Objective: To explore the protective effect of Cordyceps sinensis (CS) on nephrotoxicity of cyclosporine A (CsA) and its mechanism. Methods: The renal function of isolated perfused rats was observed before and after ...Objective: To explore the protective effect of Cordyceps sinensis (CS) on nephrotoxicity of cyclosporine A (CsA) and its mechanism. Methods: The renal function of isolated perfused rats was observed before and after three months' treatment by CS. Results: CS could improve the renal function, increase the volume of urine, Na＋ and K＋ excretion and inulin clearance rate, and reduce the resistance of renal per fusion. It was found that the activities of urinary N - acetyl-β- glucosaminidase (NAG), γ- glutamyl transferase (γ- GT) and lactate dehydrogenase (LDH) were lower in the CS treatment group than those in the control group. Conclusion: CS could protect the kidney from damage against nephrotoxicity of CsA and improve the abnormality of renal hemodynamics.展开更多
Objective: To observe the clinical effect of Yiqi Jianpi Bushen recipe (YQJPBS, 益气健脾补肾方) in antagonizing nephrotoxicity and hematological toxicity by cisplatin (CDDP). Methods: The patients with different types...Objective: To observe the clinical effect of Yiqi Jianpi Bushen recipe (YQJPBS, 益气健脾补肾方) in antagonizing nephrotoxicity and hematological toxicity by cisplatin (CDDP). Methods: The patients with different types of carcinomas were divided into two groups. One group was treated by western medicine (WM), i.e. cisplatin combined with diuretic therapy. The other group by Chinese medicine (CM). One day before chemotherapy, YQJPBS was given orally. Urinary enzyme (NAG, γ-GT, ALP) and serum erythropoietin (Epo) were used as the key monitoring indicator. Results: The early renal damage by CDDP remains near proximal convoluted tubule, which leads to the rising of urinary enzyme. So urinary enzyme of the CM group was obviously lower than that of the WM group. The lesion of renal interstitial cells that produce Epo did not cause the serum Epo of WM group to rise obviously 15 days later. As a result there was 40% patients whose RBC and Hb became lower than the standard count. While serum Epo of CM group was higher than that of WM group, only 5% patients in the CM group had their RBC and Hb lowered. Conclusion: YQJPBS can effectively antagonize nephrotoxicity and hematological toxicity induced by CDDP.展开更多
文摘Objective: To explore the protective effect of Cordyceps sinensis (CS) on nephrotoxicity of cyclosporine A (CsA) and its mechanism. Methods: The renal function of isolated perfused rats was observed before and after three months' treatment by CS. Results: CS could improve the renal function, increase the volume of urine, Na＋ and K＋ excretion and inulin clearance rate, and reduce the resistance of renal per fusion. It was found that the activities of urinary N - acetyl-β- glucosaminidase (NAG), γ- glutamyl transferase (γ- GT) and lactate dehydrogenase (LDH) were lower in the CS treatment group than those in the control group. Conclusion: CS could protect the kidney from damage against nephrotoxicity of CsA and improve the abnormality of renal hemodynamics.
文摘Objective: To observe the clinical effect of Yiqi Jianpi Bushen recipe (YQJPBS, 益气健脾补肾方) in antagonizing nephrotoxicity and hematological toxicity by cisplatin (CDDP). Methods: The patients with different types of carcinomas were divided into two groups. One group was treated by western medicine (WM), i.e. cisplatin combined with diuretic therapy. The other group by Chinese medicine (CM). One day before chemotherapy, YQJPBS was given orally. Urinary enzyme (NAG, γ-GT, ALP) and serum erythropoietin (Epo) were used as the key monitoring indicator. Results: The early renal damage by CDDP remains near proximal convoluted tubule, which leads to the rising of urinary enzyme. So urinary enzyme of the CM group was obviously lower than that of the WM group. The lesion of renal interstitial cells that produce Epo did not cause the serum Epo of WM group to rise obviously 15 days later. As a result there was 40% patients whose RBC and Hb became lower than the standard count. While serum Epo of CM group was higher than that of WM group, only 5% patients in the CM group had their RBC and Hb lowered. Conclusion: YQJPBS can effectively antagonize nephrotoxicity and hematological toxicity induced by CDDP.
