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Innovation and Practice of Training Mode for Professional Postgraduates of Acupuncture and Tuina Based on Artificial Intelligence
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作者 Mingjun LIU Xiaochao GANG +10 位作者 Zhengri CONG Junhao HU Jianfeng LIANG Chongwen ZHONG Xinyi YUAN Bing DAI Yuzhe ZHANG Lijie LI Tianyi MU Yiran HAN Chaochao HUA 《Asian Agricultural Research》 2024年第3期46-48,共3页
In view of the common problems of integrating artificial intelligence into the training of postgraduates in Acupuncture and Tuina major,this paper reviews the related research progress both at home and abroad.It puts ... In view of the common problems of integrating artificial intelligence into the training of postgraduates in Acupuncture and Tuina major,this paper reviews the related research progress both at home and abroad.It puts forward the innovative reform paths for integrating artificial intelligence into postgraduate training mode of Acupuncture and Tuina major:construct the teaching staff of artificial intelligence graduate students;innovating artificial intelligence to promote the integration of classics and scientific research;constructing the ideological and political case base of artificial intelligence courses;implementing artificial intelligence platform blended teaching;building a domestic and foreign exchange platform for artificial intelligence.Through practical research in teaching,it has achieved good teaching results and played a good demonstration,leading and radiation role in similar majors in China. 展开更多
关键词 Artificial INTELLIGENCE (AI) ACUPUNCTURE and tuina major PROFESSIONAL POSTGRADUATES Training mode
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Effects of Tuina on Obesity-Induced Insulin Resistance and Cognitive Dysfunction
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作者 Mingjun LIU Xiaochao GANG +9 位作者 Chongwen ZHONG Shaotao CHEN Yuxing TAI Yi TAN Likun ZHENG Zhengri CONG Sixian WANG Peizhe LI Qifan GUAN Yiduo LI 《Medicinal Plant》 CAS 2023年第1期87-89,共3页
This paper discusses the mechanism of insulin resistance in obesity from the research progress of Chinese and Western medicine and its oxidative stress,inflammatory reaction and abnormal lipid metabolism in cognitive ... This paper discusses the mechanism of insulin resistance in obesity from the research progress of Chinese and Western medicine and its oxidative stress,inflammatory reaction and abnormal lipid metabolism in cognitive dysfunction.It also reviews the research progress of massage,one of the external treatment methods of traditional Chinese medicine,in the treatment of insulin resistance and cognitive dysfunction in obesity,in order to provide more new ideas and new ways for clinical diagnosis and treatment of insulin resistance and related cognitive dysfunction caused by obesity. 展开更多
关键词 tuina OBESITY Insulin resistance Cognitive dysfunction
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Promoting Construction of Professional Teacher Team of Acupuncture and Tuina by Artificial Intelligence
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作者 Mingjun LIU Xiaochao GANG +5 位作者 Shaotao CHEN Chongwen ZHONG Chuping WANG Likun ZHENG Zhengri CONG Peizhe LI 《Medicinal Plant》 CAS 2023年第3期85-86,90,共3页
Artificial intelligence is a frontier science for simulating,extending and expanding human intelligence,theoretical methods,technologies and application systems.Through the survey and analysis of the current situation... Artificial intelligence is a frontier science for simulating,extending and expanding human intelligence,theoretical methods,technologies and application systems.Through the survey and analysis of the current situation of the integration of artificial intelligence into the construction of the teacher team,the corresponding research plan and path are formulated,and the artificial intelligence is fully integrated with the construction of the professional teacher team of acupuncture and tuina,and specific practices are carried out.The practical research path includes the construction of the corresponding artificial intelligence education analysis system and platform for the teaching staff,the formulation and practice of artificial intelligence training and training plans for the teaching staff,the daily intelligent education of the teaching staff and the sustainable improvement of lifelong intelligent education literacy.Through this study,it is hoped that the teaching ability and level of acupuncture and tuina teachers will be improved,and more new ideas and methods will be provided for the training and education of acupuncture and tuina professionals. 展开更多
关键词 Artificial intelligence Acupuncture and tuina Construction of professional teacher team
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The Idea and Application of Tuina in the Prevention and Treatment of COVID‑19
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作者 Zhengyu Li 《Chinese Medicine and Culture》 2020年第3期152-157,共6页
While traditional Chinese medicine has displayed a positive and effective role in saving lives of COVID‑19 patients,Tuina,which is an important component in Chinese medicine,has also shown its merits in enhancing the ... While traditional Chinese medicine has displayed a positive and effective role in saving lives of COVID‑19 patients,Tuina,which is an important component in Chinese medicine,has also shown its merits in enhancing the immune function and relieving symptoms in COVID‑19 patients.This article elaborates the long history of Tuina in treating and preventing epidemic diseases and its effect in improving the immune function.It also introduces some special Tuina methods,for instance,sputum drainage by the back‑patting method to enable the discharge of sputum;slant‑scrubbing method applied on the hypochondriac regions to bring the effect of soothing the liver to regulate qi,which may also relieve anxiety of patients with COVID‑19;and spine‑pinching method to enhance human resistance to diseases,which is more suitable for the elderly and for children with mild or common types of COVID‑19 and can also be used for health care and disease prevention among the general population.Tuina methods for children using the common children’s specific Tuina points and manipulations to improve children’s body constitution are also mentioned in the article.Self‑acupoint Tuina for health care,including acupoints for prevention purposes,acupoints for early clinical stage(mild stage)and recovery stage,as well as acupoints for children health care and specific operations,is also illustrated in the article.Moreover,basic exercises for health care,such as eight‑section brocade,Shaolin internal exercises,six‑character formula,and change of tendons,are also presented.In the final analysis,this article is aimed at some ideas and feasible applications of Tuina therapy in the prevention and treatment of COVID‑19,in the hope to provide some worthy experience and introduce methods in preventing and fighting against COVID‑19 to people all over the world. 展开更多
关键词 ACUPOINT COVID‑19 idea and application immune function prevention and treatment special tuina method specific tuina points tuina
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The Idea and Application of Tuina in the Prevention and Treatment of COVID-19
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作者 Zhengyu Li 《Chinese Medicine and Culture》 2019年第1期152-157,共6页
While traditional Chinese medicine has displayed a positive and effective role in saving lives of COVID-19 patients,Tuina,which is an important component in Chinese medicine,has also shown its merits in enhancing the ... While traditional Chinese medicine has displayed a positive and effective role in saving lives of COVID-19 patients,Tuina,which is an important component in Chinese medicine,has also shown its merits in enhancing the immune function and relieving symptoms in COVID-19 patients.This article elaborates the long history of Tuina in treating and preventing epidemic diseases and its effect in improving the immune function.It also introduces some special Tuina methods,lor instance,sputum drainage by the back-patting method to enable the discharge of sputum;slant-scrubbing method applied on the hypochondriac regions to bring the effect of soothing the liver to regulate qi,which may also relieve anxiety of patients with COVID-19;and spine-pinching method to enhance human resistance to diseases,which is more suitable for the elderly and for children with mild or common types of COVID-19 and can also be used for health care and disease prevention among the general population.Tuina methods for children using the common childreifs specific Tuina points and manipulations to improve children’s body constitution are also mentioned in the article.Self-acupoint Tuina for health care,including acupoints for prevention purposes,acupoints for early clinical stage(mild stage)and recovery stage,as well as acupoints for children health care and specific operations,is also illustrated in the article.Moreover,basic exercises for health care,such as eight-section brocade,Shaolin internal exercises,six-character formula,and change of tendons,are also presented.In the final analysis,this article is aimed at some ideas and feasible applications of Tuina therapy in the prevention and treatment of COVID-19,in the hope to provide some worthy experience and introduce methods in preventing and fighting against COVID-19 to people all over the world. 展开更多
关键词 ACUPOINT COV1D-19 idea and application immune function prevention and treatment special tuina method specific tuina points tuina
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Effect of Chinese tuina massage therapy on resting state brain functional network of patients with chronic neck pain 被引量:3
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作者 Hua Zhang Hong Chen +5 位作者 Hao Wang Duoduo Li Baolin Jia Zhongjian Tan Bin Zheng Zhiwen Weng 《Journal of Traditional Chinese Medical Sciences》 2015年第1期60-68,共9页
Objective:Cervical disease,a type of chronic pain,can greatly impact quality of life.Traditional Chinese tuina,a form of therapeutic massage and manipulation,has been shown to be effective in relieving pain and other ... Objective:Cervical disease,a type of chronic pain,can greatly impact quality of life.Traditional Chinese tuina,a form of therapeutic massage and manipulation,has been shown to be effective in relieving pain and other symptoms in patients with chronic neck pain.This study applied functional magnetic resonance imaging (fMRI) to explore the features of the resting state network of patients with chronic neck pain caused by cervical radiculopathy,and how tuina affects the causality between intrinsic brain networks.Methods:Using Granger causality analysis,effective connectivity of brain networks of 10 patients with chronic neck pain was compared with 10 healthy control subjects.Resting state fMRI data were using magnetic resonance scanning.Cervical spondylosis symptom scores were evaluated before and after 4 weeks of tuina therapy.Independent component analysis was applied to extract the specific networks related to sensation,execution,and cognition,including sensorimotor network (SMN),visual network (VN),auditory network (AN),anterior and posterior default mode network (aDMN,pDMN),left frontoparietal network and right frontoparietal network.Results:Compared with the control group,data from the treatment group revealed two major findings:before tuina therapy,SMN had a profound influence on aDMN and AN greatly affected pDMN;however,after 4 weeks of tuina therapy,aDMN and SMN showed reversed causality.Conclusion:Chronic neck pain caused by cervical radiculopathy may influence the DMN,which plays an important role in emotion,cognition,and memory,by stimulating the sensory afferent network.Tuina not only significantly relieves pain and discomfort,but also reverses the causality between aDMN and SMN. 展开更多
关键词 Chronic pain Traditional Chinese tuina Resting state network Independent component analysis Granger causality
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Tuina Therapy of Lumbar Intervertebral Disc Protrusion 被引量:3
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作者 Jiang Weizhuang(Institute of OrthoP. /Trauma China Academy of TraditionalChinese Medicine Beijing 100700, China) 《中国针灸》 CAS CSCD 北大核心 1995年第S2期249-252,共4页
TuinaTherapyofLumbarIntervertebralDiscProtrusion¥JiangWeizhuang(InstituteofOrthoP./TraumaChinaAcademyofTradi... TuinaTherapyofLumbarIntervertebralDiscProtrusion¥JiangWeizhuang(InstituteofOrthoP./TraumaChinaAcademyofTraditionalChineseMedi... 展开更多
关键词 tuina Therapy of Lumbar Intervertebral Disc Protrusion
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A Preliminary Analysis on Tuina (Massage) Mechanism 被引量:1
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作者 Liu Fuhua(Shenyang Western Railway’s Hospital,Shenyang, ) 《中国针灸》 CAS CSCD 北大核心 1995年第S2期357-357,共1页
APreliminaryAnalysisonTuina(Massage)Mechanism¥LiuFuhua(ShenyangWesternRailway'sHospital,Shenyang,)Accordingt... APreliminaryAnalysisonTuina(Massage)Mechanism¥LiuFuhua(ShenyangWesternRailway'sHospital,Shenyang,)Accordingtotheexperienceont... 展开更多
关键词 A Preliminary Analysis on tuina MASSAGE
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Effect of Tuina-SET Sling Exercise Therapy on Analgesic Substances in Serum of Patients with Nonspecific Low Back Pain 被引量:1
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作者 Fan YANG Kun NIU +3 位作者 Binhong YAN Guohui ZHANG Qian NIU Yiqiang XIE 《Medicinal Plant》 CAS 2020年第4期90-92,共3页
[Objectives]This paper aimed to investigate the effect of Tuina combined with sling exercise therapy(SET)and psoas&abdominal training on serum 5-hydroxytryptamine(5-HT)andβ-endorphin(β-EP)levels in patients with... [Objectives]This paper aimed to investigate the effect of Tuina combined with sling exercise therapy(SET)and psoas&abdominal training on serum 5-hydroxytryptamine(5-HT)andβ-endorphin(β-EP)levels in patients with nonspecific low back pain(NLBP).[Methods]Total 46 patients with NLBP who visited the Tuina Department of the First Affiliated Hospital of Hainan Medical University from August 2019 to May 2020 were randomly and evenly divided into control group and treatment group.On the basis of Tuina therapy,the patients in the control group and treatment group were treated with psoas&abdominal training and SET,respectively.After the treatment,the serum 5-HT andβ-EP levels of the patients were detected.[Results]The serum 5-HT andβ-EP levels in the treatment group were significantly improved compared with the control group(P<0.05).[Conclusions]The nerve&muscle reconstruction techniques of Tuina combined with SET or psoas&abdominal training can improve serum 5-HT andβ-EP levels in patients with NLBP. 展开更多
关键词 tuina Sling exercise training(SET) Non-specific low back pain(NLBP) 5-hydroxytryptamine(5-HT) β-endorphin(β-EP)
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Effect of pediatric tuina on hypothalamic metabolites in young rabbits using liquid chromatography-mass spectrometry
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作者 Zhifeng Liu Yi Jiao +7 位作者 Tianyuan Yu Yingqi Zhang Di Liu Hourong Wang Yajing Xu Qian Guan Taotao Lv Jian Shu 《Journal of Traditional Chinese Medical Sciences》 2022年第2期188-196,共9页
Objective: To investigate the changes in the hypothalamic metabolites of lipopolysaccharide(LPS) febrile young rabbits after the treatment with pediatric tuina.Methods: A total of 30 young rabbits were randomly assign... Objective: To investigate the changes in the hypothalamic metabolites of lipopolysaccharide(LPS) febrile young rabbits after the treatment with pediatric tuina.Methods: A total of 30 young rabbits were randomly assigned into three groups: the normal group, the model group, and the tuina group. Both the model group and the tuina group were injected intravenously with LPS. “Six antipyretic manipulations”(pushing Tianmen, pushing Kangong, kneading Taiyang,kneading Erhougaogu, clearing Tianheshui, and pushing Jizhu) were administered 1 h after the LPS injection in the tuina group. The rectal temperatures of the young rabbits were monitored during the experiment to explore the antipyretic effect. Three hours after the injection, the content of interleukin-1β(IL-1β), tumor necrosis factor(TNF)-a, and prostaglandin E;(PGE;) in the serum was detected. In addition, liquid chromatography-mass spectrometry(LC-MS) was used for the hypothalamus metabolomics.Results: Compared with the model group, the rectal temperature of the tuina group was decreased at 2 h and 3 h after the LPS injection(P =.04, P =.03, respectively), and the content of IL-1β, TNF-a, and PGE2was decreased(P =.03, P =.003, and P =.008, respectively). The metabolomics results showed that there were 23 potential biomarkers after the tuina intervention, enriching 27 pathways. Lipid metabolites,especially glycerophospholipids, were a majority of the altered metabolites. The primary metabolic pathways affected by tuina included the arachidonic acid metabolism, the GABAergic synapse, D-glutamine and D-glutamate metabolism, and the glutamatergic synapse.Conclusion: Pediatric tuina reduced the temperature of the febrile rabbits and downregulated the expression of IL-1β, TNF-a, and PGE2, and the antipyretic mechanism may be related to changes in metabolites and metabolic pathways in the hypothalamus. 展开更多
关键词 FEVER Pediatric tuina Metabolomics Liquid chromatography coupled with mass spectrometry HYPOTHALAMUS INTERLEUKIN-1B Tumor necrosis factor-a Prostaglandin E_(2)
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Traditional Chinese medicine ointment combined with tuina therapy in treatment of pain and swelling after total knee arthroplasty
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作者 Liang Xing Hui-Rong Xu +7 位作者 Qing-Lin Wang Hua Kong Hua Zhang Jing Tian Ying Ding Ru-Xin Yang Lei Zhang Bo Jiang 《World Journal of Orthopedics》 2022年第10期932-939,共8页
BACKGROUND The most effective treatment for knee joint pain is total knee arthroplasty(TKA),but the risk of pain and swelling in patients after surgery is high.Ice application,ankle pump exercise and non-steroidal ant... BACKGROUND The most effective treatment for knee joint pain is total knee arthroplasty(TKA),but the risk of pain and swelling in patients after surgery is high.Ice application,ankle pump exercise and non-steroidal anti-inflammatory painkillers are the primary clinical treatments after surgery.However,long-term use of nonsteroidal anti-inflammatory pain relievers can easily cause gastrointestinal damage.Traditional Chinese medicine(TCM)ointments and tuina therapy integrate TCM and manipulation,which effectively promotes the penetration of TCM into the skin lesions,improves local blood circulation and inflammatory reaction and has good long-term effects on patients.AIM To evaluate the efficacy of TCM ointment combined with tuina therapy in the treatment of pain and swelling after TKA.METHODS The randomized controlled clinical trial enrolled 80 patients who underwent TKA via the same procedure.The patients were randomly divided among the treatment group(n=40)and the control group(n=40).The control group was given an analgesia pump in addition to oral painkillers as the postoperative intervention.The treatment group received TCM ointment with tuina therapy in addition to the analgesia pump and oral painkillers in the postoperative period.The following variables were recorded 3 d before surgery and 3 d,7 d and 14 d after surgery:Visual analogue scale(VAS)score;skin temperature;circumferences at 15 cm above and below the patella;maximum active knee flexion angle;and the knee injury and Osteoarthritis Outcome score(KOOS).RESULTS After treatment,VAS was significantly lower in the treatment group than the control group at 7 d(t=7.536,P<0.001)and 14 d(t=8.563,P<0.001).The skin temperature of participants in the treatment group was significantly lower than that in the control group at 7 d(t=2.968,P=0.004)and 14 d(t=4.423,P<0.001).The circumference values of the two positions in the treatment group were lower than those in the control group at 7 d[t=2.315,P=0.023(above);t=2.121,P=0.037(below)]and 14 d[t=2.374,P=0.020(above);t=2.095,P=0.039(below)].After 14 d of treatment,the maximum active knee flexion angle and KOOS of the two groups were significantly improved but were significantly higher in the treatment group(P<0.05 for both).CONCLUSION TCM ointment and tuina therapy have significant advantages over standard care in the treatment of pain and swelling after TKA.This additional treatment may improve knee function but additional studies are needed to confirm our observations. 展开更多
关键词 Traditional Chinese medicine ointment tuina therapy Total knee arthroplasty PAIN SWELLING
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Tuina for treatment of atopic eczema in children under 14 years: A systematic review of randomized controlled trials
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作者 Chunli Lu Xinyan Jin +3 位作者 Darong Wu Sijia Zhu Lily Lai Jianping Liu 《Journal of Traditional Chinese Medical Sciences》 2019年第1期13-25,共13页
Objective:Due to a lack of available effective treatments for atopic eczema (AE),non-pharmaceutical therapy such as Tuina has been frequently sought after as an alternative treatment.We evaluated the benefits and harm... Objective:Due to a lack of available effective treatments for atopic eczema (AE),non-pharmaceutical therapy such as Tuina has been frequently sought after as an alternative treatment.We evaluated the benefits and harms of Tuina for children with AE under 14 years of age.Methods:We searched for randomized controlled trials (RCTs) on Tuina in seven Chinese and English databases from their inception to June 2018.We included children under 14 years of age with AE received Tuina alone or combined with conventional medicine.Two authors independently extracted data and used the Cochrane 'Risk of bias' tool to assess the methodological quality.Effects were presented as relative risk with 95% confidence interval using RevMan 5.3.Data not suitable for statistical pooling were synthesized qualitatively.Results:Nine RCTs involving 1246 children with AE were included.The trials were at unclear or high risk of bias.Tuina manipulation in each trial was different.Compared to usual care,three trials showed greater effects of Tuina alone or combined with usual care for global symptoms and signs improvement,such as itching,and skin lesions.Four trials showed that Tuina had >50% improvement in symptoms and signs.Due to clinical heterogeneity,meta-analysis was not possible.At follow-up of between 4 weeks and 6 months,five trials of Tuina alone or Tuina combined with usual care showed lower rates of relapse compared to usual care alone.Four trials reported no occurrence of severe adverse events.Conclusions:Limited evidence demonstrates that Tuina may improve symptoms and signs of AE and reduce relapse rate in children <14 yrs with AE.Tuina is generally acceptable in these trials.Further well-designed RCTs are warranted to confirm these benefits and to explore safety further. 展开更多
关键词 tuina ATOPIC ECZEMA Non-pharmaceutical therapy PEDIATRICS Systematic review
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Thoughts on the Reform of Ideological and Political Teaching of “Tuina Manipulation”
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作者 Ying Liu Xiaolei Xie Yonghua Zhao 《Journal of Educational Theory and Management》 2020年第2期46-50,共5页
Based on the current problems in the teaching of“Tuina Manipulation”course in our school,and the requirements of ideological and political teaching reform in the background of the new era,on the basis of consulting ... Based on the current problems in the teaching of“Tuina Manipulation”course in our school,and the requirements of ideological and political teaching reform in the background of the new era,on the basis of consulting related literature and experience of actual teaching conditions,exploring the integration of ideological and political education elements into massage An effective way of teaching courses,put forward the ideas of Tuina ideological and political teaching reform.Ultimately,it will achieve the goal of“integrated”teaching of basic tuina courses,professional skills practice,moral quality improvement,comprehensive quality training,and training a group of high-quality and high-level Chinese medicine talents that meet the needs of social development. 展开更多
关键词 tuina technique Ideological and political teaching reform “Integrated”teaching
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Randomized controlled study of Tuina in the treatment of insomnia:A Meta-analysis
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作者 Shao-Wei Yi Xiang-Wen Meng +3 位作者 Si-Jia Liu An-Chen Qiu Jun-Fei Zhu Yi-Ding Fan 《TMR Non-Drug Therapy》 2021年第4期19-24,共6页
Objective:To find out the clinical randomized controlled trials of Tuina in the treatment of insomnia,and to incorporate it into the research results of this subject for meta-analysis.While comparing the clinical effe... Objective:To find out the clinical randomized controlled trials of Tuina in the treatment of insomnia,and to incorporate it into the research results of this subject for meta-analysis.While comparing the clinical effects,we can compare the literature and research related to Tuina treatment of insomnia and other treatments of insomnia,and summarize its characteristics and advantages.Methods:Relevant searches were performed on CNKI,VIP,CBMdisc,WanFang,Embase,Cochrance,PubMed,etc.Find out the effects of related massage therapy on the treatment of insomnia.Clinical Randomized Controlled Medical Research Clinical Trials(RCT).According to the inclusion criteria and exclusion criteria,the literature was screened,and then the included literature was extracted as data after screening.RevMan5.3 software was used to integrate and analyze the data.Results:19 randomized controlled trials that met the criteria were classified as studies,with a total of 1625 patients.The results of Meta-analysis showed that the total effective rate of massage for insomnia(OR=4.20,95%CI:3.00-5.88,P<0.00001),suggesting that the clinical efficacy of Tuina for insomnia is better than traditional Chinese medicine,western medicine,ear point treatment and acupuncture treatment.The difference in experimental effects was statistically significant,and no adverse reactions were found.Conclusion:The use of Tuina methods combined with different types of massage treatments to treat insomnia has a good therapeutic effect and no serious adverse events occurred.However,due to the limitations of this study,more large-sample,multi-center,in-depth clinical studies are needed to provide more reliable evidence-based evidence for the clinic,in order to better serve the development of guidelines. 展开更多
关键词 tuina INSOMNIA Randomized controlled trials META-ANALYSIS
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Protective mechanisms of Tuina therapy against lipopolysaccharide-induced fever in young rabbits based on untargeted metabolomics analysis 被引量:1
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作者 LIU Di ZHANG Yingqi +7 位作者 YU Tianyuan LIU Zhifeng JIAO Yi WANG Hourong XU Yajing GUAN Qian CHEN Lulu HU Hui 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2023年第4期725-733,共9页
OBJECTIVE:To investigate the effect of Tuina on the plasma metabolites of lipopolysaccharide-induced febrile in infant rabbits.METHODS:Twenty-four infant New Zealand rabbits were selected and randomly divided into thr... OBJECTIVE:To investigate the effect of Tuina on the plasma metabolites of lipopolysaccharide-induced febrile in infant rabbits.METHODS:Twenty-four infant New Zealand rabbits were selected and randomly divided into three groups:saline,model,and Tuina.The fever model was established by injecting LPS intravenously through the ear margin vein in the model group and Tuina group,respectively.The modeling was considered successful when the anal temperature increased by 0.5℃or above within 1 h.In the Tuina group,six Tuina techniques(i.e.,opening Tianmen/the heaven gate,pushing Kangong/the superciliary arch,kneading Taiyang and the prominent bone behind the ears,clearing Tianheshui,spine pinching)that alleviate fever were performed on the young rabbits 1 h after the modeling,whereas the model and saline groups were not given Tuina treatment,with the real-time anal temperature monitored during the experiment.The plasma was taken 3 h after the modeling for liquid chromatography-mass spectrometry(LC-MS)untargeted metabolomics study.RESULTS:Our results showed a fever-reducing effects of Tuina therapy on lipopolysaccharide-induced fever in young rabbits,as indicated by a significantly lower anal temperature,maximum rise in body temperature,and body response index at 2 and 3 h after modeling in the Tuina group compared to the model group,with reductions in the PGE2 expression observed in the blood and hypothalamus.The differential metabolites including riboflavin,nicotinamide N-oxide,porphobilinogen,5-hydroxyindoleacetic acid,gamma-aminobutyric acid,and lysoPC(16:1(9Z)/0:0)were found following the Tuina intervention.Tuina primarily involves glycine-serinethreonine,arginine-proline,porphyrin-chlorophyll,pyrimidine,primary bile acid biosynthesis,and cyanoamino acid metabolic pathways.CONCLUSION:Tuina therapy has proven to be effective in reducing body temperature and down-regulating PGE2 expression in LPS-induced febrile young rabbits,with its mechanism of fever-reducing action possibly associated with the changes in plasma metabolites and metabolic pathways. 展开更多
关键词 FEVER PEDIATRICS metabolomics LIPOPOLYSACCHARIDES RIBOFLAVIN glycine tuina therapy
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Effect of Tuina along“bladder meridian”alleviating intervertebral disc degeneration by regulating the transforming growth factor-β1/Smad signaling pathway in a rabbit model
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作者 SU Chengguo ZHAO Xiaoyan +6 位作者 YE Jiangnan ZHANG Xin JIANG Yuqing GUO Junjie ZHANG Xiyuan QI Wenchuan ZHU Jun 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2023年第5期991-1000,共10页
OBJECTIVE:The aim of this study was to investigate the protective effects of Tuina(a traditional Chinese massage therapy)on intervertebral disc(IVD)degeneration and the regulatory mechanisms of the transforming growth... OBJECTIVE:The aim of this study was to investigate the protective effects of Tuina(a traditional Chinese massage therapy)on intervertebral disc(IVD)degeneration and the regulatory mechanisms of the transforming growth factor-β1(TGF-β1)/small mothers against decapentaplegic(Smad)signaling pathway.METHODS:Thirty New Zealand white rabbits were randomized into five groups:the control group,model group,model+Tuina group(Tuina group),model+TGF-β1 group(TGF-β1 group),and model+TGF-β1 inhibitor SB431542 group(SB431542 group).The model was established by posterolateral annulus fibrosus puncturing(AFP).Recombinant TGF-β1 and inhibitor SB431542 was injected into the TGF-β1 group and SB431542 group with a microsyringe,respectively.The rabbits in the Tuina group received Tuina treatment along the bladder meridian for 4 weeks.Magnetic resonance imaging(MRI)was performed on rabbits before AFP and after 4 weeks of intervention.Lumbar IVDs(L2-L3 to L4-L5)were harvested after intervention.Histopathological changes in the IVDs were measured by hematoxylin and eosin(HE)staining.Type I collagen was analyzed by immunohistochemistry detection.The expression level of matrix metalloproteinase-3(MMP3)was determined by enzyme-linked immunosorbent assay.Cell apoptosis was evaluated by terminal deoxynucleotidyl transferasemediated nick end labeling and Western blotting.Realtime polymerase chain reaction and Western blotting were used to analyze the expression of TGF-β1 and Smad2/3/4 and a disintegrin and metalloproteinase with thrombospondin motifs 5.RESULTS:Posterolateral AFP induced IVD degeneration in rabbits with histopathological damage and noticeable changes in MRI images.Tuina alleviated histopathological changes and reversed the expression of extracellular matrix degeneration-related molecules and apoptosis-related proteins.Furthermore,AFP induced the activation of TGF-β1 and Smad2/3/4,whereas Tuina therapy markedly reduced the protein expression of Smad2/3 and the gene expression of TGF-β1 and Smad2/3/4.Additionally,the TGF-β1/Smad signaling pathway was activated in the TGF-β1 group,while the TGF-β1/Smad signaling pathway was inhibited in the SB431542 group.CONCLUSION:Posterolateral AFP induced disc degeneration as determined by MRI assessment and histological analysis.Tuina alleviated disc degeneration,possibly by inhibiting the fibrotic response mediated by the TGF-β1/Smad pathway,thus alleviating extracellular matrix degeneration and reducing cell apoptosis. 展开更多
关键词 intervertebral disc degeneration transforming growth factor beta1 Smad proteins tuina APOPTOSIS extracellular matrix degradation
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Chinese Tuina remodels the synaptic structure in neuropathic pain rats by downregulating the expression of N-methyl D-aspartate receptor subtype 2B and postsynaptic density protein-95 in the spinal cord dorsal horn
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作者 HUANG Hongye WANG Bingqian +7 位作者 CHEN Shuijin FANG Jiayu WANG Xiaohua CHEN Lechun JIANG Yu ZHANG Huanzhen CHEN Jincheng LIN Zhigang 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2023年第4期715-724,共10页
OBJECTIVE:To investigate whether the Chinese massage system,Tuina,exerts analgesic effects in a rat model of chronic constriction injury(CCI)by remodeling the synaptic structure in the spinal cord dorsal horn(SCDH).ME... OBJECTIVE:To investigate whether the Chinese massage system,Tuina,exerts analgesic effects in a rat model of chronic constriction injury(CCI)by remodeling the synaptic structure in the spinal cord dorsal horn(SCDH).METHODS:Sixty-nine male Sprague–Dawley rats were randomly and evenly divided into the normal group,sham group,CCI group,CCI+Tuina group,CCI+MK-801[an N-methyl D-aspartate receptor subtype 2B(NR2B)antagonist]group,and CCI+MK-801+Tuina group.The neuropathic pain model was established using CCI with right sciatic nerve ligation.Tuina was administered 4 d after CCI surgery,using pressing manipulation for 10 min,once daily.Motor function was observed with the inclined plate test,and pain behaviors were observed by the Von Frey test and acetone spray test.At 19 d after surgery,the L3-L5 spinal cord segments were removed.Glutamate,interleukin 1β(IL-1β),and tumor necrosis factor-α(TNF-α)levels were detected by enzyme-linked immunosorbent assay.The protein expression levels of NR2B and postsynaptic density protein-95(PSD-95)were detected by Western blot,and the synaptic structure was observed by transmission electron microscopy(TEM).RESULTS:CCI reduced motor function and caused mechanical and cold allodynia in rats,increased glutamate concentration and TNF-αand IL-1βlevels,and increased expression of synapse-related proteins NR2B and PSD-95 in the SCDH.TEM revealed that the synaptic structure of SCDH neurons was altered.Most of these disease-induced changes were reversed by Tuina and intrathecal injection of MK-801(P<0.05 or<0.01).For the majority of experiments,no significant differences were found between the CCI+MK-801 and CCI+MK-801+Tuina groups.CONCLUSIONS:Chinese Tuina can alleviate pain by remodeling the synaptic structure,and NR2B and PSD-95 receptors in the SCDH may be among its targets. 展开更多
关键词 neuralgia spinal cord dorsal horn receptors N-METHYL-D-ASPARTATE disks large homolog 4 protein neuronal plasticity Chinese tuina
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腹部推拿对内脏高敏感腹泻型肠易激综合征大鼠肠道肥大细胞、TRPV1的影响
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作者 李华南 王毓岩 +4 位作者 张小凡 张玮 马菲 董桦 王金贵 《辽宁中医杂志》 CAS 北大核心 2024年第3期191-195,I0008,共6页
目的观察腹部推拿对内脏高敏感腹泻型肠易激综合征(diarrhea-type irritable bowel syndrome,IBS-D)模型大鼠肠道肥大细胞(mastcell,MC)及TRPV1表达水平的影响,探讨腹部推拿调控内脏高敏感IBS-D作用机制。方法40只SD雄性大鼠随机分为空... 目的观察腹部推拿对内脏高敏感腹泻型肠易激综合征(diarrhea-type irritable bowel syndrome,IBS-D)模型大鼠肠道肥大细胞(mastcell,MC)及TRPV1表达水平的影响,探讨腹部推拿调控内脏高敏感IBS-D作用机制。方法40只SD雄性大鼠随机分为空白组、模型组、腹部推拿组、MC阻断剂组,每组10只。采用母婴分离法+慢性应激法制备IBS-D大鼠模型。应用粪便性状(Bristol)评分、旷场试验评价干预效果,透射电镜观察结肠组织MC变化,定量PCR检测TRPV1 mRNA表达,免疫荧光法检测瞬时感受器电位香草酸亚型1(transient receptor potential vanilloid subfamily 1,TRPV1)阳性细胞数。结果(1)Bristol评分:与空白组比较,模型组Bristol评分增加(P<0.05);与模型组比较,腹部推拿组、MC阻断剂组评分降低(P<0.01)。(2)旷场试验:与空白组比较,模型组穿行方格次数、中央停留次数、中央停留时间和站立次数均显著减少(P<0.01);与模型组比较,腹部推拿组、MC阻断剂组各评分升高(P<0.05,P<0.01);与MC阻断剂组比较,腹部推拿组在站立次数方面低于MC阻断剂组(P<0.01)。(3)透射电镜:与空白组比较,模型组肠道MC微绒毛形态不规则,呈脱颗粒状态;腹部推拿组较模型组MC形态规整,脱颗粒程度不明显。MC阻断剂组形态规则与空白组近似。(4)TRPV1 mRNA表达:与空白组比较,模型组表达量明显升高(P<0.01);与模型组比较,腹部推拿组和MC阻断剂组表达量明显降低(P<0.01);与MC阻断剂组比较,腹部推拿组TRPV1 mRNA的表达略高(P<0.05)。(5)免疫荧光检测:与空白组比较,模型组TRPV1阳性细胞数显著增多,且荧光强度明显增高;与模型组比较,腹部推拿组和MC阻断剂组模型组TRPV1阳性细胞数显著减少,且荧光强度明显降低。结论腹部推拿可能借助调控肠道MC脱颗粒,降低TRPV1表达,从而对内脏高敏感IBS-D大鼠起到干预作用。 展开更多
关键词 腹部推拿 腹泻型肠易激综合征 内脏高敏感 作用机制
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基于“筋骨平衡”理论针刺推拿疗法治疗椎动脉型颈椎病的临床观察
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作者 贾峻 王志光 +2 位作者 赵国瑞 田少飞 范青 《辽宁中医杂志》 CAS 北大核心 2024年第2期161-164,共4页
目的浅析椎动脉型颈椎病(cervical spondylotic vertebral arteriopathy,CSA)患者实施基于“筋骨平衡”理论针刺推拿疗法对其中医症状积分、颈性眩晕症状与功能评估量表(cervical vertigo symptom and function assessment scale,ESCV)... 目的浅析椎动脉型颈椎病(cervical spondylotic vertebral arteriopathy,CSA)患者实施基于“筋骨平衡”理论针刺推拿疗法对其中医症状积分、颈性眩晕症状与功能评估量表(cervical vertigo symptom and function assessment scale,ESCV)评分、颈椎曲度及脑血流参数的影响。方法选择该院2019年12月—2021年12月就诊的CSA患者86例实施研究,随机数字表法分作观察组与对照组,各43例;其中对照组脱落2例,剔除1例,共完成40例;观察组脱落1例,剔除1例,共完成41例;对照组予以常规牵引疗法,观察组予以基于“筋骨平衡”理论针刺推拿疗法;比较两组治疗前与治疗后中医症状积分、ESCV评分、颈椎曲度及脑血流参数的变化,并对比两组疗效。结果治疗后,观察组中医症状积分皆显著低于对照组(P<0.05)。治疗后,观察组ESCV评分和颈椎曲度皆明显高于对照组(P<0.05)。治疗后,观察组椎底动脉及左、右椎动脉的Vs与Vd水平均显著高于对照组(P<0.05)。观察组总有效率显著高于对照组[95.12%(39/41)vs 80.00%(32/40),P<0.05]。结论基于“筋骨平衡”理论针刺推拿疗法对CSA患者疗效显著,有效改善中医症状积分、ESCV评分以及颈椎曲度,增强脑血流参数。 展开更多
关键词 筋骨平衡理论 针刺推拿 椎动脉型颈椎病 中医症状积分 脑血流参数
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背俞穴指揉弹拨法改善老年社区获得性肺炎病人排痰的效果
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作者 童俊 李军华 +1 位作者 熊桂芝 颜会萍 《护理研究》 北大核心 2024年第10期1849-1853,共5页
目的:探讨背俞穴指揉弹拨法改善老年社区获得性肺炎(CAP)病人排痰的效果。方法:纳入2021年9月—2022年11月入住巴中市某三级甲等综合医院老年病科的老年CAP病人96例为研究对象,采用随机数字表法将病人分为试验组和对照组,每组48例,对照... 目的:探讨背俞穴指揉弹拨法改善老年社区获得性肺炎(CAP)病人排痰的效果。方法:纳入2021年9月—2022年11月入住巴中市某三级甲等综合医院老年病科的老年CAP病人96例为研究对象,采用随机数字表法将病人分为试验组和对照组,每组48例,对照组接受常规背部叩击排痰护理,试验组在对照组基础上实施背俞穴指揉弹拨法。比较两组病人排痰费力改善情况、排痰有效率、经皮脉搏血氧饱和度(SpO2)、焦虑状况及住院时间。结果:干预开始后7 d,试验组病人排痰费力改善率为95.83%,高于对照组(81.25%);试验组病人干预后排痰总有效率为93.75%,高于对照组(79.17%);试验组病人干预后SpO2为(97.72±1.05)%,高于对照组[(95.23±1.27)%];试验组病人干预后焦虑程度低于对照组;试验组病人住院时间为(10.03±1.29)d,短于对照组[(12.94±1.22)d],差异均有统计学意义(P<0.05)。结论:背俞穴指揉弹拨法在一定程度上有利于改善老年CAP病人的排痰能力,提升病人血氧饱和度,改善病人焦虑状态,缩短病人住院时间。 展开更多
关键词 社区获得性肺炎 老年人 排痰 穴位疗法 推拿 护理
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