Optimal choice of stapler and digestive tract reconstruction method after distal gastrectomy for gastric cancer:A prospective case–control study

BACKGROUND Gastric cancer is the most common cause of cancer-related deaths,and is classified according to its location in the proximal,middle,or distal stomach.Surgical resection is the primary approach for treating gastric cancer.This prospective study aimed to determine the best reconstruction method after distal gastrectomy for gastric cancer.AIM To explore the efficacy of different staplers and digestive tract reconstruction(DTR)methods after radical gastrectomy and their influence on prognosis.METHODS Eighty-seven patients who underwent radical gastrectomy for distal gastric cancer at our institution between April 2017 and April 2020 were included in this study,with a follow-up period of 12-26 mo.The patients were assigned to four groups based on the stapler and DTR plan as follows:BillrothⅠ(B-I)reconstruction+linear stapler group(group A,22 cases),B-I reconstruction+circular stapler group(group B,22 cases),Billroth II(B-II)reconstruction+linear stapler group(group C,22 cases),and B-II reconstruction+circular stapler group(group D,21 cases).The pathological parameters,postoperative gastrointestinal function recovery,postoperative complications,and quality of life(QOL)were compared among the four groups.RESULTS No significant differences in the maximum diameter of the gastric tumors,total number of lymph nodes dissected,drainage tube removal time,QLQ(QOL questionnaire)-C30 and QLQ-STO22 scores at 1 year postoperatively,and incidence of complications were observed among the four groups(P>0.05).However,groups A and C(linear stapler)had significantly lower intraoperative blood loss and significantly shorter anastomosis time,operation time,first fluid diet intake time,first exhaust time,and length of postoperative hospital stay(P<0.05)than groups B and D(circular stapler).CONCLUSION Linear staplers offer several advantages for postoperative recovery.B-I and B-II reconstruction methods had similar effects on QOL.The optimal solution can be selected according to individual conditions and postoperative convenience.

Clinical efficacy and safety of double-channel anastomosis and tubular gastroesophageal anastomosis in gastrectomy

BACKGROUND With the continuous progress of surgical technology and improvements in medical standards,the treatment of gastric cancer surgery is also evolving.Proximal gastrectomy is a common treatment,but double-channel anastomosis and tubular gastroesophageal anastomosis have attracted much attention in terms of surgical options.Each of these two surgical methods has advantages and disadvantages,so it is particularly important to compare and analyze their clinical efficacy and safety.AIM To compare the surgical safety,clinical efficacy,and safety of double-channel anastomosis and tubular gastroesophageal anastomosis in proximal gastrectomy.METHODS The clinical and follow-up data of 99 patients with proximal gastric cancer who underwent proximal gastrectomy and were admitted to our hospital between January 2018 and September 2023 were included in this retrospective cohort study.According to the different anastomosis methods used,the patients were divided into a double-channel anastomosis group(50 patients)and a tubular gastroesophageal anastomosis group(49 patients).In the double-channel anastomosis,Roux-en-Y anastomosis of the esophagus and jejunum was performed after proximal gastric dissection,and then side-to-side anastomosis was performed between the residual stomach and jejunum to establish an antireflux barrier and reduce postoperative gastroesophageal reflux.In the tubular gastroesophageal anastomosis group,after the proximal end of the stomach was cut,tubular gastroplasty was performed on the distal stump of the stomach and a linear stapler was used to anastomose the posterior wall of the esophagus and the anterior wall of the stomach tube.The main outcome measure was quality of life 1 year after surgery in both groups,and the evaluation criteria were based on the postgastrectomy syndrome assessment scale.The greater the changes in body mass,food intake per meal,meal quality subscale score,and total measures of physical and mental health score,the better the condition;the greater the other indicators,the worse the condition.The secondary outcome measures were intraoperative and postoperative conditions,the incidence of postoperative long-term complications,and changes in nutritional status at 1,3,6,and 12 months after surgery.RESULTS In the double-channel anastomosis cohort,there were 35 males(70%)and 15 females(30%),33(66.0%)were under 65 years of age,and 37(74.0%)had a body mass index ranging from 18 to 25 kg/m2.In the group undergoing tubular gastroesophageal anastomosis,there were eight females(16.3%),21(42.9%)individuals were under the age of 65 years,and 34(69.4%)had a body mass index ranging from 18 to 25 kg/m2.The baseline data did not significantly differ between the two groups(P>0.05 for all),with the exception of age(P=0.021).The duration of hospitalization,number of lymph nodes dissected,intraoperative blood loss,and perioperative complication rate did not differ significantly between the two groups(P>0.05 for all).Patients in the dual-channel anastomosis group scored better on quality of life measures than did those in the tubular gastroesophageal anastomosis group.Specifically,they had lower scores for esophageal reflux[2.8(2.3,4.0)vs 4.8(3.8,5.0),Z=3.489,P<0.001],eating discomfort[2.7(1.7,3.0)vs 3.3(2.7,4.0),Z=3.393,P=0.001],total symptoms[2.3(1.7,2.7)vs 2.5(2.2,2.9),Z=2.243,P=0.025],and other aspects of quality of life.The postoperative symptoms[2.0(1.0,3.0)vs 2.0(2.0,3.0),Z=2.127,P=0.033],meals[2.0(1.0,2.0)vs 2.0(2.0,3.0),Z=3.976,P<0.001],work[1.0(1.0,2.0)vs 2.0(1.0,2.0),Z=2.279,P=0.023],and daily life[1.7(1.3,2.0)vs 2.0(2.0,2.3),Z=3.950,P<0.001]were all better than those of the tubular gastroesophageal anastomosis group.The group that underwent tubular gastroesophageal anastomosis had a superior anal exhaust score[3.0(2.0,4.0)vs 3.5(2.0,5.0),Z=2.345,P=0.019]compared to the dual-channel anastomosis group.Hemoglobin,serum albumin,total serum protein,and the rate at which body mass decreased one year following surgery did not differ significantly between the two groups(P>0.05 for all).CONCLUSION The safety of double-channel anastomosis in proximal gastric cancer surgery is equivalent to that of tubular gastric surgery.Compared with tubular gastric surgery,double-channel anastomosis is a preferred surgical technique for proximal gastric cancer.It offers advantages such as less esophageal reflux and improved quality of life.

Digestive tract reconstruction pattern as a determining factor in postgastrectomy quality of life

Postgastrectomy quality of life (QoL) is affected by various symptoms, and compared with the preoperative baseline QoL, is typically impaired for the first 6 mo after surgery. Thereafter, improvement to a stable QoL is observed at approximately 12 mo postoperatively. We consider the digestive tract reconstruction pattern to be a determining factor in postgastrectomy QoL among gastric cancer patients, and believe it requires further discussion. Proximal gastrectomy is associated with the worst postoperative QoL among gastrectomy procedures and should be performed cautiously. The trend of better QoL provided by the pouch procedure of total gastrectomy requires further robust support. Whether the use of Billroth-I gastroduodenostomy or Roux-en-Y gastrojejunostomy for distal gastrectomy is optimal remains controversial, but Roux-en-Y gastrojejunostomy is likely to be preferable. (c) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

Digestive tract reconstruction options after laparoscopic gastrectomy for gastric cancer

In addition to the popularity of laparoscopic gastrectomy(LG),many reconstructive procedures after LG have been reported.Surgical resection and lymphatic dissection determine long-term survival;however,the election of a reconstruction procedure determines the postoperative quality of life for patients with gastric cancer(GC).Presently,no consensus exists regarding the optimal reconstructive procedure.In this review,the current state of digestive tract reconstruction after LG is reviewed.According to the determining influence of the tumor site on the procedures of surgical resection and reconstruction,we divide these reconstruction procedures into three categories consistent with the resection procedures.We focus on the technical tips of every reconstruction procedure and examine the surgical outcomes(length of surgery and blood loss)and postoperative complications(anastomotic leakage and stricture)to facilitate gastrointestinal surgeons to understand the merits and demerits of every reconstruction procedure.

两种腔内吻合方法在机器人辅助远端胃切除术后毕Ⅱ式消化道重建中的应用比较

目的:初步探讨两种腔内吻合方法在机器人辅助远端胃切除术后毕Ⅱ式消化道重建中的安全性及优缺点。方法:回顾性分析2019年11月—2021年9月在南京中医药大学附属医院普外科行达芬奇机器人辅助远端胃癌根治术的64例患者的临床资料。根据吻合方法不同将其分为手工缝合吻合组(n=35)和器械辅助吻合组(n=29)。收集患者围手术期的临床资料,对比两种吻合方法在机器人辅助远端胃切除术后毕Ⅱ式消化道重建中的优缺点。结果:64例患者均顺利完成手术,所有患者均在机器人镜下完成腔内消化道重建,无中转开腹。两组患者在手术时间、术中出血量、术后首次肛门排气时间、术后首次下床活动时间、术后首次进食流质时间及术后住院时间方面无明显统计学差异。器械辅助吻合组胃肠吻合时间较手工缝合吻合组短,而手工缝合吻合组的吻合耗材费用较低,差异具有统计学意义。两组患者术后均恢复良好,无并发症发生。结论:两种腔内吻合方法在机器人辅助远端胃切除术后毕Ⅱ式消化道重建中的应用都是安全可行的,器械辅助吻合的时间更短,手工缝合吻合的费用更低。

腹腔镜下远端胃癌切除后消化道不同重建方式对患者预后影响分析

目的:探究腹腔镜下远端胃癌切除后消化道不同重建方式对患者预后的影响。方法:回顾性分析107例腹腔镜下远端胃癌切除后消化道重建患者的临床资料,术后均随访1年。根据患者消化道重建方式不同分为Ⅰ组(n=30)、II组(n=28)和R组(n=49),Ⅰ组采取Billroth-Ⅰ式吻合;Ⅱ组患者采取Billroth-Ⅱ式联合布朗吻合;R组患者采取Roux-en-Y吻合。探究各组围术期情况,比较各组术后3周内及术后1年时并发症发生情况。结果:Ⅰ组患者手术时间低于Ⅱ组及R组(P<0.05);各组患者术后3周内并发症发生率比较,差异均无统计学意义(P>0.05);术后1年,R组患者胆汁反流、反流性胃炎发生率低于Ⅰ组及Ⅱ组(P<0.05)。结论:Billroth-Ⅰ式吻合有助于缩短手术时间,但Roux-en-Y吻合在术后远期效果更具优势。

裤形吻合与RY吻合方式在胃癌全胃切除后的应用价值比较

目的:比较裤形吻合与Roux-en-Y(RY)吻合方式在胃癌全胃切除后的应用价值。方法:选取2020年1月至2023年5月我院收治的行全胃切除术治疗的胃癌患者108例作为研究对象,分为RY吻合组54例、裤形吻合组54例,两组均接受全胃切除术治疗,RY吻合组、裤形吻合组分别于胃癌全胃切除术后以RY吻合方式、裤形吻合方式行消化道重建。比较两组手术指标、术后并发症、营养指标[总蛋白(TP)、血红蛋白(Hb)、血清白蛋白(ALB)及预后营养指数(PNI)]、生命质量(QLQ-C30)及远期不良事件发生率。结果:两组患者手术指标比较无意义(P>0.05)。RY吻合组术中1例由于肠管尺寸原因更换吻合器,RY吻合组术中吻合器更换率高于裤形吻合组,但两组比较无意义(P>0.05)。裤形吻合组术后并发症总发生率低于RY吻合组(P<0.05)。裤形吻合组远期不良事件总发生率低于RY吻合组(P<0.05)。与术前比较,两组患者术后3个月、6个月营养评价指标TP、Hb、ALB、PNI均升高,且随着术后时间的延长逐渐升高(P<0.05),在两组术后指标比较中,裤形吻合组TP、Hb、ALB、PNI高于RY吻合组(P<0.05)。与术前比较,两组患者术后3个月、6个月生命质量QLQ-C30评分均升高,且随着术后时间的延长逐渐升高(P<0.05),在两组术后指标比较中,裤形吻合组生命质量QLQ-C30评分高于RY吻合组(P<0.05)。结论:与RY吻合的胃癌全胃切除后消化道重建方式比较,裤形吻合所带来的并发症较低,且裤形吻合在抗胆汁反流、反流性食管炎、食物排空障碍方面优于RY吻合,患者术后可获得更好的营养支持,患者生命质量显著提高,应用价值较高。

Uncut Roux-en-Y吻合与Billroth Ⅱ+Braun吻合在腹腔镜远端胃癌根治术中的疗效比较

目的评价腹腔镜远端胃癌根治术Uncut Roux-en-Y、BillrothⅡ+Braun这两类消化道重建途径的临床效果.方法回顾性分析江苏省苏北人民医院胃肠中心2020年1月—2022年4月治疗的102名腹腔镜远端胃癌根治术(LDG)病人的临床资料.其中42人采用Uncut Roux-en-Y吻合术,被归入URY组,60人采用BillrothⅡ联合Braun吻合术,被归入B2B组.对比两组研究对象的基本信息、围手术期相关参数、术后近期并发症与营养情况,以及术后12个月胃镜检查结果,同时采用QLQ-STO 22量表对其术后生活质量展开评估.结果两组皆顺利完成LDG手术,无1例中转开腹与围术期死亡情况.两组在手术用时、吻合时间、术中出血量、术后首次排气时间、进食流质时间、拔除引流管时间、术后住院天数上,差异无统计学意义(P>0.05).两组在术后近期并发症(含吻合口瘘、十二指肠残端瘘、切口感染、肠梗阻等)发生率上,差异无统计学意义(P>0.05).随访1年,URY组1例患者出现肝转移;B2 B组2例出现肿瘤复发,其中1例为肝转移,另1例并发腹腔广泛转移死亡.术后1年91例完成胃镜检查,其中URY组37例,B2 B组54例.URY组出现胃潴留5例(13.5%),B2 B组18例(33.3%),差异有统计学意义(χ^(2)=4.567,P=0.033);发生胆汁反流分别有3例(8.1%)、16例(29.6%),差异有统计学意义(χ^(2)=6.156,P=0.013);发生反流性胃炎分别为1例(2.7%)、12例(22.2%),差异有统计学意义(χ^(2)=6.832,P=0.009);发生反流性食管炎分别为1例(2.7%)、3例(5.6%),差异无统计学意义(χ^(2)=0.017,P=0.895).术后1年评估病人营养情况,两组血淋巴细胞计数(LC)、血红蛋白(Hb)、总蛋白(TP)、血清白蛋白(Alb)、预后营养指数(PNI)等指标比较,无明显统计学差异(P>0.05).术后1年64例完成胃癌(GC)病人生活质量调查问卷(QLQ-STO 22),URY组28例,B2B组36例.结果显示与B2B组比较,URY组减少了反流,差异有统计学意义(P<0.05).结论Uncut Roux-en-Y吻合术减少了胃潴留、胆汁反流和反流性胃炎的发生,改善了患者的生活质量.Uncut Roux-en-Y吻合术途径在LDG消化道重建方面为理想之选.

保留胃窦的调节型双通道消化道重建术对进展期胃癌患者肿瘤标志物水平及营养状态的影响

目的 探讨保留胃窦的调节型双通道消化道重建术对进展期胃癌患者肿瘤标志物水平及营养状态的影响。方法 选取2020年1月至2023年1月收治的100例进展期胃癌患者,将其随机分为对照组和观察组,各50例。对照组采用全胃切除Roux-en-Y吻合术,观察组采用保留胃窦的调节型双通道消化道重建术。比较两组的治疗效果。结果 术后2周,观察组的癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、糖类抗原72-4(CA72-4)水平低于对照组(P<0.05)。术后2周,观察组的前白蛋白(PA)、白蛋白(ALB)、铁蛋白(SF)水平高于对照组(P<0.05)。术后2周,两组的胃泌素(GAS)、胆囊收缩素(CCK)水平均降低,但观察组高于对照组(P<0.05)。观察组的并发症总发生率低于对照组(P<0.05)。结论 保留胃窦的调节型双通道消化道重建术用于进展期胃癌患者的效果较好,可下调肿瘤标志物水平,改善营养状态。

全胃切除调节型双通道间置空肠消化道重建术对进展期胃癌患者胃肠屏障功能及营养状态的影响

目的探讨全胃切除调节型双通道间置空肠消化道重建术对进展期胃癌患者胃肠屏障功能及营养状态的影响。方法选取2019年1月至2022年1月我院收治的40例进展期胃癌患者为研究对象,根据术式不同将其分为对照组和观察组,各20例。对照组采用全胃切除Roux-en-Y吻合消化道重建术治疗,观察组采用全胃切除调节型双通道间置空肠消化道重建术治疗。比较两组的治疗效果。结果术后,观察组的D-乳酸、二胺氧化酶(DAO)、内毒素(ETX)水平低于对照组(P<0.05)。术后,观察组的胆囊收缩素水平、胆囊排空率、胆囊容积优于对照组(P<0.05)。术后,观察组的白蛋白(ALB)、前白蛋白(PA)、血清铁蛋白(SF)水平高于对照组(P<0.05)。观察组的术后并发症总发生率低于对照组(P<0.05)。结论全胃切除调节型双通道间置空肠消化道重建术可改善进展期胃癌患者的胃肠屏障功能、胆囊收缩功能及营养状态,降低术后并发症发生率,值得推广。

毕Ⅰ式吻合术与ROUX-en-Y吻合术在全腹腔镜远端胃癌根治术消化道重建中的效果

目的:比较毕Ⅰ式吻合术与ROUX-en-Y吻合术在全腹腔镜远端胃癌根治术消化道重建中的应用效果。方法:选取2022年1月—2023年12月于甘肃省武威肿瘤医院行全腹腔镜远端胃癌根治术的胃癌患者120例作为研究对象,随机分为对照组和研究组,各60例。对照组采用毕Ⅰ式吻合术进行消化道重建,研究组采用ROUX-en-Y吻合术进行消化道重建。比较两组围术期指标、并发症发生情况、术后疼痛情况及炎性因子水平。结果:研究组术中出血量少于对照组,首次排气时间早于对照组,住院时间短于对照组,差异有统计学意义(P<0.05);两组手术时间比较,差异无统计学意义(P>0.05);研究组并发症总发生率低于对照组,差异有统计学意义(P=0.030);术后12h、24h、48h,研究组视觉模拟评分法评分低于对照组,差异有统计学意义(P<0.001);术后,两组白细胞介素-6、C反应蛋白水平升高,研究组低于对照组,差异有统计学意义(P<0.05)。结论:全腹腔镜远端胃癌根治术消化道重建中采用ROUX-en-Y吻合术较毕Ⅰ式吻合术效果更佳,能降低术中出血量,缩短术后恢复时间,降低并发症发生率,减轻疼痛,缓解炎性反应。

全腹腔镜下远端胃癌根治术治疗高龄胃癌患者的疗效观察

目的:探讨全腹腔镜下远端胃癌根治术治疗高龄胃癌患者的临床疗效。方法:选取2019年1月至2021年12月期间在我院接受腹腔镜下胃癌根治术的高龄胃癌患者(≥70岁)作为研究对象,经倾向性匹配后根据手术方式分为观察组与对照组,其中观察组接受全腹腔镜下远端胃癌根治术(40例),对照组接受腹腔镜辅助远端胃癌根治术(80例)。比较两组患者的手术近期疗效、术后并发症、免疫功能变化、生活质量与生存情况。结果:与对照组相比,观察组患者的术后并发症发生率相近(10%vs 23%,P=0.095),但首次下床时间、首次排气时间与术后住院时间均显著较短,差异具有统计学意义(P<0.05)。另外,观察组患者术后1周的WBC与CRP水平明显低于对照组,而CD3^(+)、CD4^(+)与CD4^(+)/CD8^(+)水平明显高于对照组。对比两组患者术后6个月的生活质量,观察组的疼痛、便秘评分明显优于对照组,差异具有统计学意义(P<0.05)。术后随访均未发现肿瘤局部复发病例。结论:与传统的腹腔镜辅助手术相比,全腹腔镜下远端胃癌根治术治疗高龄胃癌患者具有术后恢复快、对免疫功能影响小、并发症少、生活质量高等优点,值得进一步推广应用。

Comparison of long-term quality of life between Billroth-I and Roux-en-Y anastomosis after distal gastrectomy for gastric cancer: a randomized controlled trial

Background:The results of studies comparing Billroth-I(B-I)with Roux-en-Y(R-Y)reconstruction on the quality of life(QoL)are still inconsistent.The aim of this trial was to compare the long-term QoL of B-I with R-Y anastomosis after curative distal gastrectomy for gastric cancer.Methods:A total of 140 patients undergoing curative distal gastrectomy with D2 lymphadenectomy in West China Hospital,Sichuan University from May 2011 to May 2014 were randomly assigned to the B-I group(N=70)and R-Y group(N=70).The follow-up time points were 1,3,6,9,12,24,36,48,and 60 months after the operation.The final follow-up time was May 2019.The clinicopathological features,operative safety,postoperative recovery,long-term survival as well as QoL were compared,among which QoL score was the primary outcome.An intention-to-treat analysis was applied.Results:The baseline characteristics were comparable between the two groups.There were no statistically significant differences in terms of postoperative morbidity and mortality rates,and postoperative recovery between the two groups.Less estimated blood loss and shorter surgical duration were found in the B-I group.There were no statistically significant differences in 5-year overall survival(79%[55/70]of the B-I group vs.80%[56/70]of the R-Y group,P=0.966)and recurrence-free survival rates(79%[55/70]of the B-I group vs.78%[55/70]of the R-Y group,P=0.979)between the two groups.The scores of the global health status of the R-Y group were higher than those of the B-I group with statistically significant differences(postoperative 1 year:85.4±13.1 vs.88.8±16.1,P=0.033;postoperative 3 year:87.3±15.2 vs.92.8±11.3,P=0.028;postoperative 5 year:90.9±13.7 vs.96.4±5.6,P=0.010),and the reflux(postoperative 3 year:8.8±12.9 vs.2.8±5.3,P=0.001;postoperative 5 year:5.1±9.8 vs.1.8±4.7,P=0.033)and epigastric pain(postoperative 1 year:11.8±12.7 vs.6.1±8.8,P=0.008;postoperative 3 year:9.4±10.6 vs.4.6±7.9,P=0.006;postoperative 5 year:6.0±8.9 vs.2.7±4.6,P=0.022)were milder in the R-Y group than those of the B-I group at the postoperative 1,3,and 5-year time points.Conclusions:Compared with B-I group,R-Y reconstruction was associated with better long-term QoL by reducing reflux and epigastric pain,without changing survival outcomes.Trial Registration:ChiCTR.org.cn,ChiCTR-TRC-10001434.

非离断式Roux-en-Y吻合术在胃癌消化道重建中的应用效果及对胃肠道屏障功能、胆囊收缩功能的影响

目的探讨非离断式Roux-en-Y吻合术在胃癌消化道重建中的应用效果及对胃肠道屏障功能、胆囊收缩功能的影响。方法选取2020年2月至2022年2月收治的40例行胃癌消化道重建手术患者,按照吻合方法不同将其分为对照组和观察组,各20例。对照组采用传统Roux-en-Y吻合术,观察组采用非离断式Roux-en-Y吻合术。比较两组的治疗效果。结果术后1 d,观察组的血浆D-乳酸、二胺氧化酶(DAO)水平均低于对照组(P<0.05)。术后,观察组的双歧杆菌、乳杆菌、拟杆菌数量多于对照组(P<0.05)。术后1 d,观察组的胆囊收缩素水平低于对照组,胆囊容积、胆囊排空率高于对照组(P<0.05)。观察组的并发症总发生率低于对照组(P<0.05)。结论非离断式Roux-en-Y吻合术应用于胃癌消化道重建中有助于改善患者的胃肠道屏障功能、胃肠道微生态平衡及胆囊收缩功能,减少并发症发生。

不同胃肠吻合方式在全3D腹腔镜远端胃切除术后消化道重建中的应用

目的探讨不同胃肠吻合方式在胃癌患者全3D腹腔镜远端胃切除术后消化道重建中的应用价值。方法选取2019年2月至2021年2月江苏无锡江南大学附属医院收治的142例进展期胃癌患者,均行全3D腹腔镜远端胃切除术,根据消化道重建方式的不同分为R组(76例,行非离断式Roux-en-Y吻合术)和B组(66例,行BillrothⅡ式吻合术)。比较两组的围术期相关指标、术后1年的营养指标及生活质量(采用Visick分级进行评估)、术后并发症发生情况等。结果与B组相比,R组的消化道重建时间更长,术后肛门排气时间及术后住院时间更短(P<0.05),而两组的术中出血量、术后首次进食时间比较差异无显著性(P>0.05)。术后1年时,R组的预后营养指数(prognostic nutritional index,PNI)明显高于B组,生活质量明显优于B组(Visick分级Ⅰ级占比更高,Ⅳ级占比更低),差异均有显著性(P<0.05)。R组术后胆汁反流、倾倒综合征、反流性胃炎等并发症发生率均明显低于B组,差异有显著性(P<0.05)。结论与BillrothⅡ式吻合相比,胃癌患者行全3D腹腔镜远端胃切除术后采用非离断式Roux-en-Y吻合进行消化道重建虽然手术时间较长,但其并发症发生率更低,胃肠功能恢复更快,有助于改善术后生活质量。

近端胃切除抗反流消化道重建方式的研究进展

近端胃癌在中国及部分亚洲国家的发病率呈逐年上升趋势。手术是该疾病最有效、最常用的治疗方式。传统全胃切除术具有较好的根治效果,但术后难以避免营养代谢障碍、生活质量下降等并发症发生。近年来临床开展的近端胃切除术在切除肿瘤组织的同时,保留部分胃组织,有利于改善病人术后营养状况。然而近端胃切除术中破坏食管括约肌和His角,引起残胃反酸、反流,导致反流性食管炎,同样也影响病人的生活质量。为解决反流的问题,临床医师探索不同消化道重建术式,目前有报道的消化道重建方法很多,各有优劣。本文结合相关文献和临床新进展,列举目前常用消化道重建方法,总结其术后生活质量、生存结局相关文献资料,以供临床医师参考和选择。

腹腔镜胃癌根治术消化道重建方式的现状分析

胃癌现为全球第六大肿瘤,系肿瘤致死的第四大原因。胃癌的治疗目前仍以外科手术为主,并为唯一治愈手段。随着1999年第1例腹腔镜远端胃癌根治术的完成,腹腔镜胃癌手术的报道逐年增加,已成为发展趋势。消化道重建作为关键技术难点制约了腹腔镜胃癌根治术尤其全胃切除术的推广。近年来,关于重建方式的报道层出不穷,不同中心学者都分享了不同的技巧和经验,因此,本文就腹腔镜胃癌根治术消化道重建的方式和技巧做一综述。

胃癌根治性切除消化道重建术后Petersen疝11例临床分析

目的 总结胃癌胃切除消化道重建术后发生Petersen疝病人的临床特征,探讨petersen疝的诊断及处理方法。方法 2019年1月~2021年12月我院收治的Petersen疝病人11例,所有病人均行急诊手术治疗,分析病人的临床表现、影像学特征、围手术期情况及治疗后随访情况。结果 11例病人手术中有7例经小肠复位后血供恢复未行肠切除,1例术中证实小肠坏死行部分小肠切除术,切除长度为80 cm;此8例病人均再次缝合关闭Petersen间隙,术后顺利出院,随访至今均未再出现急性消化道症状或急腹症。3例术中探查证实小肠广泛坏死,其中1例行小肠次全切除术,另2例放弃进一步手术。此3例病人均于术后24小时内死亡。结论 胃癌术后Petersen疝发病急、进展快,预后不良。当急腹症病人疑有该病可能时应尽早进行腹部增强CT并积极早期剖腹探查,以避免肠坏死的发生。

食管胃结合部腺癌腹腔镜经腹-左膈肌路径近端胃加食管下段切除高位消化道重建现状

近年来,随着食管胃结合部腺癌(adenocarcinoma of esophagogastric junction,AEG)的发病率不断上升及早期病例的增加,AEG的手术治疗成为热点问题。由于AEG的解剖位置及肿瘤生物学的特殊性涉及到胸腔和腹腔两个不同的手术领域,在治疗策略的选择上仍然存在较多争议。淋巴结清扫的彻底性和消化道重建的安全性是影响治疗策略选择的关键要素。腹腔镜下经腹食管裂孔路径在完成腹腔淋巴结清扫的同时可保证下纵隔淋巴结清扫的肿瘤学安全性,是治疗食管浸润长度≤4 cm的AEG之首选手术路径。经腹食管裂孔路径操作时,可打开左侧膈肌,将下纵隔空间扩大或将腹部与左侧胸腔直接相通。这样避免传统开胸,增加操作空间和改善手术视野,既可以减轻胸部创伤,又可以更清晰、完整地清扫下纵隔淋巴结,尤其是充足的操作空间和足够的食管游离度可以使纵隔或左侧胸腔内的高位消化道重建变得更安全、可行。本中心将此路径称为经腹-左膈肌(abdominal-left diaphragmatic,ALD)路径。以食管胃侧壁吻合和双肌瓣吻合为代表的功能性消化道重建术式可经ALD路径逐步应用至更高的吻合平面,拓展了消化道重建的适应证。在保证手术安全性的同时,兼顾良好的抗反流效果。

Uncut Roux-en-Y吻合术在腹腔镜远端胃癌根治术消化道重建中的临床应用

目的:探讨非离断(Uncut)Roux-en-Y吻合术在腹腔镜远端胃癌根治术消化道重建中的临床应用。方法:回顾性分析2019年1月-2021年12月在南京医科大学附属无锡第二医院接受远端胃癌根治手术的79例患者的临床资料。根据消化道重建方式的不同分为对照组(n=30)和观察组(n=49)。对照组行Roux-en-Y吻合术,观察组行Uncut Roux-en-Y吻合术。比较两组围手术期情况和并发症,术后3个月Roux-en-Y滞留综合征(RSS)、残胃炎和胆汁反流发生率及营养状况。结果:与对照组比较,观察组消化道重建时间、首次排气时间均明显缩短,差异均有统计学意义(P<0.05)。两组围手术期并发症发生率比较,差异无统计学意义(P>0.05)。术后3个月,观察组RSS、残胃炎和胆汁反流发生率均明显低于对照组,差异均有统计学意义(P<0.05)。术后3个月,观察组总蛋白、白蛋白和血红蛋白水平均高于对照组,差异均有统计学意义(P<0.05)。结论:Uncut Roux-en-Y吻合术能够缩短消化道重建时间,降低术后RSS、残胃炎和胆汁反流发生率,改善营养状况。