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Primary gastroduodenal tuberculosis presenting as gastric outlet obstruction:A case report and review of literature 被引量:7
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作者 Abdihamid Mohamed Ali Yahye Garad Mohamed +4 位作者 Abdirahman Ahmed Mohamud Abdulkadir Nor Mohamed Mohamed Rage Ahmed Ismail Mohamud Abdullahi Tuba Saydam 《World Journal of Clinical Cases》 SCIE 2024年第8期1536-1543,共8页
BACKGROUND Mycobacterium tuberculosis(TB)is the causative agent of TB,a chronic granulo-matous illness.This disease is prevalent in low-income countries,posing a significant global health challenge.Gastrointestinal TB... BACKGROUND Mycobacterium tuberculosis(TB)is the causative agent of TB,a chronic granulo-matous illness.This disease is prevalent in low-income countries,posing a significant global health challenge.Gastrointestinal TB is one of the three forms.The disease can mimic other intra-abdominal conditions,leading to delayed diagnosis owing to the absence of specific symptoms.While gastric outlet obs-truction(GOO)remains a frequent complication,its incidence has declined with the advent of proton pump inhibitors and Helicobacter pylori eradication therapy.Gastroduodenal TB can cause upper gastrointestinal hemorrhage,obstruction,and malignancy-like tumors.CASE SUMMARY A 23-year-old male presented with recurrent epigastric pain,distension,nausea,vomiting,and weight loss,prompting a referral to a gastroenterologist clinic.Endoscopic examination revealed distorted gastric mucosa and signs of chronic inflammation.However,treatment was interrupted,possibly owing to vomiting or comorbidities such as human immunodeficiency virus infection or diabetes.Subsequent surgical intervention revealed a dilated stomach and diffuse thickening of the duodenal wall.Resection revealed gastric wall effacement with TB.CONCLUSION Primary gastric TB is rare,frequently leading to GOO.Given its rarity,suspicions should be promptly raised when encountering relevant symptoms,often requiring surgical intervention for diagnosis and treatment. 展开更多
关键词 tuberculosis Gastrointestinal tuberculosis Gastric outlet obstruction Gastroduodenal tuberculosis Case report
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Analysis of the influencing factors and clinical related characteristics of pulmonary tuberculosis in patients with type 2 diabetes mellitus 被引量:2
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作者 Han Shi Yuan Yuan +3 位作者 Xue Li Yan-Fang Li Ling Fan Xue-Mei Yang 《World Journal of Diabetes》 SCIE 2024年第2期196-208,共13页
BACKGROUND In China,the prevalence of type 2 diabetes mellitus(T2DM)among diabetic patients is estimated to be between 90%-95%.Additionally,China is among the 22 countries burdened by a high number of tuberculosis cas... BACKGROUND In China,the prevalence of type 2 diabetes mellitus(T2DM)among diabetic patients is estimated to be between 90%-95%.Additionally,China is among the 22 countries burdened by a high number of tuberculosis cases,with approximately 4.5 million individuals affected by active tuberculosis.Notably,T2DM poses a significant risk factor for the development of tuberculosis,as evidenced by the increased incidence of T2DM coexisting with pulmonary tuberculosis(T2DMPTB),which has risen from 19.3%to 24.1%.It is evident that these two diseases are intricately interconnected and mutually reinforcing in nature.AIM To elucidate the clinical features of individuals diagnosed with both T2DM and tuberculosis(T2DM-PTB),as well as to investigate the potential risk factors associated with active tuberculosis in patients with T2DM.METHODS T2DM-PTB patients who visited our hospital between January 2020 and January 2023 were selected as the observation group,Simple DM patients presenting to our hospital in the same period were the control group,Controls and case groups were matched 1:2 according to the principle of the same sex,age difference(±3)years and disease duration difference(±5)years,patients were investigated for general demographic characteristics,diabetes-related characteristics,body immune status,lifestyle and behavioral habits,univariate and multivariate analysis of the data using conditional logistic regression,calculate the odds ratio(OR)values and 95%CI of OR values.RESULTS A total of 315 study subjects were included in this study,including 105 subjects in the observation group and 210 subjects in the control group.Comparison of the results of both anthropometric and biochemical measures showed that the constitution index,systolic blood pressure,diastolic blood pressure and lymphocyte count were significantly lower in the case group,while fasting blood glucose and high-density lipoprotein cholesterol levels were significantly higher than those in the control group.The results of univariate analysis showed that poor glucose control,hypoproteinemia,lymphopenia,TB contact history,high infection,smoking and alcohol consumption were positively associated with PTB in T2DM patients;married,history of hypertension,treatment of oral hypoglycemic drugs plus insulin,overweight,obesity and regular exercise were negatively associated with PTB in T2DM patients.Results of multivariate stepwise regression analysis found lymphopenia(OR=17.75,95%CI:3.40-92.74),smoking(OR=12.25,95%CI:2.53-59.37),history of TB contact(OR=6.56,95%CI:1.23-35.03)and poor glycemic control(OR=3.37,95%CI:1.11-10.25)was associated with an increased risk of developing PTB in patients with T2DM,While being overweight(OR=0.23,95%CI:0.08-0.72)and obesity(OR=0.11,95%CI:0.02-0.72)was associated with a reduced risk of developing PTB in patients with T2DM.CONCLUSION T2DM-PTB patients are prone to worse glycemic control,higher infection frequency,and a higher proportion of people smoking,drinking alcohol,and lack of exercise.Lymphopenia,smoking,history of TB exposure,poor glycemic control were independent risk factors for T2DM-PTB,and overweight and obesity were associated with reduced risk of concurrent PTB in patients with T2DM. 展开更多
关键词 Type 2 diabetes Pulmonary tuberculosis Blood sugar INFECTION Risk factors
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Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management 被引量:1
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作者 Nguyen Quang Thu Nguyen Tran Nam Tien +3 位作者 Nguyen Thi Hai Yen Thuc-Huy Duong Nguyen Phuoc Long Huy Truong Nguyen 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第1期16-38,共23页
The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB drugs.New strategies to facilitate drug combination... The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB drugs.New strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and recommended.Liquid chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous compounds.This technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics analysis.TDM improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target window.Based on TDM,the dose would be optimized individually to achieve favorable outcomes.Pharmacometabolomics is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome evaluation.This article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two decades.Besides,we discussed the advantages and disadvantages of this technique in practical use.The pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was highlighted.Lastly,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients. 展开更多
关键词 tuberculosis Therapeutic drug monitoring LC-MS MIPD Pharmacometabolomics Precision medicine
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Treatment of primary nasal tuberculosis with anti-tumor necrosis factor immunotherapy:A case report 被引量:1
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作者 Yong-Cai Liu Min-Li Zhou +2 位作者 Ke-Jia Cheng Shui-Hong Zhou Xue Wen 《World Journal of Clinical Cases》 SCIE 2024年第17期3271-3276,共6页
BACKGROUND Primary nasal tuberculosis(TB)is a rare form of extrapulmonary TB,particularly in patients receiving anti-tumor necrosis factor(TNF)immunotherapy.As a result,its diagnosis remains challenging.CASE SUMMARY A... BACKGROUND Primary nasal tuberculosis(TB)is a rare form of extrapulmonary TB,particularly in patients receiving anti-tumor necrosis factor(TNF)immunotherapy.As a result,its diagnosis remains challenging.CASE SUMMARY A 58-year-old male patient presented to the ear,nose,and throat department with right-sided nasal obstruction and bloody discharge for 1 month.He was diagnosed with psoriatic arthritis and received anti-TNF immunotherapy for 3 years prior to presentation.Biopsy findings revealed chronic granulomatous inammation and a few acid-fast bacilli,suggestive of primary nasal TB.He was referred to our TB management department for treatment with oral anti-TB agents.After 9 months,the nasal lesions had disappeared.No recurrence was noted during follow-up.CONCLUSION The diagnosis of primary nasal TB should be considered in patients receiving TNF antagonists who exhibit thickening and crusting of the nasal septum mucosa or inferior turbinate,particularly when pathological findings suggest granulomatous inflammation. 展开更多
关键词 Primary nasal tuberculosis Anti-tumor necrosis factor immunotherapy Granulomatous inflammation Psoriatic arthritis acid-fast bacilli Case report
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Profile of Extra-Pulmonary Tuberculosis in Internal Medicine 被引量:1
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作者 Mouhamed Dieng Djiby Sow +8 位作者 Demba Diédhiou Michel Assane Ndour Boundia Djiba Mouhamed Almahy Niang Matar Ndiaye Oumar Boun Khattab Diouf Fatou Kiné Gadji Anna Sar Maïmouna Ndour Mbaye 《Open Journal of Internal Medicine》 2024年第1期64-73,共10页
Introduction: Tuberculosis is an infectious disease that mainly affects the lung. Extrapulmonary localizations are a reason for hospitalization in our health facilities. The objective of this study was to describe the... Introduction: Tuberculosis is an infectious disease that mainly affects the lung. Extrapulmonary localizations are a reason for hospitalization in our health facilities. The objective of this study was to describe the epidemiological, clinical, paraclinical and evolutionary aspects of extra pulmonary tuberculosis (EPT) at the Abass Ndao Hospital Center. Patients and Methods: This was a descriptive cross-sectional study conducted over a period of 11 years (January 1, 2010 to December 30, 2021). All patients with extrapulmonary tuberculosis hospitalized in the department of internal medicine during the recruitment period were included. Results: Fifty-two (52) patients were collected. The year 2019 recorded the most cases 23.08% (n = 20). The mean age of the patients was 40.56 ± 18.24 years. The age group 20 - 34 years 42.31% (n = 22) was the most represented. Females were in the majority 61.54% (n = 32) with a sex ratio (M/F) was 0.63. Housewives were in the majority 40.38% (n = 21). 60.87% of the cases (n = 14) came from a health facility. 38.46% of the cases had been infected. 21.74% (n = 9) were smokers. The reasons for consultation were dominated by fever (67.44%), AEG (62.79%) and cough (41.86%). Eighteen patients (40.91%) had fever. The mean time to consultation was 77.37 ± 90.3 days with extremes of 3 and 365 days. The median was 45 days. More than half of the patients 61.90% (n = 26) had anemia. Positive retroviral serology was noted in 21.43% of cases. All patients had a CRP greater than 6. More than half of the patients 51.92% (n = 27) had multifocal tuberculosis. The peritoneum 44.23% (n = 23) was the main organ affected. The average hospital stay was 9.8 ± 4.9 days with extremes of 1 and 19 days. All patients had received the protocol in force at the national level. Death was noted in 4 patients (9.52%). Conclusion: EPT is characterized in our context by a notorious diagnostic difficulty due to the multiplicity of clinical presentations, the complexity of explorations, and the problems of differential diagnosis notably with other granulomatosis, systemic lupus and cancers. This difficulty is reflected in the low rate of diagnosis with a paraclinical argument of certainty and in the long diagnostic delays. 展开更多
关键词 Extrapulmonary tuberculosis EPIDEMIOLOGY DIAGNOSIS Senegal
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Efficacy and Safety of Combined Bedaquiline and Delamanid Use among Patients with Multidrug-Resistant Tuberculosis in Beijing,China
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作者 Can Guo Lihui Nie +6 位作者 Yanhua Song Rongmei Liu Xiaoguang Wu Yuanyuan Shang Xuxia Zhang Yu Pang Mengqiu Gao 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第10期1195-1203,共9页
Objectives The combined use of bedaquiline and delamanid(BDQ-DLM)is limited by an increased risk of prolonging the QTc interval.We retrospectively evaluated patients who received DLM/BDQcontaining regimens at a TB-spe... Objectives The combined use of bedaquiline and delamanid(BDQ-DLM)is limited by an increased risk of prolonging the QTc interval.We retrospectively evaluated patients who received DLM/BDQcontaining regimens at a TB-specialized hospital.We aimed to present clinical efficacy and safety data for Chinese patients.Methods This case-control study included patients with multidrug-resistant tuberculosis(MDR-TB)treated with BDQ alone or BDQ plus DLM.Results A total of 96 patients were included in this analysis:64 in the BDQ group and 32 in the BDQ+DLM group.Among the 96 patients with positive sputum culture at the initiation of BDQ alone or BDQ combined with DLM,46 patients(71.9%)in the BDQ group and 29(90.6%)in the BDQ-DLM group achieved sputum culture conversion during treatment.The rate of sputum culture conversion did not differ between the two groups.The time to sputum culture conversion was significantly shorter in the BDQ-DLM group than in the BDQ group.The most frequent adverse event was QTc interval prolongation;however,the frequency of adverse events did not differ between the groups.Conclusion In conclusion,our results demonstrate that the combined use of BDQ and DLM is efficacious and tolerable in Chinese patients infected with MDR-TB.Patients in the BDQ-DLM group achieved sputum culture conversion sooner than those in the BDQ group. 展开更多
关键词 Multidrug resistant tuberculosis Bedaquiline Delamanid EFFICACY Safety
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From immunology to artificial intelligence: revolutionizing latent tuberculosis infection diagnosis with machine learning
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作者 Lin-Sheng Li Ling Yang +3 位作者 Li Zhuang Zhao-Yang Ye Wei-Guo Zhao Wen-Ping Gong 《Military Medical Research》 SCIE CAS CSCD 2024年第5期747-784,共38页
Latent tuberculosis infection(LTBI)has become a major source of active tuberculosis(ATB).Although the tuberculin skin test and interferon-gamma release assay can be used to diagnose LTBI,these methods can only differe... Latent tuberculosis infection(LTBI)has become a major source of active tuberculosis(ATB).Although the tuberculin skin test and interferon-gamma release assay can be used to diagnose LTBI,these methods can only differentiate infected individuals from healthy ones but cannot discriminate between LTBI and ATB.Thus,the diagnosis of LTBI faces many challenges,such as the lack of effective biomarkers from Mycobacterium tuberculosis(MTB)for distinguishing LTBI,the low diagnostic efficacy of biomarkers derived from the human host,and the absence of a gold standard to differentiate between LTBI and ATB.Sputum culture,as the gold standard for diagnosing tuberculosis,is time-consuming and cannot distinguish between ATB and LTBI.In this article,we review the pathogenesis of MTB and the immune mechanisms of the host in LTBI,including the innate and adaptive immune responses,multiple immune evasion mechanisms of MTB,and epigenetic regulation.Based on this knowledge,we summarize the current status and challenges in diagnosing LTBI and present the application of machine learning(ML)in LTBI diagnosis,as well as the advantages and limitations of ML in this context.Finally,we discuss the future development directions of ML applied to LTBI diagnosis. 展开更多
关键词 tuberculosis(TB) Latent tuberculosis infection(LTBI) Machine learning(ML) Biomarkers Differential diagnosis
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Effectiveness of Histopathological Examination of Ultrasound-guided Puncture Biopsy Samples for Diagnosis of Extrapulmonary Tuberculosis
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作者 GU Wen Fei SHI Xia +5 位作者 MA Xin YU Jun Lei XU Jin Chuan QIAN Cheng Cheng HU Zhi Dong ZHANG Hui 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第2期170-177,共8页
Objective To evaluate the diagnostic value of histopathological examination of ultrasound-guided puncture biopsy samples in extrapulmonary tuberculosis(EPTB).Methods This study was conducted at the Shanghai Public Hea... Objective To evaluate the diagnostic value of histopathological examination of ultrasound-guided puncture biopsy samples in extrapulmonary tuberculosis(EPTB).Methods This study was conducted at the Shanghai Public Health Clinical Center.A total of 115patients underwent ultrasound-guided puncture biopsy,followed by MGIT 960 culture(culture),smear,Gene Xpert MTB/RIF(Xpert),and histopathological examination.These assays were performed to evaluate their effectiveness in diagnosing EPTB in comparison to two different diagnostic criteria:liquid culture and composite reference standard(CRS).Results When CRS was used as the reference standard,the sensitivity and specificity of culture,smear,Xpert,and histopathological examination were(44.83%,89.29%),(51.72%,89.29%),(70.11%,96.43%),and(85.06%,82.14%),respectively.Based on liquid culture tests,the sensitivity and specificity of smear,Xpert,and pathological examination were(66.67%,72.60%),(83.33%,63.01%),and(92.86%,45.21%),respectively.Histopathological examination showed the highest sensitivity but lowest specificity.Further,we found that the combination of Xpert and histopathological examination showed a sensitivity of 90.80%and a specificity of 89.29%.Conclusion Ultrasound-guided puncture sampling is safe and effective for the diagnosis of EPTB.Compared with culture,smear,and Xpert,histopathological examination showed higher sensitivity but lower specificity.The combination of histopathology with Xpert showed the best performance characteristics. 展开更多
关键词 Extrapulmonary tuberculosis DIAGNOSIS BIOPSY Histopathological examination Puncture samples
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Inferring Mycobacterium Tuberculosis Drug Resistance and Transmission using Whole-genome Sequencing in a High TB-burden Setting in China
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作者 FAN Yu Feng LIU Dong Xin +11 位作者 CHEN Yi Wang OU Xi Chao MAO Qi Zhi YANG Ting Ting WANG Xi Jiang HE Wen Cong ZHAO Bing LIU Zhen Jiang ABULIMITI Maiweilanjiang AIHEMUTI Maimaitiaili GAO Qian ZHAO Yan Lin 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第2期157-169,共13页
Objective China is among the 30 countries with a high burden of tuberculosis(TB)worldwide,and TB remains a public health concern.Kashgar Prefecture in the southern Xinjiang Autonomous Region is considered as one of th... Objective China is among the 30 countries with a high burden of tuberculosis(TB)worldwide,and TB remains a public health concern.Kashgar Prefecture in the southern Xinjiang Autonomous Region is considered as one of the highest TB burden regions in China.However,molecular epidemiological studies of Kashgar are lacking.Methods A population-based retrospective study was conducted using whole-genome sequencing(WGS)to determine the characteristics of drug resistance and the transmission patterns.Results A total of 1,668 isolates collected in 2020 were classified into lineages 2(46.0%),3(27.5%),and 4(26.5%).The drug resistance rates revealed by WGS showed that the top three drugs in terms of the resistance rate were isoniazid(7.4%,124/1,668),streptomycin(6.0%,100/1,668),and rifampicin(3.3%,55/1,668).The rate of rifampicin resistance was 1.8%(23/1,290)in the new cases and 9.4%(32/340)in the previously treated cases.Known resistance mutations were detected more frequently in lineage 2 strains than in lineage 3 or 4 strains,respectively:18.6%vs.8.7 or 9%,P<0.001.The estimated proportion of recent transmissions was 25.9%(432/1,668).Multivariate logistic analyses indicated that sex,age,occupation,lineage,and drug resistance were the risk factors for recent transmission.Despite the low rate of drug resistance,drug-resistant strains had a higher risk of recent transmission than the susceptible strains(adjusted odds ratio,1.414;95%CI,1.023–1.954;P=0.036).Among all patients with drug-resistant tuberculosis(DR-TB),78.4%(171/218)were attributed to the transmission of DR-TB strains.Conclusion Our results suggest that drug-resistant strains are more transmissible than susceptible strains and that transmission is the major driving force of the current DR-TB epidemic in Kashgar. 展开更多
关键词 Mycobacterium tuberculosis Whole-genome sequencing(WGS) Transmission Drug resistance XINJIANG
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Modeling the Dynamics of Tuberculosis with Vaccination,Treatment,and Environmental Impact:Fractional Order Modeling
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作者 Muhammad Altaf Khan Mahmoud H.DarAssi +2 位作者 Irfan Ahmad Noha Mohammad Seyam Ebraheem Alzahrani 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第11期1365-1394,共30页
A mathematical model is designed to investigate Tuberculosis(TB)disease under the vaccination,treatment,andenvironmental impact with real cases.First,we introduce the model formulation in non-integer order derivativea... A mathematical model is designed to investigate Tuberculosis(TB)disease under the vaccination,treatment,andenvironmental impact with real cases.First,we introduce the model formulation in non-integer order derivativeand then,extend the model into fractional order derivative.The fractional system’s existence,uniqueness,andother relevant properties are shown.Then,we study the stability analysis of the equilibrium points.The diseasefree equilibrium(DFE)D_(0)is locally asymptotically stable(LAS)when R_(v)<1.Further,we show the globalasymptotical stability(GAS)of the endemic equilibrium(EE)D*for R_(v)>1 and D_(0)for R_(v)≤1.The existenceof bifurcation analysis in the model is investigated,and it is shown the system possesses the forward bifurcationphenomenon.Sensitivity analysis has been performed to determine the sensitive parameters that impact R_(v).Weconsider the real TB statistics from Khyber Pakhtunkhwa in Pakistan and parameterized the model.The computedbasic reproduction number obtained using the real cases is R0≈3.6615.Various numerical results regardingdisease elimination of the sensitive parameters are shown graphically. 展开更多
关键词 tuberculosis real data stability analysis parameter estimations discussion
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Influence of Temperature and Humidity on the Incidence of Pulmonary Tuberculosis in Hainan,China,2004-2018
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作者 Weixia Li Xiaodan Wang +4 位作者 Bo Bi Jingjing Lu Zhengyuan Li Li Cao Hao Zhang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第9期1080-1085,共6页
According to the World Health Organization’s Global Tuberculosis Report 2023,there were 10.6 million cases of tuberculosis(TB)worldwide in 2022,an increase of 2.8%over 2021,and 1.3 million people had already died of ... According to the World Health Organization’s Global Tuberculosis Report 2023,there were 10.6 million cases of tuberculosis(TB)worldwide in 2022,an increase of 2.8%over 2021,and 1.3 million people had already died of the disease.The report also indicated that approximately 748,000 new cases occurred in China in 2022,accounting for 7.1%of the global total,with an incidence of 52/100,000. 展开更多
关键词 tuberculosis CASES INCIDENCE
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What Mice Can Teach Us about How to Stop Drug-Resistant Tuberculosis:Correct Chemotherapy Regimen and Patient Compliance are the Key
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作者 Igor Mokrousov Tatiana Vinogradova +4 位作者 Marine Dogonadze Maria Vitovskaya Natalia Zabolotnykh Sergei Chekrygin Anna Vyazovaya 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第9期1086-1090,共5页
Despite well-known limitations,mice remain useful as model animals to study tuberculosis(TB)pathogenesis,the basic immune response,the extent of lung pathology as well as efficacy of new drugs against Mycobacterium tu... Despite well-known limitations,mice remain useful as model animals to study tuberculosis(TB)pathogenesis,the basic immune response,the extent of lung pathology as well as efficacy of new drugs against Mycobacterium tuberculosis[1,2].There are four routes of tuberculosis infection in mice:aerosol generation and exposition,intravenous injection,intranasal administration,and subcutaneous administration[3]. 展开更多
关键词 tuberculosis DRUGS injection
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Interferon-gamma release assays as a tool for differential diagnosis of gastrointestinal tuberculosis
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作者 Tsvetelina Velikova Anita Aleksandrova 《World Journal of Clinical Cases》 SCIE 2024年第27期6015-6019,共5页
In this editorial,we comment on an article published in a recent issue of the World Journal of Clinical Cases.There is a pressing need for reliable tools for diagnosing tuberculosis(TB)of the gastrointestinal tract.De... In this editorial,we comment on an article published in a recent issue of the World Journal of Clinical Cases.There is a pressing need for reliable tools for diagnosing tuberculosis(TB)of the gastrointestinal tract.Despite advancements in the diagnosis and treatment,TB remains a global health challenge.Ali et al demon-strated that TB may mimic gastrointestinal conditions,such as gastric outlet obstruction,causing a delay in the diagnosis.Furthermore,the latter complication is frequently observed during infections,including Helicobacter pylori,and rarely is related to TB,as in the presented case.In line with this,we think that laboratory tests based on interferon-gamma release assays can be a helpful tool for diagnosing latent TB paced in the gastrointestinal tract.Innovative strategies and approaches for diagnosing latent/active extra pulmonary TB are crucial for establishing the diagnosis early and enhancing treatment strategies to mitigate the global burden of TB. 展开更多
关键词 tuberculosis Gastrointestinal tuberculosis Interferon-gamma release assay IGRA Primary gastroduodenal tuberculosis Gastric outlet obstruction Case report
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Differential diagnosis of Crohn’s disease and intestinal tuberculosis based on ATR-FTIR spectroscopy combined with machine learning
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作者 Yuan-Peng Li Tian-Yu Lu +5 位作者 Fu-Rong Huang Wei-Min Zhang Zhen-Qiang Chen Pei-Wen Guang Liang-Yu Deng Xin-Hao Yang 《World Journal of Gastroenterology》 SCIE CAS 2024年第10期1377-1392,共16页
BACKGROUND Crohn’s disease(CD)is often misdiagnosed as intestinal tuberculosis(ITB).However,the treatment and prognosis of these two diseases are dramatically different.Therefore,it is important to develop a method t... BACKGROUND Crohn’s disease(CD)is often misdiagnosed as intestinal tuberculosis(ITB).However,the treatment and prognosis of these two diseases are dramatically different.Therefore,it is important to develop a method to identify CD and ITB with high accuracy,specificity,and speed.AIM To develop a method to identify CD and ITB with high accuracy,specificity,and speed.METHODS A total of 72 paraffin wax-embedded tissue sections were pathologically and clinically diagnosed as CD or ITB.Paraffin wax-embedded tissue sections were attached to a metal coating and measured using attenuated total reflectance fourier transform infrared spectroscopy at mid-infrared wavelengths combined with XGBoost for differential diagnosis.RESULTS The results showed that the paraffin wax-embedded specimens of CD and ITB were significantly different in their spectral signals at 1074 cm^(-1) and 1234 cm^(-1) bands,and the differential diagnosis model based on spectral characteristics combined with machine learning showed accuracy,specificity,and sensitivity of 91.84%,92.59%,and 90.90%,respectively,for the differential diagnosis of CD and ITB.CONCLUSION Information on the mid-infrared region can reveal the different histological components of CD and ITB at the molecular level,and spectral analysis combined with machine learning to establish a diagnostic model is expected to become a new method for the differential diagnosis of CD and ITB. 展开更多
关键词 Infrared spectroscopy Machine learning Intestinal tuberculosis Crohn’s disease Differential diagnosis Inflammatory bowel disease
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Addison's disease caused by adrenal tuberculosis may lead to misdiagnosis of major depressive disorder: A case report
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作者 Tian-Xiang Zhang Hong-Yan Xu +1 位作者 Wei Ma Jian-Bao Zheng 《World Journal of Clinical Cases》 SCIE 2024年第1期217-223,共7页
BACKGROUND Addison’s disease(AD)is a rare but potentially fatal disease in Western countries,which can easily be misdiagnosed at an early stage.Severe adrenal tuberculosis(TB)may lead to depression in patients.CASE S... BACKGROUND Addison’s disease(AD)is a rare but potentially fatal disease in Western countries,which can easily be misdiagnosed at an early stage.Severe adrenal tuberculosis(TB)may lead to depression in patients.CASE SUMMARY We report a case of primary adrenal insufficiency secondary to adrenal TB with TB in the lungs and skin in a 48-year-old woman.The patient was misdiagnosed with depression because of her depressed mood.She had hyperpigmentation of the skin,nails,mouth,and lips.The final diagnosis was adrenal TB that resulted in the insufficient secretion of adrenocortical hormone.Adrenocortical hormone test,skin biopsy,T cell spot test of TB,and adrenal computed tomography scan were used to confirm the diagnosis.The patient’s condition improved after hormone replacement therapy and TB treatment.CONCLUSION Given the current status of TB in high-burden countries,outpatient doctors should be aware of and pay attention to TB and understand the early symptoms of AD. 展开更多
关键词 Primary adrenal insufficiency Adrenal tuberculosis Fatigue HYPOTENSION HYPERKALEMIA HYPONATREMIA Depression Case report
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psk1 virulence gene-induced pulmonary and systemic tuberculosis in a young woman with normal immune function:A case report
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作者 Fan Wu Bin Yang +6 位作者 Yan Xiao Li-Li Ren Hong-Yi Chen Xin-Lan Hu Yan-Yu Pan Yu-Sheng Chen Hong-Ru Li 《World Journal of Clinical Cases》 SCIE 2024年第35期6826-6833,共8页
BACKGROUND Tuberculosis is a chronic infectious disease and an important public health pro-blem.Despite progress in controlling tuberculosis,the incidence of tuberculosis in China is still very high,with 895000 new ca... BACKGROUND Tuberculosis is a chronic infectious disease and an important public health pro-blem.Despite progress in controlling tuberculosis,the incidence of tuberculosis in China is still very high,with 895000 new cases annually.This case report des-cribes the investigation of a case of severe disseminated tuberculosis in a young adult with normal immune function,conducted to ascertain why a Mycobacterium tuberculosis(M.tuberculosis)strain caused such severe disease.CASE SUMMARY A previously healthy 28-year-old woman presented to our hospital with a 1-mo-nth history of fever and fatigue.She was diagnosed with severe disseminated pulmonary tuberculosis,spinal tuberculosis with paravertebral abscesses,and tuberculous meningitis.M.tuberculosis was isolated from bronchoal-veolar lavage fluid.She was treated with standard antituberculous therapy and underwent debridement,bone graft,and internal fixation surgery for spinal tuberculosis.She responded to therapy and regained her ability to walk following the surgery.We analysed the whole-genome sequence of the strain and designated it BLM-A21.Additional M.tuberculosis genomes were selected from the Virulence Factor Database(http://www.mgc.ac.cn/cgi-bin/VFs/genus.cgi?Genus=Mycobacterium)for comparison.An evolutionary tree of the BLM-A21 strain was built using PhyML maximum likelihood software.Further gene analysis revealed that,except for the pks1 gene,BLM-A21 had similar virulence genes to the CDC 1551 and H37Rv strains,which have lower dissemination.CONCLUSION We speculate that the pks1 virulence gene in BLM-A21 may be the key virulence gene responsible for the wide-spread dissemination of M.tuberculosis infection in this previously healthy adult with normal immune function. 展开更多
关键词 Mycobacterium tuberculosis Disseminated tuberculosis Spinal tuberculosis Tuberculous meningitis Virulence gene Whole-genome sequencing Case report
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Symptomatic bradycardia in tuberculosis-related giant bullae(vanishing lung syndrome):A case report
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作者 Reynard Laysandro Jessie Julian Mila Meha +2 位作者 Resley Ongga Mulia Mikha Nazamta Yusfiatuzzahra 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2024年第9期425-428,共4页
Rationale:Vanishing lung syndrome is rare and can be associated with a history of smoking and marijuana use.The occurrence of giant bullae can also be linked to infections,particularly tuberculosis in tropical countri... Rationale:Vanishing lung syndrome is rare and can be associated with a history of smoking and marijuana use.The occurrence of giant bullae can also be linked to infections,particularly tuberculosis in tropical countries.Patient concerns:A 26-year-old male complained of weakness,severe vomiting,and reduced breathlessness when lying on the left side.He had a history of pulmonary tuberculosis two years ago.Diagnosis:Symptomatic bradycardia in tuberculosis-related giant bullae.Interventions:The patient was recommended to undergo an elective bullectomy,but he decided not to proceed with the procedure.Atropine sulfate was administered to alleviate symptoms of bradycardia,while a standardized anti-tuberculosis regimen were started for the next six months.Outcomes:Following 7 days of intensive care treatment involving antituberculosis medications and atropine sulfate,the patient achieved hemodynamic stability,opting against bullectomy despite residual symptoms of dyspnea.Subsequent six months of antituberculosis therapy notably alleviated symptoms without requiring bullectomy.Lessons:Increasing intrathoracic pressure can also be caused mechanically by giant bullae.Cardiac symptoms in vanishing lung syndrome are reversible and can be alleviated once the underlying cause is addressed.In this case,symptomatic bradycardia was reduced only with tuberculosis treatment without bullectomy intervention。 展开更多
关键词 BRADYCARDIA Infected giant bullae tuberculosis Vanishing lung syndrome
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Macrophage polarization or repolarization in tuberculosis
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作者 Arijeet Samanta Sangita Maity +2 位作者 Raghunath Hazra Adithyan Jayaraman Santanu Kar Mahapatra 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2024年第10期435-444,共10页
Tuberculosis caused by Mycobacterium(M.)tuberculosis remains a global public health threat.Over the last few decades,anti-tubercular research mainly focused on mechanisms of identifying by which activated macrophages ... Tuberculosis caused by Mycobacterium(M.)tuberculosis remains a global public health threat.Over the last few decades,anti-tubercular research mainly focused on mechanisms of identifying by which activated macrophages can slaughter or the proliferation of M.tuberculosis bacilli prevented in a cell-dependent manner.In this regard,for disease resolution,inflammatory cytokines are very crucial.Here,we demonstrate how macrophages act as the first line of defense against the M.tuberculosis.Studies have revealed a dual role in M.tuberculosis infection played by macrophages.It is worth mentioning that the macrophages are the crucial immune effector and antigen-presenting cells that play the anti-tubercular response,which is the habitat of M.tuberculosis,hence,followed by progressing the disease protecting M.tuberculosis.This dual role can be correlated with the different macrophage polarization statuses,namely,M1 and M2.Herein,we have stated how the several polarization conditions of macrophages are directly linked to the immune responses during host and M.tuberculosis pathogen interactions.We have proposed that macrophage polarization and repolarization are of paramount significance for the anti-tubercular immune response that may involve a sterile cure of the disease.This article summarizes the immune response to M.tuberculosis,the polarization states of macrophages during M.tuberculosis and the repolarization of macrophages by some agents during some diseases including M.tuberculosis,which may be an important factor in the World Health Organization's target to cure tuberculosis by 2035. 展开更多
关键词 tuberculosis Macrophage polarization Effector responses Antitubercular immune response
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Identification of pathological characteristics in pulmonary tuberculosis using polarization-sensitive optical coherence tomography
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作者 Yun Ding Zhuoqun Yuan +3 位作者 Xiaojiang Zhao Guozheng Gao Xin Li Yanmei Liang 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第6期97-106,共10页
The low detection rate of Mycobacterium tuberculosis in clinical practice leads to a high rate of missed diagnosis for pulmonary tuberculosis(PTB).As a noninvasive,high-resolution,real-time imaging technology,polariza... The low detection rate of Mycobacterium tuberculosis in clinical practice leads to a high rate of missed diagnosis for pulmonary tuberculosis(PTB).As a noninvasive,high-resolution,real-time imaging technology,polarization-sensitive optical coherence tomography(PS-OCT)may be feasible for the rapid identification of pathological feature.This study aimed to explore the feasibility of using PS-OCT to identify pathological features of PTB.In the experiments,PTB samples containing some surrounding lung tissues were imaged using PS-OCT.It is demonstrated that PS-OCT images showed good consistency with the corresponding pathological images and were able to identify PTB-related characteristic pathological regions.We think PS-OCT can serve as an effective supplement for the diagnosis of PTB,enabling rapid and accurate diagnosis,and aiding in the understanding of the pathological characteristics and pathophysiological processes of PTB. 展开更多
关键词 Pulmonary tuberculosis PS-OCT pathological features.
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Revisiting tuberculosis as a cause of gastric outlet obstruction:Insights from a case report
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作者 Jin Meng Li-Mei Zhang +10 位作者 Zhi-Gang Wang Xiu Zhao Hai-Xia Bai Ying Wang De-Yu Chen De-Long Liu Cheng-Chun Ji Yuan Liu Lei Wang Bo-Yang Li Zhi-Tao Yin 《World Journal of Clinical Cases》 SCIE 2024年第32期6563-6565,共3页
Gastroduodenal tuberculosis(GD-TB)is exceptionally rare.The clinical manifestations of gastrointestinal TB are diverse and non-specific,which makes diagnosis difficult,leading to delayed diagnosis and high mortality.A... Gastroduodenal tuberculosis(GD-TB)is exceptionally rare.The clinical manifestations of gastrointestinal TB are diverse and non-specific,which makes diagnosis difficult,leading to delayed diagnosis and high mortality.As a peer-reviewer of World Journal of Clinical Cases,I would like to share my opinion on the article published by this journal.The patient had no family history of TB or contact with people with TB.Primary GD-TB presenting as gastric outlet obstruction and normal findings of thoracic computed tomography increased the difficulty of diagnosis and treatment in this patient.The diagnosis and treatment scheme of this typical case have reference value for the clinical treatment of GD-TB. 展开更多
关键词 tuberculosis Gastrointestinal tuberculosis Gastric outlet obstruction Gastroduodenal tuberculosis X pert Interferon-γrelease assay
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