gain, four new saponins were isolated from tlie leaves of Oplopanax elatusHaka,. The structures of the four saponins ,tentatively named cirensenoside E(1),F(2), G(3) and H(4) , were elucidated to be 28-O-α-L-rlianino...gain, four new saponins were isolated from tlie leaves of Oplopanax elatusHaka,. The structures of the four saponins ,tentatively named cirensenoside E(1),F(2), G(3) and H(4) , were elucidated to be 28-O-α-L-rlianinopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-g-Dglucopyranosyl esters of 3epi-betulinic acid 3-O-β-D-glucopyranoside (1), 3β-hydroxylup-20 (29)-en-23.28-dioic acid (2),3β, 23-di-hydroxylup-20 (29 )-en-28-oic acid (3), 3α, 23-dihydroxylup-20 (29)-en-28-oic acidt4), respectively.展开更多
our new saponins were isolated from the leaves of Oplopanax elatus Nakai.The structures of the four saponins , tentatively named compounds A(1) , B(2) , C(3) and D (4) were elucidated to be 28-O-a-L-rhamnopyranosyl (1...our new saponins were isolated from the leaves of Oplopanax elatus Nakai.The structures of the four saponins , tentatively named compounds A(1) , B(2) , C(3) and D (4) were elucidated to be 28-O-a-L-rhamnopyranosyl (1-4)-β-D-glu-copyranosyl ( 1-6 )-β-D-glucopyranosyl esters of betulinic acid 3-O-β-D-glucopyra-noside (1) . oleanolic acid 3-O-β-D-glucopyranoside (2) , 3a, 23-dihydroxyolean-12-ene-28-Oic acid ( = 3-epi-hederagenin ) (3) , 3β-hydroxyolean-12-ene-23-al-28-oic acid (=gypsogenin) (4) , respetively.展开更多
The microbial transformation of glycyrrhetinic acid（1） by Cunninghamella blakesleana CGMCC 3.970 led to the production of five new metabolites（2-6）.The structures of the metabolites were determined by extensive sp...The microbial transformation of glycyrrhetinic acid（1） by Cunninghamella blakesleana CGMCC 3.970 led to the production of five new metabolites（2-6）.The structures of the metabolites were determined by extensive spectroscopic（HR-ESIMS,1D and 2D NMR） data analyses.The involved reactions exhibited specific hydroxylations at C-24,C-7,and C-15,and oxidation at C-3.Moreover,compounds 2,5,and 6showed significant neural anti-inflammatory activity by inhibiting lipopolysaccharide-induced NO production in mouse microglia BV2 cells with IC（50） values of 0.76,0.94,and 0.16μmol/L,respectively.展开更多
文摘gain, four new saponins were isolated from tlie leaves of Oplopanax elatusHaka,. The structures of the four saponins ,tentatively named cirensenoside E(1),F(2), G(3) and H(4) , were elucidated to be 28-O-α-L-rlianinopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-g-Dglucopyranosyl esters of 3epi-betulinic acid 3-O-β-D-glucopyranoside (1), 3β-hydroxylup-20 (29)-en-23.28-dioic acid (2),3β, 23-di-hydroxylup-20 (29 )-en-28-oic acid (3), 3α, 23-dihydroxylup-20 (29)-en-28-oic acidt4), respectively.
文摘our new saponins were isolated from the leaves of Oplopanax elatus Nakai.The structures of the four saponins , tentatively named compounds A(1) , B(2) , C(3) and D (4) were elucidated to be 28-O-a-L-rhamnopyranosyl (1-4)-β-D-glu-copyranosyl ( 1-6 )-β-D-glucopyranosyl esters of betulinic acid 3-O-β-D-glucopyra-noside (1) . oleanolic acid 3-O-β-D-glucopyranoside (2) , 3a, 23-dihydroxyolean-12-ene-28-Oic acid ( = 3-epi-hederagenin ) (3) , 3β-hydroxyolean-12-ene-23-al-28-oic acid (=gypsogenin) (4) , respetively.
文摘The microbial transformation of glycyrrhetinic acid（1） by Cunninghamella blakesleana CGMCC 3.970 led to the production of five new metabolites（2-6）.The structures of the metabolites were determined by extensive spectroscopic（HR-ESIMS,1D and 2D NMR） data analyses.The involved reactions exhibited specific hydroxylations at C-24,C-7,and C-15,and oxidation at C-3.Moreover,compounds 2,5,and 6showed significant neural anti-inflammatory activity by inhibiting lipopolysaccharide-induced NO production in mouse microglia BV2 cells with IC（50） values of 0.76,0.94,and 0.16μmol/L,respectively.
