期刊文献+
共找到471篇文章
< 1 2 24 >
每页显示 20 50 100
Compact implicit integration factor methods for some complex-valued nonlinear equations 被引量:1
1
作者 张荣培 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第4期49-53,共5页
The compact implicit integration factor (cIIF) method is an efficient time discretization scheme for stiff nonlinear diffusion equations in two and three spatial dimensions. In the current work, we apply the cIIF me... The compact implicit integration factor (cIIF) method is an efficient time discretization scheme for stiff nonlinear diffusion equations in two and three spatial dimensions. In the current work, we apply the cIIF method to some complex-valued nonlinear evolutionary equations such as the nonlinear SchrSdinger (NLS) equation and the complex Ginzburg-Landau (GL) equation. Detailed algorithm formulation and practical implementation of cIIF method are performed. The numerical results indicate that this method is very accurate and efficient. 展开更多
关键词 compact implicit integration factor method finite difference nonlinear Schrodinger equa-tion complex Ginzburg Landau equation
下载PDF
Complement C3a signaling mediates production of angiogenic factors in mesenchymal stem cells
2
作者 Richard G. DiScipio Sophia K. Khaldoyanidi +1 位作者 Rosita Moya-Castro Ingrid U. Schraufstatter 《Journal of Biomedical Science and Engineering》 2013年第8期1-13,共13页
A major portion of the beneficial effect of mesenchymal stem cells (MSC) is due to the production of trophic and angiogenic factors by these cells, and one of the efforts to improve the therapeutic efficacy of these c... A major portion of the beneficial effect of mesenchymal stem cells (MSC) is due to the production of trophic and angiogenic factors by these cells, and one of the efforts to improve the therapeutic efficacy of these cells lies in enhancing this capacity. Since there is complement activation in all areas of tissue injury, and both C3a and C5a activate MSC, it was asked whether stimulation with C3a or C5a would upregulate the production of trophic factors by MSC. C3a caused significant up-regulation of various angiogenic factors, including VEGF, CXCL8/IL-8 and IL-6. In contrast there was no detectable production of the pro-inflammatory cytokines TNF-α and IL-1β in spite of nuclear translocation of NFκB. Although C5a also caused moderate up-regulation of angiogenic factors, the effect was borderline significant. Furthermore the production of angiogenic factors induced by C3a was of physiological relevance: Supernatants of MSCs cultured under serum-free conditions induced minimal tube formation of HUVECs as an in vitro measure of angiogenesis;tube formation was considerably enhanced, when supernatants from C3a-stimulated MSC were used, while C3a itself had no direct angiogenic effect on HUVECs. The signaling cascade responsible for the production of angiogenic factors by C3a or C5a could be defined as activation of the rho cascade which was necessary for nuclear translocation of NFκB p65 and of phospho-ERK1/2. Although rho was only transiently activated, inhibition of the rho or “downstream of it” of the NFκB pathway, prevented C3a-and C5a-induced up-regulation of angiogenic factors. 展开更多
关键词 MSC C3A C5A Angiogenic factor Produc-tion SIGNALING PATHWAYS
下载PDF
ON WEAK MINIMUM ABERRATION AND NUMBER OF CLEAR TWO-FACTOR INTERACTION COMPONENTS IN s_Ⅳ~(m-p) DESIGNS
3
作者 杨贵军 《Acta Mathematica Scientia》 SCIE CSCD 2010年第1期240-246,共7页
This article obtains some theoretical results on the number of clear two-factor interaction components and weak minimum aberration in an sm-pIVdesign, by considering the number of not clear two-factor interaction comp... This article obtains some theoretical results on the number of clear two-factor interaction components and weak minimum aberration in an sm-pIVdesign, by considering the number of not clear two-factor interaction components of the design. 展开更多
关键词 clear two-factor interaction component weak minimum aberration resolu-tion wordlength pattern
下载PDF
Burden of Cardiometabolic Risk Factors on Cerebrovascular Events in a Southern Italian Population
4
作者 Vincenzo Capuano Federica Marchese +6 位作者 Rocco Capuano Anna Grazia Iannone Norman Lamaida Ernesto Capuano Raffaella Sica Marzia Manilia Eduardo Capuano 《World Journal of Cardiovascular Diseases》 2021年第2期145-152,共8页
<strong>Background:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Stroke is the second leading cause of death in the world and ... <strong>Background:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Stroke is the second leading cause of death in the world and the third due to disability. However, there are few data available that identify the risk factors associated with it and their weight in different populations (population risk). </span><b><span style="font-family:Verdana;">Aim: </span></b><span style="font-family:Verdana;">Contribute to the knowledge of burden risk factors in stroke </span></span><span style="font-family:Verdana;">in a large cohort of Southern Italy</span><span style="font-family:;" "=""><span style="font-family:Verdana;">. </span><b><span style="font-family:Verdana;">Methods</span></b><span style="font-family:Verdana;">: The data refer to a randomized Campania cohort of 1200 subjects (35</span></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">74 years) enrolled in 2008-09. Ten years later (2018-19) they were re-evaluated. We analyzed data from 32 patients who reported a cerebrovascular event (stroke or TIA) with the event-free group of subjects (804 subjects: 378 men and 426 women). We evaluated: absolute risk, Odds Ratio (OR), Additional Risk (AR), Risk Attributable to the Population (PAR) and, finally, the Population Attributable risk Fraction (FAP). </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> In the comparison between the two groups (patients with events and patients without events) the risk factors with statistically significant differences were: age, Systolic Blood Pressure (SBP), BMI, cholesterol, triglycerides, glycemia and hyperinsulinemia. The ORs with the greatest impact were: blood glucose (5.1), BMI (3.3) and BPS (2.9). Linear regression analysis identified Glycemia and BMI as the only independent variables. The FAPs with the greatest impact were SBP (47.4%) and BMI (42.6%). </span><b><span style="font-family:Verdana;">Discussion and Conclusions</span></b><span style="font-family:Verdana;">: Our data confirm that the high incidence of stroke in Campania is particularly related to the high prevalence of obesity and hypertension. In the single patient, however, the risk factors with the greatest impact are: glycaemia BMI an SBP.</span></span> 展开更多
关键词 Cerebrovascular Risk factors Southern Italy Risk Attributable to the Popula-tion
下载PDF
Effect of Cultivation Conditionss on Quality Parameters of High Grade Hybrid Rape of Brassica napus L.
5
作者 赵继献 任廷波 程国平 《Agricultural Science & Technology》 CAS 2013年第1期59-68,共10页
[Objective] This study aimed to investigate the combined effects of sowing date, plant density, nitrogenous fertilizer, phosphorus fertilizer and potassium fertilizer on quality parameters of high grade hybrid rapesee... [Objective] This study aimed to investigate the combined effects of sowing date, plant density, nitrogenous fertilizer, phosphorus fertilizer and potassium fertilizer on quality parameters of high grade hybrid rapeseed. [Method] By using Youyan 599 and Sanbei 98 as experimental materials, quadratic orthogonal rotation combination with five factors was designed for this study. [Result] Erucic acid content was nega- tively correlated with sowing date and nitrogen fertilizer, positively correlated with plant density. Glucosinolate content was negatively correlated with sowing date, positively correlated with potash fertilizer amount. Oil content was negatively correlated with sowing date and nitrogen fertilizer amount, positively correlated with plant density and potash fertilizer amount. Protein content was positively correlated with sowing date and nitrogen fertilizer amount, negatively correlated with plant density and potash fer- tilizer amount. Oleic acid content was negatively correlated with phosphate fertilizer amount, positively correlated with nitrogen fertilizer amount. Palmitic acid was nega- tively correlated with potash fertilizer amount, positively correlated with sowing date, plant density, nitrogen fertilizer amount and phosphate fertilizer amount in Youyan 599, but negatively correlated with sowing date, plant density, nitrogen fertilizer amount and phosphate fertilizer amount in Sanbei 98. Stearic acid content was posi- tively correlated with sowing date, plant density, nitrogen fertilizer amount and phos- phate fertilizer amount. Linoleic acid was positively correlated with density and nitroge- nous fertilizer, but negatively correlated with potash fertilizer amount. Linolenic acid was positively correlated with nitrogen fertilizer amount and potash fertilizer amount. Eicosenoic acid was negatively correlated with sowing date. There were positive cor- relations and negative correlations among cultivation conditions and quality parame- ters, and the positive correlations and negative correlations could counteract each other. Expression of quality parameters for each treatment was the combined effect. Among the 50 pairs of simple correlations of five cultivation factors and ten quality parameters, 26 pairs were consistent between two varieties, 24 pairs of simple corre- lation were not. Sowing date, plant density, nitrogen fertilizer amount and phosphate fertilizer amount showed significant influence on erucic acid of two varieties, but small effect on palmitic acid. [Conclusion] The combined effect of the five cultivation factors could not fundamentally improve the quality traits of high grade hybrid rapeseed. 展开更多
关键词 Hybrid rapeseed Cultivation factor Quality parameters Orthogonal rota- tion combination design EFFECT
下载PDF
Influence of environmental factors on corrosion damage of aircraft structure 被引量:4
6
作者 Keliang Ren,) Shiwu Gao, Pingping Liu, and Yan Dong Department of Physics & Electrical Information, Ningxia University, Ningxia 750021, China 《Theoretical & Applied Mechanics Letters》 CAS 2011年第6期18-21,共4页
Corrosion is one of the important structural integrity concerns of aging aircraft, and it is estimated that a significant portion of airframe maintenance budgets is directed towards corrosion-related problems for both... Corrosion is one of the important structural integrity concerns of aging aircraft, and it is estimated that a significant portion of airframe maintenance budgets is directed towards corrosion-related problems for both military and commercial aircraft. In order to better understand how environmental factors influence the corrosion damage initiation and propagation on aircraft structure and to predict pre-corrosion test pieces of fatigue life and structural integrity of an effective approach, this paper uses the cellular automaton (CA) method to character the effect of electrolyte concentrations, dissolution probabilities, and temperature on the corrosion damage of a metal structure exposed to an aggressive environment, and the procedure for applying the local rules between the cells of the CA to simulate the corrosion damage evolution is formulated. The simulation results show that the different electrolyte concentrations, dissolution probabilities and temperature, the laws of the dissolution current with time are investigated and they obey the time power function. 展开更多
关键词 aircraft structure corrosion damage environmental factors cellular automaton simula- tions
下载PDF
Ant Colony Optimization for Task Allocation in Multi-Agent Systems 被引量:1
7
作者 王鲁 王志良 +1 位作者 胡四泉 刘磊 《China Communications》 SCIE CSCD 2013年第3期125-132,共8页
Task allocation is a key issue of agent cooperation mechanism in Multi-Agent Systems. The important features of an agent system such as the latency of the network infrastructure, dynamic topology, and node heterogenei... Task allocation is a key issue of agent cooperation mechanism in Multi-Agent Systems. The important features of an agent system such as the latency of the network infrastructure, dynamic topology, and node heterogeneity impose new challenges on the task allocation in Multi-Agent environments. Based on the traditional parallel computing task allocation method and Ant Colony Optimization (ACO), a novel task allocation method named Collection Path Ant Colony Optimization (CPACO) is proposed to achieve global optimization and reduce processing time. The existing problems of ACO are analyzed; CPACO overcomes such problems by modifying the heuristic function and the update strategy in the Ant-Cycle Model and establishing a threedimensional path pheromone storage space. The experimental results show that CPACO consumed only 10.3% of the time taken by the Global Search Algorithm and exhibited better performance than the Forward Optimal Heuristic Algorithm. 展开更多
关键词 multi-agent systems task alloca- tion ant colony optimization efficiency factor
下载PDF
IcarisideⅡ alleviates oxygen-glucose deprivation and reoxygenation-induced PC12 celloxidative injury by activating Nrf2 / SIRT3signaling pathway 被引量:14
8
作者 FENG Lin-ying GAO Jian-mei +2 位作者 LIU Yuan-gui SHI Jing-shan GONG Qi-hai 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2018年第9期667-668,共2页
OBJECTIVE To investigate icariside(ICS)Ⅱ protects against PC12 cel damage induced by oxygen-glucose deprivation and reoxygenation and explore its mechanism.METHODS The oxidative stress injury model was induced by oxy... OBJECTIVE To investigate icariside(ICS)Ⅱ protects against PC12 cel damage induced by oxygen-glucose deprivation and reoxygenation and explore its mechanism.METHODS The oxidative stress injury model was induced by oxygen-glucose deprivation/reoxygenation(OGD/R) 2 h/24 h in PC12 cells.N-acetyl-lcysteine(NAC),a classical anti-oxidant,was used as positive control.Pharmacodynamic experimental study groups as follows:control,control+ICS Ⅱ50 μmol·L^(-1),OGD/R,OGD/R+ICSⅡ 12.5 μmol·L^(-1),OGD/R + ICS Ⅱ 25 μmol·L^(-1),OGD/R + ICS Ⅱ50 μmol·L^(-1),and OGD/R+NAC 100 μmol·L^(-1) groups.Cell viability and lactate dehydrogenase(LDH) leakage rate were measured by MTT assay and LDH ELISA kit,respectively.Moreover,reactive oxygen species(ROS) ELISA kit was used for detection of intracellular ROS generation,Mito-SOX fluorescence staining was used for detecting production of ROS in mitochondria and mitochondrial membrane potential(MMP)was detected by rhodamine 123 dye.In addition,PC12 cells apoptosis was detected by one-step TUNEL assay.Furthermore,the expressions of nuclear factor erythroid 2-related factors(Nrf2),Keap1,HO^(-1),NQO^(-1),silent information regulator 3(SIRT3),IDH2,Bax,Bcl-2 and caspase 3 were detected by Western blotting analysis.RESULTS The results of MTT and LDH assay showed that OGD/R reduced the cell viability and improved LDH release compared with the control or ICSⅡ 50 μmol·L^(-1) alone(P<0.01).Meanwhile,OGD/R not only increased intracellular and mitochondrial ROS generation,but also elevated the fluorescence intensity of TUNEL staining,at the same time,the MMP was declined when challenged by OGD/R.Furthermore,the Western blotting results showed that OGD/R induced the increase in the expression of cytoplasm-Nrf2,Keap1,Bax and cleaved-caspase 3 level,while the decrease in the expression of nucleus-Nrf2,HO^(-1),NQO^(-1),SIRT3,IDH2 and Bcl-2(P<0.05).However,ICS Ⅱ significantly increased the viability of PC12 cells and reduced LDH leakage(P<0.01).Notably,ICS Ⅱ also suppressed ROS generation both in the intracellular and mitochondria,as well as restored MMP.It was also worthy to note that ICS Ⅱ decreased the expressions of cytoplasmNrf2,Keap1,Bax and the level of cleaved-caspase3,whereas,it increased the expressions of nucleus-Nrf2,HO^(-1),NQO^(-1),SIRT3,IDH2 and Bcl-2(P<0.05).CONCLUSION ICSⅡ reduced OGD/Rinduced oxidative damage in PC12 cells under the laboratory conditions,and its underlying mechanism may be related to the regulation of Nrf2/SIRT3 signaling pathway. 展开更多
关键词 icariside oxygen-glucose DEPRIVAtion REOXYGENAtion oxidative injury apoptosis nuclear factor ERYTHROID 2-related factors SILENT information regulator 3
下载PDF
中国竞技体操后备人才培养多元共治的影响因素研究 被引量:2
9
作者 吕万刚 季彦霞 《成都体育学院学报》 CSSCI 北大核心 2024年第3期1-10,共10页
文章主要采用建构式案例研究方法,以扎根理论编码技术为辅助,对参与竞技体操后备人才培养治理的组织进行多案例分析,构建出竞技体操后备人才培养多元共治影响因素的理论框架。研究发现:竞技体操后备人才培养多元共治的影响因素包括价值... 文章主要采用建构式案例研究方法,以扎根理论编码技术为辅助,对参与竞技体操后备人才培养治理的组织进行多案例分析,构建出竞技体操后备人才培养多元共治影响因素的理论框架。研究发现:竞技体操后备人才培养多元共治的影响因素包括价值认同、资源投入、合作机制、组织能力和制度环境。其中,价值认同是实现竞技体操后备人才培养多元共治的原动力;资源投入和合作机制均对多元共治绩效产生正向的促进作用;组织能力和制度环境通过与其他因素产生交互作用而对竞技体操后备人才培养多元共治绩效产生正向的促进作用。 展开更多
关键词 竞技体操 后备人才 多元共治 影响因素 体教融合
下载PDF
Incidence and related factors of dysphagia in stroke patients
10
作者 李红玲 王志红 +2 位作者 吴冰洁 张彤 张玉淼 《中国临床康复》 CSCD 2003年第3期498-499,共2页
AIM:To investigate the incidence and rel ated factors of dysphagia in stroke patients.METHODS:Water drinking test were applied to 100patients who received continuously by neurology and rehabilitation department afte r... AIM:To investigate the incidence and rel ated factors of dysphagia in stroke patients.METHODS:Water drinking test were applied to 100patients who received continuously by neurology and rehabilitation department afte r their condition was stable.RESULTS:Dysphagia incidence of the 100cases of stroke patients was 33%.CONCLUSION:Analysis of related factors indi-cates that incidence of dysphagia has no relationship with sex,age,position of the lesion and complications,but sh ows correlation with status of consc ious-ness,cognitive skill,character of the lesion,position,course,exerc ise abili-ty,daily life activities,buccofac ial apraxia,speech apraxia and aphasia. 展开更多
关键词 病理脑卒中 摄食-吞咽障碍 发病 相关因素
下载PDF
Vibration analysis of foam plates based on cell volume distribution
11
作者 马宇立 陈继伟 +1 位作者 刘咏泉 苏先樾 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2012年第12期1493-1504,共12页
In this paper, vibration analysis of irregular-closed-cell foam plates is per- formed. A cell volume distribution coefficient is introduced to modify the original Gibson- Ashby equations of effective Young's modulus ... In this paper, vibration analysis of irregular-closed-cell foam plates is per- formed. A cell volume distribution coefficient is introduced to modify the original Gibson- Ashby equations of effective Young's modulus of foam materials. A Burr distribution is imported to describe the cell volume distribution situation. Three Burr distribution pa- rameters are obtained and related to the cell volume range and the diversity. Based on the plate theory and the effective modulus theory, the natural frequency of foam plates is calculated with the change of the cell volume distribution parameters. The relationship between the frequencies and the cell volumes are derived. The scale factor of the average cell size is introduced and proved to be an important factor to the performance of the foam plate. The result is shown by the existing theory of size effects. It is determined that the cell volume distribution has an impact on the natural frequency of the plate structure based on the cell volume range, the diversity, and the average size, and the impact can lead to optimization of the synthesis procedure. 展开更多
关键词 closed-cell foam plate vibration natural frequency cell volume distribu-tion effective Young's modulus scale factor
下载PDF
数字基础设施是否提升了中国企业出口产品质量? 被引量:1
12
作者 张梦婷 鲍子文 《南开经济研究》 CSSCI 北大核心 2024年第6期129-147,共19页
作为数字经济高质量发展的硬件支持,数字基础设施对经济发展的促进作用已得到了日益广泛的论证。日趋严峻的国际形势对出口产品质量提出了前所未有的高要求,那么,数字基础设施发展能否有效促进中国企业出口产品质量提升?本文首先从信息... 作为数字经济高质量发展的硬件支持,数字基础设施对经济发展的促进作用已得到了日益广泛的论证。日趋严峻的国际形势对出口产品质量提出了前所未有的高要求,那么,数字基础设施发展能否有效促进中国企业出口产品质量提升?本文首先从信息基础设施与融合基础设施两个维度对城市数字基础设施发展水平进行综合测度,全面准确刻画了数字基础设施中“新一代信息技术”发展与融合应用情况,然后基于中国海关数据库与中国工业企业数据库的匹配数据,从微观企业层面系统考察了数字基础设施发展对企业出口产品质量的影响及作用机制。实证结果显示,数字基础设施发展显著促进了企业出口产品质量的提升,且该结论在独立样本(2016—2020年)、一系列稳健性检验和处理内生性问题后始终成立;机制探究结果显示,数字基础设施建设便利了要素流通和降低了交易成本,是企业出口产品质量促进效应的两个作用机制;异质性分析发现,这种促进效应在非国有、融资约束水平较低及位于外围城市的企业中更为显著。在数字经济迅猛发展背景下,本文为促进数字经济发展,政府更好地规划数字基础设施建设,助推外贸高质量发展等提供了证据支持。 展开更多
关键词 数字基础设施 企业出口产品质量 要素流通 交易成本
下载PDF
气候变化对厦门市恙虫病发病影响的研究
13
作者 柯雪梅 陈娇娜 +4 位作者 马姗姗 伍思翰 蔡春香 王小燕 黄仕杰 《中国人兽共患病学报》 CAS CSCD 北大核心 2024年第10期965-970,共6页
目的探讨厦门市气象因素对恙虫病发病的影响。方法收集厦门市2005-2023年的厦门市恙虫病和气象因素数据,采用Spearman相关性分析方法分析恙虫病发病与气象参数之间的相关关系,采用非线性回归法分析恙虫病与气象参数的数量关系。结果2005... 目的探讨厦门市气象因素对恙虫病发病的影响。方法收集厦门市2005-2023年的厦门市恙虫病和气象因素数据,采用Spearman相关性分析方法分析恙虫病发病与气象参数之间的相关关系,采用非线性回归法分析恙虫病与气象参数的数量关系。结果2005-2023年厦门市恙虫病发病呈先上升后下降的趋势,发病最高年份在2014-2016年,发病高峰季节集中在6-10月份。厦门市恙虫病月发病数与日最低气温(r=0.637,P<0.001)、日平均气温(r=0.627,P<0.001)、日最高气温(r=0.612,P<0.001)、日照时间(r=0.405,P<0.001)、平均相对湿度(r=0.346,P<0.001)及日降水量(r=0.207,P=0.002)呈正相关;与平均气压成负相关(r=-0.549,P<0.001);与平均风速无相关。厦门市恙虫病与气象指标模型回归方程为y=-206.229-11.042x_(1)+0.346x_(1)^(2)+6.266x_(2)-0.106x_(2)^(2)+5.704x_(3)-0.171x_(3)^(2)+0.502x_(4)+0.024x_(4)^(2)-0.667 x_(5)+0.006 x_(5)^(2)+0.190x_(6)-0.019x_(6)^(2)+0.184x_(7),决定系数为0.473。增加全市某大型公园人流量(x_(8))作为因变量纳入多元非线性回归分析,模型回归方程为y=-433.869-11.503x_(1)+0.381x_(1)^(2)+9.150x_(2)-0.197x_(2)^(2)+3.936x_(3)-0.132x_(3)^(2)+0.881x_(4)+0.035 x_(4)^(2)-1.048x_(5)+0.009x_(5)^(2)+0.186x_(6)-0.023x_(6)^(2)+0.421x_(7)+6.210×10^(-5)x_(8)-1.051×10-10 x_(8)^(2),决定系数为0.550。结论厦门市恙虫病发病与日最低气温、日平均气温、日最高气温、相对湿度、日降水量及平均气压等气象因素有关,不同气象因素对恙虫病发病影响有所不同。 展开更多
关键词 恙虫病 气象因素 预测模型
下载PDF
加味桂枝芍药知母汤对急性创伤性膝关节滑膜炎患者炎性因子和膝关节症状分级量化的影响
14
作者 赵玉石 李守艳 +1 位作者 高晶 蔡晓辉 《中国中医急症》 2024年第10期1766-1769,共4页
目的 观察加味桂枝芍药知母汤口服配合关节穿刺抽液倍他米松、利多卡因关节腔注射对急性创伤性膝关节滑膜炎患者的炎性因子和膝关节肿痛症状改善情况。方法 选70例急性创伤性膝关节滑膜炎患者随机分为两组,治疗组口服加味桂枝芍药知母汤... 目的 观察加味桂枝芍药知母汤口服配合关节穿刺抽液倍他米松、利多卡因关节腔注射对急性创伤性膝关节滑膜炎患者的炎性因子和膝关节肿痛症状改善情况。方法 选70例急性创伤性膝关节滑膜炎患者随机分为两组,治疗组口服加味桂枝芍药知母汤,并配合关节穿刺抽液倍他米松、利多卡因关节腔注射,对照组仅行关节穿刺抽液倍他米松、利多卡因关节腔注射;比较两组患者膝关节肿痛症状及血清炎性因子改善情况。结果 治疗组总有效率为91.43%,高于对照组的74.29%(P <0.05);治疗后两组患者Lysholm膝关节评分及症状分级量化(疼痛、肿胀、活动度、压痛和功能)评分均较治疗前增高(P <0.05),且治疗组高于对照组(P <0.05);两组患者血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平均较治疗前下降,但治疗组下降更明显(P <0.05)。结论 加味桂枝芍药知母汤口服,并配合关节穿刺抽吸积液并行倍他米松、利多卡因关节腔注射治疗急性创伤性膝关节滑膜炎可明显减轻膝关节肿痛、改善关节功能,并降低血清中IL-1、IL-6和TNF-α的水平;疗效优于单纯的关节穿刺抽吸积液并行倍他米松、利多卡因关节腔注射。 展开更多
关键词 急性创伤性膝关节滑膜炎 炎症因子 膝关节症状分级量化 加味桂枝芍药知母汤 关节穿刺
下载PDF
基于单细胞ATAC测序数据的乳腺癌上皮细胞转录因子研究
15
作者 张雅娜 牟苑菁 +2 位作者 李苇祥 赵俊焱 郭志云 《生命科学研究》 CAS 2024年第2期171-178,共8页
研究表明,乳腺肿瘤细胞染色质开放区域上的转录因子显著影响乳腺癌患者的临床表型和预后。然而,在单细胞层面,这些调控元件如何调控乳腺癌发生发展尚不明确。为此,本研究从GEO数据库中下载了45216个正常和肿瘤乳腺组织的单细胞染色质可... 研究表明,乳腺肿瘤细胞染色质开放区域上的转录因子显著影响乳腺癌患者的临床表型和预后。然而,在单细胞层面,这些调控元件如何调控乳腺癌发生发展尚不明确。为此,本研究从GEO数据库中下载了45216个正常和肿瘤乳腺组织的单细胞染色质可及性测序(single-cell ATAC sequencing,scATAC-seq)数据,并对其进行了分析。根据标记基因在细胞群的基因活性得分进行细胞类型注释后得到7种乳腺细胞类型。皮尔逊相关性分析表明,肿瘤和正常乳腺样本的上皮细胞存在明显的染色质可及性差异,且乳腺上皮细胞存在高度样本间异质性(PCC=-0.07),暗示其是乳腺肿瘤的主要恶性细胞类型。为了探究正常和恶性乳腺上皮细胞的差异可及性区域中转录因子结合基序的富集情况,在提取上皮细胞群后对4个上皮细胞亚型的特征开放区域进行了转录因子结合基序富集分析。结果表明,恶性乳腺上皮细胞有194个转录因子显著富集(P<0.001),它们可能涉及乳腺肿瘤发展和转移等调控过程。对上皮细胞亚型中富集程度较高的转录因子进行活性分数计算及转录组数据验证,结果进一步显示这些差异调控元件可能与乳腺细胞恶性发展相关。此外,对转录因子结合基序在不同乳腺癌亚型中的可及性差异进行了分析,发现SNAI2在三阴性乳腺癌样本中具有显著高的可及性,提示SNAI2在三阴性乳腺癌中具有潜在的特异性调控作用。 展开更多
关键词 乳腺癌 单细胞 单细胞染色质可及性测序(scATAC-seq) 转录因子
下载PDF
鄂尔多斯盆地旬宜地区三叠系延长组7段致密油储层孔隙发育特征及其主控因素
16
作者 王良军 岳欣欣 +1 位作者 李连生 王延鹏 《石油实验地质》 CAS CSCD 北大核心 2024年第6期1135-1144,共10页
鄂尔多斯盆地旬宜地区三叠系延长组7段为典型的致密油储层,具有低孔、低渗、非均质性强等特征,明确储层孔隙发育特征及其主控因素,有利于致密油的勘探与开发。通过岩石薄片、物性、扫描电镜、X衍射分析、压汞等实验,深入研究了致密油储... 鄂尔多斯盆地旬宜地区三叠系延长组7段为典型的致密油储层,具有低孔、低渗、非均质性强等特征,明确储层孔隙发育特征及其主控因素,有利于致密油的勘探与开发。通过岩石薄片、物性、扫描电镜、X衍射分析、压汞等实验,深入研究了致密油储层的岩石学特征、储集空间、成岩演化等储层发育特征,并揭示其主控因素。鄂尔多斯盆地旬宜地区延长组7段储层埋深在500~1250 m,岩性以岩屑长石砂岩为主,其次为长石岩屑砂岩,填隙物以方解石、白云石和泥质杂基为主;研究区储层砂体厚度大,成分成熟度高,骨架颗粒中抗风化能力较强的石英和长石等刚性矿物含量高,石英含量在30%~77%之间,平均为44.97%,长石含量在4%~52%之间,平均为31.61%;孔隙类型以粒间溶孔和颗粒溶孔为主,其次为残余粒间孔,少数为微裂缝,平均孔隙度为7.3%,平均渗透率为0.4×10-3μm^(2)。储层成岩阶段处于中成岩A期,在白垩纪完成了致密化,较差的抗压实能力、碳酸盐胶结作用、伊/蒙混层、自生石英为储层致密化的主要原因;较高的石英和长石含量、早期油气充注保存了大量原生孔隙,中成岩期持续的溶蚀作用和破碎作用为次生孔隙发育的主要原因。 展开更多
关键词 致密砂岩 储层特征 致密化 主控因素 延长组 旬宜地区 鄂尔多斯盆地
下载PDF
内蒙古通辽地震观测井水位和水温准同步变化机理分析
17
作者 丁风和 韩晓雷 +1 位作者 戴勇 朱鹏涛 《地震》 CSCD 北大核心 2024年第3期86-95,共10页
利用区域水文地质资料、水温梯度测试结果、区域地下水开采和降水等数据,分析了影响内蒙古通辽地震观测井水位和温度多年与年际变化的因素。在此基础上,构建了水动力地质模型,探讨了该井水位和水温准同步变化的机理。结果表明,区域地下... 利用区域水文地质资料、水温梯度测试结果、区域地下水开采和降水等数据,分析了影响内蒙古通辽地震观测井水位和温度多年与年际变化的因素。在此基础上,构建了水动力地质模型,探讨了该井水位和水温准同步变化的机理。结果表明,区域地下水开采和降雨是影响该井水位和温度准同步变化的主要因素,冷水渗透理论可以很好地解释该井水位和水温的准同步变化。 展开更多
关键词 水位 水温 影响因素 冷水渗透 地下水运移 通辽地震观测井
下载PDF
中药热奄包、针刺联合手法推拿对神经根型颈椎病患者血液流变学和颈椎活动度的影响 被引量:1
18
作者 范鹏 刘冬银 +6 位作者 张学新 王雷 刘伯辉 杨涛 王珊 赵家仪 郭凤红 《临床误诊误治》 CAS 2024年第14期90-94,共5页
目的探究中药热奄包、针刺联合手法推拿治疗对神经根型颈椎病患者血液流变学和颈椎活动度的影响。方法选取2022年4月至2023年3月就诊的80例神经根型颈椎病患者,据随机数字表法分为观察组和对照组各40例,对照组予针刺联合手法推拿治疗,... 目的探究中药热奄包、针刺联合手法推拿治疗对神经根型颈椎病患者血液流变学和颈椎活动度的影响。方法选取2022年4月至2023年3月就诊的80例神经根型颈椎病患者,据随机数字表法分为观察组和对照组各40例,对照组予针刺联合手法推拿治疗,观察组在此基础上联合中药热奄包治疗,2组均治疗20 d。观察比较2组临床疗效,治疗前后视觉模拟评分法(VAS)评分、颈椎功能障碍指数(NDI)、颈椎病临床评价量表(CASCS)评分、颈椎活动度、血液流变学指标和血清炎性因子水平。结果治疗后,观察组总有效率为95.00%高于对照组的77.50%(P<0.05);治疗后,观察组VAS评分和NDI均显著低于对照组,CASCS评分显著高于对照组(P<0.05,P<001);治疗后,观察组颈椎前屈、后伸、左侧屈和右侧屈活动度均高于对照组(P<001);治疗后,观察组血浆黏度、全血低切黏度、全血高切黏度均显著低于对照组(P<001);治疗后,观察组血清白细胞介素-6、白细胞介素-8和肿瘤坏死因子-α水平均低于对照组(P<001)。结论中药热奄包、针刺联合手法推拿可有效缓解神经根型颈椎病患者临床症状,改善颈椎活动度和血液流变学指标,减轻机体炎症反应。 展开更多
关键词 神经根型颈椎病 中药热奄包 针刺 手法推拿 血浆黏度 颈椎活动度 白细胞介素-6 肿瘤坏死因子-α
下载PDF
2型糖尿病病人血清沉默信息调节因子2相关酶1和叉头样转录因子O4表达与糖尿病视网膜病变的关系
19
作者 于海涛 王天立 李雪 《安徽医药》 CAS 2024年第8期1574-1578,共5页
目的探究2型糖尿病(T2DM)病人血清沉默信息调节因子2相关酶1(SIRT1)和叉头样转录因子O4(FOXO4)表达与糖尿病视网膜病变(DR)的关系。方法采用随机数字表法将2021年8月至2022年8月在七台河市人民医院收治的142例T2DM病人纳入研究,按照国... 目的探究2型糖尿病(T2DM)病人血清沉默信息调节因子2相关酶1(SIRT1)和叉头样转录因子O4(FOXO4)表达与糖尿病视网膜病变(DR)的关系。方法采用随机数字表法将2021年8月至2022年8月在七台河市人民医院收治的142例T2DM病人纳入研究,按照国际临床DR严重程度量表分为无DR组62例、非增殖性(NPDR)组50例和增殖性(PDR)组30例。采用酶联免疫吸附测定(ELISA)检测血清SIRT1和FOXO4的表达水平;Pearson法分析血清中SIRT1和FOXO4表达水平的相关性;logistic回归分析影响T2DM病人DR发生的因素。ROC曲线分析血清中SIRT1和FOXO4对T2DM病人DR发生的诊断价值。结果PDR组高密度脂蛋白胆固醇(HDL-C)[(1.22±0.15)mmol/L比(1.98±0.17)mmol/L、(1.64±0.18)mmol/L]、SIRT1水平[(3.82±0.50)μg/L比(5.36±0.56)μg/L、(4.65±0.52)μg/L]显著低于无DR组及NPDR组,NPDR组显著低于无DR组;PDR组收缩压(SBP)、三酰甘油(TG)、FOXO4[(14.63±1.48)μg/L比(12.62±1.45)μg/L、(13.74±1.46)μg/L]水平显著高于无DR组及NPDR组,NPDR组显著高于无DR组(P<0.05)。相关性分析显示,血清SIRT1和FOXO4表达水平呈负相关关系(r=−0.47,P<0.001)。logistic回归分析显示,HDL-C、SIRT1和FOXO4表达水平是影响T2DM病人DR发生的因素(P<0.05)。二者联合诊断DR发生的ROC曲线下面积(AUC)高于SIRT1和FOXO4单独诊断的AUC值(Z=32.22,P<0.001;Z=19.03,P<0.001)。结论T2DM病人血清中SIRT1表达水平显著降低,FOXO4表达水平显著升高,二者是影响T2DM病人DR发生的因素。 展开更多
关键词 糖尿病视网膜病变 2型糖尿病 沉默信息调节因子2相关酶1 叉头样转录因子O4
下载PDF
加味甘草泻心汤含漱治疗乳腺癌化疗相关口腔黏膜炎临床研究
20
作者 孙新刚 冯守含 +4 位作者 关新军 柳冬兵 朱肖肖 唐月莲 叶津津 《新中医》 CAS 2024年第3期1-6,共6页
目的:观察加味甘草泻心汤含漱治疗乳腺癌化疗相关口腔黏膜炎的疗效。方法:选择101例乳腺癌化疗相关口腔黏膜炎患者,按随机数字表法分为对照组50例和观察组51例。2组均给予紫杉类化疗方案化疗,对照组给予康复新液含漱,观察组给予加味甘... 目的:观察加味甘草泻心汤含漱治疗乳腺癌化疗相关口腔黏膜炎的疗效。方法:选择101例乳腺癌化疗相关口腔黏膜炎患者,按随机数字表法分为对照组50例和观察组51例。2组均给予紫杉类化疗方案化疗,对照组给予康复新液含漱,观察组给予加味甘草泻心汤含漱。评价2组临床疗效,比较2组口腔黏膜愈合时间、疼痛评分、口腔pH值、中医证候评分、口腔微生物数量及炎症因子水平。结果:观察组总有效率为98.04%,高于对照组82.00%(P<0.05)。治疗后,2组视觉模拟评分法(VAS)评分、口腔pH值、各项中医证候评分较治疗前降低(P<0.05);观察组VAS评分、口腔pH值、各项中医证候评分低于对照组(P<0.05),观察组口腔黏膜愈合时间短于对照组(P<0.05)。治疗后,2组口腔链球菌、韦荣球菌、奈瑟菌数量较治疗前增加(P<0.05);且观察组口腔链球菌、韦荣球菌、奈瑟菌数量多于对照组(P<0.05)。治疗后,2组血清乏氧诱导因子-1α(HIF-1α)、白细胞介素-6(IL-6)、转化生长因子-β1(TGF-β1)、肿瘤坏死因子-α(TNF-α)水平较治疗前降低(P<0.05);且观察组HIF-1α、IL-6、TGF-β1、TNF-α水平低于对照组(P<0.05)。治疗后,2组中性粒细胞、白细胞计数较治疗前增加(P<0.05);且观察组中性粒细胞、白细胞计数高于对照组(P<0.05)。结论:加味甘草泻心汤含漱治疗乳腺癌化疗相关口腔黏膜炎,可改善口腔微生物数量,抑制机体炎症,提升中性粒细胞、白细胞计数,改善口腔环境,促进口腔黏膜愈合,缓解患者疼痛,提升临床疗效。 展开更多
关键词 乳腺癌 化疗相关口腔黏膜炎 加味甘草泻心汤 含漱 口腔微生物 炎症因子
下载PDF
上一页 1 2 24 下一页 到第
使用帮助 返回顶部