The effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance （A）〈 1.0 is required when using a fiber-optic dissolution test system. The detection wa...The effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance （A）〈 1.0 is required when using a fiber-optic dissolution test system. The detection wavelength of 2 （218 nm） was replaced by 244 nm to carry out this test. The absorbance of Cimetidine solution at different temperature showed an obvious change. Calibration of Cimetidine solution should be tested at the same temperature （37° C） with the test solution. A suitable wavelength with smaller tangent slope could be chosen for in-situ dissolution test of Cimetidine tablets.展开更多
The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effec...The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying. In this study, the technique of differential spectra was employed, which made it possible to monitor the dissolution testing in situ. The results showed that the hydrolyzation of aspirin made the percentage of salicylic acid exceed the limit of free salicylic acid （4.0）, and the hydrolyzation may affect the quality detection of aspirin delayed-release tablets.展开更多
The objective of this work is to model statistically the ultraviolet radiation index (UV Index) to make forecast (extrapolate) and analyze trends. The task is relevant, due to increased UV flux and high rate of cases ...The objective of this work is to model statistically the ultraviolet radiation index (UV Index) to make forecast (extrapolate) and analyze trends. The task is relevant, due to increased UV flux and high rate of cases non-melanoma skin cancer in northeast of Brazil. The methodology utilized an Autoregressive Distributed Lag model (ADL) or Dynamic Linear Regression model. The monthly data of UV index were measured in east coast of the Brazilian Northeast (City of Natal-Rio Grande do Norte). The Total Ozone is single explanatory variable to model and was obtained from the TOMS and OMI/AURA instruments. The Predictive Mean Matching (PMM) method was used to complete the missing data of UV Index. The results mean squared error (MSE) between the observed UV index and interpolated data by model was of 0.36 and for extrapolation was of 0.30 with correlations of 0.90 and 0.91 respectively. The forecast/extrapolation performed by model for a climatological period (2012-2042) indicated a trend of increased UV (Seasonal Man-Kendall test scored τ = 0.955 and p-value 0.001) if the Total Ozone remain on this tendency to reduce. In those circumstances, the model indicated an increase of almost one unit of UV index to year 2042.展开更多
基金the Xinjiang Uygur Autonomous Region Natural Science Fund (No.2011211A041) Xinjiang Uygur Autonomous Region Science and Technology Plan (No.200910107)
文摘The effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance （A）〈 1.0 is required when using a fiber-optic dissolution test system. The detection wavelength of 2 （218 nm） was replaced by 244 nm to carry out this test. The absorbance of Cimetidine solution at different temperature showed an obvious change. Calibration of Cimetidine solution should be tested at the same temperature （37° C） with the test solution. A suitable wavelength with smaller tangent slope could be chosen for in-situ dissolution test of Cimetidine tablets.
基金supported by the Xinjiang Medical University Scientific Innovation Fund (No. XJC201129)Xinjiang Uygur Autonomous Region Natural Science Fund (No. 2011211A041)
文摘The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying. In this study, the technique of differential spectra was employed, which made it possible to monitor the dissolution testing in situ. The results showed that the hydrolyzation of aspirin made the percentage of salicylic acid exceed the limit of free salicylic acid （4.0）, and the hydrolyzation may affect the quality detection of aspirin delayed-release tablets.
文摘The objective of this work is to model statistically the ultraviolet radiation index (UV Index) to make forecast (extrapolate) and analyze trends. The task is relevant, due to increased UV flux and high rate of cases non-melanoma skin cancer in northeast of Brazil. The methodology utilized an Autoregressive Distributed Lag model (ADL) or Dynamic Linear Regression model. The monthly data of UV index were measured in east coast of the Brazilian Northeast (City of Natal-Rio Grande do Norte). The Total Ozone is single explanatory variable to model and was obtained from the TOMS and OMI/AURA instruments. The Predictive Mean Matching (PMM) method was used to complete the missing data of UV Index. The results mean squared error (MSE) between the observed UV index and interpolated data by model was of 0.36 and for extrapolation was of 0.30 with correlations of 0.90 and 0.91 respectively. The forecast/extrapolation performed by model for a climatological period (2012-2042) indicated a trend of increased UV (Seasonal Man-Kendall test scored τ = 0.955 and p-value 0.001) if the Total Ozone remain on this tendency to reduce. In those circumstances, the model indicated an increase of almost one unit of UV index to year 2042.
