Objective:To explore the main active components,main target genes and key pathways of"mulberry twig-cassia twig"in the treatment of rheumatoid arthritis based on network pharmacology Methods:The active compo...Objective:To explore the main active components,main target genes and key pathways of"mulberry twig-cassia twig"in the treatment of rheumatoid arthritis based on network pharmacology Methods:The active components and targets of drug pairs were screened by TCMSP database and Swisstargetprediction database,and the target genes of rheumatoid arthritis were obtained by GeneCards and OMIM database,and the overlapping genes were obtained,that is,the predictive target genes of"mulberry twig-cassia twig"medicine for the treatment of rheumatoid arthritis.The"drug-active ingredient-target"network and"drug-active ingredient-target-disease"network were constructed by Cytoscape 3.7.2 software.The PPI network was constructed by String platform and the key biological processes were analyzed and screened by Cytoscape 3.7.2 software.The GO analysis and KEGG pathway analysis of predictive target genes were carried out on the Metascape website,and the bubble diagram was drawn by Omicshare platform.At the same time,those genes can used to construct the"drug-component-target-pathway"network by Cytoscape 3.7.2 software.Results:A total of 12 active components,85 predictive targets,126 KEGG pathways and 1537 GO functions were obtained.Conclusion:The main active components of"mulberry twig-cassia twig"in the treatment of rheumatoid arthritis are kaempferol,beta-sitosterol and cinnamic acid,and the main target genes may be HSP90AB1、RELA,AKT1,TNF,TLR4,PTGS2 and so on.The main KEGG pathways are TNF signal pathway,estrogen pathway,HIF-1 signal pathway,NF-κB signal pathway,PI3K-Akt signal pathway and so on.The main GO function analysis is the response to lipopolysaccharide、response to oxidative stress、cytokine-mediated signaling pathway.This study shows that the"mulberry twig-cassia twig"drug pair is through the regulation of multip-compound,multi-target,multi-pathway to treat rheumatoid arthritis,providing a theoretical basis for the follow-up study of traditional Chinese medicine in the treatment of rheumatoid arthritis.展开更多
Tree Match算法是一种有效的Twig查询匹配算法,但其存在反复分析Twig模式的缺点。针对该问题,引入编译中的部分求值技术,提出一种Twig查询优化方案。通过部分求值提前完成对Twig模式的分析,生成查询专用的指令序列代替原查询程序,并给...Tree Match算法是一种有效的Twig查询匹配算法,但其存在反复分析Twig模式的缺点。针对该问题,引入编译中的部分求值技术,提出一种Twig查询优化方案。通过部分求值提前完成对Twig模式的分析,生成查询专用的指令序列代替原查询程序,并给出查询机执行引擎,从而消除重复计算,优化XML树模式查询过程。实验结果表明,在不同Twig模式下,该优化方案能够有效提高XML查询的执行效率。展开更多
Objective: To compare the clinical efficacy of Cassia Twig Tuckahoe capsule (Chinese Medicine) and Mifepristone combined with laparoscopic surgery for the treatment of endometriosis. Designs: Prospective cohort study....Objective: To compare the clinical efficacy of Cassia Twig Tuckahoe capsule (Chinese Medicine) and Mifepristone combined with laparoscopic surgery for the treatment of endometriosis. Designs: Prospective cohort study. Setting: Gynecology and Obstetrics Department, Jingzhou Central Hospital, affiliated to Yangtze University. Methods: We selected 67 patients suspected with endometriosis and divided randomly into 2 groups on patient choice. Outcome Measures: Treatment efficacy, side effects, recurrence rate and pregnancy rate. Results: Comparing the effect of treatment between the two groups, the success rate was almost same (P > 0.5). However, the disappearance of pain was faster in Cassia twig Tuckahoe group (P Conclusion: After analysis of the result, Cassia twig Tuckahoe capsule combined with Laparoscopy is superior to the Mifepristone combined with Laparoscopy. Cassia twig Tuckahoe capsule is a very propitious medicine for treating endometriosis for long term benefits.展开更多
The biochemical and physiological properties of alpine woody plants responding to elevation are associated with needles and twigs age.However,the interactions with elevation were not well studied.In this study,we inve...The biochemical and physiological properties of alpine woody plants responding to elevation are associated with needles and twigs age.However,the interactions with elevation were not well studied.In this study,we investigated age-related(current,one-year and two-year old)functional traits of Abies faxoniana in needles and twigs with elevation(2500 m,2750 m,3000 m,3250 m,and 3500 m a.s.l)at the eastern edge of the Tibetan Plateau.The macro-elements(C,N,P,K,Ca,and Mg),nonstructural carbons(soluble sugar,sucrose,and starch)and isotope composition(δ13C)were measured in needles and twigs of adult A.faxoniana trees(breast height diameter about 30 cm).There were significant age,elevation and their interaction effects on these traits(except forδ13C).Compared with twoyear-old needles and twigs,the current and one-yearold tissues possessed higher concentrations of P and K,lower Ca concentrations,as well as a lowerδ13C values and C:P and N:P ratios in needles.The current-year twigs generally had higher sucrose concentration and sucrose:starch ratio than the old ones.This study suggested that more nutrients were invested to young needles and twigs to cope with elevation for A.faxoniana than the old ones.展开更多
基金National key research and development program of China(No.2018YFC1705500)。
文摘Objective:To explore the main active components,main target genes and key pathways of"mulberry twig-cassia twig"in the treatment of rheumatoid arthritis based on network pharmacology Methods:The active components and targets of drug pairs were screened by TCMSP database and Swisstargetprediction database,and the target genes of rheumatoid arthritis were obtained by GeneCards and OMIM database,and the overlapping genes were obtained,that is,the predictive target genes of"mulberry twig-cassia twig"medicine for the treatment of rheumatoid arthritis.The"drug-active ingredient-target"network and"drug-active ingredient-target-disease"network were constructed by Cytoscape 3.7.2 software.The PPI network was constructed by String platform and the key biological processes were analyzed and screened by Cytoscape 3.7.2 software.The GO analysis and KEGG pathway analysis of predictive target genes were carried out on the Metascape website,and the bubble diagram was drawn by Omicshare platform.At the same time,those genes can used to construct the"drug-component-target-pathway"network by Cytoscape 3.7.2 software.Results:A total of 12 active components,85 predictive targets,126 KEGG pathways and 1537 GO functions were obtained.Conclusion:The main active components of"mulberry twig-cassia twig"in the treatment of rheumatoid arthritis are kaempferol,beta-sitosterol and cinnamic acid,and the main target genes may be HSP90AB1、RELA,AKT1,TNF,TLR4,PTGS2 and so on.The main KEGG pathways are TNF signal pathway,estrogen pathway,HIF-1 signal pathway,NF-κB signal pathway,PI3K-Akt signal pathway and so on.The main GO function analysis is the response to lipopolysaccharide、response to oxidative stress、cytokine-mediated signaling pathway.This study shows that the"mulberry twig-cassia twig"drug pair is through the regulation of multip-compound,multi-target,multi-pathway to treat rheumatoid arthritis,providing a theoretical basis for the follow-up study of traditional Chinese medicine in the treatment of rheumatoid arthritis.
文摘Objective: To compare the clinical efficacy of Cassia Twig Tuckahoe capsule (Chinese Medicine) and Mifepristone combined with laparoscopic surgery for the treatment of endometriosis. Designs: Prospective cohort study. Setting: Gynecology and Obstetrics Department, Jingzhou Central Hospital, affiliated to Yangtze University. Methods: We selected 67 patients suspected with endometriosis and divided randomly into 2 groups on patient choice. Outcome Measures: Treatment efficacy, side effects, recurrence rate and pregnancy rate. Results: Comparing the effect of treatment between the two groups, the success rate was almost same (P > 0.5). However, the disappearance of pain was faster in Cassia twig Tuckahoe group (P Conclusion: After analysis of the result, Cassia twig Tuckahoe capsule combined with Laparoscopy is superior to the Mifepristone combined with Laparoscopy. Cassia twig Tuckahoe capsule is a very propitious medicine for treating endometriosis for long term benefits.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA20020401)the National Natural Science Foundation of China (NO. 31770650)
文摘The biochemical and physiological properties of alpine woody plants responding to elevation are associated with needles and twigs age.However,the interactions with elevation were not well studied.In this study,we investigated age-related(current,one-year and two-year old)functional traits of Abies faxoniana in needles and twigs with elevation(2500 m,2750 m,3000 m,3250 m,and 3500 m a.s.l)at the eastern edge of the Tibetan Plateau.The macro-elements(C,N,P,K,Ca,and Mg),nonstructural carbons(soluble sugar,sucrose,and starch)and isotope composition(δ13C)were measured in needles and twigs of adult A.faxoniana trees(breast height diameter about 30 cm).There were significant age,elevation and their interaction effects on these traits(except forδ13C).Compared with twoyear-old needles and twigs,the current and one-yearold tissues possessed higher concentrations of P and K,lower Ca concentrations,as well as a lowerδ13C values and C:P and N:P ratios in needles.The current-year twigs generally had higher sucrose concentration and sucrose:starch ratio than the old ones.This study suggested that more nutrients were invested to young needles and twigs to cope with elevation for A.faxoniana than the old ones.
