This paper investigates the intensity tuning characteristics of a double longitudinal modes HeiNe laser subjected to optical feedback. The intensity undulations of the total light and the two modes are observed for di...This paper investigates the intensity tuning characteristics of a double longitudinal modes HeiNe laser subjected to optical feedback. The intensity undulations of the total light and the two modes are observed for different external cavity length. Two modulations of the internal cavity length are performed. One is only for the internal cavity length being modulated and the other is for both the internal and the external cavity length being modulated. The undulation frequency of the total light is found to be determined by the ratio of external cavity length to internal cavity length in both modulations. When the external cavity length is integral times of the internal cavity length, the fringe frequency of the total light could be seven or even more times of that in conventional optical feedback. A simple theoretical analysis is presented, which is in good agreement with the experimental results. The potential use of the experimental results is also discussed.展开更多
Neuromyelitis optica spectrum disorders, or neuromyelitis optica(NMO), is an autoimmune disease of the central nervous system that must be distinguished from multiple sclerosis. Therapeutic approaches to relapse preve...Neuromyelitis optica spectrum disorders, or neuromyelitis optica(NMO), is an autoimmune disease of the central nervous system that must be distinguished from multiple sclerosis. Therapeutic approaches to relapse prevention in NMO include immunosuppressants and monoclonal antibodies. Rituximab, a monoclonal antibody that targets CD20 antigen expressed on the surface of pre-B, mature B-lymphocytes and a small subset of T-lymphocytes, has been widely used for the treatment of NMO. In this review, we aim to summarize global experience with rituximab in NMO. We identified 13 observational studies that involved a total of 209 NMO patients treated with rituximab. Majority of rituximab-treated patients evidenced stabilization or improvements in their disability scores compared to pre-treatment period and 66% of patients remained relapse-free during treatment period. Monitoring rituximab treatment response with CD19+ or CD27+ cell counts appears to improve treatment outcomes. We offer clinical pointers on rituximab use for NMO based on the literature and authors' experience, and pose questions that would need to be addressed in future studies.展开更多
Nonlinear frequency conversion of structured beams has been of great interest recently.We present an intracavity second harmonic generation(SHG)of laser beams in transverse mode locking(TML)states with a specially des...Nonlinear frequency conversion of structured beams has been of great interest recently.We present an intracavity second harmonic generation(SHG)of laser beams in transverse mode locking(TML)states with a specially designed sandwich such as a microchip laser.The intracavity nonlinear frequency conversion process of a laser beam in a TML state to its second harmonic is theoretically and experimentally investigated,considering different relative phase and weight parameters between the basic modes in the TML beam.Comparison between the far-field SHG beam patterns of fundamental frequency transverse modes in coherently locked and incoherently superposed states demonstrates that the SHG of TML beams can carry more information.Various rarely observed far-field SHG beam patterns are obtained,and they are consistent with the theoretical analysis and numerical simulations.With the obtained SHG beams,the characteristics of the structured fundamental frequency beams can also be conversely investigated or predicted.This work may have important applications in optical 3D printing,optical trapping of particles,and free-space optical communication areas.展开更多
基金Project supported by the Major Program of the National Natural Science Foundation of China （Grant No 60438010）.
文摘This paper investigates the intensity tuning characteristics of a double longitudinal modes HeiNe laser subjected to optical feedback. The intensity undulations of the total light and the two modes are observed for different external cavity length. Two modulations of the internal cavity length are performed. One is only for the internal cavity length being modulated and the other is for both the internal and the external cavity length being modulated. The undulation frequency of the total light is found to be determined by the ratio of external cavity length to internal cavity length in both modulations. When the external cavity length is integral times of the internal cavity length, the fringe frequency of the total light could be seven or even more times of that in conventional optical feedback. A simple theoretical analysis is presented, which is in good agreement with the experimental results. The potential use of the experimental results is also discussed.
基金Supported by The National Multiple Sclerosis Society(NMSS),Guthy-Jackson Charitable Foundation,EMD-Serono/Pfizer,Biogen Idec,Serono and Novartis,and served on advisory board for Biogen Idec(Kister I)
文摘Neuromyelitis optica spectrum disorders, or neuromyelitis optica(NMO), is an autoimmune disease of the central nervous system that must be distinguished from multiple sclerosis. Therapeutic approaches to relapse prevention in NMO include immunosuppressants and monoclonal antibodies. Rituximab, a monoclonal antibody that targets CD20 antigen expressed on the surface of pre-B, mature B-lymphocytes and a small subset of T-lymphocytes, has been widely used for the treatment of NMO. In this review, we aim to summarize global experience with rituximab in NMO. We identified 13 observational studies that involved a total of 209 NMO patients treated with rituximab. Majority of rituximab-treated patients evidenced stabilization or improvements in their disability scores compared to pre-treatment period and 66% of patients remained relapse-free during treatment period. Monitoring rituximab treatment response with CD19+ or CD27+ cell counts appears to improve treatment outcomes. We offer clinical pointers on rituximab use for NMO based on the literature and authors' experience, and pose questions that would need to be addressed in future studies.
基金the support of the National Natural Science Foundation of China (NSFC) (61805013)
文摘Nonlinear frequency conversion of structured beams has been of great interest recently.We present an intracavity second harmonic generation(SHG)of laser beams in transverse mode locking(TML)states with a specially designed sandwich such as a microchip laser.The intracavity nonlinear frequency conversion process of a laser beam in a TML state to its second harmonic is theoretically and experimentally investigated,considering different relative phase and weight parameters between the basic modes in the TML beam.Comparison between the far-field SHG beam patterns of fundamental frequency transverse modes in coherently locked and incoherently superposed states demonstrates that the SHG of TML beams can carry more information.Various rarely observed far-field SHG beam patterns are obtained,and they are consistent with the theoretical analysis and numerical simulations.With the obtained SHG beams,the characteristics of the structured fundamental frequency beams can also be conversely investigated or predicted.This work may have important applications in optical 3D printing,optical trapping of particles,and free-space optical communication areas.
