Morphing wing has attracted many research attention and effort in aircraft technology development because of its advantage in lift to draft ratio and flight performance.Morphing wing technology combines the lift and c...Morphing wing has attracted many research attention and effort in aircraft technology development because of its advantage in lift to draft ratio and flight performance.Morphing wing technology combines the lift and control surfaces into a seamless wing and integrates the primary structure together with the internal control system.It makes use of the wing aeroelastic deformation induced by the control surface to gain direct force control through desirable redistribution of aerodynamic forces.However some unknown mechanical parameters of the control system and complexity of the integrated structure become a main challenge for dynamic modeling of morphing wing.To solve the problem,a method of test data based modal sensitivity analysis is presented to improve the morphing wing FE model by evaluating the unknown parameters and identifying the modeling boundary conditions.An innovative seamless morphing wing with the structure integrated with a flexible trailing edge control system is presented for the investigation.An experimental model of actuation system driven by a servo motor for the morphing wing is designed and established.By performing a vibration test and the proposed modal sensitivity analysis,the unknown torsional stiffness of the servo motor and the boundary condition of the actuation mechanism model is identified and evaluated.Comparing with the test data,the average error of the first four modal frequency of the improved FE model is reduced significantly to less than 4%.To further investigate the morphing wing modeling,a wing box and then a whole morphing wing model including the skin and integrated with the trailing edge actuation system are established and tested.By using the proposed method,the FE model is improved by relaxing the constraint between the skin and actuation mechanism.The results show that the average error of the first three modal frequency of the improved FE model is reduced to less than 6%.The research results demonstrate that the presented seamless morphing wing integrated with a flexible trailing edge control surface can improve aerodynamic characteristics.By using the test data based modal sensitivity analysis method,the unknown parameter and boundary condition of the actuation model can be determined to improve the FE model.The problem in dynamic modeling of high accuracy for a morphing wing can be solved in an effective manner.展开更多
Abducens nerve palsy（ANP） is commonly seen in patients with diabetes mellitus. The validity of acupuncture as a traditional Chinese medicine method in peripheral nerve repair is well established. However, its effica...Abducens nerve palsy（ANP） is commonly seen in patients with diabetes mellitus. The validity of acupuncture as a traditional Chinese medicine method in peripheral nerve repair is well established. However, its efficacy in randomized controlled trials remains unclear. Herein, we designed a protocol for a prospective, single-center, randomized controlled trial to investigate the effect of intraorbital electroacupuncture on diabetic ANP. We plan to recruit 60 patients with diabetic ANP, and randomly divide them into treatment and control groups. Patients in both groups will continue their glucose-lowering therapy. A neural nutrition drug will be given to both groups for six weeks. The treatment group will also receive intraorbital electroacupuncture therapy. We will assess efficacy of treatment, eyeball movement, diplopia deviation and the levels of fasting blood-glucose and glycosylated hemoglobin before treatment at 2, 4, and 6 weeks after treatment. The efficacy and recurrence will be investigated during follow-up（1 month after intervention）. This protocol was registered at Chinese Clinical Trial Registry on 16 January 2015（Chi CTR-IPR-15005836）. This study was approved by the Ethics Committee of First Affiliated Hospital of Harbin Medical University of China（approval number： 201452）. All protocols will be in accordance with Declaration of Helsinki, formulated by the World Medical Association. Written informed consent will be provided by participants. We envisage that the results of this clinical trial will provide evidence for promoting clinical use of this new therapy for management of ANP.展开更多
Pharmaco-psychosocial treatment (PPST) refers to a treatment paradigm combining pharmacotherapy with psychosocial therapy. We conducted an 18-month randomized controlled tracking study to evaluate the efficacy of soci...Pharmaco-psychosocial treatment (PPST) refers to a treatment paradigm combining pharmacotherapy with psychosocial therapy. We conducted an 18-month randomized controlled tracking study to evaluate the efficacy of social skills training (SST) in 11 individuals with schizophrenia on risperidone monotherapy. They were randomized to either SST or non-SST group, and Global Assessment Functioning (GAF) and Brief Psychiatric Rating Scale (BPRS) scores in the 2 groups showed gradual improvement. In the SST group, Digit Span Distraction Test (DSDT) at 12 and 18 months showed significant improvement. The Subjective Deficit Syndrome Scale (SDSS) scores in the SST group showed significant improvement after 6 months and showed a significant difference in comparison between the groups. After the subjective feeling of health was recovered, the items of motivation were recovered as a direct effect of SST. Some items of the Life Assessment Scale for the Mentally Ill (LASMI) score showed significant improvement (or significant trend) in only the SST group after 6 months. Items of daily life, work skills, and self-recognition were continuously improved. We report 2 cases in the SST group that had DSDT improvement in parallel with change of action and communication as a change of social function. This study is only exploratory due to the small number of cases. However, we have demonstrated potential improvement in cognitive function due to learning experiences that required working memory and attention, thus providing improvement in social life.展开更多
目的:系统评价瑞格列奈对比格列美脲分别联合二甲双胍治疗2型糖尿病的有效性和安全性,为临床提供循证依据。方法:计算机检索中国期刊全文数据库、中文科技期刊数据库、万方数据库、Pub Med、Embase、Medline、Cochrane图书馆,收集瑞格...目的:系统评价瑞格列奈对比格列美脲分别联合二甲双胍治疗2型糖尿病的有效性和安全性,为临床提供循证依据。方法:计算机检索中国期刊全文数据库、中文科技期刊数据库、万方数据库、Pub Med、Embase、Medline、Cochrane图书馆,收集瑞格列奈联合二甲双胍(试验组)对比格列美脲联合二甲双胍(对照组)治疗2型糖尿病疗效[糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平]和安全性(不良反应发生率、低血糖反应发生率、胃肠道反应发生率)的随机对照试验(RCT),对符合纳入标准的文献进行资料提取,并采用Cochrane系统评价手册5.1.0进行质量评价后,采用Rev Man 5.2统计软件进行Meta分析。结果:共纳入12项RCT,合计957例患者。Meta分析结果显示,试验组患者2 h PG降低程度显著低于对照组,差异有统计学意义[MD=-0.70,95%CI(-1.02,-0.38),P<0.001];两组患者Hb A1c降低水平[MD=0.00,95%CI(-0.24,0.25),P=0.98]、FPG降低水平[MD=0.10,95%CI(-0.17,0.36),P=0.47]、不良反应发生率[OR=0.54,95%CI(0.28,1.06),P=0.07]、低血糖反应发生率[OR=0.52,95%CI(0.13,2.06),P=0.35]和胃肠道反应发生率[OR=0.60,95%CI(0.15,2.41),P=0.47]比较,差异均无统计学意义。结论:瑞格列奈联合二甲双胍降低2 h PG效果优于格列美脲联合二甲双胍,安全性相当。展开更多
基金supported by National Natural Science Foundation of China (Grant No. 11102019)
文摘Morphing wing has attracted many research attention and effort in aircraft technology development because of its advantage in lift to draft ratio and flight performance.Morphing wing technology combines the lift and control surfaces into a seamless wing and integrates the primary structure together with the internal control system.It makes use of the wing aeroelastic deformation induced by the control surface to gain direct force control through desirable redistribution of aerodynamic forces.However some unknown mechanical parameters of the control system and complexity of the integrated structure become a main challenge for dynamic modeling of morphing wing.To solve the problem,a method of test data based modal sensitivity analysis is presented to improve the morphing wing FE model by evaluating the unknown parameters and identifying the modeling boundary conditions.An innovative seamless morphing wing with the structure integrated with a flexible trailing edge control system is presented for the investigation.An experimental model of actuation system driven by a servo motor for the morphing wing is designed and established.By performing a vibration test and the proposed modal sensitivity analysis,the unknown torsional stiffness of the servo motor and the boundary condition of the actuation mechanism model is identified and evaluated.Comparing with the test data,the average error of the first four modal frequency of the improved FE model is reduced significantly to less than 4%.To further investigate the morphing wing modeling,a wing box and then a whole morphing wing model including the skin and integrated with the trailing edge actuation system are established and tested.By using the proposed method,the FE model is improved by relaxing the constraint between the skin and actuation mechanism.The results show that the average error of the first three modal frequency of the improved FE model is reduced to less than 6%.The research results demonstrate that the presented seamless morphing wing integrated with a flexible trailing edge control surface can improve aerodynamic characteristics.By using the test data based modal sensitivity analysis method,the unknown parameter and boundary condition of the actuation model can be determined to improve the FE model.The problem in dynamic modeling of high accuracy for a morphing wing can be solved in an effective manner.
基金supported by the National Natural Science Foundation of China,No.81674052the Key Project of Natural Science Foundation of Heilongjiang Province of China,No.ZD201211a grant from the Project of Innovational Scientific Research of Harbin Medical University of China,No.2016LCZX49
文摘Abducens nerve palsy（ANP） is commonly seen in patients with diabetes mellitus. The validity of acupuncture as a traditional Chinese medicine method in peripheral nerve repair is well established. However, its efficacy in randomized controlled trials remains unclear. Herein, we designed a protocol for a prospective, single-center, randomized controlled trial to investigate the effect of intraorbital electroacupuncture on diabetic ANP. We plan to recruit 60 patients with diabetic ANP, and randomly divide them into treatment and control groups. Patients in both groups will continue their glucose-lowering therapy. A neural nutrition drug will be given to both groups for six weeks. The treatment group will also receive intraorbital electroacupuncture therapy. We will assess efficacy of treatment, eyeball movement, diplopia deviation and the levels of fasting blood-glucose and glycosylated hemoglobin before treatment at 2, 4, and 6 weeks after treatment. The efficacy and recurrence will be investigated during follow-up（1 month after intervention）. This protocol was registered at Chinese Clinical Trial Registry on 16 January 2015（Chi CTR-IPR-15005836）. This study was approved by the Ethics Committee of First Affiliated Hospital of Harbin Medical University of China（approval number： 201452）. All protocols will be in accordance with Declaration of Helsinki, formulated by the World Medical Association. Written informed consent will be provided by participants. We envisage that the results of this clinical trial will provide evidence for promoting clinical use of this new therapy for management of ANP.
文摘Pharmaco-psychosocial treatment (PPST) refers to a treatment paradigm combining pharmacotherapy with psychosocial therapy. We conducted an 18-month randomized controlled tracking study to evaluate the efficacy of social skills training (SST) in 11 individuals with schizophrenia on risperidone monotherapy. They were randomized to either SST or non-SST group, and Global Assessment Functioning (GAF) and Brief Psychiatric Rating Scale (BPRS) scores in the 2 groups showed gradual improvement. In the SST group, Digit Span Distraction Test (DSDT) at 12 and 18 months showed significant improvement. The Subjective Deficit Syndrome Scale (SDSS) scores in the SST group showed significant improvement after 6 months and showed a significant difference in comparison between the groups. After the subjective feeling of health was recovered, the items of motivation were recovered as a direct effect of SST. Some items of the Life Assessment Scale for the Mentally Ill (LASMI) score showed significant improvement (or significant trend) in only the SST group after 6 months. Items of daily life, work skills, and self-recognition were continuously improved. We report 2 cases in the SST group that had DSDT improvement in parallel with change of action and communication as a change of social function. This study is only exploratory due to the small number of cases. However, we have demonstrated potential improvement in cognitive function due to learning experiences that required working memory and attention, thus providing improvement in social life.
文摘目的:系统评价瑞格列奈对比格列美脲分别联合二甲双胍治疗2型糖尿病的有效性和安全性,为临床提供循证依据。方法:计算机检索中国期刊全文数据库、中文科技期刊数据库、万方数据库、Pub Med、Embase、Medline、Cochrane图书馆,收集瑞格列奈联合二甲双胍(试验组)对比格列美脲联合二甲双胍(对照组)治疗2型糖尿病疗效[糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平]和安全性(不良反应发生率、低血糖反应发生率、胃肠道反应发生率)的随机对照试验(RCT),对符合纳入标准的文献进行资料提取,并采用Cochrane系统评价手册5.1.0进行质量评价后,采用Rev Man 5.2统计软件进行Meta分析。结果:共纳入12项RCT,合计957例患者。Meta分析结果显示,试验组患者2 h PG降低程度显著低于对照组,差异有统计学意义[MD=-0.70,95%CI(-1.02,-0.38),P<0.001];两组患者Hb A1c降低水平[MD=0.00,95%CI(-0.24,0.25),P=0.98]、FPG降低水平[MD=0.10,95%CI(-0.17,0.36),P=0.47]、不良反应发生率[OR=0.54,95%CI(0.28,1.06),P=0.07]、低血糖反应发生率[OR=0.52,95%CI(0.13,2.06),P=0.35]和胃肠道反应发生率[OR=0.60,95%CI(0.15,2.41),P=0.47]比较,差异均无统计学意义。结论:瑞格列奈联合二甲双胍降低2 h PG效果优于格列美脲联合二甲双胍,安全性相当。
