Background: The most common surgical treatment for symptomatic uterine fibroids, particularly in women with fertility concerns, is open myomectomy. Given the high vascularity of the uterus, haemorrhage during the proc...Background: The most common surgical treatment for symptomatic uterine fibroids, particularly in women with fertility concerns, is open myomectomy. Given the high vascularity of the uterus, haemorrhage during the procedure is a serious risk that is often mitigated with a uterine tourniquet. Aim and Objectives: To evaluate the effect of uterine artery occlusion with a tourniquet during open myomectomy on ovarian reserve using serial anti-Mullerian hormone (AMH) measurements. Materials and Methods: This was a prospective longitudinal study with a quasi-experimental design and a convenient sampling technique. The study enrolled 47 women who had abdominal myomectomy between September 1, 2021, and March 31, 2022, at the University of Port Harcourt Teaching Hospital. Blood samples were collected before anaesthesia was administered in theatre, on day two, and three months after open abdominal myomectomy for anti-Mullerian hormone assay. The data was collected using a semi-structured proforma, entered into an Excel spreadsheet, and analyzed using SPSS version 25.0 with a 95% confidence interval. Statistical significance level was set at 0.05. Results: The pre-surgery AMH mean value was 1.67 ± 1.44 ng/ml, while the values after using a uterine tourniquet at myomectomy on the second day and three months later were 1.22 ± 1.24 ng/ml and 1.59 ± 1.43 ng/ml, respectively. There was no statistically significant change in AMH levels, and there was no statistically significant relationship between blood loss and tourniquet time and AMH after open abdominal myomectomy. Conclusion: The use of a uterine tourniquet and blood loss during open myomectomy has no effect on ovarian reserve.展开更多
目的:比较开腹与腹腔镜下子宫肌瘤剔除术对患者远期术后生活质量的影响,探讨最佳手术途径。方法:选取2017年1—12月于浙江大学医学院附属妇产科医院住院治疗的160例子宫肌瘤患者作为研究对象,根据治疗方式将患者分为开腹子宫肌瘤剔除术...目的:比较开腹与腹腔镜下子宫肌瘤剔除术对患者远期术后生活质量的影响,探讨最佳手术途径。方法:选取2017年1—12月于浙江大学医学院附属妇产科医院住院治疗的160例子宫肌瘤患者作为研究对象,根据治疗方式将患者分为开腹子宫肌瘤剔除术组(开腹组,n=80)和腹腔下镜子宫肌瘤剔除术组(腹腔镜组,n=80)。术后第5年进行随访,收集并记录其病史信息及随访资料,比较两组临床症状[子宫肌瘤症状严重程度问卷(uterine fibroid symptom severity scale,UFS-8)]、生命质量[欧洲五维生命质量调查问卷(European quality of life five dimension five level scale questionnaire,EQ-5D-5L)]、性生活满意度[女性性功能问卷(female sexual function index,FSFI)中的第16个问题]、术后肌瘤残留或复发情况。结果:腹腔镜组下腹部不适、乏力感评分及总分低于开腹组,差异有统计学意义(P<0.05);两组月经量增多、经血成块、经期延长、周期不规律、日间尿频、夜间尿频评分比较,差异无统计学意义(P>0.05)。腹腔镜组自我照顾、日常活动、疼痛或不舒服优于开腹组,EQ-5D-5L总分高于开腹组,差异有统计学意义(P<0.05);但两组行动能力、焦虑或沮丧比较,差异无统计学意义(P>0.05)。腹腔镜组术后性生活满意度高于开腹组,差异有统计学意义(P<0.05);但两组术后肌瘤残留或复发情况比较,差异无统计学意义(P>0.05)。结论:相比传统开腹手术,腹腔镜下子宫肌瘤剔除术术后临床症状改善更佳、生活质量提高更多,性满意度更高,但需告知若选择子宫肌瘤剔除术,术后残留及复发风险较高,术后需严密随访。展开更多
目的:探讨腹腔镜下暂时阻断子宫动脉根治性挖除子宫腺肌病手术学习曲线。方法:回顾分析常州市妇幼保健院2015年12月—2023年8月收治的151例进行腹腔镜下暂时阻断子宫动脉根治性挖除子宫腺肌病手术患者的临床资料。采用累计求和分析(cumu...目的:探讨腹腔镜下暂时阻断子宫动脉根治性挖除子宫腺肌病手术学习曲线。方法:回顾分析常州市妇幼保健院2015年12月—2023年8月收治的151例进行腹腔镜下暂时阻断子宫动脉根治性挖除子宫腺肌病手术患者的临床资料。采用累计求和分析(cumulative sum analysis,CUSUM)法绘制学习曲线,根据所得曲线的临界点将整个过程分为提高期(47例)和熟练期(104例),分析比较2组患者的临床资料和手术结果。结果:根据患者手术时间和手术例数形成手术时间序列图,拟合曲线为y=-27.17ln(x)+330.74(x=手术例数)。根据手术时间绘制的CUSUM曲线的最佳拟合曲线方程为y=-0.005x^(3)-1.387x^(2)+98.643x-253.571(x为手术例数,最优拟合系数R2=0.931,P<0.05),48例即为该手术达到熟练期所需累积的例数。提高期患者手术时间[(263.72±38.07)min vs.(201.65±48.03)min,P<0.001]、术后持续发热率(40.43%vs.22.12%,P=0.020)和术后体温[38.0(37.8,38.1)℃vs.37.7(37.5,38.0)℃,P=0.002]均高于熟练期患者。两阶段患者的术后血红蛋白水平和手术前后血红蛋白差值比较,差异均无统计学意义(P>0.05)。结论:子宫动脉临时阻断能够有效控制术中出血量,术者约需完成48例腹腔镜下暂时阻断子宫动脉根治性挖除子宫腺肌病手术达到技术熟练,但仍需不断熟练手术操作,降低患者感染风险。展开更多
文摘Background: The most common surgical treatment for symptomatic uterine fibroids, particularly in women with fertility concerns, is open myomectomy. Given the high vascularity of the uterus, haemorrhage during the procedure is a serious risk that is often mitigated with a uterine tourniquet. Aim and Objectives: To evaluate the effect of uterine artery occlusion with a tourniquet during open myomectomy on ovarian reserve using serial anti-Mullerian hormone (AMH) measurements. Materials and Methods: This was a prospective longitudinal study with a quasi-experimental design and a convenient sampling technique. The study enrolled 47 women who had abdominal myomectomy between September 1, 2021, and March 31, 2022, at the University of Port Harcourt Teaching Hospital. Blood samples were collected before anaesthesia was administered in theatre, on day two, and three months after open abdominal myomectomy for anti-Mullerian hormone assay. The data was collected using a semi-structured proforma, entered into an Excel spreadsheet, and analyzed using SPSS version 25.0 with a 95% confidence interval. Statistical significance level was set at 0.05. Results: The pre-surgery AMH mean value was 1.67 ± 1.44 ng/ml, while the values after using a uterine tourniquet at myomectomy on the second day and three months later were 1.22 ± 1.24 ng/ml and 1.59 ± 1.43 ng/ml, respectively. There was no statistically significant change in AMH levels, and there was no statistically significant relationship between blood loss and tourniquet time and AMH after open abdominal myomectomy. Conclusion: The use of a uterine tourniquet and blood loss during open myomectomy has no effect on ovarian reserve.
文摘目的:比较开腹与腹腔镜下子宫肌瘤剔除术对患者远期术后生活质量的影响,探讨最佳手术途径。方法:选取2017年1—12月于浙江大学医学院附属妇产科医院住院治疗的160例子宫肌瘤患者作为研究对象,根据治疗方式将患者分为开腹子宫肌瘤剔除术组(开腹组,n=80)和腹腔下镜子宫肌瘤剔除术组(腹腔镜组,n=80)。术后第5年进行随访,收集并记录其病史信息及随访资料,比较两组临床症状[子宫肌瘤症状严重程度问卷(uterine fibroid symptom severity scale,UFS-8)]、生命质量[欧洲五维生命质量调查问卷(European quality of life five dimension five level scale questionnaire,EQ-5D-5L)]、性生活满意度[女性性功能问卷(female sexual function index,FSFI)中的第16个问题]、术后肌瘤残留或复发情况。结果:腹腔镜组下腹部不适、乏力感评分及总分低于开腹组,差异有统计学意义(P<0.05);两组月经量增多、经血成块、经期延长、周期不规律、日间尿频、夜间尿频评分比较,差异无统计学意义(P>0.05)。腹腔镜组自我照顾、日常活动、疼痛或不舒服优于开腹组,EQ-5D-5L总分高于开腹组,差异有统计学意义(P<0.05);但两组行动能力、焦虑或沮丧比较,差异无统计学意义(P>0.05)。腹腔镜组术后性生活满意度高于开腹组,差异有统计学意义(P<0.05);但两组术后肌瘤残留或复发情况比较,差异无统计学意义(P>0.05)。结论:相比传统开腹手术,腹腔镜下子宫肌瘤剔除术术后临床症状改善更佳、生活质量提高更多,性满意度更高,但需告知若选择子宫肌瘤剔除术,术后残留及复发风险较高,术后需严密随访。
文摘目的:探讨腹腔镜下暂时阻断子宫动脉根治性挖除子宫腺肌病手术学习曲线。方法:回顾分析常州市妇幼保健院2015年12月—2023年8月收治的151例进行腹腔镜下暂时阻断子宫动脉根治性挖除子宫腺肌病手术患者的临床资料。采用累计求和分析(cumulative sum analysis,CUSUM)法绘制学习曲线,根据所得曲线的临界点将整个过程分为提高期(47例)和熟练期(104例),分析比较2组患者的临床资料和手术结果。结果:根据患者手术时间和手术例数形成手术时间序列图,拟合曲线为y=-27.17ln(x)+330.74(x=手术例数)。根据手术时间绘制的CUSUM曲线的最佳拟合曲线方程为y=-0.005x^(3)-1.387x^(2)+98.643x-253.571(x为手术例数,最优拟合系数R2=0.931,P<0.05),48例即为该手术达到熟练期所需累积的例数。提高期患者手术时间[(263.72±38.07)min vs.(201.65±48.03)min,P<0.001]、术后持续发热率(40.43%vs.22.12%,P=0.020)和术后体温[38.0(37.8,38.1)℃vs.37.7(37.5,38.0)℃,P=0.002]均高于熟练期患者。两阶段患者的术后血红蛋白水平和手术前后血红蛋白差值比较,差异均无统计学意义(P>0.05)。结论:子宫动脉临时阻断能够有效控制术中出血量,术者约需完成48例腹腔镜下暂时阻断子宫动脉根治性挖除子宫腺肌病手术达到技术熟练,但仍需不断熟练手术操作,降低患者感染风险。