<strong>Background: </strong>The formation of kidney stones is considered a complicated process. Consequently, there are many questions about the link between kidney stones formation and level of salivary ...<strong>Background: </strong>The formation of kidney stones is considered a complicated process. Consequently, there are many questions about the link between kidney stones formation and level of salivary uric acid and calculus formation on the teeth surfaces. <strong>Objectives:</strong> To evaluate the correlation between the level of salivary uric acid and kidney stones formation and their influence on dental calculus and periodontal status among Saudi patients aged 25 - 70 years. <strong>Materials and Methods:</strong> 120 Saudi male patients were examined (60 of Kidney stones patients and 60 patients of non-kidney stones patients) for clinical evaluation of plaque index (PLI), gingival index (GI), calculus index of oral hygiene (CI) and clinical attachment loss (CAL). Moreover, lab assessment of uric acid level in the collected salivary samples was done. The findings were analyzed using of ANOVA test and Tukey’s test. <strong>Results:</strong> There were statistically significant differences in clinical parameters among kidney stones patients and non-kidney stones patients (p < 0.05), but these differences were highly statistically significant in the correlation between calculus index (CI), plaque index (PLI) and gingival index (GI) among kidney stone patients in group II, moreover, PLI and clinical attachment loss (CAL) among kidney stone patients in group III (p < 0.001). The statistical analyses revealed statistically significant differences in the level of salivary uric acid (mg/dl) in the comparison between kidney stones patients and non-kidney stones patients in group I and group III, whereas there were highly statistically significant in the comparison between kidney stones patients and non-kidney stones patients in group III. <strong>Conclusion:</strong> At the end of this study, we concluded that there was a relationship between dental calculus formation, kidney stones formation, and an increase in the level of salivary uric acid.展开更多
Objective: To verify possible associations between adenosine aminohydrolase(ADA) and AMP-aminohydrolase(AMPDA) to E3 SUMO-protein ligase NSE2(NSMCE2) in patients with renal stones. And to isolate, purify and character...Objective: To verify possible associations between adenosine aminohydrolase(ADA) and AMP-aminohydrolase(AMPDA) to E3 SUMO-protein ligase NSE2(NSMCE2) in patients with renal stones. And to isolate, purify and characterize ADA in patients with renal stones and healthy group.Methods: A total of 60 renal stones patients and 50 control were enrolled in a case-control study. The blood urea, creatinine, uric acid, protein, albumin, ADA and AMPDA were measured by colorimetric tests. The serum NSMCE2 was measured by ELISA.Results: Serum ADA, AMPDA and specii c activity of enzymes showed signii cant decrease(P < 0.05) in patients with renal stones compared to control group, mean levels of sera NSMCE2 and uric acid had a signii cant increase(P < 0.01 and P < 0.05, respectively) in patients compared to control group.Conclusions: The present study suggests that ADA, AMP deaminase and NSMCE2 can be used as a indicator to monitor the DNA damage and inl ammation disorders in the patients with kidney stones.展开更多
目的探讨血尿酸及血脂水平对于肾结石的诊断价值。方法回顾性分析聊城市中医医院2020年2月—2022年1月收治的125例肾结石患者的临床资料,全部患者均经过超声检查诊断后确诊,并将其作为结石组,分为草酸钙结石组(n=32)、尿酸结石组(n=35)...目的探讨血尿酸及血脂水平对于肾结石的诊断价值。方法回顾性分析聊城市中医医院2020年2月—2022年1月收治的125例肾结石患者的临床资料,全部患者均经过超声检查诊断后确诊,并将其作为结石组,分为草酸钙结石组(n=32)、尿酸结石组(n=35)、磷酸盐结石组(n=31)、膀氨酸结石组(n=27),同时选择来院进行常规体检的健康成年人100名作为对照组。对比不同组别血尿酸及血脂水平,探讨血尿酸及血脂水平对肾结石的诊断价值。结果草酸钙结石组血尿酸水平为(425.36±98.12)μmol/L,高于尿酸结石组的(345.98±8.55)μmol/L、磷酸盐结石组的(311.55±65.14)μmol/L、膀氨酸结石组的(304.36±68.21)μmol/L、对照组的(206.36±60.12)μmol/L,差异有统计学意义(P<0.05)。草酸钙结石组、尿酸结石组、磷酸盐结石组、膀氨酸结石组总胆固醇(total cholesterol,TC)水平、三酰甘油(triglycerides,TG)水平、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)高于对照组,高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平低于对照组;草酸钙结石组TC、LDL-C水平高于尿酸结石组、磷酸盐结石组、膀氨酸结石组,HDL-C水平低于尿酸结石组、磷酸盐结石组、膀氨酸结石组;尿酸结石组TC、TG、LDL-C水平高于磷酸盐结石组、膀氨酸结石组,HDL-C水平低于磷酸盐结石组、膀氨酸结石组,差异有统计学意义(P<0.05)。将超声诊断发现肾结石作为诊断金标准,对全部肾结石患者的血尿酸及血脂水平进行检测与分析,实施受试者工作特征(receiver operating characteristic,ROC)曲线分析可见,血尿酸、TC、TG、HDL-C、LDL-C检测肾结石结果AUC分别为0.941、0.893、0.910、0.111、0.638。结论在肾结石患者当中血生化血尿酸、血脂水平明显异常,在草酸钙结石患者血清中可表现出较高的水平,用于诊断肾结石均具有较高的应用价值。展开更多
目的利用双能量CT(dual energy computed tomography,DECT)检测关节痛患者尿酸盐结晶沉积情况,探讨DECT对单独存在或合并痛风性关节炎患者的检出能力。方法对34例关节痛患者进行DECT扫描,根据血尿酸浓度是否超出正常范围将其分为病例组(...目的利用双能量CT(dual energy computed tomography,DECT)检测关节痛患者尿酸盐结晶沉积情况,探讨DECT对单独存在或合并痛风性关节炎患者的检出能力。方法对34例关节痛患者进行DECT扫描,根据血尿酸浓度是否超出正常范围将其分为病例组(n=16)及对照组(n=18),图像由DECTGOUT软件处理后,由两名医师独立进行评价,比较两组尿酸盐沉积的差异,进一步评价患者血尿酸浓度、病程长短与病灶数目的相关性。结果病例组16例患者中均发现有绿色颗粒状尿酸盐沉积,对照组均未见尿酸盐沉积,两组差异具有统计学意义(P=0.000);患者血尿酸浓度、病程长短与病灶数量无相关性(P>0.05)。结论 DECT尿酸盐结晶成像技术能够灵敏的检出单独存在或合并痛风性关节炎的患者,对早期、无创性诊断痛风性关节炎具有重要应用价值。展开更多
文摘<strong>Background: </strong>The formation of kidney stones is considered a complicated process. Consequently, there are many questions about the link between kidney stones formation and level of salivary uric acid and calculus formation on the teeth surfaces. <strong>Objectives:</strong> To evaluate the correlation between the level of salivary uric acid and kidney stones formation and their influence on dental calculus and periodontal status among Saudi patients aged 25 - 70 years. <strong>Materials and Methods:</strong> 120 Saudi male patients were examined (60 of Kidney stones patients and 60 patients of non-kidney stones patients) for clinical evaluation of plaque index (PLI), gingival index (GI), calculus index of oral hygiene (CI) and clinical attachment loss (CAL). Moreover, lab assessment of uric acid level in the collected salivary samples was done. The findings were analyzed using of ANOVA test and Tukey’s test. <strong>Results:</strong> There were statistically significant differences in clinical parameters among kidney stones patients and non-kidney stones patients (p < 0.05), but these differences were highly statistically significant in the correlation between calculus index (CI), plaque index (PLI) and gingival index (GI) among kidney stone patients in group II, moreover, PLI and clinical attachment loss (CAL) among kidney stone patients in group III (p < 0.001). The statistical analyses revealed statistically significant differences in the level of salivary uric acid (mg/dl) in the comparison between kidney stones patients and non-kidney stones patients in group I and group III, whereas there were highly statistically significant in the comparison between kidney stones patients and non-kidney stones patients in group III. <strong>Conclusion:</strong> At the end of this study, we concluded that there was a relationship between dental calculus formation, kidney stones formation, and an increase in the level of salivary uric acid.
基金Supported by the Research Management Center,International Islamic University Malaysia,Grant Scheme Project No.IIUM/504/5/29/1
文摘Objective: To verify possible associations between adenosine aminohydrolase(ADA) and AMP-aminohydrolase(AMPDA) to E3 SUMO-protein ligase NSE2(NSMCE2) in patients with renal stones. And to isolate, purify and characterize ADA in patients with renal stones and healthy group.Methods: A total of 60 renal stones patients and 50 control were enrolled in a case-control study. The blood urea, creatinine, uric acid, protein, albumin, ADA and AMPDA were measured by colorimetric tests. The serum NSMCE2 was measured by ELISA.Results: Serum ADA, AMPDA and specii c activity of enzymes showed signii cant decrease(P < 0.05) in patients with renal stones compared to control group, mean levels of sera NSMCE2 and uric acid had a signii cant increase(P < 0.01 and P < 0.05, respectively) in patients compared to control group.Conclusions: The present study suggests that ADA, AMP deaminase and NSMCE2 can be used as a indicator to monitor the DNA damage and inl ammation disorders in the patients with kidney stones.
文摘目的探讨血尿酸及血脂水平对于肾结石的诊断价值。方法回顾性分析聊城市中医医院2020年2月—2022年1月收治的125例肾结石患者的临床资料,全部患者均经过超声检查诊断后确诊,并将其作为结石组,分为草酸钙结石组(n=32)、尿酸结石组(n=35)、磷酸盐结石组(n=31)、膀氨酸结石组(n=27),同时选择来院进行常规体检的健康成年人100名作为对照组。对比不同组别血尿酸及血脂水平,探讨血尿酸及血脂水平对肾结石的诊断价值。结果草酸钙结石组血尿酸水平为(425.36±98.12)μmol/L,高于尿酸结石组的(345.98±8.55)μmol/L、磷酸盐结石组的(311.55±65.14)μmol/L、膀氨酸结石组的(304.36±68.21)μmol/L、对照组的(206.36±60.12)μmol/L,差异有统计学意义(P<0.05)。草酸钙结石组、尿酸结石组、磷酸盐结石组、膀氨酸结石组总胆固醇(total cholesterol,TC)水平、三酰甘油(triglycerides,TG)水平、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)高于对照组,高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平低于对照组;草酸钙结石组TC、LDL-C水平高于尿酸结石组、磷酸盐结石组、膀氨酸结石组,HDL-C水平低于尿酸结石组、磷酸盐结石组、膀氨酸结石组;尿酸结石组TC、TG、LDL-C水平高于磷酸盐结石组、膀氨酸结石组,HDL-C水平低于磷酸盐结石组、膀氨酸结石组,差异有统计学意义(P<0.05)。将超声诊断发现肾结石作为诊断金标准,对全部肾结石患者的血尿酸及血脂水平进行检测与分析,实施受试者工作特征(receiver operating characteristic,ROC)曲线分析可见,血尿酸、TC、TG、HDL-C、LDL-C检测肾结石结果AUC分别为0.941、0.893、0.910、0.111、0.638。结论在肾结石患者当中血生化血尿酸、血脂水平明显异常,在草酸钙结石患者血清中可表现出较高的水平,用于诊断肾结石均具有较高的应用价值。
文摘目的利用双能量CT(dual energy computed tomography,DECT)检测关节痛患者尿酸盐结晶沉积情况,探讨DECT对单独存在或合并痛风性关节炎患者的检出能力。方法对34例关节痛患者进行DECT扫描,根据血尿酸浓度是否超出正常范围将其分为病例组(n=16)及对照组(n=18),图像由DECTGOUT软件处理后,由两名医师独立进行评价,比较两组尿酸盐沉积的差异,进一步评价患者血尿酸浓度、病程长短与病灶数目的相关性。结果病例组16例患者中均发现有绿色颗粒状尿酸盐沉积,对照组均未见尿酸盐沉积,两组差异具有统计学意义(P=0.000);患者血尿酸浓度、病程长短与病灶数量无相关性(P>0.05)。结论 DECT尿酸盐结晶成像技术能够灵敏的检出单独存在或合并痛风性关节炎的患者,对早期、无创性诊断痛风性关节炎具有重要应用价值。
