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基于UG/Part Families和UG/Open创建模具标准件图形库 被引量:4
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作者 齐建 黄晓慧 《现代制造技术与装备》 2006年第1期61-64,共4页
本文以直导套为例介绍了利用UG/Open和UG/Part Families进行参数化设计的过程;包括通过部件族创建参数化图库、利用UG/Open MenuScript和UG/Open Uistyler设计用户界面、在VC中创建动态链接库以及在UG界面中调用标准件的演示。
关键词 部件族 ug/OPEN API ug/OPEN MENUSCRIPT ug/OPEN Uistyler VC
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Therapeutic Communication Methods Targeting Families and Family Members: A Literature Review
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作者 Taketo Watsuji Naohiro Hohashi 《Open Journal of Nursing》 2024年第1期11-26,共16页
Background and Purpose: Therapeutic communication is a new term in family health care nursing, defined by Hohashi (2019) as a method of family intervention, and characterized by inclusion of not only verbal conversati... Background and Purpose: Therapeutic communication is a new term in family health care nursing, defined by Hohashi (2019) as a method of family intervention, and characterized by inclusion of not only verbal conversation but also nonverbal interaction. However, specific therapeutic communication methods have not been systematized. The purpose of this study was to clarify therapeutic communication methods for families/family members from the perspectives of verbal communication and non-verbal communication through a review of existing literature. Methods: We conducted a search using the medical literature databases PubMed and Ichushi-Web using the keywords “therapeutic communication”. Analysis was performed on seven articles from PubMed and 14 articles from Ichushi-Web that described therapeutic communication methods performed by healthcare professionals for families/family members. Through directed content analysis, therapeutic communication methods were subcategorized, and classified into three categories: verbal communication, non-verbal communication, and verbal/non-verbal communication. Results: A total of 23 subcategories were extracted. Verbal communication included 11 subcategories, such as “asking questions using the communicatee’s words as they are”. Non-verbal communication included five subcategories, such as “noticing changes in the content of the communicatee’s story”. And verbal/non-verbal communication featured seven subcategories, such as “making the communicatee aware of one’s own beliefs”. Conclusion: Therapeutic communication methods included basic care/caring in family interviews/meetings, as well as verbal communication and non-verbal communication that act on family/family members’ beliefs. It is believed that changes in family/family members’ beliefs can be used to eliminate, reduce, or improve problematic conditions in the family. . 展开更多
关键词 Therapeutic Communication Family Nursing Family Interview/Meeting Family Belief Systems Theory Literature Review
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Intergenerational Trauma and Resilience among Im/Migrant Families: Child Mental Health Outcomes and Psychosocial Mechanisms of Transmission
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作者 Maggie Gillen Annekathryn Goodman +3 位作者 Fiona Danaher Rahel Bosson Mary Greenwald Rashmi Jasrasaria 《Health》 2024年第10期888-920,共33页
Research Background: Psychological stressors leading to poor mental health outcomes accumulate throughout the migration process. The impact of a parent or caregiver’s posttraumatic stress on non-traumatized children ... Research Background: Psychological stressors leading to poor mental health outcomes accumulate throughout the migration process. The impact of a parent or caregiver’s posttraumatic stress on non-traumatized children is significant and may lead to adverse development and mental health outcomes. Research Objectives: The objective of this review is to explore both the consequences of parental trauma transmission on descendants’ psychological adjustment and well-being, and the mechanisms through which trauma has been transmitted among im/migrant populations. Methods: Criteria outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guided this systemic review. The questions guiding this review are: (a) What are the consequences of parental trauma transmission on the psychological adjustment and well-being of im/migrant offspring? And (b) What are the psychosocial mechanisms of trauma and resilience transmission among im/migrant populations? Each potential study was assessed based on relevance to the review question(s). Results: Parental trauma can lead to adverse mental health outcomes among descendants including increased internalizing and externalizing problems, the adoption of coping behaviors and worldviews, and worsening school performance. Mechanisms that influence trauma transmission include parental trauma symptom severity, the parent-child dyad, social learning, and family stressors. Pathways of resilience exist across socioecological levels to include individual resilience such as coping skills and meaning making, family resilience, structural protective factors, and social and cultural protective factors. Conclusions: Despite the prevalence of traumatic events throughout the migration process, im/migrant families display strong levels of resilience. Mental health services and providers should incorporate a strength-based approach in designing interventions that are culturally responsive and take into accounts the broader ecological contexts in which im/migrant families live. 展开更多
关键词 Intergenerational Trauma Im/Migrants families RESILIENCE Mental Health
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Familial Forms of Spondyloarthritis Study of 100 Senegalese Multiplex Families
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作者 Adama Bah Chiekh Ahamadou Bamba Diaw +10 位作者 Dieynaba Sala Tamara Kane Adama Doucouré Siddiki Charifah Ramadhane Bouchrane Harine Abdel Aziz Garba Aissatou N’diaye Mondukpe Joane Immanuelle Houansou Laurine Marlyse Adogle Yaye Aminata Gueye Moustapha Niasse Saidou Diallo 《Open Journal of Rheumatology and Autoimmune Diseases》 2024年第3期132-143,共12页
Introduction: Spondyloarthritis (SpA) comprises a group of chronic inflammatory rheumatic diseases characterized by predominant axial involvement. These include ankylosing spondylitis (AS), reactive arthritis (ReA), p... Introduction: Spondyloarthritis (SpA) comprises a group of chronic inflammatory rheumatic diseases characterized by predominant axial involvement. These include ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA), arthritis associated with inflammatory bowel diseases (IBD), SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis), juvenile spondyloarthritis (JSPA), and undifferentiated SpA. Their exact cause is unknown but is believed to stem from a combination of factors. The first familial forms were described by de Blécourt et al. in 1961. The objective was to evaluate the epidemiological, clinical, therapeutic and evolutionary aspects of familial forms of SpA and in particular, to prove the severity of the disease in family members compared to index cases in the rheumatology department of the Aristide Le Dantec University Hospital in Dakar. Methodology: This was a prospective, cross-sectional and descriptive study with an analytical aim on patients with the familial form of spondyloarthritis defined by the existence of at least one other family member with SpA outside the propositus, collected within the Aristide Le Dantec rheumatology department in Dakar over a period of 10 years between January 2012 and December 2021. There were two phases of study, the first of which consisted of collecting index cases with miserly SpA and the second of which consisted of family screening after consent. The data analysed were epidemiological, clinical, paraclinical, therapeutic and evolving. Results: Out of 100 families of 1905 members, 667 SpA patients included, i.e. a prevalence of 35%, including 225 (33.73%) men and 412 women (61.17%), i.e. a ratio of 1.8. The mean age at diagnosis among relatives was 26.3 years (range 13 and 80 years), 47.14 years among the propositus, in whom the mean age at onset was 36.26 years and that of relatives 49.9 years in the first degree, 15 years in the second degree and 1 year in the third degree. The time to diagnosis was 11.20 years in the first degree, 2.5 years in the second degree, 1 year in the third degree and 10.88 years in the case of the proposes. The number of marriages in families was 420 of which 116 were consanguineous (consanguinity rate 27.62%), 19% among the propositus. HLA-B27 positive in 92% of the proposers and 33.43% in the families;70% of the propositus had an inflammatory syndrome and 17.54% in the families;87% of sacroilliitis in the propositus and 5.54% in the families. Clinical forms were dominated by undifferentiated SpA (338 cases) and APS (295 cases). The average BASFI was 3.23 on D0;2.59 in the 3rd month and 1 in the 6th month for the propositus versus 2.55 at D0;1.86 at the 3rd month and 1.55 in the 6th month in the families. Average BASDAI was 3.92 at D0;3.12 at the 3rd month and 2.07 at the 6th month in the propositus and 3 at D0;2.21 at the 3rd month and 1 at the 6th month in the families. Autoimmune associated conditions were 18 cases, degenerative 24 cases, autoinflammatory 2 metabolic cases 18 cases. They all received: NSAIDs, methotrexate, salazopyrine (11 cases) and anti-TNF-α (1 case). The evolution was generally favourable. Conclusion: SpA is on the rise in Senegalese hospitals, frequent in young people, SPA and undifferentiated SpA are the most frequent, management is essentially based on conventional care, and the disease is less severe in family members than index cases. 展开更多
关键词 familial Forms of Spondyloarthritis Propositus Senegal
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Literature Review on Support for Children and Families Experiencing Parental Bereavement
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作者 Rurie Namiki Keita Sasaki +1 位作者 Iku Taniguchi Rie Wakimizu 《Open Journal of Nursing》 2024年第4期139-163,共25页
Purpose: This study aimed to understand the actual nursing support in a wide perspective by reviewing overseas literature on support for children who have experienced parental bereavement and their families. The goal ... Purpose: This study aimed to understand the actual nursing support in a wide perspective by reviewing overseas literature on support for children who have experienced parental bereavement and their families. The goal was to identify future challenges in nursing support in clinical practice in Japan. Method: Literature searchable as of May 2023 was retrieved using PubMed, resulting in 11 relevant articles. Result: The results revealed the following: 1) For support provided to children, 13 codes were condensed into 5 subcategories and 4 categories. 2) For support provided to families, 36 codes were condensed into 11 subcategories and 4 categories. Conclusion: Open communication was found to be essential for supporting children and their families who have experienced parental bereavement. Moreover, involvement of multiple professions facilitated the provision of specialized support to address diverse needs of children and families, playing a crucial role in overcoming grief. Additionally, the effectiveness of support systems for bereaved families highlighted the need for nursing professionals in Japan to gain knowledge through learning opportunities and to establish a multi-disciplinary approach to support, thus indicating future challenges in nursing support. 展开更多
关键词 Terminal Care Family Support CHILD Parental Death Palliative Care
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Familial hypercholesterolemia:Current limitations and future breakthroughs
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作者 Ze Xiang Jia-Rui Li +2 位作者 Wei-Min Wan Shu-Hui Li Jian Wu 《World Journal of Experimental Medicine》 2024年第4期174-177,共4页
Familial hypercholesterolemia(FH)is characterized by elevated low-density lipoprotein cholesterol levels due to genetic mutations,presenting with xanthomas,corneal arch,and severe cardiovascular diseases.Early identif... Familial hypercholesterolemia(FH)is characterized by elevated low-density lipoprotein cholesterol levels due to genetic mutations,presenting with xanthomas,corneal arch,and severe cardiovascular diseases.Early identification,diagnosis,and treatment are crucial to prevent severe complications like acute myocardial infarction.Statins are the primary treatment,supplemented by Ezetimibe and proprotein convertase subtilisin/kexin type 9 inhibitors,though their effectiveness can be limited in severe cases.Over 90%of FH cases remain undiagnosed,and current treatments are often inadequate,underscoring the need for improved diagnostic and management systems.Future strategies include advancements in gene testing,precision medicine,and novel drugs,along with gene therapy approaches like AAV-mediated gene therapy and clustered regularly interspaced short palindromic repeats.Lifestyle modifications,including health education,dietary control,and regular exercise,are essential for managing FH and preventing related diseases.Research into FH-related gene mutations,especially LDLR,is critical for accurate diagnosis and effective treatment. 展开更多
关键词 familial hypercholesterolemia Genetic mutations TREATMENT LIMITATIONS Breakthroughs
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Relations Between School and Immigrant Families in Albertan Francophone School: Perspectives of Settlement Workers in Schools - A Secondary Publication
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作者 Marianne Jacquet Gwenaëlle André 《Journal of Contemporary Educational Research》 2024年第3期136-147,共12页
In recent years,Francophone schools in Alberta,a province in western Canada,have seen significant ethnocultural diversification of their school population,thus reflecting recent migratory changes in Canada.The populat... In recent years,Francophone schools in Alberta,a province in western Canada,have seen significant ethnocultural diversification of their school population,thus reflecting recent migratory changes in Canada.The population of a Francophone school board located in an agglomeration of Alberta reflects these new migratory trends.A partial ethnodemographic portrait carried out in 2003 in six of its schools indicates that 50%of the pupils come from an immigrant background and come from 23 different countries;mostly from sub-Saharan African countries.This demographic reality,confirmed more than a decade later,represents a major structural change for Francophone schools.In Alberta,as in other Canadian provinces,inclusion is at the heart of discourse and educational practices.With a transformative aim,it intends to promote ethnocultural diversity in the classroom and equal opportunities through school equity practices.This article focuses on the settlement workers in schools responsible for bridging family,community,and school cultures.The analysis of the interviews of the four workers sheds light on and questions both the institutional practices and the personal strategies put in place to face the challenges encountered in this tripartite collaboration. 展开更多
关键词 Educational inclusion and exclusion Immigration and ethnicity Interculturality and multiculturalism Family and education Help for pupils and students Actors in education Canada
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基于UG的拖拉机大灯注塑模具设计 被引量:1
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作者 宋芳 《农机化研究》 北大核心 2024年第8期264-268,共5页
以拖拉机大灯为例,分析了UG注塑模具建模的设计方法和工艺方案,建立了拖拉机大灯模型,并完成了拖拉机大灯注塑模具的设计。研究结果表明:经过UG模拟开模出来的塑料件没有出现气泡、变形、缺料和银线等缺陷,整体也没有发现熔合条纹,设计... 以拖拉机大灯为例,分析了UG注塑模具建模的设计方法和工艺方案,建立了拖拉机大灯模型,并完成了拖拉机大灯注塑模具的设计。研究结果表明:经过UG模拟开模出来的塑料件没有出现气泡、变形、缺料和银线等缺陷,整体也没有发现熔合条纹,设计的拖拉机大灯注塑模具满足设计需求。 展开更多
关键词 拖拉机 大灯 ug 注塑 模具
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基于UG动画仿真的喷雾机喷杆形变控制优化
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作者 张楠 刘旭 《农机化研究》 北大核心 2024年第4期198-202,共5页
在植保作业领域,为预防大田作物的病虫害,传统农业生产存在农药使用粗放、滥用问题,对农村生产、生活、生态“三生同步”工作开展造成了十分不利的影响。为进一步提高农药使用合理性,顺应绿色农业、精确农业、生态农业的发展理念,宽幅... 在植保作业领域,为预防大田作物的病虫害,传统农业生产存在农药使用粗放、滥用问题,对农村生产、生活、生态“三生同步”工作开展造成了十分不利的影响。为进一步提高农药使用合理性,顺应绿色农业、精确农业、生态农业的发展理念,宽幅喷杆喷雾机逐渐具备了变量喷雾的技术特征。在生产实践中,耕地表面的地形、地势等不确定因素对喷杆喷雾机喷药架造成的振动、歪斜、变型等影响会明显降低喷雾覆盖精度,导致植保质量降低。为此,以我国生产常用的28m幅宽喷药架为研究对象,分析了喷药架的形变类型,利用UG软件仿真了喷药架变形后对喷雾质量的影响,并在分析动画仿真数据基础上有针对性地进行了喷药架结构优化与技术升级,且优化后的喷药架对于多种地形的适应性均得到提升。 展开更多
关键词 喷雾机 喷杆形变 控制 动画仿真 ug
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基于UG的拖拉机齿轮传动系统仿真研究
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作者 杨玉霞 李艳钰 《农机化研究》 北大核心 2025年第1期258-261,268,共5页
设计了一款拖拉机复合行星齿轮的动力系统,并基于UG仿真软件,建立了齿轮参数化模型,得到了齿轮的渐开线和齿廓线,最后建立了齿轮传动系统仿真模型。齿轮传动系统可靠性实验表明:系统齿轮运动符合预期,满足设计要求,证实了系统的可靠性。
关键词 拖拉机 复合行星齿轮 ug 齿轮传动
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基于UG二次开发的多材料零件3D打印建模方法研究
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作者 葛正浩 王楠 +1 位作者 张新安 刘磊 《印刷与数字媒体技术研究》 CAS 北大核心 2024年第4期228-236,共9页
随着制造业的不断创新与改进,多材料三维(Three-Dimensions,3D)打印工艺的重要性日益显现,多材料建模技术是3D打印工艺的核心模块。本研究提出一种基于UG二次开发的多材料3D打印建模方法。首先利用现有3D建模软件UG(Unigraphics NX)创... 随着制造业的不断创新与改进,多材料三维(Three-Dimensions,3D)打印工艺的重要性日益显现,多材料建模技术是3D打印工艺的核心模块。本研究提出一种基于UG二次开发的多材料3D打印建模方法。首先利用现有3D建模软件UG(Unigraphics NX)创建待打印零件的3D模型,通过包围盒原理及交集算法,对3D模型所处的材料空间微分化;其次通过UG对其单个或局部小立方体添加颜色,将颜色信息通过材料颜色映射表映射为材料信息,输出多材料模型文件;最后将3D模型导入材料空间,打印出满足功能要求与外观要求的多材料零件。该建模方法可为多材料3D打印建模技术研究提供参考。 展开更多
关键词 多材料零件 ug 包围盒原理 几何空间 材料空间
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基于UG的发动机轻量化设计与节能优化研究
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作者 袁帅 《常熟理工学院学报》 2024年第5期89-95,共7页
机体轻量化是优化发动机能量利用的主要手段之一.为合理节约能源利用量,针对基于UG的发动机轻量化设计与节能优化方法展开研究.设置UG/Post Builder后置处理器,针对相关参数进行求解,完成基于UG的发动机设计模块开发.控制机体壁厚,在此... 机体轻量化是优化发动机能量利用的主要手段之一.为合理节约能源利用量,针对基于UG的发动机轻量化设计与节能优化方法展开研究.设置UG/Post Builder后置处理器,针对相关参数进行求解,完成基于UG的发动机设计模块开发.控制机体壁厚,在此基础上减少螺栓个数,并改用轻量化曲轴箱,在保证机体高压密封状态的同时,完成发动机组件的轻量化设计.仿真实验结果表明,依照轻量化方法所设计的发动机机体自重相对较小,不会因机体过重而造成能源过量消耗的问题. 展开更多
关键词 ug软件 发动机 能源节约 轻量化设计
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基于局部剖视图的UG软件应用技巧
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作者 罗若 肖振泉 《内燃机与配件》 2024年第5期104-107,共4页
本文介绍了利用UG软件创建二维、立体局部剖视图的方法,研究总结了几何体创建具有相同剖切分界线的二维、立体局部剖视图的应用技巧和符合国家标准的局部剖视图表达方法。局部剖视图相同剖切分界线的创建,分界线在二维、立体视图中的切... 本文介绍了利用UG软件创建二维、立体局部剖视图的方法,研究总结了几何体创建具有相同剖切分界线的二维、立体局部剖视图的应用技巧和符合国家标准的局部剖视图表达方法。局部剖视图相同剖切分界线的创建,分界线在二维、立体视图中的切换,是整个过程比较关键的操作,关系到视图能否创建成功。通过本文介绍的方法,绘图者可以轻松实现正交的局部剖、轴测局部剖视图的绘制,熟练掌握后可以大大提高绘图的工作效率,为绘图工作提供方便。 展开更多
关键词 机械制图 ug软件 局部剖视图
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基于轴类零件的SolidWorks与UG NX的建模方法比较
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作者 陈光霞 《南方农机》 2024年第13期140-143,167,共5页
UG NX与SolidWorks是目前机械设计中较常用的三维设计软件,而轴类零件也是机器中很常见的零件。文章多角度比较用两种软件进行轴类零件造型时,绘制草图和运行特征命令的先后顺序不同对造型过程和结果的影响,同时也比较了轴类零件上常见... UG NX与SolidWorks是目前机械设计中较常用的三维设计软件,而轴类零件也是机器中很常见的零件。文章多角度比较用两种软件进行轴类零件造型时,绘制草图和运行特征命令的先后顺序不同对造型过程和结果的影响,同时也比较了轴类零件上常见结构如退刀槽、键槽的不同造型方法。对于两种软件在轴类零件造型中的不足提出了解决办法。 展开更多
关键词 SOLIDWORKS ug NX 建模
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基于UG NX的数控多轴加工工艺改良和配套夹具设计
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作者 陈燕 《自动化应用》 2024年第1期219-220,223,共3页
首先,简要介绍了UG NX编程软件的相关知识;其次,以金属半环和电机外壳为研究对象,分析了其原有的数控加工工艺并提出了优化改进措施;再次,利用UG对研究对象进行了配套工装的仿真设计;最后,利用UG编制研究对象的目标零件多轴数控加工程序... 首先,简要介绍了UG NX编程软件的相关知识;其次,以金属半环和电机外壳为研究对象,分析了其原有的数控加工工艺并提出了优化改进措施;再次,利用UG对研究对象进行了配套工装的仿真设计;最后,利用UG编制研究对象的目标零件多轴数控加工程序,有效保障了产品的加工质量,节省了人力、物力成本,提高了生产效率。 展开更多
关键词 ug NX编程 数控多轴加工 配套工装
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基于UG12.0自动编程的复杂槽类零件数控铣削仿真与加工
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作者 姚辉苗 郭慧杰 +1 位作者 王雪英 王成帅 《机电工程技术》 2024年第1期185-188,共4页
计算机辅助设计与制造技术是制造业的趋势和方向。对于轮廓形状复杂的零件,手动数控编程技术呈现出适应能力差,一定程度制约我国制造业质量水平的快速发展。以复杂槽类零件特征分析为基础,采用UG12.0 CAD模块开展复杂槽类零件三维建模,... 计算机辅助设计与制造技术是制造业的趋势和方向。对于轮廓形状复杂的零件,手动数控编程技术呈现出适应能力差,一定程度制约我国制造业质量水平的快速发展。以复杂槽类零件特征分析为基础,采用UG12.0 CAD模块开展复杂槽类零件三维建模,应用CAM模块设置刀具、建立坐标系、创建几何体、建立加工工序、设置刀轨参数及切削层参数,开展复杂槽类零件自动编程,使用仿真加工功能验证程序的正确性,后处理导出569型Oi mate MD加工中心能识别的处理器为“FANUC-BJ”的程序。将程序导入数控系统,安装毛坯和刀具,对刀找中心点,将两把刀具的长度补偿输入参数表中,最后进行加工生产。实践表明,对于复杂槽类零件,采用UG12.0进行自动编程、数控铣削仿真和生产加工是可行的。 展开更多
关键词 ug12.0 自动编程 仿真 数控铣削
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基于UG10.0的可乐瓶底座模芯CAD/CAM的研究
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作者 龚真蕊 《机械工程与自动化》 2024年第6期123-124,127,共3页
对于结构较为复杂的零件,手工编制对应数控程序不仅计算繁琐,还很容易出现错误,影响实际加工操作,甚至造成安全事故。利用UG10.0软件CAM部分对可乐瓶底座模芯零件进行编程,包括刀具的选用、工序的选择、策略参数设置及刀路仿真,通过后... 对于结构较为复杂的零件,手工编制对应数控程序不仅计算繁琐,还很容易出现错误,影响实际加工操作,甚至造成安全事故。利用UG10.0软件CAM部分对可乐瓶底座模芯零件进行编程,包括刀具的选用、工序的选择、策略参数设置及刀路仿真,通过后处理生成零件的加工程序。该方法大大降低了编程难度,提高了编程效率及加工的安全性。 展开更多
关键词 模芯 ug10.0 加工中心 自动编程 仿真加工
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Hsa_circ_0036740 in familial adenomatous polyposis:Immune regulation and neutrophil effects in CRC based on highthroughput assay 被引量:1
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作者 ZHIWANG LI HAN YU +3 位作者 YUPING LIU WEISHENG WU HAIJING ZENG EN LI 《BIOCELL》 SCIE 2023年第11期2409-2422,共14页
Familial adenomatous polyposis(FAP)is an autosomal dominant disease with a high probability of becoming cancerous.Many RNAs potentially associated with FAP have not been identified.In this study,a circRNA(circular RNA... Familial adenomatous polyposis(FAP)is an autosomal dominant disease with a high probability of becoming cancerous.Many RNAs potentially associated with FAP have not been identified.In this study,a circRNA(circular RNA)expression profile of FAP was established using a circRNA microarray,and differentially expressed circRNAs were verified by RT-qPCR.The effects of hsa_circ_0036740 on the malignant behavior of tumor cells(proliferation,apoptosis,and epithelial mesenchymal transition)and the levels of C3A complement protein expression were evaluated.Moreover,neutrophils were isolated and co-cultured with colorectal cancer cells(CRCs),followed by measurements of MPO-DNA,citrullinated histone H3,interleukin(IL)-1β,IL-6,and IL-8 levels.Nuclear translocation of arginine deiminase 4(PAD4)was observed using immunofluorescence assays.Based on the high-throughput assay,238 downregulated circRNAs,and 38 upregulated circRNAs were identified.A Kyoto Encyclopedia of Genes and Genomes enrichment analysis suggested that immune regulation might be involved in FAP.A total of 10 DECs(differentially expressed circular RNAs)were identified by RT-qPCR,and among them,hsa_circ_0036740 showed the highest fold-change in upregulation.Results of gain-of-and loss-of-function studies revealed that hsa_circ_0036740 enhanced the malignant behavior of tumor cells,such as metastasis,proliferation,and apoptosis,with an increasing level of C3A complement.Moreover,hsa_circ_0036740 also significantly increased neutrophil extracellular trap formation and inflammation in neutrophils,as shown by an increased expression of PAD4.In conclusion,this study revealed the expression profiles of circRNAs in FAP and confirmed the possible involvement of hsa_circ_0036740 in the immune regulation mediated by neutrophils.Finally,hsa_circ_0036740 was suggested as a new therapeutic target for CRC. 展开更多
关键词 familial adenomatous polyposis Colorectal cancer Hsa_circ_0036740 Neutrophil extracellular trap Metastasis
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混合式教学在中职UG三维造型设计课程中的应用研究 被引量:1
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作者 罗忠会 桂娟 郑继明 《汽车实用技术》 2024年第4期164-168,共5页
为革新中职院校的课堂教学模式,提升课堂教学效果,现以混合式教学在中职UG三维造型设计课程的应用为研究对象,采用调查研究法,得到了中职UG三维造型设计课程的现状以及存在的问题,在研究“线上+线下”教学设计基础上,提出“以学生为中... 为革新中职院校的课堂教学模式,提升课堂教学效果,现以混合式教学在中职UG三维造型设计课程的应用为研究对象,采用调查研究法,得到了中职UG三维造型设计课程的现状以及存在的问题,在研究“线上+线下”教学设计基础上,提出“以学生为中心”和“以学习活动为中心”的课堂教学策略,并依托“超星学习通”平台,设计了“线上+线下”混合式教学新模式,并将该模式运用于中职UG三维造型设计课程中。研究结果表明,该模式提升了中职课堂教学效果,为中职课堂教学模式的改革提供参考。 展开更多
关键词 ug三维造型设计 中职院校 超星学习通 混合式教学
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Study on the variation in and selection of Fraxinus mandshurica provenances and families in northeast China
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作者 Junfei Hao Na Chen +3 位作者 Pingyu Yan Kaiyuan Xu Lei Zhang Hanguo Zhang 《Journal of Forestry Research》 SCIE CAS CSCD 2023年第2期519-529,共11页
Fraxinus mandshurica Rupr.is one of the main afforestation species in northeast China,and there is great demand for improved F.mandshurica varieties.The results of an investigation into and analysis of the growth trai... Fraxinus mandshurica Rupr.is one of the main afforestation species in northeast China,and there is great demand for improved F.mandshurica varieties.The results of an investigation into and analysis of the growth traits of F.mandshurica provenances and families showed that there were significant differences in different periods.However,variations in growth traits decreased year by year.There was a significant negative correlation between tree heights of the provenances and sunshine hours in their areas of origin.The provenances of Xinglong,Hailin and Wuchang were selected based on the volume of 18-year-old trees.The average genetic gain from the selection of fast-growing provenances was 19.4%.Ten superior fast-growing families were selected.The average volume of the selected families was22.6%,higher than that of all families.The correlation coefficient between heights at 6-year-old and at 18a was 0.838for provenances,and between heights at 4-year-old and at 18-year-old was 0.303 for families.These results indicate that early selection for height in provenances or families could be performed at 6 years or 4 years,respectively.Early selection for DBH and volume in families could start at 8 years. 展开更多
关键词 Fraxinus mandshurica PROVENANCE Family selection Early-late correlation
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