Non-small cell lung cancer(NSCLC)is a highly lethal cancer,and better treatments are urgently needed.Many studies have implicated circular RNAs(circRNAs)in the progression of multiple malignant tumors.Nonetheless,the ...Non-small cell lung cancer(NSCLC)is a highly lethal cancer,and better treatments are urgently needed.Many studies have implicated circular RNAs(circRNAs)in the progression of multiple malignant tumors.Nonetheless,the functions of circRNAs in NSCLC remain unclear.To study new targets for the treatment of NSCLC,circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant tissues.RNA was isolated and used for circRNA sequencing.Biological studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC,including their functions in cell proliferation and migration.How circRNAs function in NSCLC was explored to clarify the underlying regulatory mechanisms.We found that circUCP2 was upregulated in NSCLC tissues compared with neighboring nonmalignant tissues.circUCP2 promoted the proliferation and metastasis of NSCLC cells.circUCP2 promoted NSCLC progression by sponging miR-149 and upregulating UCP2.The circUCP2/miR-149/UCP2 axis accelerates the progression of NSCLC,and circUCP2 may therefore be a novel diagnostic biomarker for the progression of NSCLC.展开更多
解偶联蛋白2(Uncoupling protein 2,UCP2)是一种位于线粒体内的膜蛋白。研究发现在女性生殖系统恶性肿瘤细胞中检测出UCP2基因的高表达,敲除UCP2会减缓或减少恶性肿瘤细胞的增殖、迁移和入侵。UCP2抑制剂可用于女性生殖系统恶性肿瘤的...解偶联蛋白2(Uncoupling protein 2,UCP2)是一种位于线粒体内的膜蛋白。研究发现在女性生殖系统恶性肿瘤细胞中检测出UCP2基因的高表达,敲除UCP2会减缓或减少恶性肿瘤细胞的增殖、迁移和入侵。UCP2抑制剂可用于女性生殖系统恶性肿瘤的治疗且可以作为独立的生物学标志物提示预后。文章对UCP2在女性生殖系统恶性肿瘤中的研究进展进行综述。展开更多
一、ICC POSITION PAPER3的规定及其适用
银行审单中存在一个如何处理非单据化条件的问题。UCP500在保留UCP400关于审核单据标准内容的基础上，涉及了非单据条件的处理，即如果信用证中含有某些条件而未列明须提交与之相符的单据，银...一、ICC POSITION PAPER3的规定及其适用
银行审单中存在一个如何处理非单据化条件的问题。UCP500在保留UCP400关于审核单据标准内容的基础上，涉及了非单据条件的处理，即如果信用证中含有某些条件而未列明须提交与之相符的单据，银行将认为未列明此条件，且对此不予理会。该规定清楚了银行审单时对于非单据化条件的处理办法，但对于如何认定一项条件是否为非单据化条件则基本没有什么帮助。展开更多
基金supported by grants from the Science and Technology Program of Guangzhou(202102080084,Han Yang)the Key Project of Scientific Research Plan of Hunan Provincial Health Commission(C202301047982,Wei Du)+1 种基金the Wings Scientific and Technological Foundation of The First People’s Hospital of Changde City(2022ZZ05,Wei Du)the Traditional Chinese Medicine Bureau of Guangdong Province(20161062,Qing Liu).
文摘Non-small cell lung cancer(NSCLC)is a highly lethal cancer,and better treatments are urgently needed.Many studies have implicated circular RNAs(circRNAs)in the progression of multiple malignant tumors.Nonetheless,the functions of circRNAs in NSCLC remain unclear.To study new targets for the treatment of NSCLC,circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant tissues.RNA was isolated and used for circRNA sequencing.Biological studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC,including their functions in cell proliferation and migration.How circRNAs function in NSCLC was explored to clarify the underlying regulatory mechanisms.We found that circUCP2 was upregulated in NSCLC tissues compared with neighboring nonmalignant tissues.circUCP2 promoted the proliferation and metastasis of NSCLC cells.circUCP2 promoted NSCLC progression by sponging miR-149 and upregulating UCP2.The circUCP2/miR-149/UCP2 axis accelerates the progression of NSCLC,and circUCP2 may therefore be a novel diagnostic biomarker for the progression of NSCLC.
文摘解偶联蛋白2(Uncoupling protein 2,UCP2)是一种位于线粒体内的膜蛋白。研究发现在女性生殖系统恶性肿瘤细胞中检测出UCP2基因的高表达,敲除UCP2会减缓或减少恶性肿瘤细胞的增殖、迁移和入侵。UCP2抑制剂可用于女性生殖系统恶性肿瘤的治疗且可以作为独立的生物学标志物提示预后。文章对UCP2在女性生殖系统恶性肿瘤中的研究进展进行综述。
文摘一、ICC POSITION PAPER3的规定及其适用
银行审单中存在一个如何处理非单据化条件的问题。UCP500在保留UCP400关于审核单据标准内容的基础上，涉及了非单据条件的处理，即如果信用证中含有某些条件而未列明须提交与之相符的单据，银行将认为未列明此条件，且对此不予理会。该规定清楚了银行审单时对于非单据化条件的处理办法，但对于如何认定一项条件是否为非单据化条件则基本没有什么帮助。
