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Numerical simulation of materials-oriented ultra-precision diamond cutting:review and outlook 被引量:1
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作者 Liang Zhao Junjie Zhang +3 位作者 Jianguo Zhang Houfu Dai Alexander Hartmaier Tao Sun 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2023年第2期1-21,共21页
Ultra-precision diamond cutting is a promising machining technique for realizing ultra-smooth surface of different kinds of materials.While fundamental understanding of the impact of workpiece material properties on c... Ultra-precision diamond cutting is a promising machining technique for realizing ultra-smooth surface of different kinds of materials.While fundamental understanding of the impact of workpiece material properties on cutting mechanisms is crucial for promoting the capability of the machining technique,numerical simulation methods at different length and time scales act as important supplements to experimental investigations.In this work,we present a compact review on recent advancements in the numerical simulations of material-oriented diamond cutting,in which representative machining phenomena are systematically summarized and discussed by multiscale simulations such as molecular dynamics simulation and finite element simulation:the anisotropy cutting behavior of polycrystalline material,the thermo-mechanical coupling tool-chip friction states,the synergetic cutting responses of individual phase in composite materials,and the impact of various external energetic fields on cutting processes.In particular,the novel physics-based numerical models,which involve the high precision constitutive law associated with heterogeneous deformation behavior,the thermo-mechanical coupling algorithm associated with tool-chip friction,the configurations of individual phases in line with real microstructural characteristics of composite materials,and the integration of external energetic fields into cutting models,are highlighted.Finally,insights into the future development of advanced numerical simulation techniques for diamond cutting of advanced structured materials are also provided.The aspects reported in this review present guidelines for the numerical simulations of ultra-precision mechanical machining responses for a variety of materials. 展开更多
关键词 diamond cutting ultra-smooth surface material-oriented physics-based simulation model molecular dynamics finite element
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Experimental investigation for ultra-precision cutting of nickel based superalloy with the assistance of magnetic field 被引量:1
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作者 XIAO JunFeng GUO Feng +3 位作者 ZHANG Chen CHEN Xiao ZHANG JianGuo XU JianFeng 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2022年第9期2170-2177,共8页
Nickel based superalloy is an important material because of its excellent properties under high temperatures.However,it is a difficult-to-machine material due to its low thermal conductivity,which can cause undesired ... Nickel based superalloy is an important material because of its excellent properties under high temperatures.However,it is a difficult-to-machine material due to its low thermal conductivity,which can cause undesired localized high temperatures in the processing area.In this study,magnetic field-assisted end face turning experiments of nickel-based superalloy is carried out under the assistance of external magnetic fields of different strengths formed by permanent magnets.The experiment results show that,compared with ordinary machining,the chip morphology is improved,the oscillation of cutting force F_(c),F_(a),and Ffare significantly reduced by 90%,88%,and 78%,and the surface roughness Ra is improved from 23 to 13 nm,the P-V value of the fan-shaped area of the machined surface is reduced,and hardness and ductility are improved after the magnetic field is applied.The experiment results indicate that the application of a magnetic field is an efficient and convenient approach to improve the cutting performance of nickel based superalloy. 展开更多
关键词 magnetic field assisted cutting nickel based superalloy ultra-precision cutting
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Instability mechanism of mining roadway passing through fault at different angles in kilometre-deep mine and control measures of roof cutting and NPR cables 被引量:2
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作者 SUN Xiaoming WANG Jian +6 位作者 ZHAO Wenchao MING Jiang ZHANG Yong LI Zhihu MIAO Chengyu GUO Zhibiao HE Manchao 《Journal of Mountain Science》 SCIE CSCD 2024年第1期236-251,共16页
The angle α between the fault strike and the axial direction of the roadway produces different damage characteristics. In this paper, the research methodology includes theoretical analyses, numerical simulations and ... The angle α between the fault strike and the axial direction of the roadway produces different damage characteristics. In this paper, the research methodology includes theoretical analyses, numerical simulations and field experiments in the context of the Daqiang coal mine located in Shenyang, China. The stability control countermeasure of "pre-splitting cutting roof + NPR anchor cable"(PSCR-NPR) is simultaneously proposed. According to the different deformation characteristics of the roadway, the faults are innovatively classified into three types, with α of type I being 0°-30°, α of type II being 30°-60°, and α of type III being 60°-90°. The full-cycle stress evolution paths during mining roadway traverses across different types of faults are investigated by numerical simulation. Different pinch angles α lead to high stress concentration areas at different locations in the surrounding rock. The non-uniform stress field formed in the shallow surrounding rock is an important reason for the instability of the roadway. The pre-cracked cut top shifted the high stress region to the deep rock mass and formed a low stress region in the shallow rock mass. The high prestressing NPR anchor cable transforms the non-uniform stress field of the shallow surrounding rock into a uniform stress field. PSCR-NPR is applied in the fault-through roadway of Daqiang mine. The low stress area of the surrounding rock was enlarged by 3-7 times, and the cumulative convergence was reduced by 45%-50%. It provides a reference for the stability control of the deep fault-through mining roadway. 展开更多
关键词 Kilometre-deep mine Fault Mining roadway Failure mechanism Pre-splitting cutting roof High pre-stress NPR anchor cable
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Prediction of cutting force in ultra-precision machining of nonferrous metals based on strain energy
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作者 Ying Wang Zewei Yuan +1 位作者 Tianzheng Wu Heran Yan 《Nanotechnology and Precision Engineering》 CAS CSCD 2021年第4期1-11,共11页
The effects of the nonuniform cutting force and elastic recovery of processed materials in ultra-precision machining are too complex to be treated using traditional cutting theories,and it is necessary to take account... The effects of the nonuniform cutting force and elastic recovery of processed materials in ultra-precision machining are too complex to be treated using traditional cutting theories,and it is necessary to take account of factors such as size effects,the undeformed cutting thickness,the tool blunt radius,and the tool rake angle.Therefore,this paper proposes a new theoretical calculation model for accurately predicting the cutting force in ultra-precision machining,taking account of such factors.The model is first used to analyze the material deformation of the workpiece and the cutting force distribution along the cutting edge of a diamond tool.The size of the strain zone in different cutting deformation zones is then determined by using the distribution of strain work per unit volume and considering the characteristics of the stress distribution in these different deformation zones.Finally,the cutting force during ultra-precision machining is predicted precisely by calculating the material strain energy in different zones.A finite element analysis and experimental data on ultra-precision cutting of copper and aluminum are used to verify the predictions of the theoretical model.The results show that the error in the cutting force between the calculation results and predictions of the model is less than 14%.The effects of the rake face stress distribution of the diamond tool,the close contact zone,and material elastic recovery can be fully taken into account by the theoretical model.Thus,the proposed theoretical calculation method can effectively predict the cutting force in ultra-precision machining. 展开更多
关键词 ultra-precision cutting Diamond tool cutting force Strain energy Finite element analysis
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Hole cleaning evaluation and installation spacing optimization of cuttings bed remover in extended-reach drilling
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作者 Shuo Peng Wen-Jun Huang De-Li Gao 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期2005-2022,共18页
In extended-reach or long-horizontal drilling,cuttings usually deposit at the bottom of the annulus.Once cuttings accumulate to a certain thickness,complex problems such as excessive torque and drag,tubing buckling,an... In extended-reach or long-horizontal drilling,cuttings usually deposit at the bottom of the annulus.Once cuttings accumulate to a certain thickness,complex problems such as excessive torque and drag,tubing buckling,and pipe stuck probably occur,which results in a lot of non-productive time and remedial operations.Cuttings bed remover can efficiently destroy deposited cuttings in time through hydraulic and mechanical stirring effects.This paper aims to build a method for hole cleaning evaluation and installation spacing optimization of cuttings bed remover to improve the wellbore cleaning effect.Firstly,a Computational Fluid Dynamics approach with Eulerian—Eulerian multiphase model was utilized to investigate the mechanism of cuttings transportation,and a new type of cuttings bed remover was designed.Next,an evaluation method of hole cleaning effect of remover was established.After that,the effects of several drilling parameters on hole cleaning including flow rate of drilling fluid,rotational speed of drillpipe,rate of penetration,wellbore size,rheological property of drilling fluid,and remover eccentricity on the performance of cuttings bed remover were investigated.The results demonstrate that the new type of remover with streamline blade performs better than conventional removers.The efficiency of hole cleaning is greatly improved by increasing the rotational speed of drillpipe,flow rate of drilling fluid,remover eccentricity,and 6 rpm Fann dial reading for drilling fluid.While higher rate of penetration and large wellbore size result in worse hole cleaning.These findings can serve as an important guide for the structure optimization design of cuttings bed remover and installation spacing of removers. 展开更多
关键词 Extended-reach drlling Drilling hydraulics cuttings transport Hole cleaning cuttings bed remover
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Unraveling engineering disturbance effects on deformation in red-bed mudstone railway cuttings:incorporating crack-facilitated moisture diffusion
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作者 HUANG Kang DAI Zhangjun +3 位作者 YAN Chengzeng YAO Junkai CHI Zecheng CHEN Shanxiong 《Journal of Mountain Science》 SCIE CSCD 2024年第5期1663-1682,共20页
Red-bed mudstone, prevalent in southwest China, poses a formidable challenge due to its hydrophilic clay minerals, resulting in expansion, deformation, and cracking upon exposure to moisture. This study addresses upli... Red-bed mudstone, prevalent in southwest China, poses a formidable challenge due to its hydrophilic clay minerals, resulting in expansion, deformation, and cracking upon exposure to moisture. This study addresses uplift deformation disasters in high-speed railways by employing a moisture diffusion-deformation-fracture coupling model based on the finite-discrete element method(FDEM). The model integrates the influence of cracks on moisture diffusion. The investigation into various excavation depths reveals a direct correlation between depth and the formation of tensile cracks at the bottom of the railway cutting. These cracks expedite moisture migration, significantly impacting the temporal and spatial evolution of the moisture field. Additionally, crack expansion dominates hygroscopic deformation, with the lateral coordinate of the crack zone determining peak vertical displacement. Furthermore, key factors influencing deformation in railway cuttings, including the swelling factor and initial moisture content at the bottom of the cutting, are explored. The number of tensile and shear cracks increases with greater excavation depth, particularly concerning shear cracks. Higher swelling factors and initial moisture contents result in an increased total number of cracks, predominantly shear cracks. Numerical calculations provide valuable insights, offering a scientific foundation and directional guidance for the precise prevention, control, prediction, and comprehensive treatment of mudstone-related issues in high-speed railways. 展开更多
关键词 Red-bed mudstone Railway cutting FDEM Moisture diffusion DEFORMATION CRACK
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Precipitates Generation Mechanism and Surface Quality Improvement for Aluminum Alloy 6061 in Diamond Cutting
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作者 王海龙 DENG Wenping 王素娟 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第1期150-159,共10页
To improve the surface quality for aluminum alloy 6061(Al6061) in ultra-precision machining, we investigated the factors affecting the surface finish in single point diamond turning(SPDT)by studying influence of the p... To improve the surface quality for aluminum alloy 6061(Al6061) in ultra-precision machining, we investigated the factors affecting the surface finish in single point diamond turning(SPDT)by studying influence of the precipitates generation of Al6061 on surface integrity and surface roughness.Based on the Johnson-Mehl-Avrami solid phase transformation kinetics equation, theoretical and experimental studies were conducted to build the relationship between the aging condition and the type, size and number of the precipitates for Al6061. Diamond cutting experiments were conducted to machine Al6061 samples under different aging conditions. The experimental results show that, the protruding on the chip surface is mainly Mg_(2)Si and the scratches on the machined surface mostly come from the iron-containing phase(α-, β-AlFeSi).Moreover, the generated Mg_(2)Si and α-, β-AlFeSi affect the surface integrity and the diamond turned surface roughness. Especially, the achieved surface roughness in SPDT is consistent with the variation of the number of AlFeSi and Mg_(2)Si with the medium size(more than 1 μm and less than 2 μm) in Al6061. 展开更多
关键词 Al6061 PRECIPITATES aging treatment diamond cutting surface roughness
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Ground response and failure mechanism of gob-side entry by roof cutting with hard main roof
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作者 ZHU Heng-zhong XU Lei WEN Zhi-jie 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第7期2488-2512,共25页
This study is the result of long-term efforts of the authors’team to assess ground response of gob-side entry by roof cutting(GSERC)with hard main roof,aiming at scientific control for GSERC deformation.A comprehensi... This study is the result of long-term efforts of the authors’team to assess ground response of gob-side entry by roof cutting(GSERC)with hard main roof,aiming at scientific control for GSERC deformation.A comprehensive field measurement program was conducted to determine entry deformation,roof fracture zone,and anchor bolt(cable)loading.The results indicate that GSERC deformation presents asymmetric characteristics.The maximum convergence near roof cutting side is 458 mm during the primary use process and 1120 mm during the secondary reuse process.The entry deformation is closely associated with the primary development stage,primary use stage,and secondary reuse stage.The key block movement of roof cutting structure,a complex stress environment,and a mismatch in the supporting design scheme are the failure mechanism of GSERC.A controlling ideology for mining states,including regional and stage divisions,was proposed.Both dynamic and permanent support schemes have been implemented in the field.Engineering practice results indicate that the new support scheme can efficiently ensure long-term entry safety and could be a reliable approach for other engineering practices. 展开更多
关键词 gob-side entry by roof cutting ground response failure mechanism following mining states control hard main roof
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Cutting Propagation Technique of Pennisetum purpureum Schum
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作者 Yuanbin HU Jing ZHANG +2 位作者 Yanan LIU Xiaoyu LIANG Yang JI 《Plant Diseases and Pests》 2024年第2期27-31,共5页
[Objectives]The paper was to study the cutting propagation technique of Pennisetum purpureum Schum and to provide a technical reference for establishing an efficient cutting propagation method.[Methods]Six treatments ... [Objectives]The paper was to study the cutting propagation technique of Pennisetum purpureum Schum and to provide a technical reference for establishing an efficient cutting propagation method.[Methods]Six treatments were set up using P.purpureum cv.Guiminyin and P.purpureum cv.Guimu-1 as test materials,including 1-node oblique insertion,1-node oblique insertion+rooting powder,1-node transverse burial,2-node oblique insertion,2-node oblique insertion+rooting powder and 2-node transverse burial.The following indices were observed and determined for P.purpureum cuttings:emergence rate,rooting rate,root number,longest root length,fresh root weight,plant height,number of tillers,number of leaves,and fresh stem and leaf weight.[Results]In the 2-node cutting+rooting powder treatment,Guiminyin and Guimu-1 exhibited the highest survival rate,root growth indices,and stem and leaf growth indices,with the emergence rates of 94.29%and 90.26%,respectively.The 2-node cutting treatment followed closely behind,while the 1-node cutting treatment had the lowest indices.Under the same treatment,Guimuyin exhibited higher mean values for plant height,number of leaves,fresh stem and leaf weight,longest root length,and fresh root weight compared to Guimu-1.However,it had lower mean number of tillers,and emergence rate and rooting rate of the 1-node cutting treatment compared to Guimu-1.[Conclusions]The P.purpureum cuttings thrived in the 2-node cutting+rooting powder treatment,and the overall cutting effect of Guiminyin was superior to that of Guimu-1. 展开更多
关键词 Pennisetum purpureum Schum cutting PROPAGATION Emergence rate
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Cutting-edge Technological Innovation Outcome Displayed at 2024 Beijing Science and Technology Week
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作者 Zhang Yida 《China's Foreign Trade》 2024年第3期47-49,共3页
The 2024 National Science and Technology Week and Beijing Science and Technology Week opened in Shougang Park in Shijingshan District from May 25 to June 1.Under the theme of“Carrying forward the spirit of scientists... The 2024 National Science and Technology Week and Beijing Science and Technology Week opened in Shougang Park in Shijingshan District from May 25 to June 1.Under the theme of“Carrying forward the spirit of scientists and inspiring societal innovation,”this event focused on the new-generation IT technology,medical health,energy and technology,modern agriculture and intelligent manufacturing industries. 展开更多
关键词 DISTRICT cutting opened
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Endoscopic radial incision and cutting method for adult congenital duodenal webs:A case report
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作者 Hyun Deok Shin 《World Journal of Clinical Cases》 SCIE 2024年第18期3622-3628,共7页
BACKGROUND Congenital duodenal webs are rare in adults and can lead to various symptoms such as nausea,vomiting,and postprandial fullness.The treatment for this disease is mostly surgical.Endoscopic treatment techniqu... BACKGROUND Congenital duodenal webs are rare in adults and can lead to various symptoms such as nausea,vomiting,and postprandial fullness.The treatment for this disease is mostly surgical.Endoscopic treatment techniques have been developed and attempted for this disease.Endoscopic radial incision and cutting(RIC)techniques are reportedly very effective in benign anastomotic stricture.This case report highlights the effectiveness and safety of endoscopic RIC as a minimally invasive treatment for adult congenital duodenal webs.CASE SUMMARY A 23-year-old female patient with indigestion was referred to a tertiary hospital.The patient complained of postprandial fullness in the epigastric region.Previous physical examinations or blood tests indicated no abnormalities.Computed tomography revealed an eccentric broad-based delayed-enhancing mass-like lesion in the second portion of the duodenum.Endoscopy showed an enlarged gastric cavity and a significantly dilated duodenal bulb;a very small hole was observed in the distal part of the second portion,and scope passage was not possible.Gastrografin upper gastrointestinal series was performed,revealing an intraduodenal barium contrast-filled sac with a curvilinear narrow radiolucent rim,a typical"windsock"sign.Endoscopic RIC was performed on the duodenal web.The patient recovered uneventfully.Follow-up endoscopy showed a patent duodenal lumen without any residual stenosis.The patient reported complete resolution of symptoms at the 18-month follow-up.CONCLUSION Endoscopic RIC may be an effective treatment for congenital duodenal webs in adults. 展开更多
关键词 Congenital duodenal web Endoscopic treatment Radial incision and cutting method Surgery Case report
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Application of Fuyang Paper Cutting Art in Cultural and Creative Design from the Perspective of Rural Revitalization
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作者 KANG Wenwen 《Journal of Landscape Research》 2024年第3期59-62,共4页
The application significance of Fuyang paper cutting art in cultural and creative design from the perspective of rural revitalization was discussed,and the implementation principles and specific practices of applying ... The application significance of Fuyang paper cutting art in cultural and creative design from the perspective of rural revitalization was discussed,and the implementation principles and specific practices of applying the elements and techniques of Fuyang traditional paper cutting art in cultural and creative products with local features were analyzed to provide reference for rural revitalization and development of cultural industry. 展开更多
关键词 Rural revitalization Fuyang paper cutting Cultural and creative design
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Design and Numerical Simulation of Dust Removal System for Sutomotive Iongitudinal Beam Plasma Cutting
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作者 Wenqiang GAO Xudong MA Heyu TIAN 《Mechanical Engineering Science》 2024年第1期30-34,共5页
To improve the poor efficiency of the dust removal system in the plasma cutting station of automotive longitudinal beams,and reduce the cutting surface quality degradation due to dust,a bottom-side suction dust remova... To improve the poor efficiency of the dust removal system in the plasma cutting station of automotive longitudinal beams,and reduce the cutting surface quality degradation due to dust,a bottom-side suction dust removal system is designed,and the dust removal effect is optimized through the setting of the following dampers and diversion plates.The result of numerical simulation indicates that the particle collection rate can reach 99.44%,and the field test also proves the effectiveness of the dust removal system,which is of guiding significance for the transformation of other similar dust removal systems. 展开更多
关键词 plasma cutting dust removal equipment SIMULATION
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Research on the Resistance of Cutting Mechanism of Mining Longitudinal Roadheader
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作者 Mengjiao NIU Yong ZHAO Yongliang YUAN 《Mechanical Engineering Science》 2024年第1期8-12,共5页
In order to accurately obtain the dynamic characteristics of the cutting mechanism of the mining longitudinal roadheader,combined with the working principle of the mining longitudinal roadheader,the theoretical analys... In order to accurately obtain the dynamic characteristics of the cutting mechanism of the mining longitudinal roadheader,combined with the working principle of the mining longitudinal roadheader,the theoretical analysis and derivation are carried out in detail.By using ADAMS to simulate,the resistance curve and torque curve of the cutting mechanism in different directions are obtained.The results show that ADAMS can effectively predict the excavation resistance and torque of the cutting mechanism of mining longitudinal roadheader,which has certain reference value for future optimization design. 展开更多
关键词 longitudinal roadheader cutting mechanism dynamic characteristics DYNAMICS
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Mesoplasticity Approach to Studies of the Cutting Mechanism in Ultra-precision Machining 被引量:2
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作者 LEE WB Rongbin WANG Hao +2 位作者 TO Suet CHEUNG Chi Fai CHAN Chang Yuen 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2014年第2期219-228,共10页
There have been various theoretical attempts by researchers worldwide to link up different scales of plasticity studies from the nano-, micro- and macro-scale of observation, based on molecular dynamics, crystal plast... There have been various theoretical attempts by researchers worldwide to link up different scales of plasticity studies from the nano-, micro- and macro-scale of observation, based on molecular dynamics, crystal plasticity and continuum mechanics. Very few attempts, however, have been reported in ultra-precision machining studies. A mesoplasticity approach advocated by Lee and Yang is adopted by the authors and is successfully applied to studies of the micro-cutting mechanisms in ultra-precision machining. Traditionally, the shear angle in metal cutting, as well as the cutting force variation, can only be determined from cutting tests. In the pioneering work of the authors, the use of mesoplasticity theory enables prediction of the fluctuation of the shear angle and micro-cutting force, shear band formation, chip morphology in diamond turning and size effect in nano-indentation. These findings are verified by experiments. The mesoplasticity formulation opens up a new direction of studies to enable how the plastic behaviour of materials and their constitutive representations in deformation processing, such as machining can be predicted, assessed and deduced from the basic properties of the materials measurable at the microscale. 展开更多
关键词 ultra-precision machining cutting mechanism mesoplasticity shear angle prediction size effect micro-cutting force variation high frequency tool-tip vibration
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Dynamic modeling of ultra-precision fly cutting machine tool and the effect of ambient vibration on its tool tip response 被引量:1
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作者 Jianguo Ding Yu Chang +4 位作者 Peng Chen Hui Zhuang Yuanyuan Ding Hanjing Lu Yiheng Chen 《International Journal of Extreme Manufacturing》 2020年第2期120-136,共17页
The dynamic performances of an ultra-precision fly cutting machine tool(UFCMT)has a dramatic impact on the quality of ultra-precision machining.In this study,the dynamic model of an UFCMT was established based on the ... The dynamic performances of an ultra-precision fly cutting machine tool(UFCMT)has a dramatic impact on the quality of ultra-precision machining.In this study,the dynamic model of an UFCMT was established based on the transfer matrix method for multibody systems.In particular,the large-span scale flow field mesh model was created;and the variation in linear and angular stiffness of journal and thrust bearings with respect to film thickness was investigated by adopting the dynamic mesh technique.The dynamic model was proven to be valid by comparing the dynamic characteristics of the machine tool obtained by numerical simulation with the experimental results.In addition,the power spectrum density estimation method was adopted to simulate the statistical ambient vibration excitation by processing the ambient vibration signal measured over a long period of time.Applying it to the dynamic model,the dynamic response of the tool tip under ambient vibration was investigated.The results elucidated that the tool tip response was significantly affected by ambient vibration,and the isolation foundation had a good effect on vibration isolation. 展开更多
关键词 ultra-precision fly cutting machine tool transfer matrix method for multibody systems dynamic response of tool tip power spectrum density estimation method ambient vibration
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ONECUT2高表达介导胃癌复发患者5-FU化疗耐药
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作者 朱海峰 陈述 +1 位作者 龙卫国 王旭 《江苏大学学报(医学版)》 CAS 2024年第1期19-24,共6页
目的:探究One cut结构域家族成员2(ONECUT2)是否可以作为对5-FU耐药的胃癌复发患者的治疗靶点。方法:利用癌症基因组图谱(TCGA)数据库分析ONECUT2基因在胃癌患者及胃癌复发患者的表达情况。利用基因集富集分析(GSEA)评估TCGA数据库中ONE... 目的:探究One cut结构域家族成员2(ONECUT2)是否可以作为对5-FU耐药的胃癌复发患者的治疗靶点。方法:利用癌症基因组图谱(TCGA)数据库分析ONECUT2基因在胃癌患者及胃癌复发患者的表达情况。利用基因集富集分析(GSEA)评估TCGA数据库中ONECUT2表达量与药物代谢相关生物学过程的相关性。利用CCK-8细胞毒性实验评估胃癌细胞敲低或过表达ONECUT2对5-FU的耐药情况。分析30例胃癌术后复发患者ONECUT2表达量与5-FU治疗效果的相关性。结果:TCGA数据库分析显示,在经受过化疗且复发的胃癌患者中,ONECUT2高表达的患者无病间隔期(disease-free interval,DFI)更短。GSEA分析结果表明,ONECUT2高表达与异生药物代谢通路呈正相关,这提示可能与胃癌患者的耐药相关。体外实验中,敲低ONECUT2降低胃癌细胞对5-FU的半数抑制浓度(IC_(50))值;反之,过表达ONECUT2增加细胞对5-FU的IC_(50)值。30例胃癌复发患者对5-FU的药物敏感性与ONECUT2表达量相关。结论:胃癌复发患者的ONECUT2表达量更高,ONECUT2高表达与胃癌复发患者的5-FU耐药相关,可能是潜在的治疗靶点。 展开更多
关键词 One cut结构域家族成员2 胃癌复发 5-FU耐药 GSEA 细胞毒性 半数抑制浓度
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Friction behaviors in the metal cutting process:state of the art and future perspectives 被引量:3
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作者 Xiaoliang Liang Zhanqiang Liu +2 位作者 Bing Wang Chunjin Wang Chi Fai Cheung 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2023年第1期22-58,共37页
Material removal in the cutting process is regarded as a friction system with multiple input and output variables.The complexity of the cutting friction system is caused by the extreme conditions existing on the tool... Material removal in the cutting process is regarded as a friction system with multiple input and output variables.The complexity of the cutting friction system is caused by the extreme conditions existing on the tool–chip and tool–workpiece interfaces.The critical issue is significant to use knowledge of cutting friction behaviors to guide researchers and industrial manufacturing engineers in designing rational cutting processes to reduce tool wear and improve surface quality.This review focuses on the state of the art of research on friction behaviors in cutting procedures as well as future perspectives.First,the cutting friction phenomena under extreme conditions,such as high temperature,large strain/strain rates,sticking–sliding contact states,and diverse cutting conditions are analyzed.Second,the theoretical models of cutting friction behaviors and the application of simulation technology are discussed.Third,the factors that affect friction behaviors are analyzed,including material matching,cutting parameters,lubrication/cooling conditions,micro/nano surface textures,and tool coatings.Then,the consequences of the cutting friction phenomena,including tool wear patterns,tool life,chip formation,and the machined surface are analyzed.Finally,the research limitations and future work for cutting friction behaviors are discussed.This review contributes to the understanding of cutting friction behaviors and the development of high-quality cutting technology. 展开更多
关键词 cutting process friction behaviors material removal process contact condition
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Performances of a Stinger PDC cutter breaking granite: Cutting force and mechanical specific energy in single cutter tests 被引量:1
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作者 Chao Xiong Zhong-Wei Huang +4 位作者 Huai-Zhong Shi Rui-Yue Yang Gang Wu Han Chen Wen-Hao He 《Petroleum Science》 SCIE EI CAS CSCD 2023年第2期1087-1103,共17页
The Stinger PDC cutter has high rock-breaking efficiency and excellent impact and wear resistance, which can significantly increase the rate of penetration (ROP) and extend PDC bit life for drilling hard and abrasive ... The Stinger PDC cutter has high rock-breaking efficiency and excellent impact and wear resistance, which can significantly increase the rate of penetration (ROP) and extend PDC bit life for drilling hard and abrasive formation. The knowledge of force response and mechanical specific energy (MSE) for the Stinger PDC cutter is of great importance for improving the cutter's performance and optimizing the hybrid PDC bit design. In this paper, 87 single cutter tests were conducted on the granite. A new method for precisely obtaining the rock broken volume was proposed. The influences of cutting depth, cutting angle, and cutting speed on cutting force and MSE were analyzed. Besides, a phenomenological cutting force model of the Stinger PDC cutter was established by regression of experimental data. Moreover, the surface topography and fracture morphology of the cutting groove and large size cuttings were measured by a 3D profilometer and a scanning electron microscope (SEM). Finally, the rock-breaking mechanism of the Stinger PDC cutter was illustrated. The results indicated that the cutting depth has the greatest influence on the cutting force and MSE, while the cutting speed has no obvious effects, especially at low cutting speeds. As the increase of cutting depth, the cutting force increases linearly, and MSE reduces with a quadratic polynomial relationship. When the cutting angle raises from 10° to 30°, the cutting force increases linearly, and the MSE firstly decreases and then increases. The optimal cutting angle for breaking rock is approximately 20°. The Stinger PDC cutter breaks granite mainly by high concentrated point loading and tensile failure, which can observably improve the rock breaking efficiency. The key findings of this work will help to reveal the rock-breaking mechanisms and optimize the cutter arrangement for the Stinger PDC cutter. 展开更多
关键词 Stinger PDC cutter cutting force Mechanical specific energy Single cutter tests
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Stability control measures for roof cutting and NPR supporting of mining roadways in fault areas of kilometre-deep coal mine 被引量:1
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作者 SUN Xiao-ming WANG Jian +5 位作者 ZHANG Yong ZHAO Wen-chao GUO Zhi-biao HE Man-chao CHEN Feng MIAO Cheng-yu 《Journal of Mountain Science》 SCIE CSCD 2023年第10期3051-3065,共15页
The study focuses on the stability control measures for mining roadways in fault zones of deep mines,using Daqiang Coal Mine as a case study.The control system under consideration,referred to as"pre-splitting cut... The study focuses on the stability control measures for mining roadways in fault zones of deep mines,using Daqiang Coal Mine as a case study.The control system under consideration,referred to as"pre-splitting cutting roof+NPR anchor cable"(PSCR-NPR),is subjected to scrutiny through theoretical analysis,numerical modelling,and field trials.Furthermore,a comprehensive analysis is undertaken to evaluate the stability control mechanism of this particular technology.The study provides evidence that the utilization of deep-hole directional energy-concentrated blasting facilitates the attainment of directional roof cutting in roadways.The aforementioned procedure leads to the formation of a uniform structural surface on the roof of the roadway and causes modifications in the surrounding geological formation.The examination of the lateral abutment pressure and shear stress distribution,both prior to and subsequent to roof cutting,indicates that the implementation of pre-splitting techniques leads to a noteworthy reduction in pressure.The proposition of incorporating the safety factor Q for roof cutting height is suggested as a method to augment comprehension of the pressure relief phenomenon in the field of engineering.The analysis of numerical simulation has indicated that the optimal pressure relief effect of a mining roadway in a fault area is attained when the value of Q is 1.8.The NPR anchor cable exhibits noteworthy characteristics,including a high level of prestress,continuous resistance,and substantial deformation.After the excavation of the roadway,a notable reduction in radial stress occurs,leading to the reinstatement of the three-phase stress state in the surrounding rock.This restoration is attributed to the substantial prestress exerted on the radial stress.The termination point of the NPR anchor cable is strategically positioned within a stable rock formation,allowing for the utilization of the mechanical characteristics of the deep stable rock mass.This positioning serves to improve the load-bearing capacity of the surrounding rock.The mining roadway within the fault region of Daqiang Coal Mine is outfitted with the PSCR-NPR technology.The drop in shear stress experienced by the rock surrounding the roadway is estimated to be around 30%,whilst the low-stress region of the mining roadway extends by a factor of approximately 5.5.The magnitude of surface displacement convergence experiences a decrease of approximately 45%-50%.The study’s findings provide useful insights regarding the stable of mining roadway in characterized by fault zones. 展开更多
关键词 Kilometre-deep mine FAULT Mining roadway Pre-splitting cutting roof High pre-stress NPR anchor cable
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