Estimation of model parameter for transient signal is very important in many aspects. This paper presents a new Markov ARMA model Q-slice estimation algorithm for transient signal based on bispectrum. Simulation resul...Estimation of model parameter for transient signal is very important in many aspects. This paper presents a new Markov ARMA model Q-slice estimation algorithm for transient signal based on bispectrum. Simulation results show that this new method has some special features, such as higher estimation precision, lower amount of calculation, higher fitting effect even in lower signal-to-noise ratio (SNR) situation.展开更多
Many dynamic signals of mining machines are transient, such as load signals when roadheader’s cutting head being cut-in or cut-out and response signals produced by these loads.For these transient signals, the traditi...Many dynamic signals of mining machines are transient, such as load signals when roadheader’s cutting head being cut-in or cut-out and response signals produced by these loads.For these transient signals, the traditional Fourier analysis method is quite inadequate.The limitations of analysis, resolution by using Short-Time Fourier Transform (STFT) on them were discussed in this paper. Because of wavelet transform having the characteristics of flexible window and multiresolution analysis, we try to apply it to analyse these transient signal. In order to give a pratical example,using D18 wavelet and Mallat’s tree algorithm with MATLAB, the discrete wavelet transform was calculated for the simulating response signals of a three-degree-of freedom vibration system when it Was under impulse and random excitations. The results of the wavelet transform made clear its effectiveness and superiority in analysing transient signals of mining machines.展开更多
Precise fault location plays an important role in the reliability of modern power systems.With the in-creasing penetration of renewable energy sources,the power system experiences a decrease in system inertia and alte...Precise fault location plays an important role in the reliability of modern power systems.With the in-creasing penetration of renewable energy sources,the power system experiences a decrease in system inertia and alterations in steady-state characteristics following a fault occurrence.Most existing single-ended phasor domain methods assume a certain impedance of the remote-end system or consistent current phases at both ends.These problems present challenges to the applicability of con-ventional phasor-domain location methods.This paper presents a novel single-ended time domain fault location method for single-phase-to-ground faults,one which fully considers the distributed parameters of the line model.The fitting of transient signals in the time domain is real-ized to extract the instantaneous amplitude and phase.Then,to eliminate the error caused by assumptions of lumped series resistance in the Bergeron model,an im-proved numerical derivation is presented for the distrib-uted parameter line model.The instantaneous symmet-rical components are extracted for decoupling and inverse transformation of three-phase recording data.Based on the above,the equation of instantaneous phase constraint is established to effectively identify the fault location.The proposed location method reduces the negative effects of fault resistance and the uncertainty of remote end pa-rameters when relying on one-terminal data for localiza-tion.Additionally,the proposed fault analysis methods have the ability to adapt to transient processes in power systems.Through comparisons with existing methods in three different systems,the fault position is correctly identified within an error of 1%.Also,the results are not affected by sampling rates,data windows,fault inception angles,and load conditions. Index Terms—Fault location,distributed parameter line model,transient signal,renewable energy,instantaneous phase.展开更多
The phase change between periodic signals is regular. Research on the regular phenomenon between periodic signals is helpful to improve the precision of some measurements and develop some new measurement methods. So i...The phase change between periodic signals is regular. Research on the regular phenomenon between periodic signals is helpful to improve the precision of some measurements and develop some new measurement methods. So it is necessary to analyze the characteristics of the greatest common factor frequency and the least common multiple period universally existing in periodic signals. The regulation of the quantitative phase shift resolution between periodic signals is presented.The cause of difference in phase characteristics between periodic signals is explained well. In this paper we propose different application prospects based on the regular phenomenon between periodic signals, with focusing on the methods for high precision frequency measurement and transient stability measurement. The experimental results are satisfactory.展开更多
Background: Natural killer (NK) cell phenotypes have reported to be implicated in the pathomechanism of Multiple Sclerosis (MS). Several investigators have observed reduced peripheral numbers, reduced cytotoxic activi...Background: Natural killer (NK) cell phenotypes have reported to be implicated in the pathomechanism of Multiple Sclerosis (MS). Several investigators have observed reduced peripheral numbers, reduced cytotoxic activity, and altered CD56Dim and CD56Bright NK cell phenotypes. This current project, for the first time, investigates the NK cell cytotoxicity, calcium mobilisation and transient receptor potential melastatin 3 (TRPM3) surface expression. Methods: NK cell cytotoxic activity and calcium signaling were examined in CD56Dim and CD56Bright NK cells before and after stimulation using Ionomycin, Pregnenolone sulphate, 2-Aminoethoxydiphenyl borate and Thapsigargin. Purified NK cells were labelled with antibodies to determine TRPM3, CD69 and CD107a surface expression using flow cytometry. Results: Twenty-two MS patients and 22 healthy controls were recruited for this project. Twelve of the 22 previously received Alemtuzumab (Lemtrada®) and the remaining ten reported nil medication. We report TRPM3 was significantly increased in untreated MS patients compared with healthy controls and treated MS patients (p-value 0.034). There was a significant decrease in CD69 surface expression on CD56Dim NK cell phenotype for untreated MS patients (p-value 0.031) and treated MS patients (p-value 0.036). We report altered calcium mobilisation in CD56Bright NK cells and to a lesser extent CD56Dim NK cells between healthy controls, treated and untreated MS patients. Conclusion: This investigation suggests variations in TRPM3 expression and calcium mobilisation of NK cells may be implicated in the pathogenesis of MS. Further investigation is required to determine the mechanism by which alemtuzumab alters calcium signaling in NK cells.展开更多
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disabling condition of unknown cause having multi-system manifestations. Our group has investigated the potential role of transient receptor potential (...Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disabling condition of unknown cause having multi-system manifestations. Our group has investigated the potential role of transient receptor potential (TRP) ion channels in the etiology and pathomechanism of this illness. Store-operated calcium entry (SOCE) signaling is the primary intracellular calcium signaling mechanism in non-excitable cells and is associated with TRP ion channels. While the sub-family (Canonical) TRPC has been traditionally associated with this important cellular mechanism, a member of the TRPM sub-family group (Melastatin), TRPM3, has also been recently identified as participating in SOCE in white matter of the central nervous system. We have identified single nucleotide polymorphisms (SNPs) in TRP genes in natural killer (NK) cells and peripheral blood mononuclear cells (PBMCs) in CFS/ME patients. We also describe biochemical pathway changes and calcium signaling perturbations in blood cells from patients. The ubiquitous distribution of TRP ion channels and specific locations of sub-family group members such as TRPM3 suggest a contribution to systemic pathology in CFS/ME.展开更多
文摘Estimation of model parameter for transient signal is very important in many aspects. This paper presents a new Markov ARMA model Q-slice estimation algorithm for transient signal based on bispectrum. Simulation results show that this new method has some special features, such as higher estimation precision, lower amount of calculation, higher fitting effect even in lower signal-to-noise ratio (SNR) situation.
文摘Many dynamic signals of mining machines are transient, such as load signals when roadheader’s cutting head being cut-in or cut-out and response signals produced by these loads.For these transient signals, the traditional Fourier analysis method is quite inadequate.The limitations of analysis, resolution by using Short-Time Fourier Transform (STFT) on them were discussed in this paper. Because of wavelet transform having the characteristics of flexible window and multiresolution analysis, we try to apply it to analyse these transient signal. In order to give a pratical example,using D18 wavelet and Mallat’s tree algorithm with MATLAB, the discrete wavelet transform was calculated for the simulating response signals of a three-degree-of freedom vibration system when it Was under impulse and random excitations. The results of the wavelet transform made clear its effectiveness and superiority in analysing transient signals of mining machines.
文摘Precise fault location plays an important role in the reliability of modern power systems.With the in-creasing penetration of renewable energy sources,the power system experiences a decrease in system inertia and alterations in steady-state characteristics following a fault occurrence.Most existing single-ended phasor domain methods assume a certain impedance of the remote-end system or consistent current phases at both ends.These problems present challenges to the applicability of con-ventional phasor-domain location methods.This paper presents a novel single-ended time domain fault location method for single-phase-to-ground faults,one which fully considers the distributed parameters of the line model.The fitting of transient signals in the time domain is real-ized to extract the instantaneous amplitude and phase.Then,to eliminate the error caused by assumptions of lumped series resistance in the Bergeron model,an im-proved numerical derivation is presented for the distrib-uted parameter line model.The instantaneous symmet-rical components are extracted for decoupling and inverse transformation of three-phase recording data.Based on the above,the equation of instantaneous phase constraint is established to effectively identify the fault location.The proposed location method reduces the negative effects of fault resistance and the uncertainty of remote end pa-rameters when relying on one-terminal data for localiza-tion.Additionally,the proposed fault analysis methods have the ability to adapt to transient processes in power systems.Through comparisons with existing methods in three different systems,the fault position is correctly identified within an error of 1%.Also,the results are not affected by sampling rates,data windows,fault inception angles,and load conditions. Index Terms—Fault location,distributed parameter line model,transient signal,renewable energy,instantaneous phase.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.10978017 and 61201288)
文摘The phase change between periodic signals is regular. Research on the regular phenomenon between periodic signals is helpful to improve the precision of some measurements and develop some new measurement methods. So it is necessary to analyze the characteristics of the greatest common factor frequency and the least common multiple period universally existing in periodic signals. The regulation of the quantitative phase shift resolution between periodic signals is presented.The cause of difference in phase characteristics between periodic signals is explained well. In this paper we propose different application prospects based on the regular phenomenon between periodic signals, with focusing on the methods for high precision frequency measurement and transient stability measurement. The experimental results are satisfactory.
文摘Background: Natural killer (NK) cell phenotypes have reported to be implicated in the pathomechanism of Multiple Sclerosis (MS). Several investigators have observed reduced peripheral numbers, reduced cytotoxic activity, and altered CD56Dim and CD56Bright NK cell phenotypes. This current project, for the first time, investigates the NK cell cytotoxicity, calcium mobilisation and transient receptor potential melastatin 3 (TRPM3) surface expression. Methods: NK cell cytotoxic activity and calcium signaling were examined in CD56Dim and CD56Bright NK cells before and after stimulation using Ionomycin, Pregnenolone sulphate, 2-Aminoethoxydiphenyl borate and Thapsigargin. Purified NK cells were labelled with antibodies to determine TRPM3, CD69 and CD107a surface expression using flow cytometry. Results: Twenty-two MS patients and 22 healthy controls were recruited for this project. Twelve of the 22 previously received Alemtuzumab (Lemtrada®) and the remaining ten reported nil medication. We report TRPM3 was significantly increased in untreated MS patients compared with healthy controls and treated MS patients (p-value 0.034). There was a significant decrease in CD69 surface expression on CD56Dim NK cell phenotype for untreated MS patients (p-value 0.031) and treated MS patients (p-value 0.036). We report altered calcium mobilisation in CD56Bright NK cells and to a lesser extent CD56Dim NK cells between healthy controls, treated and untreated MS patients. Conclusion: This investigation suggests variations in TRPM3 expression and calcium mobilisation of NK cells may be implicated in the pathogenesis of MS. Further investigation is required to determine the mechanism by which alemtuzumab alters calcium signaling in NK cells.
文摘Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disabling condition of unknown cause having multi-system manifestations. Our group has investigated the potential role of transient receptor potential (TRP) ion channels in the etiology and pathomechanism of this illness. Store-operated calcium entry (SOCE) signaling is the primary intracellular calcium signaling mechanism in non-excitable cells and is associated with TRP ion channels. While the sub-family (Canonical) TRPC has been traditionally associated with this important cellular mechanism, a member of the TRPM sub-family group (Melastatin), TRPM3, has also been recently identified as participating in SOCE in white matter of the central nervous system. We have identified single nucleotide polymorphisms (SNPs) in TRP genes in natural killer (NK) cells and peripheral blood mononuclear cells (PBMCs) in CFS/ME patients. We also describe biochemical pathway changes and calcium signaling perturbations in blood cells from patients. The ubiquitous distribution of TRP ion channels and specific locations of sub-family group members such as TRPM3 suggest a contribution to systemic pathology in CFS/ME.
