Basal or bolus dose, which is the key factor in CSII?

Objective: To observe the value of HbA1c level evaluating the total daily basal insulin dose by continuous subcuta- neous insulin infusion (CSII) in 268 patients with type 2 diabetes mellitus. Methods: 5-point capillary blood glucose was moni- tored in pre- and post-CSII and the insulin dose which could stabilize blood glucose was defined as the total daily dose of insulin, including basal and bolus total dose. Correlation between HbA1c level and total daily dose of insulin in patients with type 2 dia- betes mellitus was analyzed. Correlation between HbA1c level and 5-point capillary blood glucose was also analyzed. Results: Obvious correlation was observed between HbA1c level and the basal total daily dose of insulin if HbA1c was more than 9.3% (r=0.635, P<0.05). The average of 5-point capillary blood glucose was best correlated with HbA1c and fasting blood glucose next best. Conclusion: HbA1c level can forecast basal total daily dose of insulin in CSII.

2型糖尿病患者血糖水平与胰岛素需要量的相关性

目的探讨胰岛素泵治疗不同血糖水平2型糖尿病（T2DM）患者基础胰岛素及进餐大剂量需要量的范围。方法111例T2DM,根据第1天平均血糖（MBG）分为7~10 mmol/L（A组）,10~11.1 mmol/L（B组）,11.1~13.9 mmol/L（C组）,13.9~22 mmol/L（D组）4组,持续皮下胰岛素输注（CSII）治疗8 d,比较MBG及胰岛素变化。结果第8天4组MBG均降低,4组间差异无统计学意义（P〉0.05）。A、B、C、D组基础总量（TBD）95%可信区间（CI）分别为：（11.57,14.85）、（13.06,17.03）、（14.48,18.12）、（19.87,25.24）,进餐大剂量（DD）95%CI分别为：（14.04,16.96）、（13.78,17.12）、（17.00,20.61）、（21.07,27.55）,TBD/DD95%CI分别为：（0.78,0.94）、（0.86,1.21）、（0.80,0.96）、（0.88,1.07）,4组间TBD、DD差异有统计学意义（P〈0.01）,而TBD/DD差异无统计学意义（P〉0.05）。结论 CSII短期治疗T2DM效果确切,不同血糖水平患者TBD、DD需要量不同,但TBD/DD无差异。