Dietary xylo‑oligosaccharides and arabinoxylans improved growth efficiency by reducing gut epithelial cell turnover in broiler chickens

Background One of the main roles of the intestinal mucosa is to protect against environmental hazards.Supple-mentation of xylo-oligosaccharides(XOS)is known to selectively stimulate the growth of beneficial intestinal bacteria and improve gut health and function in chickens.XOS may have an impact on the integrity of the intestinal epithelia where cell turnover is critical to maintain the compatibility between the digestive and barrier functions.The aim of the study was to evaluate the effect of XOS and an arabinoxylan-rich fraction(AXRF)supplementation on gut func-tion and epithelial integrity in broiler chickens.Methods A total of 128 broiler chickens(Ross 308)were assigned into one of two different dietary treatments for a period of 42 d:1)control diet consisting of a corn/soybean meal-based diet;or 2)a control diet supplemented with 0.5%XOS and 1%AXRF.Each treatment was randomly distributed across 8 pens(n=8)with 8 chickens each.Feed intake and body weight were recorded weekly.On d 42,one male chicken per pen was selected based on aver-age weight and euthanized,jejunum samples were collected for proteomics analysis.Results Dietary XOS/AXRF supplementation improved feed efficiency(P<0.05)from d 1 to 42 compared to the con-trol group.Proteomic analysis was used to understand the mechanism of improved efficiency uncovering 346 dif-ferentially abundant proteins(DAP)(Padj<0.00001)in supplemented chickens compared to the non-supplemented group.In the jejunum,the DAP translated into decreased ATP production indicating lower energy expenditure by the tissue(e.g.,inhibition of glycolysis and tricarboxylic acid cycle pathways).In addition,DAP were associated with decreased epithelial cell differentiation,and migration by reducing the actin polymerization pathway.Put-ting the two main pathways together,XOS/AXRF supplementation may decrease around 19%the energy required for the maintenance of the gastrointestinal tract.Conclusions Dietary XOS/AXRF supplementation improved growth efficiency by reducing epithelial cell migration and differentiation(hence,turnover),actin polymerization,and consequently energy requirement for maintenance of the jejunum of broiler chickens.

Hydrogen evolution reaction activity enhancement from active site turnover mechanism

Although heteroatom doping is an effective way to improve the catalytic activity of transition metal phosphides(TMPs),the mechanism of activity enhancement needs to be further refined.To this end,we synthesized a Co-doped Ni_(2)P catalyst as a research model and found that the introduction of heterogeneous Co reconstructed the charge distribution around the P site,which effectively enhanced the hydrogen evolution reaction(HER)activity of the pure Ni_(2)P.Based on in-situ Raman real-time monitoring technology,we monitored for the first time that Co doping triggered a switch of the active site(from the original Co-active site to the P-active site),which promoted the adsorption of H_(2)O to enhance the HER activity.The density functional theory(DFT)calculations indicated that the P site of Co-Ni_(2)P expressed the highest activity and the Ni site of pure Ni_(2)P expressed the highest activity,which further confirms the in-situ Raman monitoring results.The active site turnover mechanism discovered in this study will undoubtedly provide more rational and targeted ideas for future catalyst design.

Association of bone turnover biomarkers with severe intracranial and extracranial artery stenosis in type 2 diabetes mellitus patients

BACKGROUND Intracranial and extracranial artery stenosis is associated with cerebral infarction.Vascular calcification and atherosclerosis are the main causes of stenosis and major risk factors for cardiovascular and cerebrovascular events in patients with type 2 diabetes mellitus(T2DM).Bone turnover biomarkers(BTMs)are associated with vascular calcification,atherosclerosis,glucose,and lipid metabolism.AIM To investigate the association of circulating BTM levels with severe intracranial and extracranial artery stenosis in patients with T2DM.METHODS For this cross-sectional study including 257 T2DM patients,levels of the BTMs serum osteocalcin(OC),C-terminal cross-linked telopeptide of type I collagen(CTX),and procollagen type I N-peptide were measured by electrical chemiluminescent immunoassay,and artery stenosis was assessed by color Doppler and transcranial Doppler.Patients were grouped according to the existence and location(intracranial vs.extracranial)of artery stenosis.Correlations between BTM levels,previous stroke,stenosis location,and glucose and lipid metabolism were analyzed.RESULTS T2DM patients with severe artery stenosis had a higher frequency of previous stroke and levels of all three tested BTMs(all P<0.05)than patients without.Some differences in OC and CTX levels were observed according to the location of artery stenosis.Significant associations were also observed between BTM levels and some glucose and lipid homeostasis parameters.On multivariate logistic regression analysis,all BTMs were significant predictors of artery stenosis in T2DM patients with and without adjustment for confounding factors(all P<0.001),and receiver operating characteristic curve analysis demonstrated the ability of BTM levels to predict artery stenosis in T2DM patients.CONCLUSION BTM levels were found to be independent risk factors for severe intracranial and extracranial artery stenosis and were differentially associated with glucose and lipid metabolism in patients with T2DM.Therefore,BTMs may be promising biomarkers and potential therapeutic targets for artery stenosis.

Applying zeta diversity to understand species turnover patterns of small mammals in the Mountains of Southwest China

DEAR EDITOR,Mountainous regions are generally characterized by high species turnover,yet studies applying novel conceptual frameworks to analyze the spatial structure and organization of montane biota along elevational gradients remain scarce.Based on the zeta diversity framework—a novel turnover metric that focuses on average number of species shared across sites—and a comprehensive presence-absence dataset of small mammals collected from 22 elevational gradients in the Mountains of Southwest China(MSC).

The Impact of Saudi Nurses’ Happiness on Their Turnover Intentions

Highly happy nurses are more productive, engaged and loyal. If nurses are satisfied, then their intention to leave is low. Aim: to investigate the impact of Saudi nurses’ happiness on their intention to turnover in the Kingdom of Saudi Arabia. Research Hypothesis: H0. There is no relationship between the nurses’ happiness on their intention to turnover among Saudi nurses. H1. The happy Saudi nurses will have a lower turnover intention among Saudi nurses in the Medina region. Design: Quantitative, cross-sectional, and correlational study designs have been used. Setting: Big public hospital in Medina from June to October 2022. Sample: A quota, convenience sample of 281 Saudi nurses. Tools: A. Oxford happiness inventory to measure the nurses’ happiness. B. Turnover Intention Scale to evaluate the Saudi nurses’ intention to leave their current job. Results: More than half of the nurses had moderate happiness, but more than 75% of the Saudi nurses had a desire to leave. The relationship between happiness and turnover intentions is negative. Conclusion: Magnet-like work environments in Saudi Arabia are critical to recruit and retain nurses with critical nursing shortages. Recommendations: Encourage governmental policy-makers to formulate national policies and KPIs in order to make them happy and retain them. .

An Analysis of Amazon’s High Turnover Rate

Amazon’s internal and external environments were analyzed using PEST and SWOT models.Taking into account of relevant literature on strategic human resource management(SHRM)and models like the Harvard model and the human resource management/industrial relation(HRM/IR)model,the reasons for Amazon’s employee high turnover rate were analyzed.In this paper,several solutions to this issue are indicated,including improving incentive policies and organizing training.At the end of this paper,my personal experiences and the lessons learned throughout the course are summarized.

Factors Affecting Nurses’ Turnover in Alhassa Governmental Hospitals

Nurse turnover can negatively impact delivering patient care in the health facilities which will affect the patient’s health and reduce the quality of care. The MOH faces a serious challenge or high nursing staff turnover and the intention to leave the workforce. Aim: To explore one of the significant human recourse problems in the MOH and affecting the healthcare system, which is, factors affecting nurses’ turnover in governmental hospitals using Alhassa governmental hospitals as a case study. Method: A quantitative research method used to explore the factors affecting nurses’ turnover in the governmental hospitals in Alhassa. Result: According to the study finding, management style was a factor more likely to indicate nurses’ turnover. It defines the impact of management style and works environment on nurses’ and clients’ systems. Individual factors were the second influence on their turnover. The balance between nurses’ work and their family need was the first issue that had affected their work. Organization factors are also an influence on the nurses’ turnover in Alhassa region. Conclusion: Nurses’ turnover is a significant issue in a human resource in MOH. This study first applied in Alhassa region that highlighted the factors that affect nurses’ turnover. Nurses’ turnover is a continuous problem that occurs in the health facilities related to management method causes, personal causes or organizational causes. Management style was the most influences on nurses’ turnover in this study changing or modifying management style that can intent nurses to continue their work in the hospital in Alhassa region.

A cross-sectional study on nurse turnover intention and influencing factors in Jiangsu Province, China

Background:Nurses'turnover has been a major concern globally,which is strongly influenced by nurses'intent to leave.However,only a few large sample studies on the predictive factors associated with nurses'turnover intention were conducted in Jiangsu Province.This study mainly aims to examine the level and factors that influence nurses to leave their work in Jiangsu Province of Eastern China.Methods:A cross-sectional survey of 1978 nurses was conducted at 48 hospitals in 14 key cities throughout Jiangsu Province.The turnover intention in nurses was measured by the scale of intent to leave the profession.The work environment of nurses was measured by the Chinese version of the Practice Environment Scale.A multiple linear regression model was applied to analyse the factors associated with turnover intention.Results:The resignation rate of nurses in the hospitals of Jiangsu Province ranged from 0.64%to 12.71%in 2016.The mean scores were 15.50±3.44 for turnover intention,and 3.06±0.51 for work environment.Involvement in hospital affairs,resource adequacy,age,professional title,year(s)working,employment type and education level were the predictors of nurse intent to leave(P<0.05).Conclusion:The work environment of nurses in hospitals must be improved in staffing and resource and nurses'involvement in hospital affairs.The current study corroborates that nurses have high turnover intention.Thus,effective measures are needed to improve nurse accomplishment,professional status,participation in hospital affairs and career planning to reduce their turnover intention.

The impact of work support and organizational career growth on nurse turnover intention in China

Objective:The paper aimed to explore the impact of work support and potential for career advancement on the nurse turnover intention in order to find an effective approach to curb high turnover.Methods:A cross-sectional survey of 526 nurses from eight teaching hospitals in Tianjin,China,was conducted to test the hypothesized multilevel model.The organizational career growth scale,work support scale,and the nurse turnover intention scale were used to measure the effect of organizational career growth and work support on nurse turnover intention.Finally,SPSS 17.0 and AMOS 17.0 software were used to analyse the relationship of these variables.Results:The score of the three scales nurse turnover,organizational career growth,and work support were 1.98±0.60,2.40±0.50,and 4.06±0.98,respectively.The total and direct effects of work support on turnover intention were
0.361(p<0.01)and
0.147(p<0.01),respectively.The indirect effect was
0.169 with a 95%bootstrap confidence interval of
0.257 to
0.102.Conclusion:The study showed a lack of work support negatively and directly associated with nurse turnover intention.Additional opportunities for career growth within the organization may strengthen the effect of work support and consequently increase the retention of qualified nursing staff.

Assessment of bone turnover and bone quality in type 2 diabetic bone disease： current concepts and future directions

Substantial evidence exists that in addition to the well-known complications of diabetes, increased fracture risk is an important morbidity. This risk is probably due to altered bone properties in diabetes. Circulating biochemical markers of bone turnover have been found to be decreased in type 2 diabetes （T2D） and may be predictive of fractures independently of bone mineral density （BMD）. Serum sclerostin levels have been found to be increased in T2D and appear to be predictive of fracture risk independent of BMD. Bone imaging technologies, including trabecular bone score （TBS） and quantitative CT testing have revealed differences in diabetic bone as compared to non-diabetic individuals. Specifically, high resolution peripheral quantitative CT （HRpQCT） imaging has demonstrated increased cortical porosity in diabetic postmenopausal women. Other factors such as bone marrow fat saturation and advanced glycation endproduct （AGE） accumulation might also relate to bone cell function and fracture risk in diabetes. These data have increased our understanding of how T2D adversely impacts both bone metabolism and fracture risk.

Trends of soil organic matter turnover in the salt marsh of the Yangtze River estuary

Characteristics and tidal flat trends of soil organic matter （SOM） turnover were studied for the Chongmingdongtan Salt Marsh in the Yangtze River estuary, based on analyses of stable carbon isotope composition （δ^13C）, grain sizes and contents of particulate organic carbon （POC）, total nitrogen （TN） and inorganic carbon （TIC） for three cores excavated from high tidal flat, middle tidal flat and bare flat. Results demonstrate that correlations between soil POC contents and δ^13C values of the salt marsh cores were similar to those between soil organic carbon （SOC） contents and δ^13C values of the upper soil layers of mountainous soil profiles with different altitudes. SOM of salt marsh was generally younger than 100 years, and originated mainly from topsoil erosions in catchments of the Yangtze River. Correlations of TN content with C/N ratio, POC content with TIC content and POC content with δ^13C values for the cores suggest that turnover degrees of SOM from the salt marsh are overall low, and trends of SOM turnover are clear from the bare flat to the high tidal flat. Bare flat samples show characteristics of original sediments, with minor SOM turnover. Turnover processes of SOM have occurred and are discernable in the high and middle tidal flats, and the mixing degrees of SOM compartments with different turnover rates increase with evolution of the muddy tidal flat. The exclusive strata structure of alternate muddy laminae and silty laminae originated from dynamic depositional processes on muddy tidal flat was a great obstacle to vertical migration of dissolved materials, and SOM turnover was then constrained. The muddy tidal flat processes exerted direct influences on sequestration and turnover of SOM in the salt marsh, and had great constraints on the spatial and temporal characteristics of SOM turnover of the Chongmingdongtan Salt Marsh in the Yangtze River estuary.

Variation patterns of fine root biomass, production and turnover in Chinese forests

China's forests cover 208.3 million ha and span a wide range of climates and a large variety of forest types, including tropical, temperate, and boreal forests. However, the variation patterns of fine root (< 2 mm in diameter) biomass, production, and turnover from the south to the north are unclear. This study summarizes fine root biomass (FRB), production (FRP) and turnover rate (FRT) in China's forests as reported by 140 case studies published from 1983 to 2014. The results showed that the mean values of FRB, FRP and FRT in China's forests were 278 g m(-2), 366 g m(-2) a(-1), and 1.19 a(-1), respectively. Compared with other studies at the regional or global scales, FRB in China's forests was lower, FRP was similar to estimates at the global scale, but FRT was much higher. FRB, FRP, and FRT in China's forests increased with increasing mean annual precipitation (MAP), indicating that fine root variables were likely related to MAP, rather than mean annual temperature or latitude. This is possibly due to the small variation in temperature but greater variation in precipitation during the growing season. These findings suggest that spatiotemporal variation in precipitation has a more profound impact on fine root dynamics in China's forests, and this will impact carbon and nutrient cycles driven by root turnover in the future.

Reduced turnover rate of topsoil organic carbon in old-growth forests:a case study in subtropical China

Background:Old-growth forests are irreplaceable with respect to climate change mitigation and have considerable carbon(C)sink potential in soils.However,the relationship between the soil organic carbon(SOC)turnover rate and forest development is poorly understood,which hinders our ability to assess the C sequestration capacity of soil in old-growth forests.Methods:In this study,we evaluated the SOC turnover rate by calculating the isotopic enrichment factor β(defined as the slope of the regression between ^(13)C natural abundance and log-transformed C concentrations)along 0-30 cm soil profiles in three successional forests in subtropical China.A lower β(steeper slope)is associated with a higher turnover rate.The three forests were a 60-year-old P.massoniana forest(PF),a 100-year-old coniferous and broadleaved mixed forest(MF),and a 400-year-old monsoon evergreen broadleaved forest(BF).We also analyzed the soil physicochemical properties in these forests to examine the dynamics of SOC turnover during forest succession and the main regulators.Results:The β value for the upper 30-cm soils in the BF was significantly(p<0.05)higher than that in the PF,in addition to the SOC stock,although there were nonsignificant differences between the BF and MF.The β value was significantly(p<0.05)positively correlated with the soil recalcitrance index,total nitrogen,and available nitrogen contents but was significantly(p<0.01)negatively correlated with soil pH.Conclusions:Our results demonstrate that SOC has lower turnover rates in old-growth forests,accompanied by higher soil chemical recalcitrance,nitrogen status,and lower soil pH.This finding helps to elucidate the mechanism underlying C sequestration in old-growth forest soils,and emphasizes the important value of old-growth forests among global C sinks.

Abusive supervision and turnover intention: Mediating effects of psychological empowerment of nurses

Objective: This study aims to determine the mediating effects of psychological empowerment on abusive supervision and turnover intention as perceived by nurses to provide information to change the status of nurse turnover.Methods: A cross-sectional survey (a questionnaire examining perceptions of abusive supervision,measurement of psychological empowerment,and questionnaire for turnover intention) was used to collect data.A total of 1127 clinical nurses,who were recruited through convenience sampling,participated in the survey.Results: Nurses' average perceived abusive supervision,psychological empowerment,and turnover intention scores were 1.62 ± 0.95,3.24 ± 0.83,and 14.17 ± 3.78,respectively.Psychological empowerment was found to mediate the relationship between abusive supervision and turnover intention (P< 0.01).Turnover intention tends to be stronger and psychological empowerment reduced when nurse managers adopt an abusive leadership style.Conclusions: Nurses' psychological empowerment is an intermediary variable that predicts the relationship between abusive supervision and turnover intention.Nurse managers should manage abusive supervision to increase nurses' psychological empowerment and decrease turnover intention.

An experimental analysis on the turnover time of railway freight transportation based on the impact strength of factors

Based on the factors impact strength model(FISM), we studied on calculation formulas of influence strength and key elements of FISM, and analyzed the turnover time of railway freight transportation of China. The results show that wagon transfer time is the most critical factor among the three subjective factors of wagons turnover time. The FISM based analysis of wagon transfer time show that the wagon turnover time is significantly correlated with transit time with resorting. Among the seven factors of detention time of transit time with resorting, the time of waiting to departing, converging, and waiting to break-up are key factors, while the time of make-up, break-up, arrival and departure are general factors. We carried out one empirical research based on the data of Baoji East Railway Station in 2015. The results of empirical research and FISM are consistent completely.

Pool Sizes and Turnover of Soil Organic Carbon of Farmland Soil in Karst Area of Guilin

The three-pool and first-order model separates the mineralizable organic carbon into active,slow,and passive carbon pools.This paper used the model and decomposition curves of the soil organic carbon to fit the active pool and its decomposition rate,slow pool and its decomposition rate.The results showed that the size of the active pool from different profiles accounted for 2.09%-3.08% of the total soil organic carbon and the mean residue time was 3.57-17.21 days.And the size of the slow pool accounted for 3.19%-43.55% and the mean residue time was 1.12-4.94 years.Acid hydrolysis（6M HCl） was used to fractionate the passive organic carbon,which accounted for 50.83%-94.44% of the total soil organic carbon.

Organizational commitment and turnover intention among rural nurses in the Philippines: Implications for nursing management

Objectives:The unrelenting migration trend of Filipino nurses to other countries has threatened the quality of patient care services in the country.This study explored the extent of nurses'organizational commitment and turnover intention in the Philippines.Furthermore,predictors of nurses'organizational commitment and turnover intention were identified.Methods:A cross-sectional research design was adopted for this study.Two hundred nurses from nine rural hospitals in the Central Philippines were asked to participate in the study and 166 nurses responded(an 83%response rate).Two standardized instruments were used:the Organizational Commitment Questionnaire and the Six-item Turnover Intention Inventory Scale.Results:Findings revealed that Philippine nurses were moderately committed(3.13±0.24)to and were undecided(2.42±0.67)whether or not to leave their organization.Nurses'age(P=0.006),gender,(t=-2.25,P=0.026),education(t=2.38,P<0.001),rank(t=4.38,P<0.001),and work experience(t=2.18,P=0.031)correlated significantly with organizational commitment,while nurses'age(P=0.028)and education(t=1.99,P=0.048)correlated significantly with turnover intention.An inverse relationship was identified between the organizational commitment and turnover intention(r=-0.22,P=0.005).Conclusion:The findings of this study highlight the need for formulation and implementation of interventions to promote life-long commitment in nurses and to reduce turnover rates.

Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women

Growth differentiation factor 11 （GDF11） is an important circulating factor that regulates aging. However, the role of GDF11 in bone metabolism remains unclear. The present study was undertaken to investigate the relationship between serum GDF11 level, bone mass, and bone turnover markers in postmenopausal Chinese women. Serum GDF11 level, bone turnover biochemical markers, and bone mineral density （BMD） were determined in 169 postmenopausal Chinese women （47-78 years old）. GDF11 serum levels increased with aging. There were negative correlations between GDF11 and BMD at the various skeletal sites. After adjusting for age and body mass index （BMI）, the correlations remained statistically significant. In the multiple linear stepwise regression analysis, age or years since menopause, BMI, GDF11, and estradiol were independent predictors of BMD. A significant negative correlation between GDF11 and bone alkaline phosphatase （BAP） was identified and remained significant after adjusting for age and BMI. No significant correlation was noted between cross-linked N-telopeptides of type I collagen （NTX） and GDF11. In conclusion, GDF11 is an independent negative predictor of BMD and correlates with a biomarker of bone formation, BAP, in postmenopausal Chinese women. GDF11 potentially exerts a negative effect on bone mass by regulating bone formation.

Nurse turnover research in China:A bibliometric analysis from 2000 to 2015

Objectives:The study was conducted to make a bibliometric analysis of published literature in order to assess the research status of nurse turnover in China.Methods:We obtained 239 papers from two major electronic databases,CNKI and Wanfang from 2000 to 2015(updated to 31st,December).Articles in languages other than Chinese were excluded.The keywords used were‘nurses’or‘nursing staff’and‘leave’or‘intend to leave’.Results:A total of 239 articles met the inclusion criteria,including 33 masters'dissertations and 206 journal articles.206 articles were published in twenty-five kinds of journals in China.Nursing journals had the biggest share,about(88%,181/206).82%(196/239)articles are quantitative research.239 articles come from 26 different provinces,cities or autonomous regions.The top ten regions which have the largest number of publications are Beijing,Shandong,Shanghai,Guangdong,Heilongjiang,Jiangsu,Hunan,Zhejiang,Hubei,Liaoning provinces.The coauthored articles account for 75%of all the publications.Only a small fraction of research works has obtained fundings.Conclusion:Further studies are greatly needed on the development of sound measures to tackle nurse turnover and shortage.The following improvements should be made,such as strengthening nursing researcher'consciousness and capability and increasing nursing fundings in China.

Correlation of Serum Leptin Level with Bone Mineral Density and Bone Turnover Markers in Chinese Adolescent Dancers

Objective To investigate plasma leptin concentrations in adolescent female dancers and to determine whether leptin has some effects on their bone mineral density （BMD） and bone turnover markers. Methods Sixty dancers aged 15-17 years and 77 healthy controls were enrolled in the study. Bone mineral density （BMD） and body composition were detected by dual energy X-ray absorptiometry. Serum leptin concentrations were measured by radioimmunoassay （RIA）. Two bone turnover markers, bone-specific alkaline phosphatase （BAP） and tartrate-resistant acid phosphatase（TRACP）, were determined by ELISA. Results The dancers had a lower fat mass and a lower leptin level than the controls, while they had a relatively higher BMD of the total body and legs after adjustment for BMI and age. The levels of bone resorption and formation of markers were higher in the dancers than in the controls. Leptin was positively correlated with BMI, body weight, fat mass, and percentage of body fat. In dancers, Leptin was positively correlated with the BMD of the total body and the left leg. However, after adjustment for BMI, no correlation of serum leptin concentrations with BMD values was found in either dancers or controls. Nor correlation was found between leptin and bone turnover markers after adjustment for BMI. Conelusion The leptin profile is different between the controls and the dancers with a lower BMI and a lower fat mass. Circulating plasma leptin level depends on BMI and is not a direct determinant of BMD in Chinese adolescent dancers.