Poems are the products of national culture, and A Dream of Red Mansions (A DRM) is the collection of Chinese culture in the era when the novel was written, so poems in A DRM express a wealth of cultural messages. Acco...Poems are the products of national culture, and A Dream of Red Mansions (A DRM) is the collection of Chinese culture in the era when the novel was written, so poems in A DRM express a wealth of cultural messages. According to the Limits of Translatability raised by Catford in 1965, cultural untranslatability occurs when a relevant situational feature for the SL text is absent in the TL. So this paper aims to find problems of cultranslation of poems in A DRM, and tries to further restrict cultural untranslatability by applying compensation strategies.展开更多
As is known to all in the translation field,the problem of translatability and untranslatability has been a long-debated is sue in the field of translation.And the phenomenon of untranslatability is especially promine...As is known to all in the translation field,the problem of translatability and untranslatability has been a long-debated is sue in the field of translation.And the phenomenon of untranslatability is especially prominent in translation of literary works.This paper tries to discuss,from theory and practice,the phenomenon of untranslatability and its compensation strategies in trans lation between Chinese and English.It is roughly divided into two parts,wherein the first part deals with the phenomenon of un translatability,explaining its causes and giving some examples,and the second part deals with the compensation strategies,intro ducing several methods of compensation and taking The Original of Laura written by the deceased Russian-American writer Nabokov as an example.With the development of intercultural communication in the world and the great efforts of translators,the untranslatable words today can be translatable tomorrow.展开更多
There is a strange phenomenon that the translated works of Chinese classics have not been enjoyed by a large readership abroad,stemming from the untranslatability of poetry,an inherent nature of poetry translation.It ...There is a strange phenomenon that the translated works of Chinese classics have not been enjoyed by a large readership abroad,stemming from the untranslatability of poetry,an inherent nature of poetry translation.It is argued with theoretical analyses coupled by case studies that linguistic untranslatability(including intralingual inequivalence,interlingual inequivalence),cultural untranslatability(intercultural inequivalence),translator's inadequacy and governmental or institutional translation briefs contribute to problem mentioned.It is hoped that once the factors influencing untranslatability of poetry is realized,translators'presumptuousness along with despondence can be lessened or even eradicated with a production of a better version free from overrepresentation or underrepresentation or misrepresentation of the originals.展开更多
Translation is not only an exchange activity among languages, but also a process about transformation and communication of culture. Language and culture is a unity that language is the essential part of culture while ...Translation is not only an exchange activity among languages, but also a process about transformation and communication of culture. Language and culture is a unity that language is the essential part of culture while culture is the nature and content of language communication. Because of its own history and distinctive geographical environment, culture has its unique ethnic features and psychological construction. All of these culture elements reflect on language. For different languages, there are great differences about the glyph, sound, words, rhetorical devices, and idioms. Such differences in language and culture between English and Chinese can cause the limitation of translatability in the process of translation.展开更多
Translation is a field full of paradoxes. The question of whether or not languages are translatable has been argued for many years in the history of translation. There are many opposite idea on this question, for exam...Translation is a field full of paradoxes. The question of whether or not languages are translatable has been argued for many years in the history of translation. There are many opposite idea on this question, for example, to what degree languages are translatable, and all this problems relating to translatability and untranslatability have always been difficult questions for further studying. Also, idioms are major components of a language. They are experience and lessons that people learned from years of hard work and life experiences, and they reflect the wisdom of human beings. In a word, when it comes to the translatability and untranslatability of Chinese idioms, there usually exist more obvious problems. Because Chinese idioms have certain ethnic characteristics and distinguishable cultural meanings, and more importantly they are deeply rooted in national culture and society. This essay first introduced the relationship between Untranslatability and Translatability, and then discussed the features of Chinese idioms, and later this essay mainly discussed the translatability and untranslatability in a translating process from a perspective of the translation of Chinese idioms. Finally, it gives some practical ways to reduce the untranslatability of Chinese idioms.展开更多
The issue of the translatability of poetry is still under hot discussion. Translation of poetry was, and still is by some, believed as impossibility, for the myth of untranslatability looks upon poetry as beauty itsel...The issue of the translatability of poetry is still under hot discussion. Translation of poetry was, and still is by some, believed as impossibility, for the myth of untranslatability looks upon poetry as beauty itself which is untouchable for once it is touched it is destroyed[1]. From different perspectives, such as the perspective of word formation, pun, reduplicated words etc, the author argues that poetic translation is translatable, and that poetry and aesthetics can be reproduced in another language and culture if accommodation is made.展开更多
Classical poetry is a kind of special classical literature with highly concise language,rich emotion,profound implication and certain rhythm.The development of poetry translation is related to the spread of Chinese cl...Classical poetry is a kind of special classical literature with highly concise language,rich emotion,profound implication and certain rhythm.The development of poetry translation is related to the spread of Chinese classical culture.There are many opinions about translatability and Untranslatability of poetry translation.The translation of meaning is relatively easy,while the rhetoric technique closely related to the form of expression is more difficult,which is the key to express the poet's feelings.There⁃fore,this paper aims to explore the untranslatability of onomatopoeia in poetry by combining with the Book of Songs.展开更多
In cross-cultural communication,a translator has to study the cultural differences prior to his efficient linguistic transference. As a matter of fact, the cultural differences across nations always create sorts of un...In cross-cultural communication,a translator has to study the cultural differences prior to his efficient linguistic transference. As a matter of fact, the cultural differences across nations always create sorts of untranslatable factors.The cultural universals, however, make cultural exchange and linguistic transference possible. A translator, in this sense, shall resort to some balancing point in translating.展开更多
This paper aimed to probe the influence of culture on advertising translation between Chinese language and English language. Based on an analysis of the samples of advertisements in both Chinese and English languages,...This paper aimed to probe the influence of culture on advertising translation between Chinese language and English language. Based on an analysis of the samples of advertisements in both Chinese and English languages, it is found that cultural differences in terms of value, Referent association, and historical and cultural background can affect the process of Advertising Translation. It is suggested that the strategy of domestication and translation methods such as neutralization, conversion can be adopted to minimize cultural Untranslatability in Advertising Translation.展开更多
Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate...Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this condition.Psychoneuroimmunoendocrinology(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a whole.The initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and well-being.In the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are interconnected.Finally,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.展开更多
The Tbx family is first known through the study of their functions in the body and limbs,and its members Tbx4 and Tbx5 genes are important factors in determining the characteristics of the appendages.Pampus argenteus ...The Tbx family is first known through the study of their functions in the body and limbs,and its members Tbx4 and Tbx5 genes are important factors in determining the characteristics of the appendages.Pampus argenteus is one of the important economical marine fishes widely distributed in offshore areas.Therefore,it is necessary to study the role of Tbx family genes in the deletion of pelvic fin in P.argenteus.In this study,we cloned Tbx4 and Tbx5 cDNA sequence of P.argenteus(GenBank:MH709128 and MH712458).The Western blot and real time PCR were used to detect the expressions of Tbx4 and Tbx5 in different developmental stages and tissues of P.argenteus.In addition,whole-mount in-situ hybridization was used to study the localization of Tbx4 and Tbx5 genes in different developmental stages of P.argenteus.Results show that the translation of Tbx4 mRNA was inhibited during the critical period of pelvic fin development.Among different tissues,Tbx4 protein levels were the lowest in the abdominal epithelium,and even lower than that in the pectoral fin,suggesting that the protein expression was also inhibited in the abdominal epithelium of adult P.argenteus.Therefore,the results indicated that upstream genes regulation led to the key stage-specific and low expression of Tbx4 during pelvic fin development and in the abdominal epithelium.展开更多
Introductory comments:The identification and validation of disease-modifying proteins are fundamental aspects in drug development.However,the m ultifactority of n eurodegen era tive diseases poses a real challenge for...Introductory comments:The identification and validation of disease-modifying proteins are fundamental aspects in drug development.However,the m ultifactority of n eurodegen era tive diseases poses a real challenge for targeted therapies.Furthermore,the behavior of individually(over-)expressed to rget proteins in vitro is likely to differ from their actual functional behavior when embedded in cascades and pathways in vivo.展开更多
Maintenance of protein homeostasis or“proteostasis”is essential for the functioning and viability of cells.This is in particular the case for cells like neurons that cannot self-renew and acquire unique functional p...Maintenance of protein homeostasis or“proteostasis”is essential for the functioning and viability of cells.This is in particular the case for cells like neurons that cannot self-renew and acquire unique functional properties during their lifetime.Cellular proteostatic stress responses are in place to protect cells from damage in case of proteostatic challenges.The integrated stress response(ISR)is one of the key proteostatic stress responses in the cell(Costa-Mattioli and Walter,2020).The ISR is the downstream convergence point for the four stress-induced eIF2αkinases(EIF2AK1-4)that control stress-regulated protein translation via phosphorylation of the translation factor eIF2α.ISR activation results in a transient reduction of global translation while it concomitantly enhances the translation of specific mRNAs,including that encoding the activating transcription factor 4(ATF4).Together,the translational control mediated by the ISR results in a temporary reduction of the overall protein load and the selectively increased expression of proteins that contribute to restoration of the proteostatic balance.展开更多
Existing studies have underscored the pivotal role of N-acetyltransferase 10(NAT10) in various cancers. However, the outcomes of protein-protein interactions between NAT10 and its protein partners in head and neck squ...Existing studies have underscored the pivotal role of N-acetyltransferase 10(NAT10) in various cancers. However, the outcomes of protein-protein interactions between NAT10 and its protein partners in head and neck squamous cell carcinoma(HNSCC) remain unexplored. In this study, we identified a significant upregulation of RNA-binding protein with serine-rich domain 1(RNPS1) in HNSCC, where RNPS1 inhibits the ubiquitination degradation of NAT10 by E3 ubiquitin ligase, zinc finger SWIM domain-containing protein 6(ZSWIM6), through direct protein interaction, thereby promoting high NAT10 expression in HNSCC. This upregulated NAT10 stability mediates the enhancement of specific tRNA ac^(4)C modifications, subsequently boosting the translation process of genes involved in pathways such as IL-6 signaling, IL-8 signaling, and PTEN signaling that play roles in regulating HNSCC malignant progression, ultimately influencing the survival and prognosis of HNSCC patients. Additionally, we pioneered the development of TRMC-seq, leading to the discovery of novel t RNA-ac^(4)C modification sites, thereby providing a potent sequencing tool for tRNAac^(4)C research. Our findings expand the repertoire of tRNA ac^(4)C modifications and identify a role of tRNA ac^(4)C in the regulation of mRNA translation in HNSCC.展开更多
Translation regulation is an important layer of gene expression:Generation of genome-wide expression datasets at multi-omics levels in spatial,temporal,and cell-type resolution is essential for deciphering brain compl...Translation regulation is an important layer of gene expression:Generation of genome-wide expression datasets at multi-omics levels in spatial,temporal,and cell-type resolution is essential for deciphering brain complexity.Regulation of gene expression is a highly dynamic process aiming at the production of precise levels of gene products to guarantee optimal cellular function,in response to physiological cues.Speedy advances in next-generation sequencing enabled the understanding of epigenomic and transcriptomic dynamic landscapes of different brain regions along development,aging,and disease progression.However,the correlation of the“transcriptome”with protein levels is poor because numerous mRNAs are subjected to manipulation of their translation efficiency,to warrant a favorable result under certain conditions.Hence,it is widely accepted that regulation at the translation level is a vital layer of gene expression.Quantification of actively translated mRNA populations(i.e.,“translatome”)is a more reliable predictor of the“proteome”(Wang et al.,2020).展开更多
We take phase modulation to create discrete phase-controlled sources and realize the super-bunching effect by a phasecorrelated method. From theoretical and numerical simulations, we find the space translation invaria...We take phase modulation to create discrete phase-controlled sources and realize the super-bunching effect by a phasecorrelated method. From theoretical and numerical simulations, we find the space translation invariance of the bunching effect is a key point for the ghost imaging realization. Experimentally, we create the orderly phase-correlated discrete sources which can realize high-visibility second-order ghost imaging than the result with chaotic sources. Moreover, some factors affecting the visibility of ghost image are discussed in detail.展开更多
In a multi-bubble system, the bubble behavior is modulated by the primary acoustic field and the secondary acoustic field. To explore the translational motion of bubbles in cavitation liquids containing high-concentra...In a multi-bubble system, the bubble behavior is modulated by the primary acoustic field and the secondary acoustic field. To explore the translational motion of bubbles in cavitation liquids containing high-concentration cavitation nuclei,evolutions of bubbles are recorded by a high-speed camera, and translational trajectories of several representative bubbles are traced. It is found that translational motion of bubbles is always accompanied by the fragmentation and coalescence of bubbles, and for bubbles smaller than 10 μm, the possibility of bubble coalescence is enhanced when the spacing of bubbles is less than 30 μm. The measured signals and their spectra show the presence of strong negative pressure, broadband noise,and various harmonics, which implies that multiple interactions of bubbles appear in the region of high-intensity cavitation.Due to the strong coupling effect, the interaction between bubbles is random. A simplified triple-bubble model is developed to explore the interaction patterns of bubbles affected by the surrounding bubbles. Patterns of bubble interaction, such as attraction, repulsion, stable spacing, and rebound of bubbles, can be predicted by the theoretical analysis, and the obtained results are in good agreement with experimental observations. Mass exchange between the liquid and bubbles as well as absorption in the cavitation nuclei also plays an important role in multi-bubble cavitation, which may account for the weakening of the radial oscillations of bubbles.展开更多
In this paper,we investigate spacelike graphs defined over a domain Ω⊂M^(n) in the Lorentz manifold M^(n)×ℝ with the metric−ds^(2)+σ,where M^(n) is a complete Riemannian n-manifold with the metricσ,Ωhas piece...In this paper,we investigate spacelike graphs defined over a domain Ω⊂M^(n) in the Lorentz manifold M^(n)×ℝ with the metric−ds^(2)+σ,where M^(n) is a complete Riemannian n-manifold with the metricσ,Ωhas piecewise smooth boundary,and ℝ denotes the Euclidean 1-space.We prove an interesting stability result for translating spacelike graphs in M^(n)×ℝ under a conformal transformation.展开更多
BACKGROUND Hepatocellular carcinoma(HCC),a major contributor to cancer-related deaths,is particularly prevalent in Asia,largely due to hepatitis B virus infection.Its prognosis is generally poor.This case report contr...BACKGROUND Hepatocellular carcinoma(HCC),a major contributor to cancer-related deaths,is particularly prevalent in Asia,largely due to hepatitis B virus infection.Its prognosis is generally poor.This case report contributes to the medical literature by detailing a unique approach in treating a large HCC through multidisciplinary collaboration,particularly in patients with massive HCC complicated by ruptured bleeding,a scenario not extensively documented previously.CASE SUMMARY The patient presented with large HCC complicated by intratumoral bleeding.Treatment involved a multidisciplinary approach,providing individualized care.The strategy included drug-eluting bead transarterial chemoembolization,sorafenib-targeted therapy,laparoscopic partial hepatectomy,and standardized sintilimab monoclonal antibody therapy.Six months after treatment,the patient achieved complete radiological remission,with significant symptom relief.Imaging studies showed no lesions or recurrence,and clinical assessments confirmed complete remission.This report is notable as possibly the first docu-mented case of successfully treating such complex HCC conditions through integrated multidisciplinary efforts,offering new insights and a reference for future similar cases.CONCLUSION This study demonstrated effective multidisciplinary treatment for massive HCC with intratumoral bleeding,providing insights for future similar cases.展开更多
The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image processing.Prediction comprises estimating FFA from fundus camera im...The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image processing.Prediction comprises estimating FFA from fundus camera imaging,single-phase FFA from scanning laser ophthalmoscopy(SLO),and three-phase FFA also from SLO.Although many deep learning models are available,a single model can only perform one or two of these prediction tasks.To accomplish three prediction tasks using a unified method,we propose a unified deep learning model for predicting FFA images from fundus structure images using a supervised generative adversarial network.The three prediction tasks are processed as follows:data preparation,network training under FFA supervision,and FFA image prediction from fundus structure images on a test set.By comparing the FFA images predicted by our model,pix2pix,and CycleGAN,we demonstrate the remarkable progress achieved by our proposal.The high performance of our model is validated in terms of the peak signal-to-noise ratio,structural similarity index,and mean squared error.展开更多
文摘Poems are the products of national culture, and A Dream of Red Mansions (A DRM) is the collection of Chinese culture in the era when the novel was written, so poems in A DRM express a wealth of cultural messages. According to the Limits of Translatability raised by Catford in 1965, cultural untranslatability occurs when a relevant situational feature for the SL text is absent in the TL. So this paper aims to find problems of cultranslation of poems in A DRM, and tries to further restrict cultural untranslatability by applying compensation strategies.
文摘As is known to all in the translation field,the problem of translatability and untranslatability has been a long-debated is sue in the field of translation.And the phenomenon of untranslatability is especially prominent in translation of literary works.This paper tries to discuss,from theory and practice,the phenomenon of untranslatability and its compensation strategies in trans lation between Chinese and English.It is roughly divided into two parts,wherein the first part deals with the phenomenon of un translatability,explaining its causes and giving some examples,and the second part deals with the compensation strategies,intro ducing several methods of compensation and taking The Original of Laura written by the deceased Russian-American writer Nabokov as an example.With the development of intercultural communication in the world and the great efforts of translators,the untranslatable words today can be translatable tomorrow.
文摘There is a strange phenomenon that the translated works of Chinese classics have not been enjoyed by a large readership abroad,stemming from the untranslatability of poetry,an inherent nature of poetry translation.It is argued with theoretical analyses coupled by case studies that linguistic untranslatability(including intralingual inequivalence,interlingual inequivalence),cultural untranslatability(intercultural inequivalence),translator's inadequacy and governmental or institutional translation briefs contribute to problem mentioned.It is hoped that once the factors influencing untranslatability of poetry is realized,translators'presumptuousness along with despondence can be lessened or even eradicated with a production of a better version free from overrepresentation or underrepresentation or misrepresentation of the originals.
文摘Translation is not only an exchange activity among languages, but also a process about transformation and communication of culture. Language and culture is a unity that language is the essential part of culture while culture is the nature and content of language communication. Because of its own history and distinctive geographical environment, culture has its unique ethnic features and psychological construction. All of these culture elements reflect on language. For different languages, there are great differences about the glyph, sound, words, rhetorical devices, and idioms. Such differences in language and culture between English and Chinese can cause the limitation of translatability in the process of translation.
文摘Translation is a field full of paradoxes. The question of whether or not languages are translatable has been argued for many years in the history of translation. There are many opposite idea on this question, for example, to what degree languages are translatable, and all this problems relating to translatability and untranslatability have always been difficult questions for further studying. Also, idioms are major components of a language. They are experience and lessons that people learned from years of hard work and life experiences, and they reflect the wisdom of human beings. In a word, when it comes to the translatability and untranslatability of Chinese idioms, there usually exist more obvious problems. Because Chinese idioms have certain ethnic characteristics and distinguishable cultural meanings, and more importantly they are deeply rooted in national culture and society. This essay first introduced the relationship between Untranslatability and Translatability, and then discussed the features of Chinese idioms, and later this essay mainly discussed the translatability and untranslatability in a translating process from a perspective of the translation of Chinese idioms. Finally, it gives some practical ways to reduce the untranslatability of Chinese idioms.
文摘The issue of the translatability of poetry is still under hot discussion. Translation of poetry was, and still is by some, believed as impossibility, for the myth of untranslatability looks upon poetry as beauty itself which is untouchable for once it is touched it is destroyed[1]. From different perspectives, such as the perspective of word formation, pun, reduplicated words etc, the author argues that poetic translation is translatable, and that poetry and aesthetics can be reproduced in another language and culture if accommodation is made.
文摘Classical poetry is a kind of special classical literature with highly concise language,rich emotion,profound implication and certain rhythm.The development of poetry translation is related to the spread of Chinese classical culture.There are many opinions about translatability and Untranslatability of poetry translation.The translation of meaning is relatively easy,while the rhetoric technique closely related to the form of expression is more difficult,which is the key to express the poet's feelings.There⁃fore,this paper aims to explore the untranslatability of onomatopoeia in poetry by combining with the Book of Songs.
文摘In cross-cultural communication,a translator has to study the cultural differences prior to his efficient linguistic transference. As a matter of fact, the cultural differences across nations always create sorts of untranslatable factors.The cultural universals, however, make cultural exchange and linguistic transference possible. A translator, in this sense, shall resort to some balancing point in translating.
文摘This paper aimed to probe the influence of culture on advertising translation between Chinese language and English language. Based on an analysis of the samples of advertisements in both Chinese and English languages, it is found that cultural differences in terms of value, Referent association, and historical and cultural background can affect the process of Advertising Translation. It is suggested that the strategy of domestication and translation methods such as neutralization, conversion can be adopted to minimize cultural Untranslatability in Advertising Translation.
基金funded by grants from the Fondo de Investigacion de la Seguridad Social(Spain)(FIS PI-14/01935)the Spanish Ministerio de Ciencia y Tecnologia+4 种基金Instituto de Salud Carlos III(PI051871,CIBERehd)the Spanish Ministerio de Economia y Competitividad(SAF2017-86343-R)the Comunidad de Madrid(P2022/BMD-7321)HALEKULANY S.L.PROACAPITAL and MJR.
文摘Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this condition.Psychoneuroimmunoendocrinology(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a whole.The initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and well-being.In the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are interconnected.Finally,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.
基金Supported by the National Natural Science Foundation of China(Nos.31872586,42076118)the Major Project of Science,Technology and Innovation 2025 in Ningbo City(No.2021Z003)the K.C.Wong Magna Fund in Ningbo University。
文摘The Tbx family is first known through the study of their functions in the body and limbs,and its members Tbx4 and Tbx5 genes are important factors in determining the characteristics of the appendages.Pampus argenteus is one of the important economical marine fishes widely distributed in offshore areas.Therefore,it is necessary to study the role of Tbx family genes in the deletion of pelvic fin in P.argenteus.In this study,we cloned Tbx4 and Tbx5 cDNA sequence of P.argenteus(GenBank:MH709128 and MH712458).The Western blot and real time PCR were used to detect the expressions of Tbx4 and Tbx5 in different developmental stages and tissues of P.argenteus.In addition,whole-mount in-situ hybridization was used to study the localization of Tbx4 and Tbx5 genes in different developmental stages of P.argenteus.Results show that the translation of Tbx4 mRNA was inhibited during the critical period of pelvic fin development.Among different tissues,Tbx4 protein levels were the lowest in the abdominal epithelium,and even lower than that in the pectoral fin,suggesting that the protein expression was also inhibited in the abdominal epithelium of adult P.argenteus.Therefore,the results indicated that upstream genes regulation led to the key stage-specific and low expression of Tbx4 during pelvic fin development and in the abdominal epithelium.
基金supported by the Walter Benjamin and Research Grant Programs of the German Research Foundation(Deutsche Forschungsgemeinschaft,DFG,Germany,#446812474,#504079349[PANABC])(to SMS),the DFG(#437446827)the Research Program of the University Medical Center Gottingen(to MR)。
文摘Introductory comments:The identification and validation of disease-modifying proteins are fundamental aspects in drug development.However,the m ultifactority of n eurodegen era tive diseases poses a real challenge for targeted therapies.Furthermore,the behavior of individually(over-)expressed to rget proteins in vitro is likely to differ from their actual functional behavior when embedded in cascades and pathways in vivo.
基金supported by ZonMW and Stichting Proefdiervrij (#114022506)PPP Allo wance made available by Health~Holland,Top Sector Life Sciences&Health,to stimulate public-private partnerships (#LSHM17014 and LSHM18024)+3 种基金Alzheimer Nederland (grant WE.03-2017-10)European Commission (Joint Programming Initiative Neurodegenerative Diseases/JPco-fuND (ZonMW#733051062)Weston Brain Institute (#NR1 60014)ZonMW Memorabel/Alzheimer Nederland (#733050101)(to WS)
文摘Maintenance of protein homeostasis or“proteostasis”is essential for the functioning and viability of cells.This is in particular the case for cells like neurons that cannot self-renew and acquire unique functional properties during their lifetime.Cellular proteostatic stress responses are in place to protect cells from damage in case of proteostatic challenges.The integrated stress response(ISR)is one of the key proteostatic stress responses in the cell(Costa-Mattioli and Walter,2020).The ISR is the downstream convergence point for the four stress-induced eIF2αkinases(EIF2AK1-4)that control stress-regulated protein translation via phosphorylation of the translation factor eIF2α.ISR activation results in a transient reduction of global translation while it concomitantly enhances the translation of specific mRNAs,including that encoding the activating transcription factor 4(ATF4).Together,the translational control mediated by the ISR results in a temporary reduction of the overall protein load and the selectively increased expression of proteins that contribute to restoration of the proteostatic balance.
基金supported by the National Natural Science Foundation of China(82173362 and 81872409)the Guangdong Basic and Applied Basic Research Foundation(2019A1515110110)。
文摘Existing studies have underscored the pivotal role of N-acetyltransferase 10(NAT10) in various cancers. However, the outcomes of protein-protein interactions between NAT10 and its protein partners in head and neck squamous cell carcinoma(HNSCC) remain unexplored. In this study, we identified a significant upregulation of RNA-binding protein with serine-rich domain 1(RNPS1) in HNSCC, where RNPS1 inhibits the ubiquitination degradation of NAT10 by E3 ubiquitin ligase, zinc finger SWIM domain-containing protein 6(ZSWIM6), through direct protein interaction, thereby promoting high NAT10 expression in HNSCC. This upregulated NAT10 stability mediates the enhancement of specific tRNA ac^(4)C modifications, subsequently boosting the translation process of genes involved in pathways such as IL-6 signaling, IL-8 signaling, and PTEN signaling that play roles in regulating HNSCC malignant progression, ultimately influencing the survival and prognosis of HNSCC patients. Additionally, we pioneered the development of TRMC-seq, leading to the discovery of novel t RNA-ac^(4)C modification sites, thereby providing a potent sequencing tool for tRNAac^(4)C research. Our findings expand the repertoire of tRNA ac^(4)C modifications and identify a role of tRNA ac^(4)C in the regulation of mRNA translation in HNSCC.
基金funded by the Israel Science Foundation(grants No.1036/12 and 1228/20)(to OES).
文摘Translation regulation is an important layer of gene expression:Generation of genome-wide expression datasets at multi-omics levels in spatial,temporal,and cell-type resolution is essential for deciphering brain complexity.Regulation of gene expression is a highly dynamic process aiming at the production of precise levels of gene products to guarantee optimal cellular function,in response to physiological cues.Speedy advances in next-generation sequencing enabled the understanding of epigenomic and transcriptomic dynamic landscapes of different brain regions along development,aging,and disease progression.However,the correlation of the“transcriptome”with protein levels is poor because numerous mRNAs are subjected to manipulation of their translation efficiency,to warrant a favorable result under certain conditions.Hence,it is widely accepted that regulation at the translation level is a vital layer of gene expression.Quantification of actively translated mRNA populations(i.e.,“translatome”)is a more reliable predictor of the“proteome”(Wang et al.,2020).
基金Project supported by the National Natural Science Foundation of China(Grant No.62105188)。
文摘We take phase modulation to create discrete phase-controlled sources and realize the super-bunching effect by a phasecorrelated method. From theoretical and numerical simulations, we find the space translation invariance of the bunching effect is a key point for the ghost imaging realization. Experimentally, we create the orderly phase-correlated discrete sources which can realize high-visibility second-order ghost imaging than the result with chaotic sources. Moreover, some factors affecting the visibility of ghost image are discussed in detail.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11974232 and 12374441)the Fund from the Yulin Science and Technology Bureau,China(Grant No.CXY-2022-178).
文摘In a multi-bubble system, the bubble behavior is modulated by the primary acoustic field and the secondary acoustic field. To explore the translational motion of bubbles in cavitation liquids containing high-concentration cavitation nuclei,evolutions of bubbles are recorded by a high-speed camera, and translational trajectories of several representative bubbles are traced. It is found that translational motion of bubbles is always accompanied by the fragmentation and coalescence of bubbles, and for bubbles smaller than 10 μm, the possibility of bubble coalescence is enhanced when the spacing of bubbles is less than 30 μm. The measured signals and their spectra show the presence of strong negative pressure, broadband noise,and various harmonics, which implies that multiple interactions of bubbles appear in the region of high-intensity cavitation.Due to the strong coupling effect, the interaction between bubbles is random. A simplified triple-bubble model is developed to explore the interaction patterns of bubbles affected by the surrounding bubbles. Patterns of bubble interaction, such as attraction, repulsion, stable spacing, and rebound of bubbles, can be predicted by the theoretical analysis, and the obtained results are in good agreement with experimental observations. Mass exchange between the liquid and bubbles as well as absorption in the cavitation nuclei also plays an important role in multi-bubble cavitation, which may account for the weakening of the radial oscillations of bubbles.
基金supported in part by the NSFC(11801496,11926352)the Fok Ying-Tung Education Foundation(China)the Hubei Key Laboratory of Applied Mathematics(Hubei University).
文摘In this paper,we investigate spacelike graphs defined over a domain Ω⊂M^(n) in the Lorentz manifold M^(n)×ℝ with the metric−ds^(2)+σ,where M^(n) is a complete Riemannian n-manifold with the metricσ,Ωhas piecewise smooth boundary,and ℝ denotes the Euclidean 1-space.We prove an interesting stability result for translating spacelike graphs in M^(n)×ℝ under a conformal transformation.
基金Supported by Gansu Provincial Hospital Internal Medicine Research Fund Project,No.22GSSYD-47"Innovation Star"Project for Graduate Students of Gansu University of Chinese Medicine,No.2023CXZX-756the Natural Science Foundation of Gansu Province,No.21JR11RA187.
文摘BACKGROUND Hepatocellular carcinoma(HCC),a major contributor to cancer-related deaths,is particularly prevalent in Asia,largely due to hepatitis B virus infection.Its prognosis is generally poor.This case report contributes to the medical literature by detailing a unique approach in treating a large HCC through multidisciplinary collaboration,particularly in patients with massive HCC complicated by ruptured bleeding,a scenario not extensively documented previously.CASE SUMMARY The patient presented with large HCC complicated by intratumoral bleeding.Treatment involved a multidisciplinary approach,providing individualized care.The strategy included drug-eluting bead transarterial chemoembolization,sorafenib-targeted therapy,laparoscopic partial hepatectomy,and standardized sintilimab monoclonal antibody therapy.Six months after treatment,the patient achieved complete radiological remission,with significant symptom relief.Imaging studies showed no lesions or recurrence,and clinical assessments confirmed complete remission.This report is notable as possibly the first docu-mented case of successfully treating such complex HCC conditions through integrated multidisciplinary efforts,offering new insights and a reference for future similar cases.CONCLUSION This study demonstrated effective multidisciplinary treatment for massive HCC with intratumoral bleeding,providing insights for future similar cases.
基金supported in part by the Gusu Innovation and Entrepreneurship Leading Talents in Suzhou City,grant numbers ZXL2021425 and ZXL2022476Doctor of Innovation and Entrepreneurship Program in Jiangsu Province,grant number JSSCBS20211440+6 种基金Jiangsu Province Key R&D Program,grant number BE2019682Natural Science Foundation of Jiangsu Province,grant number BK20200214National Key R&D Program of China,grant number 2017YFB0403701National Natural Science Foundation of China,grant numbers 61605210,61675226,and 62075235Youth Innovation Promotion Association of Chinese Academy of Sciences,grant number 2019320Frontier Science Research Project of the Chinese Academy of Sciences,grant number QYZDB-SSW-JSC03Strategic Priority Research Program of the Chinese Academy of Sciences,grant number XDB02060000.
文摘The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image processing.Prediction comprises estimating FFA from fundus camera imaging,single-phase FFA from scanning laser ophthalmoscopy(SLO),and three-phase FFA also from SLO.Although many deep learning models are available,a single model can only perform one or two of these prediction tasks.To accomplish three prediction tasks using a unified method,we propose a unified deep learning model for predicting FFA images from fundus structure images using a supervised generative adversarial network.The three prediction tasks are processed as follows:data preparation,network training under FFA supervision,and FFA image prediction from fundus structure images on a test set.By comparing the FFA images predicted by our model,pix2pix,and CycleGAN,we demonstrate the remarkable progress achieved by our proposal.The high performance of our model is validated in terms of the peak signal-to-noise ratio,structural similarity index,and mean squared error.