Jiu Ai Tu(The Moxa Treatment)from the Song dynasty is the earliest surviving painting that focuses on the subject of acupuncture and moxibustion.This paper takes the medical activities depicted in the artwork as its r...Jiu Ai Tu(The Moxa Treatment)from the Song dynasty is the earliest surviving painting that focuses on the subject of acupuncture and moxibustion.This paper takes the medical activities depicted in the artwork as its research object and systematically analyzes the external treatment methods for abscesses during the Song dynasty reflected in Jiu Ai Tu.By examining the understanding of abscesses during that period,the paper explores the level of development in external medicine techniques.By analyzing the medical awareness and behaviors of patients when facing such severe illnesses,it aims to explore the societal cognition and experiences regarding health and disease.The paper attempts to present the folk medical ecology of the Song dynasty represented by Jiu Ai Tu.展开更多
Objective:To determine the active components of Eupolyphaga sinensis Walker(Tu Bie Chong)and explore the mechanisms underlying its fracture-healing ability.Methods: A modified Einhorn method was used to develop a rat ...Objective:To determine the active components of Eupolyphaga sinensis Walker(Tu Bie Chong)and explore the mechanisms underlying its fracture-healing ability.Methods: A modified Einhorn method was used to develop a rat tibial fracture model.Progression of bone healing was assessed using radiological methods.Safranin O/fast green and CD31 immunohistochemical staining were performed to evaluate the growth of bone cells and angiogenesis at the fracture site.Methylthiazoletetrazolium blue and wound healing assays were used to analyze cell viability and migration.The Transwell assay was used to explore the invasion capacity of the cells.Tubule formation assays were used to assess the angiogenesis capacity of human vascular endothelial cells(HUVECs).qRT-PCR was used to evaluate the changes in gene transcription levels.Results: Tu Bie Chong fraction 3(TF3)significantly shortened the fracture healing time in model rats.X-ray results showed that on day 14,fracture healing in the TF3 treatment group was significantly better than that in the control group(P=.0086).Tissue staining showed that cartilage growth and the number of H-shaped blood vessels at the fracture site of the TF3 treatment group were better than those of the control group.In vitro,TF3 significantly promoted the proliferation and wound healing of MC3T3-E1s and HUVECs(all P<.01).Transwell assays showed that TF3 promoted the migration of HUVECs,but inhibited the migration of MC3T3-E1 cells.Tubule formation experiments confirmed that TF3 markedly promoted the ability of vascular endothelial cells to form microtubules.Gene expression analysis revealed that TF3 significantly promoted the expression of VEGFA,SPOCD1,NGF,and NGFR in HUVECs.In MC3T3-E1 cells,the transcript levels of RUNX2 and COL2A1 were significantly elevated following TF3 treatment.Conclusion: TF3 promotes fracture healing by promoting bone regeneration associated with the RUNX2 pathway and angiogenesis associated with the VEGFA pathway.展开更多
We analyzed the two hypervariable segments HVS-I and HVS-II of 108 Chinese Tu ethnic minority group samples for forensic and population genetics purposes, Comparing with Anderson sequence, 79 polymorphic loci in HVS-I...We analyzed the two hypervariable segments HVS-I and HVS-II of 108 Chinese Tu ethnic minority group samples for forensic and population genetics purposes, Comparing with Anderson sequence, 79 polymorphic loci in HVS-I and 40 in HVS-II were found in Chinese Tu ethnic minority group mtDNA sequences, and 90 and 64 haplotypes were then defined. Haplotype diversity and the mean pairwise differences were 0.9903±0.0013 and 5.7785 in HVS-I, and 0.9777±0.0013 and 3.5819 in HVS-II, respectively. By analyzing the hypervariable domain from nucleotide 1,6180 to 1,6193 in HVS-I, we defined some new types of sequence variations. We also compared the relationship between Tu population and other populations using mtDNA HVS-I sequences. According to Rst genetic distances, the phylogenetic tree showed that the Tu population, the Xi＇an Han population, the Chinese Korean, and the Mongol ethnic group were in a clade. This indicated a close genetic relationship between them. There were far relations between the Tu population and other Chinese southern Han populations, Siberian, European, African, and other foreign populations. The results suggest that Tu population has a multi-origin and has also merged with other local populations.展开更多
TZ Eri and TU Her are both classic Algol-type systems(Algols). By observing and collecting times of minimum light, we constructed the O-C curves for the two systems. The long-time upward and downward parabolas shown i...TZ Eri and TU Her are both classic Algol-type systems(Algols). By observing and collecting times of minimum light, we constructed the O-C curves for the two systems. The long-time upward and downward parabolas shown in these diagrams are considered to be the result of the combination of mass transfer and angular momentum loss. The secular orbital period change rates are d P/dt = 4.74(±0.12) ×10-7 d yr-1 and d P/dt =-2.33(±0.01) × 10-6 d yr-1, respectively. There are also cyclic variations in their O-C curves which might be caused by the light-travel time effect(LTTE). A circumbinary star may exist in the TZ Eri system with a mass of at least 1.34 M⊙, while there are possibly two celestial bodies that almost follow a 2 : 1 resonance orbit around the TU Her binary pair. Their masses are at least 2.43 M⊙and 1.27 M⊙.展开更多
Based on the differential forms and exterior derivatives of fractional orders, Wu first presented the generalized Tu formula to construct the generalized Hamiltonian structure of the fractional soliton equation. We ap...Based on the differential forms and exterior derivatives of fractional orders, Wu first presented the generalized Tu formula to construct the generalized Hamiltonian structure of the fractional soliton equation. We apply the generalized Tu formula to calculate the fractional Dirac soliton equation hierarchy and its Hamiltonian structure. The method can be generalized to the other fractional soliton hierarchy.展开更多
Objective Tu Jia ethnomedicine is a unique medical system inherited and adhibited by Tu Jia minority living in central-south China. Panax japonicus C. A. Mey.(Bai San Qi,白三七) is recognized as an effective and rare ...Objective Tu Jia ethnomedicine is a unique medical system inherited and adhibited by Tu Jia minority living in central-south China. Panax japonicus C. A. Mey.(Bai San Qi,白三七) is recognized as an effective and rare medicinal plant to treat weakness, fatigue and rheumatism in Tu Jia ethnomedicine. This paper is to discover more substance evidence for the application of Tu Jia ethnomedicine. Methods Column chromatography and preparative high performance liquid chromatography (HPLC) was applied for isolation and purification;1H-NMR, 13C-NMR, 1H-1H COSY, HSQC and HMBC NMR spectra were applied for structure identification;Methyl thiazolyl tetrazolim (MTT) assays were applied for cytotoxicity evaluation. Results Totally 12 known compounds were isolated by column chromatography and preparative HPLC from rhizomes of Panax japonicus C. A. Mey.(Bai San Qi,白三七). Structures of these compounds were identified by their NMR spectra. All the 12 compounds were triterpenoid saponins. Five of them were oleanolic acid type, and the remaining 7 were dammarane type. Eleven compounds were assayed for their cytotoxic activity against Hep G2 human liver cancer cell lines and BGC-823 human gastric cancer cell lines. Three of the 11 showed relatively dominant cytotoxicity against these cell lines. Conclusions A total of 12 known compounds have been identified from Panax japonicus C. A. Mey.(Bai San Qi,白三七);NMR spectra of compounds with similar skeletons showed regular characteristics;3 compounds showed relatively dominant cytotoxicity against Hep G2 and BGC-823 cancer cell lines, and the result can be valued as weak while setting the taxol as a positive control.展开更多
This article verified that the Tu state mentioned in the oracle inscriptions was the Xia people after the Xia Dynasty had been conquered by Tang, the first king of the Shang Dynasty m c.a. 16th century B.C. The state...This article verified that the Tu state mentioned in the oracle inscriptions was the Xia people after the Xia Dynasty had been conquered by Tang, the first king of the Shang Dynasty m c.a. 16th century B.C. The state of Xia, which originated from Yu, was entitled "Xia Hou"; its king was hence called "Xia Hou Di" (Emperor of Xia Hou), e.g."Xia Hou Di Qi". The Xia people, together with the Yin (Shang) people, and the Zhou people, were the so-called "people of San Dai" (Three Dynasties). As mentioned in "Lunyu, Bayi", they founded the states, with the Xia people being associated with the pine, the Yin people with the cypress, and the Zhou people with the chestnut.展开更多
The selection of the second person pronouns embodies the power and solidarity relations in social communication.The paper studies"Ni/Nin"in Chinese and"Tu/Vous"in French from sociolinguistic,cultur...The selection of the second person pronouns embodies the power and solidarity relations in social communication.The paper studies"Ni/Nin"in Chinese and"Tu/Vous"in French from sociolinguistic,cultural and pragmatic perspectives by basing on"Power and Solidarity".Through the comparative study of this two pairs,not only can we observe the historical pro cess of personal pronouns,and analyze the similarities and dissimilarities of the two languages which hide behind Chinese and French cultural backgrounds,but also may further understand their pragmatic principles in various context.展开更多
A new Lie algebra, which is far different form the known An-1, is established, for which the corresponding loop algebra is given. From this, two isospectral problems are revealed, whose compatibility condition reads a...A new Lie algebra, which is far different form the known An-1, is established, for which the corresponding loop algebra is given. From this, two isospectral problems are revealed, whose compatibility condition reads a kind of zero curvature equation, which permits Lax integrable hierarchies of soliton equations. To aim at generating Hamiltonian structures of such soliton-equation hierarchies, a beautiful Killing-Cartan form, a generalized trace functional of matrices, is given, for which a generalized Tu formula （GTF） is obtained, while the trace identity proposed by Tu Guizhang [J. Math. Phys. 30 （1989） 330] is a special case of the GTF. The computing formula on the constant γ to be determined appearing in the GTF is worked out, which ensures the exact and simple computation on it. Finally, we take two examples to reveal the applications of the theory presented in the article. In details, the first example reveals a new Liouville-integrable hierarchy of soliton equations along with two potential functions and Hamiltonian structure. To obtain the second integrable hierarchy of soliton equations, a higher-dimensional loop algebra is first constructed. Thus, the second example shows another new Liouville integrable hierarchy with 5-potential component functions and bi- Hamiltonian structure. The approach presented in the paper may be extensively used to generate other new integrable soliton-equation hierarchies with multi-Hamiltonian structures.展开更多
PHYSIOLOGICAL AND PATHOLOGICAL MECHANISMS INVOLVED IN ANGIOGENESIS AND OVARIAN FUNCTION Angiogenesis is the process of blood vessel formation in which new vessels sprout and mature from a pre-existing vasculature.Vess...PHYSIOLOGICAL AND PATHOLOGICAL MECHANISMS INVOLVED IN ANGIOGENESIS AND OVARIAN FUNCTION Angiogenesis is the process of blood vessel formation in which new vessels sprout and mature from a pre-existing vasculature.Vessel formation is critical during tissue development in embryogenesis(vasculogenesis)and in several pathological conditions.However,in healthy tissues,physiological angiogenesis is mainly limited to the reproductive system.The ovarian vasculature particularly associated with the dominant structures(preovulatory follicle and corpus luteum)during the ovarian cycle is one of the few sites where nonpathological development and regression of blood vessels occurs in the adult.Recently,local factors such as VEGFA and angiopoietins,which act specifically on vascular endothelial or support cells(pericytes or smooth muscle)to control angiogenesis,were identified in the ovary of several species,including nonhuman primates and women.展开更多
LECTURES“Miguel Lillo”Lecture A1 THE ANCIENT TUCMA UNDER THE TAWANTINSUYU AND THE SPANISH EMPIRES During the fourth or fifth century AD the so called Ancient States appeared in the American continent.These States,wh...LECTURES“Miguel Lillo”Lecture A1 THE ANCIENT TUCMA UNDER THE TAWANTINSUYU AND THE SPANISH EMPIRES During the fourth or fifth century AD the so called Ancient States appeared in the American continent.These States,which lay in what is now Mexico,Guatemala and Belize,reached their highest point with the appearance of the Aztec and Mayan Empires.In South America,this phenomenon took place in the Andean section of Ecuador,Peru,Bolivia,Chile and Argentina and culminated with the expansion and conquest of the Inca Empire or Tawantinsuyu,starting in the 15th century.The Incas invaded and conquered the northern half of Chile,the Andean Northwest of Argentina and the Cuyo area,which became part of that State.展开更多
Objective To investigate possible causes resulting in the differences in the spermatogenesis suppression on individual treated with levonorgestrel (LNG) implants and testosterone undecanoate (TU) injectableMethods Tot...Objective To investigate possible causes resulting in the differences in the spermatogenesis suppression on individual treated with levonorgestrel (LNG) implants and testosterone undecanoate (TU) injectableMethods Totally 21 Chinese male volunteers were given treatment with LNG implants (four rods, 75 mg/rod) and intramuscular injection of TU (500 mg,bimonthly for 3 times). According to the effects of treatment, they were divided into two groups, namely, azoospermia group (group A) and oligozoospermia group (group O). Then seminal FSH, LH, T and estradiol (E2) were determined by immunoenzymetric assay, while seminal and serum dihydrotachysterol (DHT) and serum sex hormone binding globulin (SHBG) were by radioimmunoassay, and seminal transferrin (Tf) by scatter turbidimetry assay.Results Seminal FSH, LH and serum DHT, SHBG, FTI (T/SHBG ×100) levels were significantly lower in group A than in group O, while higher seminal concentrations ofE2 were observed in azoospermia group.Conclusion The differences in the spermatogenic suppression in Chinese men might be attributed to different rate of peripheral androgen metabolism, variations in serum SHBG levels, 5á-reductase activity and individual aromatase activity during LNG plus TU administration. In addition, seminal sex hormones might be more sensitive indexes to assess the extent of feedback inhibition on hypothalamus-pituitary-testis with exogenous testosterone plus progestogen in the efficacy hormone male contraceptive trials.展开更多
Objective:The mechanism of Chinese herbal medicine"Bi xie and Tu fuling"on the treatment of gouty arthritis was explored through network pharmacological methods.Methods:First,the TCMSP Chinese medicine syste...Objective:The mechanism of Chinese herbal medicine"Bi xie and Tu fuling"on the treatment of gouty arthritis was explored through network pharmacological methods.Methods:First,the TCMSP Chinese medicine system pharmacology database and analysis platform were used to define the bioavailability(OB)30%and drug-likeness(DL)0.18.Database to mine genetic targets related to gouty arthritis disease.Finally,the two genes are intersected to construct a Chinese medicine regulatory network of Chinese medicine-components-target genes-disease.The genes in the network are used to construct a protein interaction network to find core genes for analysis of GO and KEGG.Results:There were a total of 84 active ingredients in Chinese medicine Poria and Poria cocos,and 17 effective ingredients and 180 genetic targets were obtained after screening.600 disease targets for gouty arthritis were identified,and 58 were common target genes for both.PPI network analysis revealed that IL1β,VEGFA,MAPK1,IL10,and PTGS2 may be drugs for treating gouty arthritis.Key targets.GO enrichment analysis identified 1,399 entries(P<0.05),of which biological processes mainly include biological stimulation,biological regulation,cell metabolism,etc;KEGG pathway enrichment analysis identified 152 signal pathways,of which signal pathways involved inflammation,metabolism,In terms of aging,mainly including the IL-4,IL-10,IL-13,IL-17signal pathway,etc.Conclusion:"Bi xie and Tu fuling"drugs have anti-inflammatory and immunological effects on gouty arthritis through multiple targets and multiple pathways.The mechanism of lowering uric acid and protecting liver and kidney is not clear.It needs molecular biology research to improve it.The mechanism of the action of the"Bi xie and Tu fuling"medicine pair provides new ideas for the clinical prescriptions.展开更多
基金financed from the grant of the National Social Science Foundation General Project(No.23BZS010)。
文摘Jiu Ai Tu(The Moxa Treatment)from the Song dynasty is the earliest surviving painting that focuses on the subject of acupuncture and moxibustion.This paper takes the medical activities depicted in the artwork as its research object and systematically analyzes the external treatment methods for abscesses during the Song dynasty reflected in Jiu Ai Tu.By examining the understanding of abscesses during that period,the paper explores the level of development in external medicine techniques.By analyzing the medical awareness and behaviors of patients when facing such severe illnesses,it aims to explore the societal cognition and experiences regarding health and disease.The paper attempts to present the folk medical ecology of the Song dynasty represented by Jiu Ai Tu.
基金supported by“the Fundamental Research Funds for the Central Universities”(2020-JYB-ZDGG-054)“Beijing university of Chinese medicine XINAO Award Fund”(2019)Beijing University of Chinese Medicine Scientific Research and Development Fund(2170072220002).
文摘Objective:To determine the active components of Eupolyphaga sinensis Walker(Tu Bie Chong)and explore the mechanisms underlying its fracture-healing ability.Methods: A modified Einhorn method was used to develop a rat tibial fracture model.Progression of bone healing was assessed using radiological methods.Safranin O/fast green and CD31 immunohistochemical staining were performed to evaluate the growth of bone cells and angiogenesis at the fracture site.Methylthiazoletetrazolium blue and wound healing assays were used to analyze cell viability and migration.The Transwell assay was used to explore the invasion capacity of the cells.Tubule formation assays were used to assess the angiogenesis capacity of human vascular endothelial cells(HUVECs).qRT-PCR was used to evaluate the changes in gene transcription levels.Results: Tu Bie Chong fraction 3(TF3)significantly shortened the fracture healing time in model rats.X-ray results showed that on day 14,fracture healing in the TF3 treatment group was significantly better than that in the control group(P=.0086).Tissue staining showed that cartilage growth and the number of H-shaped blood vessels at the fracture site of the TF3 treatment group were better than those of the control group.In vitro,TF3 significantly promoted the proliferation and wound healing of MC3T3-E1s and HUVECs(all P<.01).Transwell assays showed that TF3 promoted the migration of HUVECs,but inhibited the migration of MC3T3-E1 cells.Tubule formation experiments confirmed that TF3 markedly promoted the ability of vascular endothelial cells to form microtubules.Gene expression analysis revealed that TF3 significantly promoted the expression of VEGFA,SPOCD1,NGF,and NGFR in HUVECs.In MC3T3-E1 cells,the transcript levels of RUNX2 and COL2A1 were significantly elevated following TF3 treatment.Conclusion: TF3 promotes fracture healing by promoting bone regeneration associated with the RUNX2 pathway and angiogenesis associated with the VEGFA pathway.
文摘We analyzed the two hypervariable segments HVS-I and HVS-II of 108 Chinese Tu ethnic minority group samples for forensic and population genetics purposes, Comparing with Anderson sequence, 79 polymorphic loci in HVS-I and 40 in HVS-II were found in Chinese Tu ethnic minority group mtDNA sequences, and 90 and 64 haplotypes were then defined. Haplotype diversity and the mean pairwise differences were 0.9903±0.0013 and 5.7785 in HVS-I, and 0.9777±0.0013 and 3.5819 in HVS-II, respectively. By analyzing the hypervariable domain from nucleotide 1,6180 to 1,6193 in HVS-I, we defined some new types of sequence variations. We also compared the relationship between Tu population and other populations using mtDNA HVS-I sequences. According to Rst genetic distances, the phylogenetic tree showed that the Tu population, the Xi＇an Han population, the Chinese Korean, and the Mongol ethnic group were in a clade. This indicated a close genetic relationship between them. There were far relations between the Tu population and other Chinese southern Han populations, Siberian, European, African, and other foreign populations. The results suggest that Tu population has a multi-origin and has also merged with other local populations.
基金partly supported by the National Natural Science Foundation of China (Nos. 11573063 and 11611530685)the Key Science Foundation of Yunnan Province (No. 2017FA001)the CAS “Light of West China” Program and the CAS Interdisciplinary Innovation Team
文摘TZ Eri and TU Her are both classic Algol-type systems(Algols). By observing and collecting times of minimum light, we constructed the O-C curves for the two systems. The long-time upward and downward parabolas shown in these diagrams are considered to be the result of the combination of mass transfer and angular momentum loss. The secular orbital period change rates are d P/dt = 4.74(±0.12) ×10-7 d yr-1 and d P/dt =-2.33(±0.01) × 10-6 d yr-1, respectively. There are also cyclic variations in their O-C curves which might be caused by the light-travel time effect(LTTE). A circumbinary star may exist in the TZ Eri system with a mass of at least 1.34 M⊙, while there are possibly two celestial bodies that almost follow a 2 : 1 resonance orbit around the TU Her binary pair. Their masses are at least 2.43 M⊙and 1.27 M⊙.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 11271008,61072147,and 11071159 )the Shanghai Leading Academic Discipline Project,China (Grant No. J50101)
文摘Based on the differential forms and exterior derivatives of fractional orders, Wu first presented the generalized Tu formula to construct the generalized Hamiltonian structure of the fractional soliton equation. We apply the generalized Tu formula to calculate the fractional Dirac soliton equation hierarchy and its Hamiltonian structure. The method can be generalized to the other fractional soliton hierarchy.
基金the funding support from the National Natural Science Foundation of China (No. 81703819 and No. 81874369)Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine (No. 2017-04)+1 种基金Hunan Provincial Key Laboratory of Dong Medicine (No. 2015TP1020-02)Students Research Innovative Program of Hunan Province (No. 2018413)
文摘Objective Tu Jia ethnomedicine is a unique medical system inherited and adhibited by Tu Jia minority living in central-south China. Panax japonicus C. A. Mey.(Bai San Qi,白三七) is recognized as an effective and rare medicinal plant to treat weakness, fatigue and rheumatism in Tu Jia ethnomedicine. This paper is to discover more substance evidence for the application of Tu Jia ethnomedicine. Methods Column chromatography and preparative high performance liquid chromatography (HPLC) was applied for isolation and purification;1H-NMR, 13C-NMR, 1H-1H COSY, HSQC and HMBC NMR spectra were applied for structure identification;Methyl thiazolyl tetrazolim (MTT) assays were applied for cytotoxicity evaluation. Results Totally 12 known compounds were isolated by column chromatography and preparative HPLC from rhizomes of Panax japonicus C. A. Mey.(Bai San Qi,白三七). Structures of these compounds were identified by their NMR spectra. All the 12 compounds were triterpenoid saponins. Five of them were oleanolic acid type, and the remaining 7 were dammarane type. Eleven compounds were assayed for their cytotoxic activity against Hep G2 human liver cancer cell lines and BGC-823 human gastric cancer cell lines. Three of the 11 showed relatively dominant cytotoxicity against these cell lines. Conclusions A total of 12 known compounds have been identified from Panax japonicus C. A. Mey.(Bai San Qi,白三七);NMR spectra of compounds with similar skeletons showed regular characteristics;3 compounds showed relatively dominant cytotoxicity against Hep G2 and BGC-823 cancer cell lines, and the result can be valued as weak while setting the taxol as a positive control.
文摘This article verified that the Tu state mentioned in the oracle inscriptions was the Xia people after the Xia Dynasty had been conquered by Tang, the first king of the Shang Dynasty m c.a. 16th century B.C. The state of Xia, which originated from Yu, was entitled "Xia Hou"; its king was hence called "Xia Hou Di" (Emperor of Xia Hou), e.g."Xia Hou Di Qi". The Xia people, together with the Yin (Shang) people, and the Zhou people, were the so-called "people of San Dai" (Three Dynasties). As mentioned in "Lunyu, Bayi", they founded the states, with the Xia people being associated with the pine, the Yin people with the cypress, and the Zhou people with the chestnut.
文摘The selection of the second person pronouns embodies the power and solidarity relations in social communication.The paper studies"Ni/Nin"in Chinese and"Tu/Vous"in French from sociolinguistic,cultural and pragmatic perspectives by basing on"Power and Solidarity".Through the comparative study of this two pairs,not only can we observe the historical pro cess of personal pronouns,and analyze the similarities and dissimilarities of the two languages which hide behind Chinese and French cultural backgrounds,but also may further understand their pragmatic principles in various context.
文摘A new Lie algebra, which is far different form the known An-1, is established, for which the corresponding loop algebra is given. From this, two isospectral problems are revealed, whose compatibility condition reads a kind of zero curvature equation, which permits Lax integrable hierarchies of soliton equations. To aim at generating Hamiltonian structures of such soliton-equation hierarchies, a beautiful Killing-Cartan form, a generalized trace functional of matrices, is given, for which a generalized Tu formula （GTF） is obtained, while the trace identity proposed by Tu Guizhang [J. Math. Phys. 30 （1989） 330] is a special case of the GTF. The computing formula on the constant γ to be determined appearing in the GTF is worked out, which ensures the exact and simple computation on it. Finally, we take two examples to reveal the applications of the theory presented in the article. In details, the first example reveals a new Liouville-integrable hierarchy of soliton equations along with two potential functions and Hamiltonian structure. To obtain the second integrable hierarchy of soliton equations, a higher-dimensional loop algebra is first constructed. Thus, the second example shows another new Liouville integrable hierarchy with 5-potential component functions and bi- Hamiltonian structure. The approach presented in the paper may be extensively used to generate other new integrable soliton-equation hierarchies with multi-Hamiltonian structures.
文摘PHYSIOLOGICAL AND PATHOLOGICAL MECHANISMS INVOLVED IN ANGIOGENESIS AND OVARIAN FUNCTION Angiogenesis is the process of blood vessel formation in which new vessels sprout and mature from a pre-existing vasculature.Vessel formation is critical during tissue development in embryogenesis(vasculogenesis)and in several pathological conditions.However,in healthy tissues,physiological angiogenesis is mainly limited to the reproductive system.The ovarian vasculature particularly associated with the dominant structures(preovulatory follicle and corpus luteum)during the ovarian cycle is one of the few sites where nonpathological development and regression of blood vessels occurs in the adult.Recently,local factors such as VEGFA and angiopoietins,which act specifically on vascular endothelial or support cells(pericytes or smooth muscle)to control angiogenesis,were identified in the ovary of several species,including nonhuman primates and women.
文摘LECTURES“Miguel Lillo”Lecture A1 THE ANCIENT TUCMA UNDER THE TAWANTINSUYU AND THE SPANISH EMPIRES During the fourth or fifth century AD the so called Ancient States appeared in the American continent.These States,which lay in what is now Mexico,Guatemala and Belize,reached their highest point with the appearance of the Aztec and Mayan Empires.In South America,this phenomenon took place in the Andean section of Ecuador,Peru,Bolivia,Chile and Argentina and culminated with the expansion and conquest of the Inca Empire or Tawantinsuyu,starting in the 15th century.The Incas invaded and conquered the northern half of Chile,the Andean Northwest of Argentina and the Cuyo area,which became part of that State.
文摘Objective To investigate possible causes resulting in the differences in the spermatogenesis suppression on individual treated with levonorgestrel (LNG) implants and testosterone undecanoate (TU) injectableMethods Totally 21 Chinese male volunteers were given treatment with LNG implants (four rods, 75 mg/rod) and intramuscular injection of TU (500 mg,bimonthly for 3 times). According to the effects of treatment, they were divided into two groups, namely, azoospermia group (group A) and oligozoospermia group (group O). Then seminal FSH, LH, T and estradiol (E2) were determined by immunoenzymetric assay, while seminal and serum dihydrotachysterol (DHT) and serum sex hormone binding globulin (SHBG) were by radioimmunoassay, and seminal transferrin (Tf) by scatter turbidimetry assay.Results Seminal FSH, LH and serum DHT, SHBG, FTI (T/SHBG ×100) levels were significantly lower in group A than in group O, while higher seminal concentrations ofE2 were observed in azoospermia group.Conclusion The differences in the spermatogenic suppression in Chinese men might be attributed to different rate of peripheral androgen metabolism, variations in serum SHBG levels, 5á-reductase activity and individual aromatase activity during LNG plus TU administration. In addition, seminal sex hormones might be more sensitive indexes to assess the extent of feedback inhibition on hypothalamus-pituitary-testis with exogenous testosterone plus progestogen in the efficacy hormone male contraceptive trials.
基金National administration of TCM base special fund(No.JDZX2015277)Beijing municipal science and technology commission science and technology star project(No.Z191100001119025)
文摘Objective:The mechanism of Chinese herbal medicine"Bi xie and Tu fuling"on the treatment of gouty arthritis was explored through network pharmacological methods.Methods:First,the TCMSP Chinese medicine system pharmacology database and analysis platform were used to define the bioavailability(OB)30%and drug-likeness(DL)0.18.Database to mine genetic targets related to gouty arthritis disease.Finally,the two genes are intersected to construct a Chinese medicine regulatory network of Chinese medicine-components-target genes-disease.The genes in the network are used to construct a protein interaction network to find core genes for analysis of GO and KEGG.Results:There were a total of 84 active ingredients in Chinese medicine Poria and Poria cocos,and 17 effective ingredients and 180 genetic targets were obtained after screening.600 disease targets for gouty arthritis were identified,and 58 were common target genes for both.PPI network analysis revealed that IL1β,VEGFA,MAPK1,IL10,and PTGS2 may be drugs for treating gouty arthritis.Key targets.GO enrichment analysis identified 1,399 entries(P<0.05),of which biological processes mainly include biological stimulation,biological regulation,cell metabolism,etc;KEGG pathway enrichment analysis identified 152 signal pathways,of which signal pathways involved inflammation,metabolism,In terms of aging,mainly including the IL-4,IL-10,IL-13,IL-17signal pathway,etc.Conclusion:"Bi xie and Tu fuling"drugs have anti-inflammatory and immunological effects on gouty arthritis through multiple targets and multiple pathways.The mechanism of lowering uric acid and protecting liver and kidney is not clear.It needs molecular biology research to improve it.The mechanism of the action of the"Bi xie and Tu fuling"medicine pair provides new ideas for the clinical prescriptions.
