based on Hencky＇s total strain theory of plasticity,ultimate bending capacity of steel pipes can be determined analytically assuming an elastic-linear strain hardening material,the simplified analytical solution is proposed as well.Good agreement is observed when ultimate bending capacities obtained from analytical solutions are compared with experimental results from full-size tests of steel pipes.Parametric study conducted as part of this paper indicates that the strain hardening effect has significant influence on the ultimate bending capacity of steel pipes.It is shown that pipe considering strain hardening yields higher bending capacity than that of pipe assumed as elastic-perfectly plastic material.Thus,the ignorance of strain hardening effect,as commonly assumed in current codes,may underestimate the ultimate bending capacity of steel pipes.The solutions proposed in this paper are applicable in the design of offshore/onshore steel pipes,supports of offshore platforms and other tubular structural steel members.展开更多
文摘Objective: To observe the effects of S-adenosylmethio-nine (SAMe) in the treatment of cholestasis after totalparenteral nutrition (TPN).Methods: Thirty SD rats were randomly divided intocontrol group, hypercalorie group, hypercalorie+SAMegroup, sepsis group and sepsis+SAMe group to com-pare their states of cholestasis. Sixteen patients re-ceived SAMe because of cholestasis after prolongedTPN, and the therapeutic efficacy was observed.Results: Bile flow was obviously decreased and theserum levels of total bile acid and gamma-glutamyltranspeptidase(γ-GT) were markedly increased in thehypercalorie and sepsis groups. Meanwhile, hepatocytefatty degeneration, dilatation of cholangioles, and bilesludge could be seen microscopically. SAMe adminis-tration in the hypercalorie+SAMe and sepsis+SAMegroups could increase the bile flow, decrease theserum levels of total bile acid and γ-GT, reduce thepathological damage to the liver, and clear the bilesludge in the cholangioles. Cholestasis and abnormalliver function were the main manifestations of the 16patients before SAMe administration. After SAMe treat-ment for 3 weeks, serum levels of total bilirubin, al-kaline phosphatase(AKP), γ-GT, alanine aminotrans-ferase(ALT), and aspartate aminotransferase(AST)were obviously decreased, and normalized in the 4thweek.Conclusion: SAMe could prevent and treat cholestasiswithout discontinuation of TPN.
基金financially supported by the National Natural Science Foundation of China(Grant No.51309236)the Opening Fund of State Key Laboratory of Ocean Engineering(Shanghai Jiao Tong University)(Grant No.1314)+2 种基金the Opening Fund of State Key Laboratory of Hydraulic Engineering Simulation and Safety(Tianjin University)(Grant No HESS-1411)the Opening Fund of State Key Laboratory of Coastal and Offshore Engineering(Dalian University of Technology)(Grant No.LP1507)the Science Foundation of China University of Petroleum,Beijing(Grant Nos.2462015YQ0403 and 2462015YQ0408)
文摘Based on Hencky＇s total strain theory of plasticity,ultimate bending capacity of steel pipes can be determined analytically assuming an elastic-linear strain hardening material,the simplified analytical solution is proposed as well.Good agreement is observed when ultimate bending capacities obtained from analytical solutions are compared with experimental results from full-size tests of steel pipes.Parametric study conducted as part of this paper indicates that the strain hardening effect has significant influence on the ultimate bending capacity of steel pipes.It is shown that pipe considering strain hardening yields higher bending capacity than that of pipe assumed as elastic-perfectly plastic material.Thus,the ignorance of strain hardening effect,as commonly assumed in current codes,may underestimate the ultimate bending capacity of steel pipes.The solutions proposed in this paper are applicable in the design of offshore/onshore steel pipes,supports of offshore platforms and other tubular structural steel members.
