Reconstructing early transmission networks of SARS-CoV-2 using a genomic mutation model

The coronavirus disease 2019(COVID-19)pandemic has greatly damaged human society,but the origins and early transmission patterns of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pathogen remain unclear.Here,we reconstructed the transmission networks of SARS-CoV-2 during the first three and six months since its first report based on ancestor-offspring relationships using BANAL-52-referenced mutations.We explored the position(i.e.,root,middle,or tip)of early detected samples in the evolutionary tree of SARS-CoV-2.In total,6799 transmission chains and 1766 transmission networks were reconstructed,with chain lengths ranging from 1-9 nodes.The root node samples of the 1766 transmission networks were from 58 countries or regions and showed no common ancestor,indicating the occurrence of many independent or parallel transmissions of SARS-CoV-2 when first detected(i.e.,all samples were located at the tip position of the evolutionary tree).No root node sample was found in any sample(n=31,all from the Chinese mainland)collected in the first 15 days from 24 December 2019.Results using six-month data or RaTG13-referenced mutation data were similar.The reconstruction method was verified using a simulation approach.Our results suggest that SARS-CoV-2 may have already been spreading independently worldwide before the outbreak of COVID-19 in Wuhan,China.Thus,a comprehensive global survey of human and animal samples is essential to explore the origins of SARS-CoV-2 and its natural reservoirs and hosts.

Determination of Weak Points Based on Risk Theory and Application to Transmission Network Planning

In the traditional power transmission network planning,deterministic analysis methods are widely used.In such methods,all contingencies are deemed to have the same occurrence probability,which is not reasonable.In this paper,risk assessment is introduced to the process of transmission network planning considering the probabilistic characteristics of contingencies.Risk indices are given to determine the weak points of the transmission network based on local information,such as bus risk,line overload risk,contingency severity.The indices are calculated by the optimal cost control method based on risk theory,which can help planners to quickly determine weak points in the planning and find solution to them.For simplification,only line overload violation is considered.Finally,the proposed method is validated by an IEEE-RTS test system and a real power system in China from two aspects.In the first case,the original system is evaluated by the proposed method to find the weak points,and then four planning schemes are established,among which the best scheme is selected.In the second case,four initial planning schemes are established by combining the experiences of planners,and after the evaluation by using the proposed method,the best planning scheme is improved based on the information of weak points in the initial schemes,and the risk of improved scheme is reduced from 42 531.86 MW·h per year to 4 431.26 MW·h per year.

Particle Swarm Optimization and Its Application in Transmission Network Expansion Planning

The author introduced particle swarm optimization as a new method for power transmission network expansion planning. A new discrete method for particle swarm optimization was developed,which is suitable for power transmission network expansion planning, and requires less computer s memory.The optimization fitness function construction, parameter selection, convergence judgement, and their characters were analyzod.Numerical simulation demonstrated the effectiveness and correctness or the method. This paper provides an academic and practical basis of particle swarm optimization in application of transmission network expansion planning for further investigation.

Advances in research of HIV transmission networks

Transmission network analysis is a crucial evaluation tool aiming to explore the characteristics of the human immunodeficiency virus epidemic,develop evidence-based prevention strategies,and contribute to various areas of human immunodeficiency virus/acquired immunodeficiency syndrome prevention and control.Over recent decades,transmission networks have made tremendous strides in terms of modes,methods,applications,and various other aspects.Transmission network methods,including social,sexual,and molecular transmission networks,have played a pivotal role.Each transmission network research method has its advantages,as well as its limitations.In this study,we established a systematic review of these aforementioned transmission networks with respect to their definitions,applications,limitations,recent progress,and synthetic applications.

Transmission Network Expansion Planning Considering Uncertainties in Loads and Renewable Energy Resources

This paper proposes a novel method for transmission network expansion planning(TNEP)that take into account uncertainties in loads and renewable energy resources.The goal of TNEP is to minimize the expansion cost of candidate lines without any load curtailment.A robust linear optimization algorithm is adopted to minimize the load curtailment with uncertainties considered under feasible expansion costs.Hence,the optimal planning scheme obtained through an iterative process would be to serve loads and provide a sufficient margin for renewable energy integration.In this paper,two uncertainty budget parameters are introduced in the optimization process to limit the considered variation ranges for both the load and the renewable generation.Simulation results obtained from two test systems indicate that the uncertainty budget parameters used to describe uncertainties are essential to arrive at a compromise for the robustness and optimality,and hence,offer a range of preferences to power system planners and decision makers.

A Scenario-Based Robust Transmission Network Expansion Planning Method for Consideration of Wind Power Uncertainties

This paper uses a novel scenario generation method for tackling the uncertainties of wind power in the transmission network expansion planning(TNEP)problem.A heuristic moment matching(HMM)method is first applied to generate the typical scenarios for capturing the stochastic features of wind power,including expectation,standard deviation,skewness,kurtosis,and correlation of multiple wind farms.Then,based on the typical scenarios,a robust TNEP problem is presented and formulated.The solution of the problem is robust against all the scenarios that represent the stochastic features of wind power.Three test systems are used to verify the HMM method and is compared against Taguchi’s Orthogonal Array(OA)method.The simulation results show that the HMM method has better performance than the OA method in terms of the trade-off between robustness and economy.Additionally,the main factors influencing the planning scheme are studied,including the number of scenarios,wind farm capacity,and penalty factors,which provide a reference for system operators choosing parameters.

Transmission network expansion planning with embedded constraints of short circuit currents and N-1 security

An approach of transmission network expan-sion planning with embedded constraints of short circuit currents and N-1 security is proposed in this paper.The problem brought on by the strong nonlinearity property of short circuit currents is solved with a linearization method based on the DC power flow.The model can be converted to a mixed-integer linear programming problem,realizing the optimization of planning model that considers the constraints of linearized short circuit currents and N-1 security.To compensate the error caused by the assump-tions of DC power flow,the compensation factor is pro-posed.With this factor,an iterative algorithm that can compensate the linearization error is then presented.The case study based on the IEEE 118-bus system shows that the proposed model and approach can be utilized to:opti-mize the construction strategy of transmission lines;ensure the N-1 security of the network;and effectively limit the short circuit currents of the system.

Risk-based maintenance scheduling of generating units in the deregulated environment considering transmission network congestion

In restructured power systems,the traditional approaches of unit maintenance scheduling(UMS)need to undergo major changes in order to be compatible with new competitive structures.Performing the maintenance on generating units may decrease the security level of transmission network and result in electricity shortage in power system;as a result,it can impose a kind of cost on transmission network as called security cost.Moreover,taking off line a generating unit for performing maintenance can change power flow in some transmission lines,and may lead to network congestion.In this study,generating unit maintenance is scheduled considering security and congestion cost with N-1 examination for transmission lines random failures.The proposed UMS approach would lead to optimum operation of power system in terms of economy and security.To achieve this goal,the optimal power flow(OPF)compatible with market mechanism is implemented.Moreover,the electricity price discovery mechanism as locational marginal pricing(LMP)is restated to analyze the impacts of UMS on nodal electricity price.Considering security and congestion cost simultaneously,this novel approach can reveal some new costs which are imposed to transmission network on behalf of generation units;as a result,it provides a great opportunity to perform maintenance in a fair environment for both generating companies(GenCo)and transmission companies(TransCo).At the end,simulation results on nine-bus test power system demonstrate that by using this method,the proposed UMS can guarantee fairness among market participants including GenCos and TransCo and ensure power system security.

Distributionally Robust Co-optimization of Transmission Network Expansion Planning and Penetration Level of Renewable Generation

Transmission network expansion can significantly improve the penetration level of renewable generation.However,existing studies have not explicitly revealed and quantified the trade-off between the investment cost and penetration level of renewable generation.This paper proposes a distributionally robust optimization model to minimize the cost of transmission network expansion under uncertainty and maximize the penetration level of renewable generation.The proposed model includes distributionally robust joint chance constraints,which maximize the minimum expectation of the renewable utilization probability among a set of certain probability distributions within an ambiguity set.The proposed formulation yields a twostage robust optimization model with variable bounds of the uncertain sets,which is hard to solve.By applying the affine decision rule,second-order conic reformulation,and duality,we reformulate it into a single-stage standard robust optimization model and solve it efficiently via commercial solvers.Case studies are carried on the Garver 6-bus and IEEE 118-bus systems to illustrate the validity of the proposed method.

Best-retransmission count selection for environment optimization over wireless heterogeneous networks

This paper proposes an environment-aware best- retransmission count selected optimization control scheme over IEEE 802.11 multi-hop wireless networks. The proposed scheme predicts the wireless resources by using statistical channel state and provides maximum retransmission count optimization based on wireless channel environment state to improve the packet delivery success ratio. The media access control （MAC） layer selects the best-retransmission count by perceiving the types of packet loss in wireless link and using the wireless channel charac- teristics and environment information, and adjusts the packet for- warding adaptively aiming at improving the packet retransmission probability. Simulation results show that the best-retransmission count selected scheme achieves a higher packet successful delivery percentage and a lower packet collision probability than the corresponding traditional MAC transmission control protocols.

Theoretical Analysis of Measurement in Operation Efficiency in Optical Cable Transmission Networks

It is necessary to study dynamic operation efficiency of transmission networks in order to realize high intensification of communication networks. The operation efficiency discussed here should exist not only in logic-circuit layer, but also in both path layer and medium layer. A theoretical method of the measurement of layers and comprehensive evaluations is presented based on the concept of transmission efficiency.

A New Method of Transmission Network Flexible Planning Using the Connection Number

Because connection number can express and process synthetic uncertainties caused by various uncertainties in the transmission network planning, a connection number model (CNM) was presented to compare the values of connection number logically. This paper proposed a novel model for transmission network flexible planning with uncertainty. In the proposed planning model both certainty and uncertainty information were included, and the cost-benefit analysis method was used to evaluate the candidate schemes in the objective function. Its good adaptability and flexibility were illustrated through two examples.

Transmission Network Expansion Planning Considering the Generators’Contribution to Uncertainty Accommodation

This paper presents an optimization for transmission network expansion planning(TNEP)under uncertainty circumstances.This TNEP model introduces the approach of parameter sets to describe the range that all possible realizations of uncertainties in load and renewable generation can reach.While optimizing the TNEP solution,the output of each generator is modeled as an uncertain variable to linearly respond to changes caused by uncertainties,which is constrained by the extent to which uncertain parameters may change the operational range of generators,and network topology.This paper demonstrates that the robust optimization approach is effective to make the problem with uncertainties tractable by converting it into a deterministic optimization,and with the genetic algorithm,the optimal TNEP solution is derived iteratively.Compared with other robust TNEP results tested on IEEE 24-bus systems,the proposed method produces a least-cost expansion plan without losing robustness.In addition,the contribution that each generator can make to accommodate with every uncertainty is optimally quantified.Effects imposed by different uncertainty levels are analyzed to provide a compromise of the conservativeness of TNEP solutions.

Prospects for the Implementation of HIV Molecular Transmission Network–Informed AIDS Prevention and Control in China

The human immunodeficiency virus(HIV)-infected population with a transmission link has a strong genetic similarity in viral gene sequences that tend to cluster.In recent years,a strategy for guiding HIV/acquired immunodeficiency syndrome(AIDS)prevention using sequence-based transmission networks has been proposed.The execution of this strategy provides an opportunity to effectively control the spread of the AIDS epidemic in China.HIV molecular transmission network research has been actively pursued by a number of Chinese research groups.Medium-and long-term strategies were created with the goal of using HIV molecular transmission networks to guide targeted prevention and control in China.Technical guidelines for HIV transmission network monitoring and intervention have been written and released.Pilot studies are continuing in the meantime.Despite the fact that this strategy has a bright future,there are still many challenges to overcome to achieve the intended AIDS prevention and control goals.

Efficient Broadcast Retransmission Based on Network Coding for InterPlaNetary Internet

In traditional wireless broadcast networks,a corrupted packet must be retransmitted even if it has been lost by only one receiver.Obviously,this is not bandwidth-efficient for the receivers that already hold the retransmitted packet.Therefore,it is important to develop a method to realise efficient broadcast transmission.Network coding is a promising technique in this scenario.However,none of the proposed schemes achieves both high transmission efficiency and low computational complexity simultaneously so far.To address this problem,a novel Efficient Opportunistic Network Coding Retransmission(EONCR)scheme is proposed in this paper.This scheme employs a new packet scheduling algorithm which uses a Packet Distribution Matrix(PDM)directly to select the coded packets.The analysis and simulation results indicate that transmission efficiency of EONCR is over 0.1,more than the schemes proposed previously in some simulation conditions,and the computational overhead is reduced substantially.Hence,it has great application prospects in wireless broadcast networks,especially energyand bandwidth-limited systems such as satellite broadcast systems and Planetary Networks(PNs).

Effects of information transmission delay and channel blocking on synchronization in scale-free Hodgkin-Huxley neuronal networks

In this paper,we investigate the evolution of spatiotemporal patterns and synchronization transitions in dependence on the information transmission delay and ion channel blocking in scale-free neuronal networks.As the underlying model of neuronal dynamics,we use the Hodgkin-Huxley equations incorporating channel blocking and intrinsic noise.It is shown that delays play a significant yet subtle role in shaping the dynamics of neuronal networks.In particular,regions of irregular and regular propagating excitatory fronts related to the synchronization transitions appear intermittently as the delay increases.Moreover,the fraction of working sodium and potassium ion channels can also have a significant impact on the spatiotemporal dynamics of neuronal networks.As the fraction of blocked sodium channels increases,the frequency of excitatory events decreases,which in turn manifests as an increase in the neuronal synchrony that,however,is dysfunctional due to the virtual absence of large-amplitude excitations.Expectedly,we also show that larger coupling strengths improve synchronization irrespective of the information transmission delay and channel blocking.The presented results are also robust against the variation of the network size,thus providing insights that could facilitate understanding of the joint impact of ion channel blocking and information transmission delay on the spatiotemporal dynamics of neuronal networks.

Problem of Network Transmission Based on Linux Server and Its Solution

Using Linux server as a gateway between the local area network and the Internet may lead to slow pace in network transmission and even data loss. In this study,the above problem and its solution were discussed.

Reliability Strategies for Data Transmission in Wireless Mesh Network

Wireless Mesh Network (WMN) is a new-type wireless network. Its core idea is that any of its wireless equipment can act as both an Access Point (AP) and a router. Each node in the network can send and receive signals as well as directly communicate with one or several peer nodes. One important issue to be considered in wireless Mesh networks is how to secure reliable data transmission in multi-hop links. To solve the problem, the 3GPP system architecture proposes two functionalities: ARQ and HARQ. This paper presents two HARQ schemes, namely hop-by-hop and edge-to-edge, and three ARQ schemes: hop-by-hop, edge-to-edge, and last-hop. Moreover, it proposes three solutions for WMNs from the perspective of protocol stock design: layered cooperative mechanism, relay ARQ mechanism and multi-hop mechanism.