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Syntheses of Novel Asymmetric Cyclopentanone Dyes and Measurement of Two-photon Absorption Cross-section
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作者 WANGTao WUFei-peng +4 位作者 SHIMeng-quan GUOHeng-chang WUCheng-yin JIANGHong-bing GONGQi-huang 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2003年第4期470-473,共4页
A simple synthesis route with a high yield of novel asymmetric cyclopentanone dyes 3a-3e and their highly two-photon up-converted fluorescences are reported. The dyes have good solubilities in most of ordinary solvent... A simple synthesis route with a high yield of novel asymmetric cyclopentanone dyes 3a-3e and their highly two-photon up-converted fluorescences are reported. The dyes have good solubilities in most of ordinary solvents, a wide UV absorption wavelength range from 380-540 nm, and high fluorescence quantum yields. The two-photon absorption cross-sections of dyes 3a-3e were measured in chloroform by a two-photon induced fluorescence method. All of these properties of the new dyes make them suitable for being used as two-photon fluorescent probes. 展开更多
关键词 TWO-PHOTON up-converted fluorescence CYCLOPENTANONE Fluorescent probe
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Utilizing the ultrasensitive Schistosoma up-converting phosphor lateral flow circulating anodic antigen(UCP-LF CAA)assay for sample pooling-strategies 被引量:2
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作者 Paul L.A.M.Corstjens Pytsje T.Hoekstra +1 位作者 Claudia J.de Dood Govert J.van Dam 《Infectious Diseases of Poverty》 SCIE 2017年第1期1379-1391,共13页
Background:Methodological applications of the high sensitivity genus-specific Schistosoma CAA strip test,allowing detection of single worm active infections(ultimate sensitivity),are discussed for efficient utilizatio... Background:Methodological applications of the high sensitivity genus-specific Schistosoma CAA strip test,allowing detection of single worm active infections(ultimate sensitivity),are discussed for efficient utilization in sample pooling strategies.Besides relevant cost reduction,pooling of samples rather than individual testing can provide valuable data for large scale mapping,surveillance,and monitoring.Method:The laboratory-based CAA strip test utilizes luminescent quantitative up-converting phosphor(UCP)reporter particles and a rapid user-friendly lateral flow(LF)assay format.The test includes a sample preparation step that permits virtually unlimited sample concentration with urine,reaching ultimate sensitivity(single worm detection)at 100%specificity.This facilitates testing large urine pools from many individuals with minimal loss of sensitivity and specificity.The test determines the average CAA level of the individuals in the pool thus indicating overall worm burden and prevalence.When requiring test results at the individual level,smaller pools need to be analysed with the pool-size based on expected prevalence or when unknown,on the average CAA level of a larger group;CAA negative pools do not require individual test results and thus reduce the number of tests.Results:Straightforward pooling strategies indicate that at sub-population level the CAA strip test is an efficient assay for general mapping,identification of hotspots,determination of stratified infection levels,and accurate monitoring of mass drug administrations(MDA).At the individual level,the number of tests can be reduced i.e.in low endemic settings as the pool size can be increased as opposed to prevalence decrease.Conclusions:At the sub-population level,average CAA concentrations determined in urine pools can be an appropriate measure indicating worm burden.Pooling strategies allowing this type of large scale testing are feasible with the various CAA strip test formats and do not affect sensitivity and specificity.It allows cost efficient stratified testing and monitoring of worm burden at the sub-population level,ideally for large-scale surveillance generating hard data for performance of MDA programs and strategic planning when moving towards transmission-stop and elimination. 展开更多
关键词 Schistosomiasis Diagnostics Sample pooling Mass drug administration Circulating anodic antigen Lateral flow Strip test up-converting reporter particle UCP-LF CAA
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Up-converted ultraviolet luminescence of Er3+:BaGd2Zn05phosphors for healthy illumination
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作者 Ya ZHANG Qingzhi CUI +3 位作者 Zhanyong WANG Gan LIU Tian TIAN Jiayue XU 《Frontiers of Materials Science》 SCIE CSCD 2016年第3期328-333,共6页
Moderate level of exposure to the solar irradiation containing UV component is essential for health care. To incorporate the UV-emitting phosphors into the commercial YAG-based white light-emitting diode introduces th... Moderate level of exposure to the solar irradiation containing UV component is essential for health care. To incorporate the UV-emitting phosphors into the commercial YAG-based white light-emitting diode introduces the possibilities of healthy illumination to individuals' daily lives. 1 mol.% E3*-doped BaGd2ZnO5(BGZ) particles were synthesized via sol-gel method and efficient up-converted luminescence peaked at 380 nm was detected under 480 nm excitation. The mixed phosphors with varied mass ratio of Er3+:BGZ and Ce3+:YAG particles were encapsulated to form LEDs. The study of the LEDs indicated that the introduction of BGZ component favored the enhancement of color-rendering index and the neutralization of the white light emitting. The WLED with the BGZ/YAG ratio of 8:2 was recommendable for its excellent overall white light luminous performances and UV intensity of 84.55 mW/cm2. The UV illumination dose of the WLEDs with mixed YAG and BGZ was controllable by adjusting the ratio, the illumination distance and the illumination time. Er3+:BGZ phosphors are promising UV- emitting phosphors for healthy indoor illumination. 展开更多
关键词 Er3+:BaGd2ZnOs up-converted ultraviolet LED healthy illumination
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Visible to ultraviolet up-conversion in a novel rare earth-free up-converting phosphor
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作者 En Zhou Liu Jun Fan +2 位作者 Xiao Yun Hu Wen Qian Hou Hong Zhe Dai 《Chinese Chemical Letters》 SCIE CAS CSCD 2012年第1期117-120,共4页
A novel up-converting phosphor,Na_xAl_yF_(x+3y)/CaF2(0.3 〈 x 〈 0.5,0 〈 y 〈 0.1) composite,is prepared by a hydrothermal process at 180°C and an annealing treatment at 500℃.X-ray diffraction(XRD) patte... A novel up-converting phosphor,Na_xAl_yF_(x+3y)/CaF2(0.3 〈 x 〈 0.5,0 〈 y 〈 0.1) composite,is prepared by a hydrothermal process at 180°C and an annealing treatment at 500℃.X-ray diffraction(XRD) pattern indicates that Na_xAl_yF_(x+3y)/CaF_2 is a composite consisting of NaF,Na_3 AlF_6,and CaF_2.The up-conversion luminescence properties of this phosphor are investigated by fluorescence spectrometer.Results show that Na_xAl_yF_(x+3y)/CaF_2 exhibits visible-to-ultraviolet up-conversion luminescence properties.The emission peaks at 316 and 336 nm are observed when excited by 610 nm,the luminescence lifetime of the emissions is great than 18 ms,and the internal fluorescence quantum yield is 4.2%.Additionally,the luminescent mechanism of this phosphor is also mentioned. 展开更多
关键词 up-converting phosphor Luminescence properties Fluorides CaF_2
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Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia 被引量:4
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作者 Youthanavanh Vonghachack Somphou Sayasone +9 位作者 Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt 《Infectious Diseases of Poverty》 SCIE 2017年第1期1123-1135,共13页
Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes ... Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. 展开更多
关键词 Cambodia Food-borne trematodes Kato-Katz Lao People’s Democratic Republic Point-of-care circulating cathodic antigen Schistosoma mekongi SEROLOGY Soil-transmitted helminths up-converting phosphorlateral-flow circulating anodic antigen
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Rapid Detection of Serum Procalcitonin by Immunochromatograghy Technology Based on Freeze-dried Up-conversion Nanoparticles/Antibody Conjugates 被引量:2
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作者 Lijiang Lei Yang Zhou +1 位作者 Yuwang Han Hongman Zhang 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2017年第12期1861-1868,共8页
Procalcitonin (PCT) is a sensitive and specific biomarker for sepsis diagnosis and widely used as a biomarker to improve the diagnosis of bacterial infections and to guide the antibiotic therapy. In our work, an imp... Procalcitonin (PCT) is a sensitive and specific biomarker for sepsis diagnosis and widely used as a biomarker to improve the diagnosis of bacterial infections and to guide the antibiotic therapy. In our work, an improved up-converting nanoparticle (UCP) technology based on the immunochromatographic assay (UPT-ICA) was developed for rapid and quantitative detection of PCT. In order to further improve the accuracy, sensitivity and stability of the assay on the basis of our previous study, the UCP coupling with rnonoclonal antibody of PCT (UCP-Abl) was freeze-dried under certain conditions. And the detections of PCT levels with UCP-Abl conjugates before and after freeze-drying were evaluated. The results show that, compared to the UCP-Abl conjugates without freeze-drying, the detection sensitivity of freeze-dried UCP-Abl is slightly improved, having a lower immunochromatogragh background and better stability. This improved method can provide a rapid, accurate, and relatively easy way for the clinical detection of PCT. 展开更多
关键词 PROCALCITONIN up-converting nanoparticles technology immunochromatographic assay FREEZE-DRYING
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