A series of new 2 (alkylthio) 5,7 dimethyl 1,2,4 triazolopyrimidines and 3 (alkylthio) 5,7 dimethyl 1,2,4 triazolopyrimidines have been synthesized. These derivatives were evaluated for inhibitory effects on...A series of new 2 (alkylthio) 5,7 dimethyl 1,2,4 triazolopyrimidines and 3 (alkylthio) 5,7 dimethyl 1,2,4 triazolopyrimidines have been synthesized. These derivatives were evaluated for inhibitory effects on 85 7 mmol·L 1 K + and 10 4 mmol·L -1 NE (nor epinephrine) induced contraction of rat aorta strips.展开更多
A novel difused heterocyclic compounds containing 1,2,4 triazolopyrimidine and 1,2,4 triazolo 1,3,4 thiadiazoles are designed and synthesized based on the staring material 2 mercapto 5,7 dimethyl 1,2,4 triazolopyrimid...A novel difused heterocyclic compounds containing 1,2,4 triazolopyrimidine and 1,2,4 triazolo 1,3,4 thiadiazoles are designed and synthesized based on the staring material 2 mercapto 5,7 dimethyl 1,2,4 triazolopyrimidine. All compounds synthesized are identified by 1H NMR, MS and elemental analyses. Preliminary bioassay indicates that some compounds display fungicidal activity to some extent. Further bioassay are on the way.展开更多
The crystal structure of the title compound (C25H28N5O5P,Mr=509.49) has been determined by single-crystal X-ray diffraction.The crystal is of monoclinic,space group P21/c with a=13.0726(4),b=13.4513(4),c=15.103...The crystal structure of the title compound (C25H28N5O5P,Mr=509.49) has been determined by single-crystal X-ray diffraction.The crystal is of monoclinic,space group P21/c with a=13.0726(4),b=13.4513(4),c=15.103(1),β=93.650(1)°,V=2650.29(14)3,Z=4,Dc= 1.277 g/cm3,F(000)=1072,μ(MoKα)=0.147 mm-1,the final R=0.0748 and wR=0.1956 for 3186 observed reflections (I 〉 2σ(I)).The fused triazolopyrimidine system ring is coplanar,the dihedral angles between the triazolopyrimidine and C(1)-C(3)-C(5) phenyl,the triazolopyrimidine and C(17)-C(19)-C(21) phenyl,and the two phenyl rings are 66.87,58.79 and 80.11o,respectively.Intramolecular N(5)-H(5A)…O(3) and intermolecular C(2)-H(2)…N(4),C(18)-H(18)…O(3),C(19)-H(19)…O(2) and C(24)-H(24C)…N(4) hydrogen bonds together with C-H…π interactions contribute to the stability of the structure and result in a three-dimensional framework.The preliminary bioassay indicates that the title compound exhibits moderate herbicidal activity against dicotyledonous plants (Brassica campestris L) at the concentration of 100 mg/L.展开更多
Separation of rare earth dements by solvent extraction has actually been widely used in various fields from analytical chemistry to hydrometallurgy. A representative ore sample obtained from Kadabora Batholiths-Easter...Separation of rare earth dements by solvent extraction has actually been widely used in various fields from analytical chemistry to hydrometallurgy. A representative ore sample obtained from Kadabora Batholiths-Eastern Desert of Egypt, containing the multiple oxides rare earth minerals: Samarskite, Fergusonite, Betafite, and Pyrochlore, was subjected to sulfuric acid leaching. Different sets of equilibrium loading experiments were carded out on a bench scale for the extraction of rare earths (cerium and yttrium) from the sulfate leach liquor using 8,9-dihydro[1,2,4]triazolo[1,5-a]quinazolin-6(TH)-one {TQ} dissolved in methylene chloride. Stripping was carded out by 20% sodium hydroxide. A rare earth cake was produced by oxalic acid precipitation. Its purity reached 87.3%.展开更多
文摘A series of new 2 (alkylthio) 5,7 dimethyl 1,2,4 triazolopyrimidines and 3 (alkylthio) 5,7 dimethyl 1,2,4 triazolopyrimidines have been synthesized. These derivatives were evaluated for inhibitory effects on 85 7 mmol·L 1 K + and 10 4 mmol·L -1 NE (nor epinephrine) induced contraction of rat aorta strips.
文摘A novel difused heterocyclic compounds containing 1,2,4 triazolopyrimidine and 1,2,4 triazolo 1,3,4 thiadiazoles are designed and synthesized based on the staring material 2 mercapto 5,7 dimethyl 1,2,4 triazolopyrimidine. All compounds synthesized are identified by 1H NMR, MS and elemental analyses. Preliminary bioassay indicates that some compounds display fungicidal activity to some extent. Further bioassay are on the way.
基金Supported by the NNSFC (No. 20872046)NSF of Hubei Province (No. 2008CDB086)
文摘The crystal structure of the title compound (C25H28N5O5P,Mr=509.49) has been determined by single-crystal X-ray diffraction.The crystal is of monoclinic,space group P21/c with a=13.0726(4),b=13.4513(4),c=15.103(1),β=93.650(1)°,V=2650.29(14)3,Z=4,Dc= 1.277 g/cm3,F(000)=1072,μ(MoKα)=0.147 mm-1,the final R=0.0748 and wR=0.1956 for 3186 observed reflections (I 〉 2σ(I)).The fused triazolopyrimidine system ring is coplanar,the dihedral angles between the triazolopyrimidine and C(1)-C(3)-C(5) phenyl,the triazolopyrimidine and C(17)-C(19)-C(21) phenyl,and the two phenyl rings are 66.87,58.79 and 80.11o,respectively.Intramolecular N(5)-H(5A)…O(3) and intermolecular C(2)-H(2)…N(4),C(18)-H(18)…O(3),C(19)-H(19)…O(2) and C(24)-H(24C)…N(4) hydrogen bonds together with C-H…π interactions contribute to the stability of the structure and result in a three-dimensional framework.The preliminary bioassay indicates that the title compound exhibits moderate herbicidal activity against dicotyledonous plants (Brassica campestris L) at the concentration of 100 mg/L.
文摘Separation of rare earth dements by solvent extraction has actually been widely used in various fields from analytical chemistry to hydrometallurgy. A representative ore sample obtained from Kadabora Batholiths-Eastern Desert of Egypt, containing the multiple oxides rare earth minerals: Samarskite, Fergusonite, Betafite, and Pyrochlore, was subjected to sulfuric acid leaching. Different sets of equilibrium loading experiments were carded out on a bench scale for the extraction of rare earths (cerium and yttrium) from the sulfate leach liquor using 8,9-dihydro[1,2,4]triazolo[1,5-a]quinazolin-6(TH)-one {TQ} dissolved in methylene chloride. Stripping was carded out by 20% sodium hydroxide. A rare earth cake was produced by oxalic acid precipitation. Its purity reached 87.3%.