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High-speed performance self-powered short wave ultraviolet radiation detectors based onκ(ε)-Ga_(2)O_(3) 被引量:1
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作者 Aleksei Almaev Alexander Tsymbalov +5 位作者 Bogdan Kushnarev Vladimir Nikolaev Alexei Pechnikov Mikhail Scheglov Andrei Chikiryaka Petr Korusenko 《Journal of Semiconductors》 EI CAS CSCD 2024年第4期56-62,共7页
High-speed solar-blind short wavelength ultraviolet radiation detectors based onκ(ε)-Ga_(2)O_(3)layers with Pt contacts were demonstrated and their properties were studied in detail.Theκ(ε)-Ga_(2)O_(3)layers were ... High-speed solar-blind short wavelength ultraviolet radiation detectors based onκ(ε)-Ga_(2)O_(3)layers with Pt contacts were demonstrated and their properties were studied in detail.Theκ(ε)-Ga_(2)O_(3)layers were deposited by the halide vapor phase epitaxy on patterned GaN templates with sapphire substrates.The spectral dependencies of the photoelectric properties of struc-tures were analyzed in the wavelength interval 200-370 nm.The maximum photo to dark current ratio,responsivity,detectiv-ity and external quantum efficiency of structures were determined as:180.86 arb.un.,3.57 A/W,1.78×10^(12) Hz^(0.5)∙cm·W^(-1) and 2193.6%,respectively,at a wavelength of 200 nm and an applied voltage of 1 V.The enhancement of the photoresponse was caused by the decrease in the Schottky barrier at the Pt/κ(ε)-Ga_(2)O_(3)interface under ultraviolet exposure.The detectors demon-strated could functionalize in self-powered mode due to built-in electric field at the Pt/κ(ε)-Ga_(2)O_(3)interface.The responsivity and external quantum efficiency of the structures at a wavelength of 254 nm and zero applied voltage were 0.9 mA/W and 0.46%,respectively.The rise and decay times in self-powered mode did not exceed 100 ms. 展开更多
关键词 κ(ε)-gallium oxide solar-blind shortwave ultraviolet radiation detectors self-powered operation mode
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基于InVEST和Geodetector模型的合肥生境质量时空演变及影响因素分析 被引量:1
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作者 智菲 周振宏 +2 位作者 赵铭 杨宗霖 高超群 《河北环境工程学院学报》 CAS 2024年第3期49-54,共6页
依据2000年、2010年和2020年3期土地利用数据,运用耦合模型探究合肥2000—2020年间生境质量时空变化特征并对影响因子进行分析。结果表明:2000—2020年合肥生境质量指数平均值分别为0.185、0.181、0.178,呈逐年下降趋势,较低质量区域向... 依据2000年、2010年和2020年3期土地利用数据,运用耦合模型探究合肥2000—2020年间生境质量时空变化特征并对影响因子进行分析。结果表明:2000—2020年合肥生境质量指数平均值分别为0.185、0.181、0.178,呈逐年下降趋势,较低质量区域向低质量区域的转移面积最大。合肥生境质量退化度在2000—2020年逐年下降,呈现出“环状增长”的空间分布特征。高退化度区域主要分布在低值区域外围,呈现非连续性扩张。区域生产总值、坡度以及高程是主要影响因子,双因子增强效应显著,年末总人口和人口密度为主导单因子。 展开更多
关键词 合肥市 InvEST模型 地理探测器 生境质量 驱动因子
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CVTD: A Robust Car-Mounted Video Text Detector
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作者 Di Zhou Jianxun Zhang +2 位作者 Chao Li Yifan Guo Bowen Li 《Computers, Materials & Continua》 SCIE EI 2024年第2期1821-1842,共22页
Text perception is crucial for understanding the semantics of outdoor scenes,making it a key requirement for building intelligent systems for driver assistance or autonomous driving.Text information in car-mounted vid... Text perception is crucial for understanding the semantics of outdoor scenes,making it a key requirement for building intelligent systems for driver assistance or autonomous driving.Text information in car-mounted videos can assist drivers in making decisions.However,Car-mounted video text images pose challenges such as complex backgrounds,small fonts,and the need for real-time detection.We proposed a robust Car-mounted Video Text Detector(CVTD).It is a lightweight text detection model based on ResNet18 for feature extraction,capable of detecting text in arbitrary shapes.Our model efficiently extracted global text positions through the Coordinate Attention Threshold Activation(CATA)and enhanced the representation capability through stacking two Feature Pyramid Enhancement Fusion Modules(FPEFM),strengthening feature representation,and integrating text local features and global position information,reinforcing the representation capability of the CVTD model.The enhanced feature maps,when acted upon by Text Activation Maps(TAM),effectively distinguished text foreground from non-text regions.Additionally,we collected and annotated a dataset containing 2200 images of Car-mounted Video Text(CVT)under various road conditions for training and evaluating our model’s performance.We further tested our model on four other challenging public natural scene text detection benchmark datasets,demonstrating its strong generalization ability and real-time detection speed.This model holds potential for practical applications in real-world scenarios. 展开更多
关键词 Deep learning text detection Car-mounted video text detector intelligent driving assistance arbitrary shape text detector
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Flexibility potential of Cs_(2)BX_(6)(B=Hf,Sn,Pt,Zr,Ti;X=I,Br,Cl)with application in photovoltaic devices and radiation detectors
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作者 Songya Wang Changcheng Chen +11 位作者 Shaohang Shi Ziyi Zhang Yan Cai Shuli Gao Wen Chen Shuangna Guo Elyas Abduryim Chao Dong Xiaoning Guan Ying Liu Gang Liu Pengfei Lu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第8期271-287,I0006,共18页
As interest in double perovskites is growing,especially in applications like photovoltaic devices,understanding their mechanical properties is vital for device durability.Despite extensive exploration of structure and... As interest in double perovskites is growing,especially in applications like photovoltaic devices,understanding their mechanical properties is vital for device durability.Despite extensive exploration of structure and optical properties,research on mechanical aspects is limited.This article builds a vacancyordered double perovskite model,employing first-principles calculations to analyze mechanical,bonding,electronic,and optical properties.Results show Cs_(2)Hfl_(6),Cs_(2)SnBr_(6),Cs_(2)SnI_(6),and Cs_(2)PtBr_(6)have Young's moduli below 13 GPa,indicating flexibility.Geometric parameters explain flexibility variations with the changes of B and X site composition.Bonding characteristic exploration reveals the influence of B and X site electronegativity on mechanical strength.Cs_(2)SnBr_(6)and Cs_(2)PtBr_(6)are suitable for solar cells,while Cs_(2)HfI_(6)and Cs_(2)TiCl_(6)show potential for semi-transparent solar cells.Optical property calculations highlight the high light absorption coefficients of up to 3.5×10^(5) cm^(-1)for Cs_(2)HfI_(6)and Cs_(2)TiCl_(6).Solar cell simulation shows Cs_(2)PtBr_(6)achieves 22.4%of conversion effciency.Cs_(2)ZrCl_(6)holds promise for ionizing radiation detection with its 3.68 eV bandgap and high absorption coefficient.Vacancy-ordered double perovskites offer superior flexibility,providing valuable insights for designing stable and flexible devices.This understanding enhances the development of functional devices based on these perovskites,especially for applications requiring high stability and flexibility. 展开更多
关键词 Double perovskite Mechanical properties Flexible PHOTOvOLTAIC Radiation detectors
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Design and performance evaluation of a large field-of-view dual-particle time-encoded imager based on a depth-of-interaction detector
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作者 Dong Zhao Xu-Wen Liang +6 位作者 Ping-Kun Cai Wei Cheng Wen-Bao Jia Da-Qian Hei Qing Shan Yong-Sheng Ling Chao Shi 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第4期1-14,共14页
Time-encoded imaging is useful for identifying potential special nuclear materials and other radioactive sources at a distance.In this study,a large field-of-view time-encoded imager was developed for gamma-ray and ne... Time-encoded imaging is useful for identifying potential special nuclear materials and other radioactive sources at a distance.In this study,a large field-of-view time-encoded imager was developed for gamma-ray and neutron source hotspot imaging based on a depth-of-interaction(DOI)detector.The imager primarily consists of a DOI detector system and a rotary dual-layer cylindrical coded mask.An EJ276 plastic scintillator coupled with two SiPMs was designed as the DOI detector to increase the field of view and improve the imager performance.The difference in signal time at both ends and the log of the signal amplitude ratio were used to calculate the interaction position resolution.The position resolution of the DOI detector was calibrated using a collimated Cs-137 source,and the full width at half maximum of the reconstruction position of the Gaussian fitting curve was approximately 4.4 cm.The DOI detector can be arbitrarily divided into several units to independently reconstruct the source distribution images.The unit length was optimized via Am-Be source-location experiments.A multidetector filtering method is proposed for image denoising.This method can effectively reduce image noise caused by poor DOI detector position resolution.The vertical field of view of the imager was(-55°,55°)when the detector was placed in the center of the coded mask.A DT neutron source at 20 m standoff could be located within 2400 s with an angular resolution of 3.5°. 展开更多
关键词 Time-encoded imager Depth-of-interaction detector Dual-particle imaging Hotspot imaging
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Method for detector description conversion from DD4hep to Filmbox
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作者 Zhao-Yang Yuan Tian-Zi Song +3 位作者 Yu-Jie Zeng Kai-Xuan Huang Yu-Mei Zhang Zheng-Yun You 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第9期115-126,共12页
DD4hep serves as a generic detector description toolkit recommended for offline software development in next-generation high-energy physics(HEP)experiments.Conversely,Filmbox(FBX)stands out as a widely used 3D modelin... DD4hep serves as a generic detector description toolkit recommended for offline software development in next-generation high-energy physics(HEP)experiments.Conversely,Filmbox(FBX)stands out as a widely used 3D modeling file format within the 3D software industry.In this paper,we introduce a novel method that can automatically convert complex HEP detector geometries from DD4hep description into 3D models in the FBX format.The feasibility of this method was dem-onstrated by its application to the DD4hep description of the Compact Linear Collider detector and several sub-detectors of the super Tau-Charm facility and circular electron-positron collider experiments.The automatic DD4hep–FBX detector conversion interface provides convenience for further development of applications,such as detector design,simulation,visualization,data monitoring,and outreach,in HEP experiments. 展开更多
关键词 detector description DD4hep FBX GEOMETRY Offline software
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Self-powered UVC detectors based on α-Ga_(2)O_(3) with enchanted speed performance
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作者 Aleksei Almaev Alexander Tsymbalov +4 位作者 Bogdan Kushnarev Vladimir Nikolaev Alexei Pechnikov Mikhail Scheglov Andrei Chikiryaka 《Journal of Semiconductors》 EI CAS CSCD 2024年第8期74-80,共7页
Detectors were developed for detecting irradiation in the short-wavelength ultraviolet(UVC)interval using high-quality single-crystallineα-Ga_(2)O_(3) films with Pt interdigital contacts.The films ofα-Ga_(2)O_(3) we... Detectors were developed for detecting irradiation in the short-wavelength ultraviolet(UVC)interval using high-quality single-crystallineα-Ga_(2)O_(3) films with Pt interdigital contacts.The films ofα-Ga_(2)O_(3) were grown on planar sapphire substrates with c-plane orientation using halide vapor phase epitaxy.The spectral dependencies of the photo to dark current ratio,responsivity,external quantum efficiency and detectivity of the structures were investigated in the wavelength interval of 200−370 nm.The maximum of photo to dark current ratio,responsivity,external quantum efficiency,and detectivity of the structures were 1.16×10^(4) arb.un.,30.6 A/W,1.65×10^(4)%,and 6.95×10^(15) Hz^(0.5)·cm/W at a wavelength of 230 nm and an applied voltage of 1 V.The high values of photoelectric properties were due to the internal enhancement of the photoresponse associated with strong hole trapping.Theα-Ga_(2)O_(3) film-based UVC detectors can function in self-powered operation mode due to the built-in electric field at the Pt/α-Ga_(2)O_(3) interfaces.At a wavelength of 254 nm and zero applied voltage,the structures exhibit a responsivity of 0.13 mA/W and an external quantum efficiency of 6.2×10^(−2)%.The UVC detectors based on theα-Ga_(2)O_(3) films demonstrate high-speed performance with a rise time of 18 ms in self-powered mode. 展开更多
关键词 HvPE gallium oxide solar-blind ultraviolet detector self-powered mode
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Structural design of mid-infrared waveguide detectors based on InAs/GaAsSb superlattice
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作者 PEI Jin-Di CHAI Xu-Liang +1 位作者 WANG Yu-Peng ZHOU Yi 《红外与毫米波学报》 SCIE EI CAS CSCD 北大核心 2024年第4期457-463,共7页
In the realm of near-infrared spectroscopy,the detection of molecules has been achieved using on-chip waveguides and resonators.In the mid-infrared band,the integration and sensitivity of chemical sensing chips are of... In the realm of near-infrared spectroscopy,the detection of molecules has been achieved using on-chip waveguides and resonators.In the mid-infrared band,the integration and sensitivity of chemical sensing chips are often constrained by the reliance on off-chip light sources and detectors.In this study,we demonstrate an InAs/GaAsSb superlattice mid-infrared waveguide integrated detector.The GaAsSb waveguide layer and the InAs/GaAsSb superlattice absorbing layer are connected through evanescent coupling,facilitating efficient and highquality detection of mid-infrared light with minimal loss.We conducted a simulation to analyze the photoelectric characteristics of the device.Additionally,we investigated the factors that affect the integration of the InAs/GaAs⁃Sb superlattice photodetector and the GaAsSb waveguide.Optimal thicknesses and lengths for the absorption lay⁃er are determined.When the absorption layer has a thickness of 0.3μm and a length of 50μm,the noise equiva⁃lent power reaches its minimum value,and the quantum efficiency can achieve a value of 68.9%.The utilization of waveguide detectors constructed with Ⅲ-Ⅴ materials offers a more convenient means of integrating mid-infra⁃red light sources and achieving photoelectric detection chips. 展开更多
关键词 InAs/GaAsSb superlattice waveguide detector evanescent coupling GaAsSb waveguide
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Hybrid 2D/3D Graphitic Carbon Nitride-Based High-Temperature Position-Sensitive Detector
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作者 Xuexia Chen Dongwen Yang +6 位作者 Xun Yang Qing Lou Zhiyu Liu Yancheng Chen Chaofan Lv Lin Dong Chongxin Shan 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2024年第1期275-283,共9页
Ultraviolet position-sensitive detectors(PSDs)are expected to undergo harsh environments,such as high temperatures,for a wide variety of applications in military,civilian,and aerospace.However,no report on relevant PS... Ultraviolet position-sensitive detectors(PSDs)are expected to undergo harsh environments,such as high temperatures,for a wide variety of applications in military,civilian,and aerospace.However,no report on relevant PSDs operating at high temperatures can be found up to now.Herein,we design a new 2D/3D graphitic carbon nitride(g-C_(3)N_(4))/gallium nitride(GaN)hybrid heterojunction to construct the ultraviolet high-temperature-resistant PSD.The g-C_(3)N_(4)/GaN PSD exhibits a high position sensitivity of 355 mV mm^(-1),a rise/fall response time of 1.7/2.3 ms,and a nonlinearity of 0.5%at room temperature.The ultralow formation energy of-0.917 eV atom^(-1)has been obtained via the thermodynamic phase stability calculations,which endows g-C_(3)N_(4)with robust stability against heat.By merits of the strong built-in electric field of the 2D/3D hybrid heterojunction and robust thermo-stability of g-C_(3)N_(4),the g-C_(3)N_(4)/GaN PSD delivers an excellent position sensitivity and angle detection nonlinearity of 315 mV mm^(-1)and 1.4%,respectively,with high repeatability at a high temperature up to 700 K,outperforming most of the other counterparts and even commercial silicon-based devices.This work unveils the high-temperature PSD,and pioneers a new path to constructing g-C_(3)N_(4)-based harsh-environment-tolerant optoelectronic devices. 展开更多
关键词 graphitic carbon nitride high-temperature stability lateral photovoltaic effect position-sensitive detectors two-dimensional materials
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Metal-Halide Perovskite Submicrometer-Thick Films for Ultra-Stable Self-Powered Direct X-Ray Detectors
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作者 Marco Girolami Fabio Matteocci +7 位作者 Sara Pettinato Valerio Serpente Eleonora Bolli Barbara Paci Amanda Generosi Stefano Salvatori Aldo Di Carlo Daniele M.Trucchi 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第9期410-431,共22页
Metal-halide perovskites are revolutionizing the world of X-ray detectors,due to the development of sensitive,fast,and cost-effective devices.Self-powered operation,ensuring portability and low power consumption,has a... Metal-halide perovskites are revolutionizing the world of X-ray detectors,due to the development of sensitive,fast,and cost-effective devices.Self-powered operation,ensuring portability and low power consumption,has also been recently demonstrated in both bulk materials and thin films.However,the signal stability and repeatability under continuous X-ray exposure has only been tested up to a few hours,often reporting degradation of the detection performance.Here it is shown that self-powered direct X-ray detectors,fabricated starting from a FAPbBr_(3)submicrometer-thick film deposition onto a mesoporous TiO_(2)scaffold,can withstand a 26-day uninterrupted X-ray exposure with negligible signal loss,demonstrating ultra-high operational stability and excellent repeatability.No structural modification is observed after irradiation with a total ionizing dose of almost 200 Gy,revealing an unexpectedly high radiation hardness for a metal-halide perovskite thin film.In addition,trap-assisted photoconductive gain enabled the device to achieve a record bulk sensitivity of 7.28 C Gy^(−1)cm^(−3)at 0 V,an unprecedented value in the field of thin-film-based photoconductors and photodiodes for“hard”X-rays.Finally,prototypal validation under the X-ray beam produced by a medical linear accelerator for cancer treatment is also introduced. 展开更多
关键词 Metal-halide perovskite thin films Direct X-ray detectors Self-powered devices Operational stability Medical linear accelerator
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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source
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作者 Qiang Li Li‑Jiao Wang +70 位作者 Jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong Zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Gong Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng Wang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui Zhang Hang‑Chang Zhang Lin‑Hao Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第8期58-68,共11页
Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron radiography.Its complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron s... Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron radiography.Its complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and detector.Consequently,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above keV.The white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to MeV.Neutron-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low noise.In this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the Back-n.Individual heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be identified.In particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time. 展开更多
关键词 Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification
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罗汉果苷V调控高糖状态巨噬细胞M1极化促进骨髓间充质干细胞的成骨分化
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作者 叶枝茂 惠久莹 +2 位作者 钟晓霞 麦昱颖 李昊 《中国组织工程研究》 CAS 北大核心 2025年第19期3968-3975,共8页
背景:糖尿病微环境会造成巨噬细胞过度M1极化,这种高糖炎症状态会抑制骨髓间充质干细胞的成骨分化,从而影响糖尿病骨缺损的愈合。研究表明罗汉果苷Ⅴ具有抗炎、抗氧化、降血糖的作用,但其能否调节高糖炎症状态下巨噬细胞M1极化及骨髓间... 背景:糖尿病微环境会造成巨噬细胞过度M1极化,这种高糖炎症状态会抑制骨髓间充质干细胞的成骨分化,从而影响糖尿病骨缺损的愈合。研究表明罗汉果苷Ⅴ具有抗炎、抗氧化、降血糖的作用,但其能否调节高糖炎症状态下巨噬细胞M1极化及骨髓间充质干细胞的成骨分化尚不清楚。目的:探讨罗汉果苷Ⅴ在高糖炎症状态下调节巨噬细胞M1型极化对骨髓间充质干细胞成骨分化的影响。方法:构建糖尿病C57BL/6小鼠模型,从正常和糖尿病小鼠分离骨髓来源巨噬细胞,分别培养于低糖和高糖培养基。使用脂多糖和干扰素γ作为炎症刺激诱导骨髓来源巨噬细胞的M1型极化,同时以160,320,640μmol/L罗汉果苷Ⅴ干预,用流式细胞术检测F4/80^(+)CD86^(+)细胞比例,qRT-PCR检测诱导型一氧化氮合酶、白细胞介素1β、白细胞介素6的mRNA表达水平,ELISA检测骨髓来源巨噬细胞上清液中肿瘤坏死因子α水平。分离C57BL/6小鼠骨髓间充质干细胞,分别使用低糖或高糖成骨诱导液诱导成骨分化,添加M1型巨噬细胞条件培养基作为炎症刺激,以及320μmol/L罗汉果苷Ⅴ干预,成骨诱导14 d后采用qRT-PCR检测碱性磷酸酶、Runt相关因子2、骨钙素、骨桥蛋白的mRNA表达水平,成骨诱导21 d后进行茜素红染色及定量分析。结果与结论:①流式细胞术结果显示320,640μmol/L罗汉果苷Ⅴ组的F4/80^(+)CD86^(+)细胞比例明显低于高糖炎症对照组(P<0.05);②qRT-PCR结果显示160,320,640μmol/L罗汉果苷Ⅴ组的诱导型一氧化氮合酶、白细胞介素6的mRNA相对表达量较高糖炎症对照组显著降低(P<0.05),320,640μmol/L罗汉果苷Ⅴ组白细胞介素1β的mRNA相对表达量较高糖炎症对照组显著降低(P<0.05);③ELISA结果显示160,320,640μmol/L罗汉果苷Ⅴ组的肿瘤坏死因子α分泌水平较高糖炎症对照组显著降低(P<0.05);④320μmol/L罗汉果苷Ⅴ干预后,高糖炎症状态下骨髓间充质干细胞的钙盐沉积增加(P<0.05),且碱性磷酸酶、Runt相关因子2和骨桥蛋白的mRNA相对表达量增加(P<0.05)。结果表明,罗汉果苷Ⅴ可通过抑制高糖炎症状态下骨髓来源巨噬细胞的M1型极化及炎症因子表达,促进骨髓间充质干细胞的成骨分化。 展开更多
关键词 罗汉果苷Ⅴ 巨噬细胞 M1型极化 骨髓间充质干细胞 炎症反应 成骨分化 高糖
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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine
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作者 Jiang-Yu Bian Yu-Fang Feng +1 位作者 Wen-Ting He Tong Zhang 《World Journal of Clinical Oncology》 2025年第1期25-33,共9页
BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohor... BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment. 展开更多
关键词 Metastatic colorectal cancer BRAF v600E mutation Integrated Chinese and Western medicine Cohort study
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基于V-detector算法的滚动轴承故障诊断方法 被引量:2
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作者 杨先勇 周晓军 +2 位作者 林勇 张文斌 沈路 《浙江大学学报(工学版)》 EI CAS CSCD 北大核心 2010年第9期1805-1810,共6页
针对实值阴性选择(RNS)算法的检测器尺寸不能自适应变化的问题,提出基于变检测半径的RNS算法(V-detector)的轴承故障诊断方法.将计算轴承振动信号局域波分解后各基本模式分量的关联维数作为特征向量,并根据故障模式将其划分为多个自体... 针对实值阴性选择(RNS)算法的检测器尺寸不能自适应变化的问题,提出基于变检测半径的RNS算法(V-detector)的轴承故障诊断方法.将计算轴承振动信号局域波分解后各基本模式分量的关联维数作为特征向量,并根据故障模式将其划分为多个自体样本集,采用V-detector算法训练多个检测器集,用其对轴承故障进行诊断.结果表明:自体半径过小则误诊率高,自体半径过大则检测器灵敏度低,这都将导致准确率减小;覆盖率越高,则准确率越高、计算花费越大,当覆盖率≥95%时,覆盖率对准确率的影响远小于其对计算花费的影响;相对于基于RNS的诊断方法,V-detector算法具有同样高的准确率,且计算花费显著减小、稳定性更高,可有效地识别轴承故障. 展开更多
关键词 滚动轴承 故障诊断 vdetector算法 人工免疫系统 局域波分解
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Fabrication of SiGe/Si Multi-Quantum Wells Resonant-Cavity-Enhanced Detector 被引量:2
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作者 李传波 毛荣伟 +6 位作者 左玉华 成步文 时文华 赵雷 罗丽萍 余金中 王启明 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2004年第12期1576-1579,共4页
A SiGe/Si multi-quantum wells resonant-cavity-enhanced(RCE) detector with high reflectivity bottom mirror is fabricated by a new method.The bottom mirror is deposited in the hole,which is etched from the backside of t... A SiGe/Si multi-quantum wells resonant-cavity-enhanced(RCE) detector with high reflectivity bottom mirror is fabricated by a new method.The bottom mirror is deposited in the hole,which is etched from the backside of the sample by ethylenediamine-pyrocatechol-water(EPW) solution with the buried SiO 2 layer in SOI substrate as the etching-stop layer.Reflectivity spectrum indicates that the mirror deposited in the hole has a reflectivity as high as 99% in the range of 1.2~1.5μm.The peak responsivity of the RCE detector at 1.344μm is 1.2mA/W and the full width at half maximum is 12nm.Compared with the conventional p-i-n photodetector,the responsivity of RCE detector is enhanced 8 times. 展开更多
关键词 RCE detector SOI SIGE
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基于视觉感知与V-detector的水质异常检测方法 被引量:4
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作者 金章赞 肖刚 +1 位作者 陈久军 高飞 《信息与控制》 CSCD 北大核心 2011年第1期130-136,共7页
为了快速准确地对水质进行评价分析,提出了一种新的水质异常检测方法.该方法将视觉感知技术与人工免疫系统中的否定选择原理相结合.首先采用视觉驱动的生物监测技术对水质指标进行采集,然后利用基于否定选择原理的可变V-detector算法对... 为了快速准确地对水质进行评价分析,提出了一种新的水质异常检测方法.该方法将视觉感知技术与人工免疫系统中的否定选择原理相结合.首先采用视觉驱动的生物监测技术对水质指标进行采集,然后利用基于否定选择原理的可变V-detector算法对水质指标进行评价分析.由于视觉感知技术具有敏感性、综合性以及人工免疫系统具有自组织、自学习、自识别等特点,故该方法能够快速准确地对水质进行实时检测评价.实验结果表明该方法是一种实用的水质检测评价方法. 展开更多
关键词 水质异常检测 视觉感知 否定选择 v-detector
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A Novel High-Voltage Detector Integrated into SPIC by Using FFLR 被引量:1
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作者 韩磊 叶星宁 陈星弼 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2001年第10期1250-1254,共5页
A novel high voltage detector that can be integrated into SPIC (Smart Power IC) is proposed.The structure is designed on the basis of normal junction terminal technique of FFLR (Floating Field Limiting Rings) system.... A novel high voltage detector that can be integrated into SPIC (Smart Power IC) is proposed.The structure is designed on the basis of normal junction terminal technique of FFLR (Floating Field Limiting Rings) system.The field limiting ring as a voltage divider,is used to optimize the surface field.The voltage of main junction increases from 0 to a high value,while the utmost ring is designed to vary within a small range,which can be handled by using low voltage logic circuits.An example of 400V rings system is analyzed and simulated for this structure.The results prove that the high voltage detector can detect high voltage in SPIC.The structure can be integrated into SPIC.Besides,it is compatible with CMOS or BCD(Bipolar CMOS Dmos) technology,without any additional processes required. 展开更多
关键词 FFLR high voltage detector voltage divider detector ring
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甘氨双唑钠对离体V_(79)细胞的放射增敏作用 被引量:25
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作者 郑秀龙 高建国 +3 位作者 张洪 朱勤 孟祥顺 赵芳 《辐射研究与辐射工艺学报》 CAS CSCD 北大核心 1995年第4期213-218,共6页
以离体细胞克隆形成法进一步研究了甘氨双唑钠(SGDD)对乏氧V79细胞的放射增敏作用。结果表明:SGDD的毒性较低,且对乏氧细胞的毒性比有氧时强。它对有氧细胞无增敏作用,但在乏氧情况下,对V79细胞有明显的放射增敏效... 以离体细胞克隆形成法进一步研究了甘氨双唑钠(SGDD)对乏氧V79细胞的放射增敏作用。结果表明:SGDD的毒性较低,且对乏氧细胞的毒性比有氧时强。它对有氧细胞无增敏作用,但在乏氧情况下,对V79细胞有明显的放射增敏效果,当SGDD在1.38mmol/L以下时,其SER值随浓度的增加而增高,C1.6=0.48mmol/L(C1.6代表SER为1.6时所需增敏剂的浓度),SER最大值2.3时的浓度为1.38mmol/L,不到ID50的1/70。另外,SGDD与MISO和甲硝唑同时对比的实验,显示SGDD的SER值大于MISO,并大大地高于其母体化合物甲硝唑。本研究进一步证实了我们先前分子与细胞实验的结果,SGDD是一种低毒、寓效,且能选择性地增强乏氧细胞的放射敏感性的放射增敏剂,有希望成为提高肿瘤放疗效果的新药。 展开更多
关键词 甘氨双唑钠 v79细胞 放射增敏
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黄芪总黄酮对羟自由基所致V_(79)细胞DNA链断裂损伤的防护作用研究 被引量:10
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作者 汪德清 沈文梅 +4 位作者 田亚平 刘国廉 杨素霞 周淑珍 孙仲怡 《中国药理学通报》 CSCD 北大核心 1995年第4期311-313,共3页
报道黄芪总黄酮对羟自由基所致细胞DNA损伤的防护效能。结果表明在黄芪总黄酮浓度为0.4g·L-1时即有防护作用,当浓度为0.8g·L-1时对羟自由基所致细胞DNA链断裂损伤即有极显著的防护效果。
关键词 羟自由基 v79细胞 DNA损伤 黄芪总黄酮 FADU
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V区温度及螺杆转速对挤压膨化牛肉制品理化性质的影响 被引量:1
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作者 张根生 田阳 +2 位作者 李思锦 韩冰 费英敏 《中国调味品》 CAS 北大核心 2024年第3期68-73,91,共7页
利用挤压膨化技术加工高粱-山药-牛肉混合物料,以水溶性、吸水性、色差值、粒度、质构、膨化度、糊化度及红外光谱各基团峰值为指标,分析V区温度和螺杆转速对挤压膨化产品理化性质的影响。结果表明,提高V区温度能够提高产品的红度值、... 利用挤压膨化技术加工高粱-山药-牛肉混合物料,以水溶性、吸水性、色差值、粒度、质构、膨化度、糊化度及红外光谱各基团峰值为指标,分析V区温度和螺杆转速对挤压膨化产品理化性质的影响。结果表明,提高V区温度能够提高产品的红度值、黄度值、硬度、脆度和咀嚼度,吸水性、水溶性、粒度、膨化度、糊化度及红外光谱各基团峰值呈先上升后下降的趋势,亮度值显著下降(P<0.05);同时,随着螺杆转速的提升,产品的红度值、黄度值和糊化度显著下降(P<0.05),吸水性、水溶性、粒度和膨化度呈先上升后下降的趋势,硬度、脆度、咀嚼度及红外光谱各基团峰值先下降后上升,亮度值显著下降(P<0.05)。综合理化指标确定V区温度最佳值为150℃,螺杆转速最佳值为160 r/min。 展开更多
关键词 挤压膨化 理化性质 v区温度 螺杆转速
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