Low-Earth Orbit Satellite Constellations(LEO-SCs)provide global,high-speed,and low latency Internet access services,which bridges the digital divide in the remote areas.As inter-satellite links are not supported in in...Low-Earth Orbit Satellite Constellations(LEO-SCs)provide global,high-speed,and low latency Internet access services,which bridges the digital divide in the remote areas.As inter-satellite links are not supported in initial deployment(i.e.the Starlink),the communication between satellites is based on ground stations with radio frequency signals.Due to the rapid movement of satellites,this hybrid topology of LEO-SCs and ground stations is time-varying,which imposes a major challenge to uninterrupted service provisioning and network management.In this paper,we focus on solving two notable problems in such a ground station-assisted LEO-SC topology,i.e.,traffic engineering and fast reroute,to guarantee that the packets are forwarded in a balanced and uninterrupted manner.Specifically,we employ segment routing to support the arbitrary path routing in LEO-SCs.To solve the traffic engineering problem,we proposed two source routings with traffic splitting algorithms,Delay-Bounded Traffic Splitting(DBTS)and DBTS+,where DBTS equally splits a flow and DBTS+favors shorter paths.Simu-lation results show that DBTS+can achieve about 30%lower maximum satellite load at the cost of about 10%more delay.To guarantee the fast recovery of failures,two fast reroute mechanisms,Loop-Free Alternate(LFA)and LFA+,are studied,where LFA pre-computes an alternate next-hop as a backup while LFA+finds a 2-segment backup path.We show that LFA+can increase the percentage of protection coverage by about 15%.展开更多
Wireless sensor networks(WSNs)are characterized by heterogeneous traffic types(audio,video,data)and diverse application traffic requirements.This paper introduces three traffic classes following the defined model of h...Wireless sensor networks(WSNs)are characterized by heterogeneous traffic types(audio,video,data)and diverse application traffic requirements.This paper introduces three traffic classes following the defined model of heterogeneous traffic differentiation in WSNs.The requirements for each class regarding sensitivity to QoS(Quality of Service)parameters,such as loss,delay,and jitter,are described.These classes encompass real-time and delay-tolerant traffic.Given that QoS evaluation is a multi-criteria decision-making problem,we employed the AHP(Analytical Hierarchy Process)method for multi-criteria optimization.As a result of this approach,we derived weight values for different traffic classes based on key QoS factors and requirements.These weights are assigned to individual traffic classes to determine transmission priority.This study provides a thorough comparative analysis of the proposed model against existing methods,demonstrating its superior performance across various traffic scenarios and its implications for future WSN applications.The results highlight the model’s adaptability and robustness in optimizing network resources under varying conditions,offering insights into practical deployments in real-world scenarios.Additionally,the paper includes an analysis of energy consumption,underscoring the trade-offs between QoS performance and energy efficiency.This study presents the development of a differentiated services model for heterogeneous traffic in wireless sensor networks,considering the appropriate QoS framework supported by experimental analyses.展开更多
Background:Most bone-related injuries to grassroots troops are caused by training or accidental injuries.To establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroot...Background:Most bone-related injuries to grassroots troops are caused by training or accidental injuries.To establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone regeneration.Methods:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABaTiO_(3),PBT)nanoparticles into a chitosan/gelatin(Cs/Gel)matrix.The physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBT were analyzed.Cell and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in vivo.Results:The incorporation of BaTiO_(3) into the scafold improved its mechanical properties and increased self-generated electricity.Due to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBT hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to M2 phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECM)mineralization of MC3T3-E1 cells.The in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury model.The underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage M2 polarization.Conclusion:The piezoelectric Cs/Gel/PHA/PBT hydrogels developed here with favorable immunomodulation,angiogenesis,and osteogenesis functions may be used as a substitute in periosteum injuries,thereby offering the novel strategy of applying piezoelectric stimulation in bone tissue engineering for the enhancement of combat efectiveness in grassroots troops.展开更多
Traffic Engineering(TE)enables management of traffic in a manner that optimizes utilization of network resources in an efficient and balanced manner.However,existing TE solutions face issues relating to scalability an...Traffic Engineering(TE)enables management of traffic in a manner that optimizes utilization of network resources in an efficient and balanced manner.However,existing TE solutions face issues relating to scalability and complexity.In recent years,Segment Routing(SR)has emerged as a promising source routing paradigm.As one of the most important applications of SR,Segment Routing Traffic Engineering(SR-TE),which enables a headend to steer traffic along specific paths represented as ordered lists of instructions called segment lists,has the capability to overcome the above challenges due to its flexibility and scalability.In this paper,we conduct a comprehensive survey on SR-TE.A thorough review of SR-TE architecture is provided in the first place,reviewing the core components and implementation of SR-TE such as SR Policy,Flexible Algorithm and SR-native algorithm.Strengths of SR-TE are also discussed,as well as its major challenges.Next,we dwell on the recent SR-TE researches on routing optimization with various intents,e.g.,optimization on link utilization,throughput,QoE(Quality of Experience)and energy consumption.Afterwards,node management for SR-TE are investigated,including SR node deployment and candidate node selection.Finally,we discuss the existing challenges of current research activities and propose several research directions worth of future exploration.展开更多
An approach to traffic engineering that uses differentiated services (DS) andmulti-protocol label switching (MPLS) to provide quantitative network quality of service (QoS)guarantees over an IP network was proposed. Th...An approach to traffic engineering that uses differentiated services (DS) andmulti-protocol label switching (MPLS) to provide quantitative network quality of service (QoS)guarantees over an IP network was proposed. The traffic associated with assured forwarding (AF)Per-Hop behavior (PHB) in differentiated services enabled IP network was modeled. Furthermore, theeffect of such traffic on network resources with die objective of developing efficient trafficengineering methodologies was analyzed and the optimization problem relating to traffic engineeringin DS networks with an MPLS core was formulated. The service received by TCP and UDP flows when theyshare either a link or a MPLS traffic trunk was also compared and found that in order to benefitfrom traffic engineering, MPLS trunks should be implemented end-end (first router to last router).If some part of the network is MPLS trunk-unaware, the benefits are reduced or eliminated.展开更多
A new coarse-grained differentiated least interference routing algorithm(CDLI) with DiffServ-Aware was presented.This algorithm is composed of off-line and on-line stages,taking into account both real-time traffic and...A new coarse-grained differentiated least interference routing algorithm(CDLI) with DiffServ-Aware was presented.This algorithm is composed of off-line and on-line stages,taking into account both real-time traffic and best-effort traffic.Off-line stage is to determine the shortest path set disjointed path(DP) database for real-time traffic,and to identify link critical value by traffic profile information of real-time traffic and DP database.On-line stage is at first to select route in the DP database for real-time traffic,if there is no path to meet the needs,the dynamic routing will be operated.On-line routing algorithm chooses the relatively short path for real-time traffic to meet their bandwidth requirements,and for best-effort traffic it chooses a lighter load path.The simulation results show that compared with the dynamic online routing algorithm(DORA) and constrained shortest path first(CSPF) algorithm,the new algorithm can significantly improve network throughput and reduce the average path length of real-time traffic.This guarantees quality of service(QoS) of real-time traffic while improving the utilization of network resources.展开更多
Endothelial cells (TEC_3 cells) derived from mouse embryonic stem (ES) cells were used as seed cells to construct blood vessels. Tissue engineered blood vessels were made by seeding 8 × 10~6 smooth muscle cells (...Endothelial cells (TEC_3 cells) derived from mouse embryonic stem (ES) cells were used as seed cells to construct blood vessels. Tissue engineered blood vessels were made by seeding 8 × 10~6 smooth muscle cells (SMCs) obtained from rabbit arteries onto a sheet of nonwoven polyglycolic acid (PGA) fibers, which was used as a biodegradable polymer scaffold. After being cultured in DMEM medium for 7 days in vitro, SMCs grew well on the PGA fibers, and the cell-PGA sheet was then wrapped around a silicon tube, and implanted subcutaneously into nude mice. After 6~8 weeks, the silicon tube was replaced with another silicon tube in smaller diameter, and then the TEC_3 cells (endothelial cells differentiated from mouse ES cells) were injected inside the engineered vessel tube as the test group. In the control group only culture medium was injected. Five days later, the engineered vessels were harvested for gross observation, histological and immunohistochemical analysis. The preliminary results demonstrated that the SMC-PGA construct could form a tubular structure in 6~8 weeks and PGA fibers were completely degraded. Histological and immunohistochemical analysis of the newly formed tissue revealed a typical blood vessel structure, including a lining of endothelial cells (ECs) on the lumimal surface and the presence of SMC and collagen in the wall. No EC lining was found in the tubes of control group. Therefore, the ECs differentiated from mouse ES cells can serve as seed cells for endothelium lining in tissue engineered blood vessels.展开更多
The purpose of this study was to assess fetal bovine acellular dermal matrix as a scaffold for supporting the differentiation of bone marrow mesenchymal stem cells into neural cells fol-lowing induction with neural di...The purpose of this study was to assess fetal bovine acellular dermal matrix as a scaffold for supporting the differentiation of bone marrow mesenchymal stem cells into neural cells fol-lowing induction with neural differentiation medium. We performed long-term, continuous observation of cell morphology, growth, differentiation, and neuronal development using several microscopy techniques in conjunction with immunohistochemistry. We examined speciifc neu-ronal proteins and Nissl bodies involved in the differentiation process in order to determine the neuronal differentiation of bone marrow mesenchymal stem cells. The results show that bone marrow mesenchymal stem cells that differentiate on fetal bovine acellular dermal matrix display neuronal morphology with unipolar and bi/multipolar neurite elongations that express neuro-nal-speciifc proteins, includingβIII tubulin. The bone marrow mesenchymal stem cells grown on fetal bovine acellular dermal matrix and induced for long periods of time with neural differen-tiation medium differentiated into a multilayered neural network-like structure with long nerve ifbers that was composed of several parallel microifbers and neuronal cells, forming a complete neural circuit with dendrite-dendrite to axon-dendrite to dendrite-axon synapses. In addition, growth cones with filopodia were observed using scanning electron microscopy. Paraffin sec-tioning showed differentiated bone marrow mesenchymal stem cells with the typical features of neuronal phenotype, such as a large, round nucleus and a cytoplasm full of Nissl bodies. The data suggest that the biological scaffold fetal bovine acellular dermal matrix is capable of supporting human bone marrow mesenchymal stem cell differentiation into functional neurons and the subsequent formation of tissue engineered nerve.展开更多
This paper discusses traffic engineering with multi protocol label switching (MPLS) in a backbone of Internet data center (IDC) network. The traditional SPF routing limitations are analyzed and the traffic engineerin...This paper discusses traffic engineering with multi protocol label switching (MPLS) in a backbone of Internet data center (IDC) network. The traditional SPF routing limitations are analyzed and the traffic engineering concept is given. MPLS, resource reservation protocol (RSVP) and enhanced link status Protocols intermediate system to intermediate system (IS IS) are reviewed to provide a background for traffic engineering, the general issues of designing an MPLS system of IDC network for traffic engineering are then discussed. Finally a practical example with MPLS traffic engineering is shown.展开更多
This paper studies the performance of Traffic Engineering (TE) signal protocols used for load balancing in Multi-Protocol Label Switching (MPLS) networks, namely;Constraint Based Routed Label Distribution Protocol LDP...This paper studies the performance of Traffic Engineering (TE) signal protocols used for load balancing in Multi-Protocol Label Switching (MPLS) networks, namely;Constraint Based Routed Label Distribution Protocol LDP (CR-LDP) and Resource Reservation Protocol (RSVP). Furthermore, the performance of an MPLS network uses these TE signal protocols is compared to that of a conventional Internet Protocol (IP) network. Different applications including voice, video, File Transfer Protocol (FTP) and Hyperlink Text Transfer Protocol (HTTP) are used for the performance evaluation. Simulation results show superior performance of the MPLS network with CR-LDP TE signal protocol in all tested applications.展开更多
The emergence of Segment Routing(SR)provides a novel routing paradigm that uses a routing technique called source packet routing.In SR architecture,the paths that the packets choose to route on are indicated at the in...The emergence of Segment Routing(SR)provides a novel routing paradigm that uses a routing technique called source packet routing.In SR architecture,the paths that the packets choose to route on are indicated at the ingress router.Compared with shortest-path-based routing in traditional distributed routing protocols,SR can realize a flexible routing by implementing an arbitrary flow splitting at the ingress router.Despite the advantages of SR,it may be difficult to update the existing IP network to a full SR deployed network,for economical and technical reasons.Updating partial of the traditional IP network to the SR network,thus forming a hybrid SR network,is a preferable choice.For the traffic is dynamically changing in a daily time,in this paper,we propose a Weight Adjustment algorithm WASAR to optimize routing in a dynamic hybrid SR network.WASAR algorithm can be divided into three steps:firstly,representative Traffic Matrices(TMs)and the expected TM are obtained from the historical TMs through ultrascalable spectral clustering algorithm.Secondly,given the network topology,the initial network weight setting and the expected TM,we can realize the link weight optimization and SR node deployment optimization through a Deep Reinforcement Learning(DRL)algorithm.Thirdly,we optimize the flow splitting ratios of SR nodes in a centralized online manner under dynamic traffic demands,in order to improve the network performance.In the evaluation,we exploit historical TMs to test the performance of the obtained routing configuration in WASAR.The extensive experimental results validate that our proposed WASAR algorithm has superior performance in reducing Maximum Link Utilization(MLU)under the dynamic traffic.展开更多
Our previous study showed that cell cycle exit and neuronal differentiation 1(CEND1)may participate in neural stem cell cycle exit and oriented differentiation.However,whether CEND1-transfected neural stem cells can i...Our previous study showed that cell cycle exit and neuronal differentiation 1(CEND1)may participate in neural stem cell cycle exit and oriented differentiation.However,whether CEND1-transfected neural stem cells can improve the prognosis of traumatic brain injury remained unclear.In this study,we performed quantitative proteomic analysis and found that after traumatic brain injury,CEND1 expression was downregulated in mouse brain tissue.Three days after traumatic brain injury,we transplanted CEND1-transfected neural stem cells into the area surrounding the injury site.We found that at 5 weeks after traumatic brain injury,transplantation of CEND1-transfected neural stem cells markedly alleviated brain atrophy and greatly improved neurological function.In vivo and in vitro results indicate that CEND1 overexpression inhibited the proliferation of neural stem cells,but significantly promoted their neuronal differentiation.Additionally,CEND1 overexpression reduced protein levels of Notch1 and cyclin D1,but increased levels of p21 in CEND1-transfected neural stem cells.Treatment with CEND1-transfected neural stem cells was superior to similar treatment without CEND1 transfection.These findings suggest that transplantation of CEND1-transfected neural stem cells is a promising cell therapy for traumatic brain injury.This study was approved by the Animal Ethics Committee of the School of Biomedical Engineering of Shanghai Jiao Tong University,China(approval No.2016034)on November 25,2016.展开更多
Differential evolution (DE) algorithm has been shown to be a simple and efficient evolutionary algorithm for global optimization over continuous spaces, and has been widely used in both benchmark test functions and re...Differential evolution (DE) algorithm has been shown to be a simple and efficient evolutionary algorithm for global optimization over continuous spaces, and has been widely used in both benchmark test functions and real-world applications. This paper introduces a novel mutation operator, without using the scaling factor F, a conventional control parameter, and this mutation can generate multiple trial vectors by incorporating different weighted values at each generation, which can make the best of the selected multiple parents to improve the probability of generating a better offspring. In addition, in order to enhance the capacity of adaptation, a new and adaptive control parameter, i.e. the crossover rate CR, is presented and when one variable is beyond its boundary, a repair rule is also applied in this paper. The proposed algorithm ADE is validated on several constrained engineering design optimization problems reported in the specialized literature. Compared with respect to algorithms representative of the state-of-the-art in the area, the experimental results show that ADE can obtain good solutions on a test set of constrained optimization problems in engineering design.展开更多
Segment Routing(SR)is a new routing paradigm based on source routing and provide traffic engineering(TE)capabilities in IP network.By extending interior gateway protocol(IGP),SR can be easily applied to IP network.How...Segment Routing(SR)is a new routing paradigm based on source routing and provide traffic engineering(TE)capabilities in IP network.By extending interior gateway protocol(IGP),SR can be easily applied to IP network.However,upgrading current IP network to a full SR one can be costly and difficult.Hybrid IP/SR network will last for some time.Aiming at the low flexibility problem of static TE policies in the current SR networks,this paper proposes a Deep Reinforcement Learning(DRL)based TE scheme.The proposed scheme employs multi-path transmission and use DRL to dynamically adjust the traffic splitting ratio among different paths based on the network traffic distribution.As a result,the network congestion can be mitigated and the performance of the network is improved.Simulation results show that our proposed scheme can improve the throughput of the network by up to 9%than existing schemes.展开更多
The study of Quality of Service (QoS) has become of great importance since the Internet is used to support a wide variety of new services and applications with its legacy structure. Current Internet architecture is ba...The study of Quality of Service (QoS) has become of great importance since the Internet is used to support a wide variety of new services and applications with its legacy structure. Current Internet architecture is based on the Best Effort (BE) model, which attempts to deliver all traffic as soon as possible within the limits of its abilities, but without any guarantee about throughput, delay, packet loss, etc. We develop a three-layer policy based architecture which can be deployed to control network resources intelligently and support QoS sensi-tive applications such as real-time voice and video streams along with standard applications in the Internet. In order to achieve selected QoS parameter values (e.g. loss, delay and PDV) within the bounds set through SLAs for high priority voice traffic in the Internet, we used traffic engineering techniques and policy based routing supported by Border Gateway Protocol (BGP). Use of prototype and simulations validates function-ality of our architecture.展开更多
Based on traffic engineering, the network topology is described with network graph. An algorithm for the derivation of data communication capability in network links and the analysis of connectivity performance betwee...Based on traffic engineering, the network topology is described with network graph. An algorithm for the derivation of data communication capability in network links and the analysis of connectivity performance between node pairs is given through standardized transformation of the original descriptive matrix for the link performance, and resolution of transitive closure for adjacent-incident matrix of network in view of randomness of network events, which provides a feasible way for analysis and improvement of network performance.展开更多
General multi-protocol label switching(GMPLS) based on traffic engineering is one of the possible methods to implement all-optical network. This method implements the network with IP technique and guarantees the quali...General multi-protocol label switching(GMPLS) based on traffic engineering is one of the possible methods to implement all-optical network. This method implements the network with IP technique and guarantees the quality of service with traffic engineering. Based on the establishment of selecting schemes of optical path and methods of traffic calculation, the wavelength routing algorithm of all-optical network based on traffic engineering is presented by combining with prior route of shortest path and traffic engineering, the algorithm procedures are given, and the actual examples are introduced as well as the analysis on simulation calculation. This research results have certain significance for the achievement of optical switching technique of all-optical network.展开更多
Nowadays the number of cores that are integrated into NoC (Network on Chip) systems is steadily increasing, and real application traffic, running in such multi-core environments requires more and more bandwidth. In th...Nowadays the number of cores that are integrated into NoC (Network on Chip) systems is steadily increasing, and real application traffic, running in such multi-core environments requires more and more bandwidth. In that sense, NoC architectures should be properly designed so as to provide efficient traffic engineering, as well as QoS support. Routing algorithm choice in conjunction with other parameters, such as network size and topology, traffic features (time and spatial distribution), as well as packet injection rate, packet size, and buffering capability, are all equivalently critical for designing a robust NoC architecture, on the grounds of traffic engineering and QoS provision. In this paper, a thorough numerical investigation is achieved by taking into consideration the criticality of selecting the proper routing algorithm, in conjunction with all the other aforementioned parameters. This is done via implementation of four routing evaluation traffic scenarios varying each parameter either individually, or as a set, thus exhausting all possible combinations, and making compact decisions on proper routing algorithm selection in NoC architectures. It has been shown that the simplicity of a deterministic routing algorithm such as XY, seems to be a reasonable choice, not only for random traffic patterns but also for non-uniform distributed traffic patterns, in terms of delay and throughput for 2D mesh NoC systems.展开更多
This study compares the Adomian Decomposition Method (ADM) and the Variational Iteration Method (VIM) for solving nonlinear differential equations in engineering. Differential equations are essential for modeling dyna...This study compares the Adomian Decomposition Method (ADM) and the Variational Iteration Method (VIM) for solving nonlinear differential equations in engineering. Differential equations are essential for modeling dynamic systems in various disciplines, including biological processes, heat transfer, and control systems. This study addresses first, second, and third-order nonlinear differential equations using Mathematica for data generation and graphing. The ADM, developed by George Adomian, uses Adomian polynomials to handle nonlinear terms, which can be computationally intensive. In contrast, VIM, developed by He, directly iterates the correction functional, providing a more straightforward and efficient approach. This study highlights VIM’s rapid convergence and effectiveness of VIM, particularly for nonlinear problems, where it simplifies calculations and offers direct solutions without polynomial derivation. The results demonstrate VIM’s superior efficiency and rapid convergence of VIM compared with ADM. The VIM’s minimal computational requirements make it practical for real-time applications and complex system modeling. Our findings align with those of previous research, confirming VIM’s efficiency of VIM in various engineering applications. This study emphasizes the importance of selecting appropriate methods based on specific problem requirements. While ADM is valuable for certain nonlinearities, VIM’s approach is ideal for many engineering scenarios. Future research should explore broader applications and hybrid methods to enhance the solution’s accuracy and efficiency. This comprehensive comparison provides valuable guidance for selecting effective numerical methods for differential equations in engineering.展开更多
Traffic management is an important contribution in the sustainable development of urban traffic.The complexity of traffic problems determines the difficulty of traffic management.Therefore,traffic management needs the...Traffic management is an important contribution in the sustainable development of urban traffic.The complexity of traffic problems determines the difficulty of traffic management.Therefore,traffic management needs the guidance of scientific theories.This paper explores traffic management systems engineering for management road traffic.First,the paper looks at the contents of road traffic management from a systems perspective.Second,the paper briefly describes systems engineering,and explains the necessity and feasibility of the combination of the traffic management and systems engineering.At last,the paper puts forward the concept of traffic management systems engineering using a systems framework.展开更多
文摘Low-Earth Orbit Satellite Constellations(LEO-SCs)provide global,high-speed,and low latency Internet access services,which bridges the digital divide in the remote areas.As inter-satellite links are not supported in initial deployment(i.e.the Starlink),the communication between satellites is based on ground stations with radio frequency signals.Due to the rapid movement of satellites,this hybrid topology of LEO-SCs and ground stations is time-varying,which imposes a major challenge to uninterrupted service provisioning and network management.In this paper,we focus on solving two notable problems in such a ground station-assisted LEO-SC topology,i.e.,traffic engineering and fast reroute,to guarantee that the packets are forwarded in a balanced and uninterrupted manner.Specifically,we employ segment routing to support the arbitrary path routing in LEO-SCs.To solve the traffic engineering problem,we proposed two source routings with traffic splitting algorithms,Delay-Bounded Traffic Splitting(DBTS)and DBTS+,where DBTS equally splits a flow and DBTS+favors shorter paths.Simu-lation results show that DBTS+can achieve about 30%lower maximum satellite load at the cost of about 10%more delay.To guarantee the fast recovery of failures,two fast reroute mechanisms,Loop-Free Alternate(LFA)and LFA+,are studied,where LFA pre-computes an alternate next-hop as a backup while LFA+finds a 2-segment backup path.We show that LFA+can increase the percentage of protection coverage by about 15%.
文摘Wireless sensor networks(WSNs)are characterized by heterogeneous traffic types(audio,video,data)and diverse application traffic requirements.This paper introduces three traffic classes following the defined model of heterogeneous traffic differentiation in WSNs.The requirements for each class regarding sensitivity to QoS(Quality of Service)parameters,such as loss,delay,and jitter,are described.These classes encompass real-time and delay-tolerant traffic.Given that QoS evaluation is a multi-criteria decision-making problem,we employed the AHP(Analytical Hierarchy Process)method for multi-criteria optimization.As a result of this approach,we derived weight values for different traffic classes based on key QoS factors and requirements.These weights are assigned to individual traffic classes to determine transmission priority.This study provides a thorough comparative analysis of the proposed model against existing methods,demonstrating its superior performance across various traffic scenarios and its implications for future WSN applications.The results highlight the model’s adaptability and robustness in optimizing network resources under varying conditions,offering insights into practical deployments in real-world scenarios.Additionally,the paper includes an analysis of energy consumption,underscoring the trade-offs between QoS performance and energy efficiency.This study presents the development of a differentiated services model for heterogeneous traffic in wireless sensor networks,considering the appropriate QoS framework supported by experimental analyses.
基金supported by the National Natural Science Foundation of China(82202352,82271629)the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(ZNLH202202)+1 种基金the China Postdoctoral Science Foundation Funded Project(2023M732711)the Wenzhou Medical University grant(QTJ23004)。
文摘Background:Most bone-related injuries to grassroots troops are caused by training or accidental injuries.To establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone regeneration.Methods:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABaTiO_(3),PBT)nanoparticles into a chitosan/gelatin(Cs/Gel)matrix.The physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBT were analyzed.Cell and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in vivo.Results:The incorporation of BaTiO_(3) into the scafold improved its mechanical properties and increased self-generated electricity.Due to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBT hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to M2 phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECM)mineralization of MC3T3-E1 cells.The in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury model.The underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage M2 polarization.Conclusion:The piezoelectric Cs/Gel/PHA/PBT hydrogels developed here with favorable immunomodulation,angiogenesis,and osteogenesis functions may be used as a substitute in periosteum injuries,thereby offering the novel strategy of applying piezoelectric stimulation in bone tissue engineering for the enhancement of combat efectiveness in grassroots troops.
基金partially supported by Chinese National Research Fund(NSFC)No.62172189 and 61772235Natural Science Foundation of Guangdong Province No.2020A1515010771Science and Technology Program of Guangzhou No.202002030372.
文摘Traffic Engineering(TE)enables management of traffic in a manner that optimizes utilization of network resources in an efficient and balanced manner.However,existing TE solutions face issues relating to scalability and complexity.In recent years,Segment Routing(SR)has emerged as a promising source routing paradigm.As one of the most important applications of SR,Segment Routing Traffic Engineering(SR-TE),which enables a headend to steer traffic along specific paths represented as ordered lists of instructions called segment lists,has the capability to overcome the above challenges due to its flexibility and scalability.In this paper,we conduct a comprehensive survey on SR-TE.A thorough review of SR-TE architecture is provided in the first place,reviewing the core components and implementation of SR-TE such as SR Policy,Flexible Algorithm and SR-native algorithm.Strengths of SR-TE are also discussed,as well as its major challenges.Next,we dwell on the recent SR-TE researches on routing optimization with various intents,e.g.,optimization on link utilization,throughput,QoE(Quality of Experience)and energy consumption.Afterwards,node management for SR-TE are investigated,including SR node deployment and candidate node selection.Finally,we discuss the existing challenges of current research activities and propose several research directions worth of future exploration.
文摘An approach to traffic engineering that uses differentiated services (DS) andmulti-protocol label switching (MPLS) to provide quantitative network quality of service (QoS)guarantees over an IP network was proposed. The traffic associated with assured forwarding (AF)Per-Hop behavior (PHB) in differentiated services enabled IP network was modeled. Furthermore, theeffect of such traffic on network resources with die objective of developing efficient trafficengineering methodologies was analyzed and the optimization problem relating to traffic engineeringin DS networks with an MPLS core was formulated. The service received by TCP and UDP flows when theyshare either a link or a MPLS traffic trunk was also compared and found that in order to benefitfrom traffic engineering, MPLS trunks should be implemented end-end (first router to last router).If some part of the network is MPLS trunk-unaware, the benefits are reduced or eliminated.
基金Project(2003AA781011) supported by the National High-Tech Research and Development of Program of China Project(20072022) supported by Science and Technology Foundation of Liaoning Province,China
文摘A new coarse-grained differentiated least interference routing algorithm(CDLI) with DiffServ-Aware was presented.This algorithm is composed of off-line and on-line stages,taking into account both real-time traffic and best-effort traffic.Off-line stage is to determine the shortest path set disjointed path(DP) database for real-time traffic,and to identify link critical value by traffic profile information of real-time traffic and DP database.On-line stage is at first to select route in the DP database for real-time traffic,if there is no path to meet the needs,the dynamic routing will be operated.On-line routing algorithm chooses the relatively short path for real-time traffic to meet their bandwidth requirements,and for best-effort traffic it chooses a lighter load path.The simulation results show that compared with the dynamic online routing algorithm(DORA) and constrained shortest path first(CSPF) algorithm,the new algorithm can significantly improve network throughput and reduce the average path length of real-time traffic.This guarantees quality of service(QoS) of real-time traffic while improving the utilization of network resources.
基金supported by the national“973”tissue engineering project of China(G1999054300)Shanghai Science and Technology Development Foundation(03DJ14021)
文摘Endothelial cells (TEC_3 cells) derived from mouse embryonic stem (ES) cells were used as seed cells to construct blood vessels. Tissue engineered blood vessels were made by seeding 8 × 10~6 smooth muscle cells (SMCs) obtained from rabbit arteries onto a sheet of nonwoven polyglycolic acid (PGA) fibers, which was used as a biodegradable polymer scaffold. After being cultured in DMEM medium for 7 days in vitro, SMCs grew well on the PGA fibers, and the cell-PGA sheet was then wrapped around a silicon tube, and implanted subcutaneously into nude mice. After 6~8 weeks, the silicon tube was replaced with another silicon tube in smaller diameter, and then the TEC_3 cells (endothelial cells differentiated from mouse ES cells) were injected inside the engineered vessel tube as the test group. In the control group only culture medium was injected. Five days later, the engineered vessels were harvested for gross observation, histological and immunohistochemical analysis. The preliminary results demonstrated that the SMC-PGA construct could form a tubular structure in 6~8 weeks and PGA fibers were completely degraded. Histological and immunohistochemical analysis of the newly formed tissue revealed a typical blood vessel structure, including a lining of endothelial cells (ECs) on the lumimal surface and the presence of SMC and collagen in the wall. No EC lining was found in the tubes of control group. Therefore, the ECs differentiated from mouse ES cells can serve as seed cells for endothelium lining in tissue engineered blood vessels.
基金supported by a grant from Construction Project of Gansu Provincial Animal Cell Engineering Center,No.0808NTGA013Program for Innovative Research Team in University of Ministry of Education of China,No.IRT13091
文摘The purpose of this study was to assess fetal bovine acellular dermal matrix as a scaffold for supporting the differentiation of bone marrow mesenchymal stem cells into neural cells fol-lowing induction with neural differentiation medium. We performed long-term, continuous observation of cell morphology, growth, differentiation, and neuronal development using several microscopy techniques in conjunction with immunohistochemistry. We examined speciifc neu-ronal proteins and Nissl bodies involved in the differentiation process in order to determine the neuronal differentiation of bone marrow mesenchymal stem cells. The results show that bone marrow mesenchymal stem cells that differentiate on fetal bovine acellular dermal matrix display neuronal morphology with unipolar and bi/multipolar neurite elongations that express neuro-nal-speciifc proteins, includingβIII tubulin. The bone marrow mesenchymal stem cells grown on fetal bovine acellular dermal matrix and induced for long periods of time with neural differen-tiation medium differentiated into a multilayered neural network-like structure with long nerve ifbers that was composed of several parallel microifbers and neuronal cells, forming a complete neural circuit with dendrite-dendrite to axon-dendrite to dendrite-axon synapses. In addition, growth cones with filopodia were observed using scanning electron microscopy. Paraffin sec-tioning showed differentiated bone marrow mesenchymal stem cells with the typical features of neuronal phenotype, such as a large, round nucleus and a cytoplasm full of Nissl bodies. The data suggest that the biological scaffold fetal bovine acellular dermal matrix is capable of supporting human bone marrow mesenchymal stem cell differentiation into functional neurons and the subsequent formation of tissue engineered nerve.
文摘This paper discusses traffic engineering with multi protocol label switching (MPLS) in a backbone of Internet data center (IDC) network. The traditional SPF routing limitations are analyzed and the traffic engineering concept is given. MPLS, resource reservation protocol (RSVP) and enhanced link status Protocols intermediate system to intermediate system (IS IS) are reviewed to provide a background for traffic engineering, the general issues of designing an MPLS system of IDC network for traffic engineering are then discussed. Finally a practical example with MPLS traffic engineering is shown.
文摘This paper studies the performance of Traffic Engineering (TE) signal protocols used for load balancing in Multi-Protocol Label Switching (MPLS) networks, namely;Constraint Based Routed Label Distribution Protocol LDP (CR-LDP) and Resource Reservation Protocol (RSVP). Furthermore, the performance of an MPLS network uses these TE signal protocols is compared to that of a conventional Internet Protocol (IP) network. Different applications including voice, video, File Transfer Protocol (FTP) and Hyperlink Text Transfer Protocol (HTTP) are used for the performance evaluation. Simulation results show superior performance of the MPLS network with CR-LDP TE signal protocol in all tested applications.
基金supported by the MSIT(Ministry of Science,ICT),Korea,under the ITRC(Information Technology Research Center)support program(IITP-2020-2016-0-00465)supervised by the IITP(Institute for Information&Communications Technology Planning&Evaluation).
文摘The emergence of Segment Routing(SR)provides a novel routing paradigm that uses a routing technique called source packet routing.In SR architecture,the paths that the packets choose to route on are indicated at the ingress router.Compared with shortest-path-based routing in traditional distributed routing protocols,SR can realize a flexible routing by implementing an arbitrary flow splitting at the ingress router.Despite the advantages of SR,it may be difficult to update the existing IP network to a full SR deployed network,for economical and technical reasons.Updating partial of the traditional IP network to the SR network,thus forming a hybrid SR network,is a preferable choice.For the traffic is dynamically changing in a daily time,in this paper,we propose a Weight Adjustment algorithm WASAR to optimize routing in a dynamic hybrid SR network.WASAR algorithm can be divided into three steps:firstly,representative Traffic Matrices(TMs)and the expected TM are obtained from the historical TMs through ultrascalable spectral clustering algorithm.Secondly,given the network topology,the initial network weight setting and the expected TM,we can realize the link weight optimization and SR node deployment optimization through a Deep Reinforcement Learning(DRL)algorithm.Thirdly,we optimize the flow splitting ratios of SR nodes in a centralized online manner under dynamic traffic demands,in order to improve the network performance.In the evaluation,we exploit historical TMs to test the performance of the obtained routing configuration in WASAR.The extensive experimental results validate that our proposed WASAR algorithm has superior performance in reducing Maximum Link Utilization(MLU)under the dynamic traffic.
基金supported by the National Natural Science Foundation of China,No.81701895Shanghai Jiao Tong University Medicine-Engineering Research Fund,China,No.YG2016QN20(both to FY)。
文摘Our previous study showed that cell cycle exit and neuronal differentiation 1(CEND1)may participate in neural stem cell cycle exit and oriented differentiation.However,whether CEND1-transfected neural stem cells can improve the prognosis of traumatic brain injury remained unclear.In this study,we performed quantitative proteomic analysis and found that after traumatic brain injury,CEND1 expression was downregulated in mouse brain tissue.Three days after traumatic brain injury,we transplanted CEND1-transfected neural stem cells into the area surrounding the injury site.We found that at 5 weeks after traumatic brain injury,transplantation of CEND1-transfected neural stem cells markedly alleviated brain atrophy and greatly improved neurological function.In vivo and in vitro results indicate that CEND1 overexpression inhibited the proliferation of neural stem cells,but significantly promoted their neuronal differentiation.Additionally,CEND1 overexpression reduced protein levels of Notch1 and cyclin D1,but increased levels of p21 in CEND1-transfected neural stem cells.Treatment with CEND1-transfected neural stem cells was superior to similar treatment without CEND1 transfection.These findings suggest that transplantation of CEND1-transfected neural stem cells is a promising cell therapy for traumatic brain injury.This study was approved by the Animal Ethics Committee of the School of Biomedical Engineering of Shanghai Jiao Tong University,China(approval No.2016034)on November 25,2016.
文摘Differential evolution (DE) algorithm has been shown to be a simple and efficient evolutionary algorithm for global optimization over continuous spaces, and has been widely used in both benchmark test functions and real-world applications. This paper introduces a novel mutation operator, without using the scaling factor F, a conventional control parameter, and this mutation can generate multiple trial vectors by incorporating different weighted values at each generation, which can make the best of the selected multiple parents to improve the probability of generating a better offspring. In addition, in order to enhance the capacity of adaptation, a new and adaptive control parameter, i.e. the crossover rate CR, is presented and when one variable is beyond its boundary, a repair rule is also applied in this paper. The proposed algorithm ADE is validated on several constrained engineering design optimization problems reported in the specialized literature. Compared with respect to algorithms representative of the state-of-the-art in the area, the experimental results show that ADE can obtain good solutions on a test set of constrained optimization problems in engineering design.
基金supported by the National Key R&D Project(No.2020YFB1804803)the Research and Development Program in Key Areas of Guangdong Province(No.2018B010113001)。
文摘Segment Routing(SR)is a new routing paradigm based on source routing and provide traffic engineering(TE)capabilities in IP network.By extending interior gateway protocol(IGP),SR can be easily applied to IP network.However,upgrading current IP network to a full SR one can be costly and difficult.Hybrid IP/SR network will last for some time.Aiming at the low flexibility problem of static TE policies in the current SR networks,this paper proposes a Deep Reinforcement Learning(DRL)based TE scheme.The proposed scheme employs multi-path transmission and use DRL to dynamically adjust the traffic splitting ratio among different paths based on the network traffic distribution.As a result,the network congestion can be mitigated and the performance of the network is improved.Simulation results show that our proposed scheme can improve the throughput of the network by up to 9%than existing schemes.
文摘The study of Quality of Service (QoS) has become of great importance since the Internet is used to support a wide variety of new services and applications with its legacy structure. Current Internet architecture is based on the Best Effort (BE) model, which attempts to deliver all traffic as soon as possible within the limits of its abilities, but without any guarantee about throughput, delay, packet loss, etc. We develop a three-layer policy based architecture which can be deployed to control network resources intelligently and support QoS sensi-tive applications such as real-time voice and video streams along with standard applications in the Internet. In order to achieve selected QoS parameter values (e.g. loss, delay and PDV) within the bounds set through SLAs for high priority voice traffic in the Internet, we used traffic engineering techniques and policy based routing supported by Border Gateway Protocol (BGP). Use of prototype and simulations validates function-ality of our architecture.
文摘Based on traffic engineering, the network topology is described with network graph. An algorithm for the derivation of data communication capability in network links and the analysis of connectivity performance between node pairs is given through standardized transformation of the original descriptive matrix for the link performance, and resolution of transitive closure for adjacent-incident matrix of network in view of randomness of network events, which provides a feasible way for analysis and improvement of network performance.
基金National Key Lab of Broad Band Fiber Transmission and Communication System Technology , Ministry ofEducation
文摘General multi-protocol label switching(GMPLS) based on traffic engineering is one of the possible methods to implement all-optical network. This method implements the network with IP technique and guarantees the quality of service with traffic engineering. Based on the establishment of selecting schemes of optical path and methods of traffic calculation, the wavelength routing algorithm of all-optical network based on traffic engineering is presented by combining with prior route of shortest path and traffic engineering, the algorithm procedures are given, and the actual examples are introduced as well as the analysis on simulation calculation. This research results have certain significance for the achievement of optical switching technique of all-optical network.
文摘Nowadays the number of cores that are integrated into NoC (Network on Chip) systems is steadily increasing, and real application traffic, running in such multi-core environments requires more and more bandwidth. In that sense, NoC architectures should be properly designed so as to provide efficient traffic engineering, as well as QoS support. Routing algorithm choice in conjunction with other parameters, such as network size and topology, traffic features (time and spatial distribution), as well as packet injection rate, packet size, and buffering capability, are all equivalently critical for designing a robust NoC architecture, on the grounds of traffic engineering and QoS provision. In this paper, a thorough numerical investigation is achieved by taking into consideration the criticality of selecting the proper routing algorithm, in conjunction with all the other aforementioned parameters. This is done via implementation of four routing evaluation traffic scenarios varying each parameter either individually, or as a set, thus exhausting all possible combinations, and making compact decisions on proper routing algorithm selection in NoC architectures. It has been shown that the simplicity of a deterministic routing algorithm such as XY, seems to be a reasonable choice, not only for random traffic patterns but also for non-uniform distributed traffic patterns, in terms of delay and throughput for 2D mesh NoC systems.
文摘This study compares the Adomian Decomposition Method (ADM) and the Variational Iteration Method (VIM) for solving nonlinear differential equations in engineering. Differential equations are essential for modeling dynamic systems in various disciplines, including biological processes, heat transfer, and control systems. This study addresses first, second, and third-order nonlinear differential equations using Mathematica for data generation and graphing. The ADM, developed by George Adomian, uses Adomian polynomials to handle nonlinear terms, which can be computationally intensive. In contrast, VIM, developed by He, directly iterates the correction functional, providing a more straightforward and efficient approach. This study highlights VIM’s rapid convergence and effectiveness of VIM, particularly for nonlinear problems, where it simplifies calculations and offers direct solutions without polynomial derivation. The results demonstrate VIM’s superior efficiency and rapid convergence of VIM compared with ADM. The VIM’s minimal computational requirements make it practical for real-time applications and complex system modeling. Our findings align with those of previous research, confirming VIM’s efficiency of VIM in various engineering applications. This study emphasizes the importance of selecting appropriate methods based on specific problem requirements. While ADM is valuable for certain nonlinearities, VIM’s approach is ideal for many engineering scenarios. Future research should explore broader applications and hybrid methods to enhance the solution’s accuracy and efficiency. This comprehensive comparison provides valuable guidance for selecting effective numerical methods for differential equations in engineering.
文摘Traffic management is an important contribution in the sustainable development of urban traffic.The complexity of traffic problems determines the difficulty of traffic management.Therefore,traffic management needs the guidance of scientific theories.This paper explores traffic management systems engineering for management road traffic.First,the paper looks at the contents of road traffic management from a systems perspective.Second,the paper briefly describes systems engineering,and explains the necessity and feasibility of the combination of the traffic management and systems engineering.At last,the paper puts forward the concept of traffic management systems engineering using a systems framework.