In order to solve negative phase sequence problem of V connection transformer in the high speed and heavy haul electrical railway of China, the hybrid compensative co-phase traction power supply system which based on ...In order to solve negative phase sequence problem of V connection transformer in the high speed and heavy haul electrical railway of China, the hybrid compensative co-phase traction power supply system which based on passive and active compensation is proposed. Firstly, There construction and capacity distribution are analyzed, and the compensation current of active equipment is gave;Second, the feature of the hybrid compensative schemes are discussed. In the end, the related simulation results have confirmed the effectiveness of the compensation schemes in this paper.展开更多
Background:Triple-negative breast cancer(TNBC)is a heterogeneous,recurring cancer characterized by a high rate of metastasis,poor prognosis,and lack of efficient therapies.KBU2046,a small molecule inhibitor,can inhibi...Background:Triple-negative breast cancer(TNBC)is a heterogeneous,recurring cancer characterized by a high rate of metastasis,poor prognosis,and lack of efficient therapies.KBU2046,a small molecule inhibitor,can inhibit cell motility in malignant tumors,including breast cancer.However,the specific targets and the corresponding mechanism of its function remain unclear.Methods:In this study,we employed(3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium)(MTS)assay and transwell assay to investigate the impact of KBU2046 on the proliferation and migration of TNBC cells in vitro.RNA-Seq was used to explore the targets of KBU2046 that inhibit the motility of TNBC.Finally,confirmed the predicted important signaling pathways through RT-qPCR and western blotting.Results:In this study,we found that KBU2046 functioned as a novel transforming growth factor-β(TGF-β1)inhibitor,effectively suppressing tumor cell motility in vitro.Mechanistically,it directly down-regulated leucine-rich repeat-containing 8 family,member E(LRRC8E),latent TGFβ-binding protein 3(LTBP3),dynein light chain 1(DNAL1),and MAF family of bZIP transcription factors(MAFF)genes,along with reduced protein expression of the integrin family.Additionally,KBU2046 decreased phosphorylation levels of Raf and ERK.This deactivation of the ERK signaling pathway impeded cancer invasion and metastasis.Conclusions:In summary,these findings advocate for the utilization of TGF-β1 as a diagnostic and prognostic biomarker and as a therapeutic target in TNBC.Furthermore,our data underscore the potential of KBU2046 as a novel therapeutic strategy for combating cancer metastasis.展开更多
Correlation between site occupation evolution of alloying elements in L12 phase and growth of DO22 phase in Ni75Al7.5V17.5 was studied using microscopic phase field model. The results demonstrate that the growing proc...Correlation between site occupation evolution of alloying elements in L12 phase and growth of DO22 phase in Ni75Al7.5V17.5 was studied using microscopic phase field model. The results demonstrate that the growing process of DO22 phase can be divided into two stages. At the early stage, composition in the centre part of L12 phase almost remains unchanged, and the nucleation and growth of DO22 phase is controlled by the decrease of interface between L12 phases. At the late stage, part of V for growth of DO22 phase is supplied from the centre part of L12 phase and mainly comes from Al sublattice, the excess Ni spared from the decreasing L12 phase migrates into the centre part of L12 phase and occupies the Ni sublattices exclusively, while the excess Al mainly occupies the Al sublattice. At the late stage, the growth of DO22 phase is controlled by the evolution of antisite atoms and ternary additions in the centre part of L12 phase.展开更多
Based on the microscopic phase-field model, the correlation between site occupation evolution of alloying elements in Ni3V-DO22 phase and growth of Ni3Al-L12 phase was studied during the phase transformation of Ni75Al...Based on the microscopic phase-field model, the correlation between site occupation evolution of alloying elements in Ni3V-DO22 phase and growth of Ni3Al-L12 phase was studied during the phase transformation of Ni75Al4.2V20.8. The results demonstrate that the growth of L12 phase can be divided into two stages: at the early stage, the composition of alloying elements in DO22 phase almost remains unchanged; at the late stage, the compositions of Ni and Al decrease while V increases in DO22 phase. Part of alloying elements for L12 phase growth are supplied from the site occupation evolution of alloying elements on three kinds of sublattices in DO22 phase. Ni is mainly supplied from V sublattice, and part of Al is supplied from NiⅠ and V sites at the centre of DO22 phase. The excessive V from the decreasing DO22 phase migrates into the centre of DO22 phase and mainly occupies V and NiII sites. It is the site occupation evolution of antisite atoms and ternary additions in DO22 phase that controls the growth rate of L12 phase at the late stage.展开更多
Deformation-induced ferrite transformation (DIFT) has been proved to be an effective approach to refine ferrite grains. This paper shows that the ferrite grains can further be refined through combination of DIFT and...Deformation-induced ferrite transformation (DIFT) has been proved to be an effective approach to refine ferrite grains. This paper shows that the ferrite grains can further be refined through combination of DIFT and V or V-N microalloying. Vanadium dissolved in γ matrix restrains DIFT. During deformation, vanadium carbonitrides rapidly precipitate due to strain-induced precipitation, which causes decrease in vanadium dissolved in matrix and indirectly accelerates DIFT. Under heavy deformation, deformation induced ferrite (DIF) grains in V microalloyed steel were finer than those in V free steel. The more V added to steel, the finer DIF grains obtained. Moreover, the addition of N to V microalloyed steels can remarkably accelerate precipitation of V, and then promote DIFT. However, DIF grains in V-N microalloyed steel easily coarsen.展开更多
The effect of strain rate and deformation temperature on theα→βphase transformation in 47Zr-45Ti-5Al-3V alloy with an initial widmanstattenαstructure was investigated.At the deformation temperature of 550°C,t...The effect of strain rate and deformation temperature on theα→βphase transformation in 47Zr-45Ti-5Al-3V alloy with an initial widmanstattenαstructure was investigated.At the deformation temperature of 550°C,the volume fraction ofαphase decreased with increasing strain rate.At 600 and 650°C,the volume fraction ofαphase firstly increased to a maximum value with increasing strain rate from 1×10-3 to 1×10-2 s-1,and then decreased.At 700°C,the microstructure consisted of singleβphase.At a given strain rate,the volume fraction ofαphase decreased with increasing deformation temperature.With decreasing strain rate and increasing deformation temperature,the volume fraction and size of globularαphase increased.At 650°C and 1×10-3 s-1,the lamellarαphase was fully globularized.The variation in the volume fraction and morphology ofαphase with strain rate and deformation temperature significantly affected the hardness of 47Zr-45Ti-5Al-3V alloy.展开更多
文摘In order to solve negative phase sequence problem of V connection transformer in the high speed and heavy haul electrical railway of China, the hybrid compensative co-phase traction power supply system which based on passive and active compensation is proposed. Firstly, There construction and capacity distribution are analyzed, and the compensation current of active equipment is gave;Second, the feature of the hybrid compensative schemes are discussed. In the end, the related simulation results have confirmed the effectiveness of the compensation schemes in this paper.
基金support from various funding sources,including the National Natural Science Foundation of China(Grant Nos.U21A20415,82002531)Hebei Provincial Key Research Projects(Grant No.223777157D)the Beijing Health Promotion Association,China(2022).
文摘Background:Triple-negative breast cancer(TNBC)is a heterogeneous,recurring cancer characterized by a high rate of metastasis,poor prognosis,and lack of efficient therapies.KBU2046,a small molecule inhibitor,can inhibit cell motility in malignant tumors,including breast cancer.However,the specific targets and the corresponding mechanism of its function remain unclear.Methods:In this study,we employed(3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium)(MTS)assay and transwell assay to investigate the impact of KBU2046 on the proliferation and migration of TNBC cells in vitro.RNA-Seq was used to explore the targets of KBU2046 that inhibit the motility of TNBC.Finally,confirmed the predicted important signaling pathways through RT-qPCR and western blotting.Results:In this study,we found that KBU2046 functioned as a novel transforming growth factor-β(TGF-β1)inhibitor,effectively suppressing tumor cell motility in vitro.Mechanistically,it directly down-regulated leucine-rich repeat-containing 8 family,member E(LRRC8E),latent TGFβ-binding protein 3(LTBP3),dynein light chain 1(DNAL1),and MAF family of bZIP transcription factors(MAFF)genes,along with reduced protein expression of the integrin family.Additionally,KBU2046 decreased phosphorylation levels of Raf and ERK.This deactivation of the ERK signaling pathway impeded cancer invasion and metastasis.Conclusions:In summary,these findings advocate for the utilization of TGF-β1 as a diagnostic and prognostic biomarker and as a therapeutic target in TNBC.Furthermore,our data underscore the potential of KBU2046 as a novel therapeutic strategy for combating cancer metastasis.
基金Projects (50941020, 10902086, 50875217, 20903075) supported by the National Natural Science Foundation of ChinaProjects (SJ08-ZT05, SJ08-B14) supported by the Natural Science Foundation of Shaanxi Province, China
文摘Correlation between site occupation evolution of alloying elements in L12 phase and growth of DO22 phase in Ni75Al7.5V17.5 was studied using microscopic phase field model. The results demonstrate that the growing process of DO22 phase can be divided into two stages. At the early stage, composition in the centre part of L12 phase almost remains unchanged, and the nucleation and growth of DO22 phase is controlled by the decrease of interface between L12 phases. At the late stage, part of V for growth of DO22 phase is supplied from the centre part of L12 phase and mainly comes from Al sublattice, the excess Ni spared from the decreasing L12 phase migrates into the centre part of L12 phase and occupies the Ni sublattices exclusively, while the excess Al mainly occupies the Al sublattice. At the late stage, the growth of DO22 phase is controlled by the evolution of antisite atoms and ternary additions in the centre part of L12 phase.
基金Projects(51174168,51274167)supported by the National Natural Science Foundation of ChinaProject(2013M532082)supported by Postdoctoral Science Foundation of ChinaProjects(13R21421700,13R21421800)supported by the Postdoctoral Science Foundation of Shanghai,China
文摘Based on the microscopic phase-field model, the correlation between site occupation evolution of alloying elements in Ni3V-DO22 phase and growth of Ni3Al-L12 phase was studied during the phase transformation of Ni75Al4.2V20.8. The results demonstrate that the growth of L12 phase can be divided into two stages: at the early stage, the composition of alloying elements in DO22 phase almost remains unchanged; at the late stage, the compositions of Ni and Al decrease while V increases in DO22 phase. Part of alloying elements for L12 phase growth are supplied from the site occupation evolution of alloying elements on three kinds of sublattices in DO22 phase. Ni is mainly supplied from V sublattice, and part of Al is supplied from NiⅠ and V sites at the centre of DO22 phase. The excessive V from the decreasing DO22 phase migrates into the centre of DO22 phase and mainly occupies V and NiII sites. It is the site occupation evolution of antisite atoms and ternary additions in DO22 phase that controls the growth rate of L12 phase at the late stage.
文摘Deformation-induced ferrite transformation (DIFT) has been proved to be an effective approach to refine ferrite grains. This paper shows that the ferrite grains can further be refined through combination of DIFT and V or V-N microalloying. Vanadium dissolved in γ matrix restrains DIFT. During deformation, vanadium carbonitrides rapidly precipitate due to strain-induced precipitation, which causes decrease in vanadium dissolved in matrix and indirectly accelerates DIFT. Under heavy deformation, deformation induced ferrite (DIF) grains in V microalloyed steel were finer than those in V free steel. The more V added to steel, the finer DIF grains obtained. Moreover, the addition of N to V microalloyed steels can remarkably accelerate precipitation of V, and then promote DIFT. However, DIF grains in V-N microalloyed steel easily coarsen.
基金Project(201629) supported by the Scientific Research Foundation for Introduced Talent of Guizhou University,ChinaProjects(20164014,20165654) supported by the Hundred-level Innovative Talents Project of Guizhou Province,ChinaProject(20146013) supported by the Science and Technology of Guizhou Province,China
文摘The effect of strain rate and deformation temperature on theα→βphase transformation in 47Zr-45Ti-5Al-3V alloy with an initial widmanstattenαstructure was investigated.At the deformation temperature of 550°C,the volume fraction ofαphase decreased with increasing strain rate.At 600 and 650°C,the volume fraction ofαphase firstly increased to a maximum value with increasing strain rate from 1×10-3 to 1×10-2 s-1,and then decreased.At 700°C,the microstructure consisted of singleβphase.At a given strain rate,the volume fraction ofαphase decreased with increasing deformation temperature.With decreasing strain rate and increasing deformation temperature,the volume fraction and size of globularαphase increased.At 650°C and 1×10-3 s-1,the lamellarαphase was fully globularized.The variation in the volume fraction and morphology ofαphase with strain rate and deformation temperature significantly affected the hardness of 47Zr-45Ti-5Al-3V alloy.