Objective This study aimed to combine tumor abnormal protein(TAP) and high-sensitivity C-reactive protein(hs-CRP) level detection to diagnose endometrial cancer in patients with endometrial thickness less than 8 mm, a...Objective This study aimed to combine tumor abnormal protein(TAP) and high-sensitivity C-reactive protein(hs-CRP) level detection to diagnose endometrial cancer in patients with endometrial thickness less than 8 mm, and to provide a reference for clinical screening and diagnosis. Methods Clinical data from 19 cases of endometrial cancer, diagnosed on the basis of pathological findings, were collected from September 2014 to December 2015. The inclusion criteria were as follows: the patients were first diagnosed with endometrial thickness less than 8 mm and were all in menopause. Perimenopausal patients(n = 26) with uterine fibroids seen during the same period were selected as a control group. Serum TAP and hs-CRP levels of the patients in the two groups were simultaneously determined on admission. Results We found that both TAP and hs-CRP levels in the experimental group were higher than those in the control group [(182.95 ± 72.14) μm^2 vs.(133.19 ± 55.18) μm^2, P = 0.019;(7.52 ± 19.03) mg/L vs.(1.66 ± 2.31) mg/L, P = 0.136]. The sensitivity of TAP for the diagnosis of endometrial cancer was 73.68%, the specificity was 69.23%, and the Youden index was 0.4291. The diagnostic sensitivity and specificity of hs-CRP was 15.79% and 100%, respectively, and the Youden index was 0.1579. After plotting the receiver operating characteristics curves, the optimal cut-off value for TAP in diagnosing endometrial cancer was found to be 160.662 μm^2 and that for hs-CRP was 1.07 mg/L. Conclusion For patients suspected of having endometrial cancer with endometrial thickness less than 8 mm, combined detection of TAP and hs-CRP levels can be used as a screening tool and can provide new ideas regarding clinical diagnosis and treatment.展开更多
目的：探讨异常糖链糖蛋白（TAP）作为消化道肿瘤（GITs）诊断、预后判断指标的可能性。方法选取新疆医科大学第五附属医院门诊或住院的病例、健康体检者为研究对象，将其分为GITs患者组120例、GITs高危人群组123例和正常人群组117例；...目的：探讨异常糖链糖蛋白（TAP）作为消化道肿瘤（GITs）诊断、预后判断指标的可能性。方法选取新疆医科大学第五附属医院门诊或住院的病例、健康体检者为研究对象，将其分为GITs患者组120例、GITs高危人群组123例和正常人群组117例；检测3组研究对象TAP的表达，并随访1年半，分析TAP表达与肿瘤发生或复发的关系。结果三组间TAP阳性＋临界表达率存在统计学差异（ P＜0．001）；TAP诊断GITs的灵敏度、特异度、阳性预测值、阴性预测值和约登指数分别为88．33％、85．83％、75．71％、93．64％和0．74；非 GITs 人群 TAP 阳性者肿瘤发生比例（23．53％）显著高于 TAP 阴性者（0．49％）（P＜0．001）；GITs患者TAP阳性者复发率（33．33％）显著高于阴性者（6．90％）（P＜0．001）。结论 TAP可以作为消化道肿瘤诊断、早期预防、疗效监测以及预后判断的指标。展开更多
基金Supported by a grant from the Medical and Health Technology Development Program in Shandong Province(No.2015WS0407)
文摘Objective This study aimed to combine tumor abnormal protein(TAP) and high-sensitivity C-reactive protein(hs-CRP) level detection to diagnose endometrial cancer in patients with endometrial thickness less than 8 mm, and to provide a reference for clinical screening and diagnosis. Methods Clinical data from 19 cases of endometrial cancer, diagnosed on the basis of pathological findings, were collected from September 2014 to December 2015. The inclusion criteria were as follows: the patients were first diagnosed with endometrial thickness less than 8 mm and were all in menopause. Perimenopausal patients(n = 26) with uterine fibroids seen during the same period were selected as a control group. Serum TAP and hs-CRP levels of the patients in the two groups were simultaneously determined on admission. Results We found that both TAP and hs-CRP levels in the experimental group were higher than those in the control group [(182.95 ± 72.14) μm^2 vs.(133.19 ± 55.18) μm^2, P = 0.019;(7.52 ± 19.03) mg/L vs.(1.66 ± 2.31) mg/L, P = 0.136]. The sensitivity of TAP for the diagnosis of endometrial cancer was 73.68%, the specificity was 69.23%, and the Youden index was 0.4291. The diagnostic sensitivity and specificity of hs-CRP was 15.79% and 100%, respectively, and the Youden index was 0.1579. After plotting the receiver operating characteristics curves, the optimal cut-off value for TAP in diagnosing endometrial cancer was found to be 160.662 μm^2 and that for hs-CRP was 1.07 mg/L. Conclusion For patients suspected of having endometrial cancer with endometrial thickness less than 8 mm, combined detection of TAP and hs-CRP levels can be used as a screening tool and can provide new ideas regarding clinical diagnosis and treatment.
文摘目的：探讨异常糖链糖蛋白（TAP）作为消化道肿瘤（GITs）诊断、预后判断指标的可能性。方法选取新疆医科大学第五附属医院门诊或住院的病例、健康体检者为研究对象，将其分为GITs患者组120例、GITs高危人群组123例和正常人群组117例；检测3组研究对象TAP的表达，并随访1年半，分析TAP表达与肿瘤发生或复发的关系。结果三组间TAP阳性＋临界表达率存在统计学差异（ P＜0．001）；TAP诊断GITs的灵敏度、特异度、阳性预测值、阴性预测值和约登指数分别为88．33％、85．83％、75．71％、93．64％和0．74；非 GITs 人群 TAP 阳性者肿瘤发生比例（23．53％）显著高于 TAP 阴性者（0．49％）（P＜0．001）；GITs患者TAP阳性者复发率（33．33％）显著高于阴性者（6．90％）（P＜0．001）。结论 TAP可以作为消化道肿瘤诊断、早期预防、疗效监测以及预后判断的指标。
