Aiming at the problem that the mathematical expressions in unstructured text fields of documents are hard to be extracted automatically, rapidly and effectively, a method based on Hidden Markov Model (HMM) is proposed...Aiming at the problem that the mathematical expressions in unstructured text fields of documents are hard to be extracted automatically, rapidly and effectively, a method based on Hidden Markov Model (HMM) is proposed. Firstly, this method trained the HMM model through employing the symbol combination features of mathematical expressions. Then, some preprocessing works such as removing labels and filtering words were carried out. Finally, the preprocessed text was converted into an observation sequence as the input of the HMM model to determine which is the mathematical expression and extracts it. The experimental results show that the proposed method can effectively extract the mathematical expressions from the text fields of documents, and also has the relatively high accuracy rate and recall rate.展开更多
通过多目标智能优化算法研究微震震源定位存在的模型组合合理性未阐明、易陷入局部最优解、定位结果波动性较大等问题。为解决这些问题,首先在到时差模型与到时差商模型基础上设计4个不同的微震震源定位数学模型,两两组合构建6个多目标...通过多目标智能优化算法研究微震震源定位存在的模型组合合理性未阐明、易陷入局部最优解、定位结果波动性较大等问题。为解决这些问题,首先在到时差模型与到时差商模型基础上设计4个不同的微震震源定位数学模型,两两组合构建6个多目标优化定位模型;再设计3组基于不同台网形状(三维多面体、二维长方形、一维直线型)的微震震源正演仿真实验和1组工程数据验证实验,并引入多目标蚁狮优化(multi-objective ant lion optimization,MOALO)算法求解这些模型;最后采用多个统计指标评判各个模型组合定位效果的优劣。结果表明,数学模型组合(TDA-P1,TDQA)结合MOALO算法的多目标优化定位策略能够得到较高的微震震源定位精度,且模型稳健性较好,优于其他模型组合和传统多目标定位方法,在微震监测领域具有一定的应用价值。展开更多
Radiation therapy is a longstanding cancer treatment. More recently, it has been demonstrated that radiation therapy(RT) elicits anti-cancer immune response. For this reason, there is a growing interest in combining R...Radiation therapy is a longstanding cancer treatment. More recently, it has been demonstrated that radiation therapy(RT) elicits anti-cancer immune response. For this reason, there is a growing interest in combining RT with immunotherapy, specifically with checkpoint inhibitors such as anti-CTLA-4 and anti-PDL1. In the present paper, we develop a mathematical model of combination therapy with RT and anti-PD-L1.The model is used to compare different schedules in clinical trials. Simulations of the model show that applying both RT and anti-PD-L1 at the same week has more benefits than applying them in separate adjacent weeks.Furthermore, applying anti-PD-L1 before RT has more benefits than applying RT before anti-PD-L1.展开更多
文摘Aiming at the problem that the mathematical expressions in unstructured text fields of documents are hard to be extracted automatically, rapidly and effectively, a method based on Hidden Markov Model (HMM) is proposed. Firstly, this method trained the HMM model through employing the symbol combination features of mathematical expressions. Then, some preprocessing works such as removing labels and filtering words were carried out. Finally, the preprocessed text was converted into an observation sequence as the input of the HMM model to determine which is the mathematical expression and extracts it. The experimental results show that the proposed method can effectively extract the mathematical expressions from the text fields of documents, and also has the relatively high accuracy rate and recall rate.
文摘通过多目标智能优化算法研究微震震源定位存在的模型组合合理性未阐明、易陷入局部最优解、定位结果波动性较大等问题。为解决这些问题,首先在到时差模型与到时差商模型基础上设计4个不同的微震震源定位数学模型,两两组合构建6个多目标优化定位模型;再设计3组基于不同台网形状(三维多面体、二维长方形、一维直线型)的微震震源正演仿真实验和1组工程数据验证实验,并引入多目标蚁狮优化(multi-objective ant lion optimization,MOALO)算法求解这些模型;最后采用多个统计指标评判各个模型组合定位效果的优劣。结果表明,数学模型组合(TDA-P1,TDQA)结合MOALO算法的多目标优化定位策略能够得到较高的微震震源定位精度,且模型稳健性较好,优于其他模型组合和传统多目标定位方法,在微震监测领域具有一定的应用价值。
基金supported by the Fundamental Research Funds for the Central Universities (Grant No. 19XNLG14)the Research Funds of Renmin University of ChinaNational Natural Science Foundation of China (Grant Nos. 11501568 and 11571364)
文摘Radiation therapy is a longstanding cancer treatment. More recently, it has been demonstrated that radiation therapy(RT) elicits anti-cancer immune response. For this reason, there is a growing interest in combining RT with immunotherapy, specifically with checkpoint inhibitors such as anti-CTLA-4 and anti-PDL1. In the present paper, we develop a mathematical model of combination therapy with RT and anti-PD-L1.The model is used to compare different schedules in clinical trials. Simulations of the model show that applying both RT and anti-PD-L1 at the same week has more benefits than applying them in separate adjacent weeks.Furthermore, applying anti-PD-L1 before RT has more benefits than applying RT before anti-PD-L1.
