Impact of dietary nutrition regimens based on body composition analysis on bone metabolism in Alzheimer’s disease patients

BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine disorders.However,its potential in providing nutritional guidance for patients with Alzheimer’s disease(AD)remains relatively unexplored.AIM To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD patients.METHODS This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December 2024.Based on data from previous similar studies,the patients were randomly assigned to either a routine diet(RD)group(n=48)or a personalized nutrition(PN)group(n=48).The RD group received conventional dietary guidance,while the PN group received individualized diet intervention measures based on human BCA.The intervention period lasted for 12 weeks.Bone mineral density(BMD),body mass index(BMI),muscle mass,mineral content,osteocalcin,25-hydroxyvitamin D,procollagen type I N-terminal propeptide(PINP),beta C-terminal telopeptide of type I collagen(β-CTX),and serum calcium were measured and compared between the two groups before and 12 weeks after the intervention.RESULTS No significant differences were observed between groups in terms of age,sex,height,BMI,or other baseline data(P>0.05).In both groups,BMI did not show significant changes after the intervention(P>0.05),whereas muscle mass and mineral content were significantly increased(P<0.05).After the intervention,BMI in the PN group did not differ significantly from that of the RD group,but muscle mass and mineral content were significantly higher in the PN group(P<0.05).After the intervention,a higher proportion of patients in the PN group had a T score>-1 compared to the RD group(P<0.05).The mini-mental state examination(MMSE)score was similar in both groups before the intervention.However,12 weeks after the intervention,the MMSE score in the PN group was significantly higher than that in the RD group(P<0.05).In both groups,the MMSE score significantly increased 12 weeks post-intervention compared to pre-intervention levels(P<0.05).Before the intervention,the levels of osteocalcin,serum calcium,PINP,β-CTX,and 25-hydroxyvitamin D were not significantly different between the two groups(P>0.05).After 12 weeks of intervention,the PN group exhibited higher levels of osteocalcin,serum calcium,and 25-hydroxyvitamin D,as well as lower levels of PINP andβ-CTX,compared to the RD group(P<0.05).In both groups,osteocalcin,serum calcium,and 25-hydroxyvitamin D levels were significantly higher,while PINP andβ-CTX levels were significantly lower after 12 weeks of intervention compared to baseline(P<0.05).CONCLUSION The human BCA-based dietary nutrition regimen plays a crucial role in improving BMD and bone metabolism,with effects that surpass those of conventional nutrition strategies.The findings of this study provide strong evidence for the nutritional management of AD patients.

A Bayesian multi-model inference methodology for imprecise momentindependent global sensitivity analysis of rock structures

Traditional global sensitivity analysis(GSA)neglects the epistemic uncertainties associated with the probabilistic characteristics(i.e.type of distribution type and its parameters)of input rock properties emanating due to the small size of datasets while mapping the relative importance of properties to the model response.This paper proposes an augmented Bayesian multi-model inference(BMMI)coupled with GSA methodology(BMMI-GSA)to address this issue by estimating the imprecision in the momentindependent sensitivity indices of rock structures arising from the small size of input data.The methodology employs BMMI to quantify the epistemic uncertainties associated with model type and parameters of input properties.The estimated uncertainties are propagated in estimating imprecision in moment-independent Borgonovo’s indices by employing a reweighting approach on candidate probabilistic models.The proposed methodology is showcased for a rock slope prone to stress-controlled failure in the Himalayan region of India.The proposed methodology was superior to the conventional GSA(neglects all epistemic uncertainties)and Bayesian coupled GSA(B-GSA)(neglects model uncertainty)due to its capability to incorporate the uncertainties in both model type and parameters of properties.Imprecise Borgonovo’s indices estimated via proposed methodology provide the confidence intervals of the sensitivity indices instead of their fixed-point estimates,which makes the user more informed in the data collection efforts.Analyses performed with the varying sample sizes suggested that the uncertainties in sensitivity indices reduce significantly with the increasing sample sizes.The accurate importance ranking of properties was only possible via samples of large sizes.Further,the impact of the prior knowledge in terms of prior ranges and distributions was significant;hence,any related assumption should be made carefully.

Transitivity Analysis of the Energy in China’s New Era

At present,with the steady development of the global economy,more and more countries begin to pay attention to the impact of ecological environment on economic development and human society,so the ecological environment has become a global issue that cannot be ignored in today’s era.Therefore,from the perspective of the ecological philosophy of Diversity&Harmony as well as Interaction&Co-existence,this paper will conduct ecological discourse analysis on the Energy in China’s New Era based on the transitivity system of systemic-functional grammar,and use the Corpus analysis software UAM Corpus Tool 3.3x to label and make statistics on the transitivity system,aiming to explore the distribution characteristics of the transitivity system in this white paper.Through the transitivity analysis of the white paper,this study helps readers to have a deeper understanding of the positive significance contained in the white paper.To a certain extent,it enables readers at home and abroad to understand China’s stance on energy issues and the positive image of China in energy ecology.It also awaken readers’awareness of environmental protection and acquire good habits of resource conservation to be in harmony between human and nature for sustainable development.

Discourse Analysis of the Belt and Road Initiative From the Perspective of Central Asian Countries: A Case Study of the Republic of Kazakhstan

This study employs Norman Fairclough’s Critical Discourse Analysis(CDA)three-dimensional model,using the Republic of Kazakhstan as a case study,to delve into the discourse construction of China’s Belt and Road Initiative(BRI)in Central Asian countries.Through detailed analysis of policy documents,media reports,and public discussions in Central Asian countries,this paper reveals how the BRI constructs specific social practices,discourse events,and textual meanings within these nations.The findings indicate that through this global development strategy,China has not only strengthened its economic ties with Central Asian countries but has also exerted profound influences on political,cultural,and social levels.

Comparative Analysis of Improving Effects of 12 Maize Populations with Improved S_1 Selection Method

ln this study, 12 maize populations were improved with the improved S1 selection method, aiming to increase the improvement efficiency of maize popula-tions. The results showed that number of rows per spike, number of grains per row and 100-grain weight were the three important component traits of maize yield. The highest genetic increment was found in Mengqun 2, fol owed by Mengqun 4, Mengqun 1 and other 7 maize populations. Negative genetic increment was shown in Mengqun 3 and 3 introduced foreign maize populations. Some changes were shown in spikes, plant traits and genetic diversity of maize populations. Based on our results, we concluded that Mengqun 2, Mengqun 4, Zhongzong 7, Mengqun C and Mengqun A could be directly used for the line breeding by selfing for their higher genetic increment of yield and better improvement effects of other agricultural traits. Compared with these 5 populations, the improvement potential of other maize populations was limited for their lower genetic increment.

Analysis on the Theory of Blow-up and Verification on Numerical Prediction of Heavy Rain in Sichuan Basin

By dint of V-3θ diagram from the Blown-up theory,a continuous heavy rain process in western Sichuan basin from July 14 to 17,2009 is analyzed in this paper.Situation field and precipitation of ECWMF and T213 are verified and discussed.Results show that V-3θ diagram can describe the heavy rain process accurately.Combining with additional conventional weather charts,experience and numerical forecast products,the heavy rain falling area is determined.The forecast accuracy of situation field of EC is significantly higher than that of T213 and the forecast accuracy of T213 for heavy rain forecast is relatively low.

Conceptual Analysis of Self-Management in Patients with Hypertension

Objective:To clarify the concept of self-management in hypertensive patients by analyzing the definition,attributes,and measurement tools through a literature review.Methods:An Internet-based search of the databases was conducted using Academic Search Complete,Medical Line,CINAHL,Health Source:Nursing/Scholarly Edition,and Google Scholar.In the search process,keywords or free text were combined by using Boolean operators,with the search terms“self of management”or“self-management,”“concept*analysis”or“concept*definition,”and Walker and Avant’s concept analysis method was used.Results:Analysis of relevant literature summarized the conceptual attributes of self-management in hypertensive patients as the active participation of patients in the treatment process;the presence of interaction provided by patients and health care providers;the use of certain health management tools;and the aim of maintaining and improving the health status and living capacity of hypertensive patients.Conclusion:The concept of self-management for hypertensive patients was clarified,which helps to promote the application of hypertensive self-management in clinical work and improve outcomes and quality of life for patients with hypertension.

R/S AND WAVELET ANALYSIS ON EVOLUTIONARYPROCESS OF REGIONAL ECONOMIC DISPARITY IN CHINA DURING PAST 50 YEARS

This paper shows the dynamic process of regional disparity of economic development in China in the past 50 years from a new insight by using the rescaled range statistic (R/S) analysis and wavelet analysis of the Theil index sequence with different time scales. The main conclusions are: 1) The regional disparity of economic development in China, including the inter-provincial disparity, inter-regional disparity and intra-regional disparity, has existed for many years. Theil index by the comparative price has revealed the true trend for comparative disparity of regional economic development from 1952 to 2000. 2) Decomposition of Theil index indicates that the dynamic trend of comparative inter-provincial disparity in the coastal region is in line with dynamic trend of inter-provincial disparity in the whole China. 3) The R/S analysis results tell us that during 1966-1978, the Hurst exponent H=0.504 approximate to 0.5, which indicates that in that period the evolution of comparative inter-provincial disparity of economic development showed a random characteristic, and in the other periods, i.e. 1952-1965, 1979-1990 and 1991-2000, the Hurst exponent H>0.5, which indicates that in those periods the evolution of the comparative inter-provincial disparity of economic development in China had a long-enduring characteristic. 4) By using wavelet analysis at different time scale, we arrived at a conclusion that the evolutionary process of the disparity of economic development of China is not a simple inverted U shape but a compound of several U shapes. The result tells us that the evolutionary plot of inter-provincial disparity in China follows the inverted U on the whole at the higher scale, 24 ( 16 years). That is to say, the disparity tends to rise in the first stage of economic development, and fall slowly over the peak in the second stage of economic development. However, if we shorten the time scale to 23 ( 8 years), then a link of several U shapes will appear.

Data-Driven Structural Design Optimization for Petal-Shaped Auxetics Using Isogeometric Analysis

Focusing on the structural optimization of auxetic materials using data-driven methods,a back-propagation neural network(BPNN)based design framework is developed for petal-shaped auxetics using isogeometric analysis.Adopting a NURBSbased parametric modelling scheme with a small number of design variables,the highly nonlinear relation between the input geometry variables and the effective material properties is obtained using BPNN-based fitting method,and demonstrated in this work to give high accuracy and efficiency.Such BPNN-based fitting functions also enable an easy analytical sensitivity analysis,in contrast to the generally complex procedures of typical shape and size sensitivity approaches.

Rietveld Quantitative Analysis of Carbides Precipitation in Normalized-tempered 2.25Cr-1Mo-0.25V Steel

The quantitative determination of the mass fractions of precipitates in steels is very difficult using traditional materials characterization techniques. The Rietveld full-pattern fitting algorithm was introduced to solve this problem. The precipitated multicomponents’ mass fraction of M3C, MC, M7C3 and M23C6 were evaluated precisely and relatively quickly. It is found evolution of carbides apparently occurs during tempering at high temperatures, and a two-step transformation mechanism is proposed for M7C3 during early tempering treatment. The method is an effective way on the investigation of precipitation kinetics, which may play a promising role in propertities’ enhancement and design of the heat-resistant steels.

SSTA SIGNAL CHARACTERISTIC ANALYSIS OVER THE INDIAN OCEAN DURING RAINY SEASON IN CHINA

The teleconnection distribution characteristics of sea surface temperature (SST) over the India Ocean and the precipitation during rainy season in China were studied by using the methods of EOF and CCA. The results indicate that the change of SST field will affect the change of rain belt during rainy seasons in China, and greatly affect the precipitation in northwest and southwest China, the Yangzi and Yellow River downstream basins. Strong signal phenomena of SSTA over India Ocean were revealed that showed the anoma-lous distribution of drought and flood in China. It shows that the precipitation during rainy seasons in China may be forecast by analyzing SST distribution characteristics over the India Ocean.

Probabilistic Model Checking-Based Survivability Analysis in Vehicle-to-Vehicle Networks

Probabilistic model checking has been widely applied to quantitative analysis of stochastic systems, e.g., analyzing the performance, reliability and survivability of computer and communication systems. In this paper, we extend the application of probabilistic model checking to the vehicle to vehicle(V2V) networks. We first develop a continuous-time Markov chain(CTMC) model for the considered V2V network, after that, the PRISM language is adopted to describe the CTMC model, and continuous-time stochastic logic is used to describe the objective survivability properties. In the analysis, two typical failures are considered, namely the node failure and the link failure, respectively induced by external malicious attacks on a target V2V node, and interrupt in a communication link. Considering these failures, their impacts on the network survivability are demonstrated. It is shown that with increasing failure strength, the network survivability is reduced. On the other hand, the network survivability can be improved with increasing repair rate. The proposed probabilistic model checking-based approach can be effectively used in survivability analysis for the V2V networks, moreover, it is anticipated that the approach can be conveniently extended to other networks.

A Comprehensive Analysis of Plug in Hybrid Electric Vehicles to Commercial Campus (V2C)

Vehicle to grid is an emerging technology that utilizes plug in hybrid electric vehicle batteries to benefit electric utilities during times when the vehicle is parked and connected to the electric grid. In its current form however, vehicle to grid implementation poses many challenges that may not be easily overcome and many existing studies neglect critical aspects such as battery cost or driving profiles. The goal of this research is to ease some of these challenges by examining a vehicle to grid scenario on a university campus, as an example of a commercial campus, based on time of use electricity rates. An analysis of this scenario is conducted on a vehicle battery as well as a stationary battery for comparison. It is found that vehicle to campus and a stationary battery both have the potential to prove economical based on battery cost and electricity rates.

Analysis of the geometrical dependence of auxetic behavior in reentrant structures by finite elements

Materials with a negative Poisson＇s ratio（PR）are called auxetics;they are characterized by expansion/contraction when tensioned/compressed.Given this counterintuitive behavior,they present very particular characteristics and mechanical behavior.Geometrical models have been developed to justify and artificiall reproduce such materials＇ auxetic behavior.The focus of this study is the exploration of a reentrant model by analyzing the variation in the PR of reentrant structures as a function of geometrical and base material parameters.It is shown that,even in the presence of protruding ribs,there may not be auxetic behavior,and this depends on the geometry of each reentrant structure.Values determined for these parameters can be helpful as approximate reference data in the design and fabrication of auxetic lattices using reentrant geometries.

Stability Analysis on Speed Control System of Autonomous Underwater Vehicle

The stability of the motion control system is one of the decisive factors of the control quality for Autonomous Underwater Vehicle（AUV）.The divergence of control,which the unstable system may be brought about,is fatal to the operation of AUV.The stability analysis of the PD and S-surface speed controllers based on the Lyapunov＇s direct method is proposed in this paper.After decoupling the six degree-of-freedom（DOF）motions of the AUV,the axial dynamic behavior is discussed and the condition is deduced,in which the parameters selection within stability domain can guarantee the system asymptotically stable.The experimental results in a tank and on the sea have successfully verified the algorithm reliability,which can be served as a good reference for analyzing other AUV nonlinear control systems.

Spatial Quantitative Analysis of Garlic Price Data Based on ArcGIS Technology

In order to solve the hidden regional relationship among garlic prices,this paper carries out spatial quantitative analysis of garlic price data based on ArcGIS technology.The specific analysis process is to collect prices of garlic market from 2015 to 2017 in different regions of Shandong Province,using the Moran's Index to obtain monthly Moran indicators are positive,so as to analyze the overall positive relationship between garlic prices;then using the geostatistical analysis tool in ArcGIS to draw a spatial distribution Grid diagram,it was found that the price of garlic has a significant geographical agglomeration phenomenon and showed a multi-center distribution trend.The results showed that the agglomeration centers are Jining,Dongying,Qingdao,and Yantai.At the end of the article,according to the research results,constructive suggestions were made for the regulation of garlic price.Using Moran’s Index and geostatistical analysis tools to analyze the data of garlic price,which made up for the lack of position correlation in the traditional analysis methods and more intuitively and effectively reflected the trend of garlic price from low to high from west to east in Shandong Province and showed a pattern of circular distribution.

Convergence ball and error analysis of Ostrowski-Traub’s method

Under the hypotheses that the second-order and third-order derivatives of a function are bounded, an estimate of the radius of the convergence ball of Ostrowski-Traub＇s method is obtained. An error analysis is given which matches the convergence order of the method. Finally, two examples are provided to show applications of our theorem.

Ergodic sensitivity analysis of one-dimensional chaotic maps

Sensitivity analysis in chaotic dynamical systems is a challenging task from a computational point of view.In this work,we present a numerical investigation of a novel approach,known as the space-split sensitivity or S3 algorithm.The S3 algorithm is an ergodic-averaging method to differentiate statistics in ergodic,chaotic systems,rigorously based on the theory of hyperbolic dynamics.We illustrate S3 on one-dimensional chaotic maps,revealing its computational advantage over na?ve finite difference computations of the same statistical response.In addition,we provide an intuitive explanation of the key components of the S3 algorithm,including the density gradient function.

Analysis of the elastic-plastic indentation properties of materials with varying ratio of hardness to Young’s modulus

The elastic-plastic indentation properties of materials with varying ratio of hardness to Young’s modulus(H/E) were analyzed with the finite element method. And the indentation stress fields of materials with varying ratio H/E on the surface were studied by the experiment. The results show that the penetration depth, contact radius, plastic pile-up and the degree of elastic recovery depend strongly on the ratio H/E. Moreover, graphs were established to describe the relationship between the elastic-plastic indentation parameters and H/E. The established graphs can be used to predict the H/E of materials when compared with experimental data.

Long-Term Geophysical Observations and Analysis of the World's Deepest Borehole

Objective In order to reduce the interfering noise from the earth surface, scientists have carried out multi-geophysical borehole observations and the related study. This study aims at improving signal-to-noise ratio obtained from the observation data to obtain zero noise data, which will be of great help to improve geophysical studies. Insights from this study will be significant for the earthquake disaster reduction, resource exploration and environmental protection.