The antidepressant trimipramine（Tri） enantiomers were successfully separated by capillary electrophoresis（CE） coupled with electrochemiluminescence（ECL） detection in aqueous-organic media. A dual cyclodextrin（C...The antidepressant trimipramine（Tri） enantiomers were successfully separated by capillary electrophoresis（CE） coupled with electrochemiluminescence（ECL） detection in aqueous-organic media. A dual cyclodextrin（CD） system combining β-CD and hydroxypropyl-β-cyclodextrin（HP-β-CD） was used as chiral selector. Acetonitrile（ACN） was added to the running buffer to improve the separation efficiency, detection sensitivity and repeatability. The method was also successfully applied to the chiral separation of Tri in spiked human urine sample.展开更多
基金Supported by the National Natural Science Foundation of China(No20875085)the Fund of Chinese Academy of Sciences(NoKJCX2-YW-H11)
文摘The antidepressant trimipramine（Tri） enantiomers were successfully separated by capillary electrophoresis（CE） coupled with electrochemiluminescence（ECL） detection in aqueous-organic media. A dual cyclodextrin（CD） system combining β-CD and hydroxypropyl-β-cyclodextrin（HP-β-CD） was used as chiral selector. Acetonitrile（ACN） was added to the running buffer to improve the separation efficiency, detection sensitivity and repeatability. The method was also successfully applied to the chiral separation of Tri in spiked human urine sample.
