设计了一种基于ESP8266-01为无线传输模块与Arduino UNO R3为主控模块所构成的无线式(WiFi)远程温湿度调节系统。其中DHT11传感器把所测得的数据缓存到Arduino UNO R3,当温湿度超过上限及时报警,保证工作人员的安全。同时Arduino UNO R...设计了一种基于ESP8266-01为无线传输模块与Arduino UNO R3为主控模块所构成的无线式(WiFi)远程温湿度调节系统。其中DHT11传感器把所测得的数据缓存到Arduino UNO R3,当温湿度超过上限及时报警,保证工作人员的安全。同时Arduino UNO R3用端口TX发送给无线传输模块,ESP8266-01再用无线方式传输温湿度值给装有TCP/UDP调试助手软件的移动设备,实现移动设备及时查看功能,且移动设备还可控制继电器总开关和调节LED亮度。该设计具有较大的应用前景。展开更多
Background: Glutamine and glutamate are known to play important roles in cancer biology. However, no detailed information is available in terms of their levels of involvement in various biological processes across dif...Background: Glutamine and glutamate are known to play important roles in cancer biology. However, no detailed information is available in terms of their levels of involvement in various biological processes across different cancer types, whereas such knowledge could be critical for understanding the distinct characteristics of different cancer types. Our computational study aimed to examine the functional roles of glutamine and glutamate across different cancer types.Methods: We conducted a comparative analysis of gene expression data of cancer tissues versus normal control tissues of 11 cancer types to understand glutamine and glutamate metabolisms in cancer. Specifically, we developed a linear regression model to assess differential contributions by glutamine and/or glutamate to each of seven biological processes in cancer versus control tissues.Results: While our computational predictions were consistent with some of the previous observations, multiple novel predictions were made:(1) glutamine is generally not involved in purine synthesis in cancer except for breast cancer, and is similarly not involved in pyridine synthesis except for kidney cancer;(2) glutamine is generally not involved in ATP production in cancer;(3) glutamine's contribution to nucleotide synthesis is minimal if any in cancer;(4) glutamine is not involved in asparagine synthesis in cancer except for bladder and lung cancers; and(5) glutamate does not contribute to serine synthesis except for bladder cancer.Conclusions: We comprehensively predicted the roles of glutamine and glutamate metabolisms in selected metabolic pathways in cancer tissues versus control tissues, which may lead to novel approaches to therapeutic development targeted at glutamine and/or glutamate metabolism. However, our predictions need further functional validation.展开更多
文摘设计了一种基于ESP8266-01为无线传输模块与Arduino UNO R3为主控模块所构成的无线式(WiFi)远程温湿度调节系统。其中DHT11传感器把所测得的数据缓存到Arduino UNO R3,当温湿度超过上限及时报警,保证工作人员的安全。同时Arduino UNO R3用端口TX发送给无线传输模块,ESP8266-01再用无线方式传输温湿度值给装有TCP/UDP调试助手软件的移动设备,实现移动设备及时查看功能,且移动设备还可控制继电器总开关和调节LED亮度。该设计具有较大的应用前景。
基金supported by Georgia Research Alliance and the National Natural Science Foundation of China(Grant Nos.81320108025,61402194,61572227)the Science-Technology Development Project from Jilin Province(Nos.20160101259JC,20160204022GX,20170520063JH)
文摘Background: Glutamine and glutamate are known to play important roles in cancer biology. However, no detailed information is available in terms of their levels of involvement in various biological processes across different cancer types, whereas such knowledge could be critical for understanding the distinct characteristics of different cancer types. Our computational study aimed to examine the functional roles of glutamine and glutamate across different cancer types.Methods: We conducted a comparative analysis of gene expression data of cancer tissues versus normal control tissues of 11 cancer types to understand glutamine and glutamate metabolisms in cancer. Specifically, we developed a linear regression model to assess differential contributions by glutamine and/or glutamate to each of seven biological processes in cancer versus control tissues.Results: While our computational predictions were consistent with some of the previous observations, multiple novel predictions were made:(1) glutamine is generally not involved in purine synthesis in cancer except for breast cancer, and is similarly not involved in pyridine synthesis except for kidney cancer;(2) glutamine is generally not involved in ATP production in cancer;(3) glutamine's contribution to nucleotide synthesis is minimal if any in cancer;(4) glutamine is not involved in asparagine synthesis in cancer except for bladder and lung cancers; and(5) glutamate does not contribute to serine synthesis except for bladder cancer.Conclusions: We comprehensively predicted the roles of glutamine and glutamate metabolisms in selected metabolic pathways in cancer tissues versus control tissues, which may lead to novel approaches to therapeutic development targeted at glutamine and/or glutamate metabolism. However, our predictions need further functional validation.
