Objective:To study the relationship between VAP-1,NT-proBNP,NLRP3 protein expression and survival status of patients with COPD.Methods:130 patients with COPD admitted from February 2015 to June 2016 were followed up f...Objective:To study the relationship between VAP-1,NT-proBNP,NLRP3 protein expression and survival status of patients with COPD.Methods:130 patients with COPD admitted from February 2015 to June 2016 were followed up for 2 years and were divided into death group(28 cases)and survival group(102 cases)according to the prognosis.The levels of serum VAP-1,NT-proBNP and NLRP3 protein were detected by ELISA.Logistic regression analysis of risk factors affecting the survival of patients with COPD,Spearman correlation analysis of the relationship between serum factors,and plot the survival curve of patients.Results:The serum levels of VAP-1,NT-proBNP,and NLRP3 in the survival group were significantly lower or shorter than those in the death group,and the lung function was significantly better than the death group,mainly in the I to III grades,with significant difference(P<0.05).Serum VAP-1,NT-proBNP,NLRP3,duration of disease,and pulmonary function grading can be used as independent prognostic risk factors for survival in patients with COPD.The Spearman correlation analysis showed that the expression levels of VAP-1,NT-proBNP and NLRP3 protein were positively correlated(r values were greater than 0,P values were less than 0.05).The mortality of patients with positive VAP-1,NT-proBNP and NLRP3 protein expression levels was significantly higher than that of the negative group(P<0.05).Conclusion:Serum VAP-1,NT-proBNP and NLRP3 are independent risk factors for the survival of patients.There is a positive correlation between the expression levels of each factor.The higher the level of expression,the worse the prognosis.展开更多
目的探讨降钙素原(PCT)、髓系细胞表达的触发受体-1(TREM-1)联合肺部感染评分(CPIS)评分对新生儿呼吸机相关性肺炎(VAP)早期诊断的临床价值。方法以88例有创机械通气患儿作为研究对象,所有患儿均在机械通气后第1天、第3天、第7天采集外...目的探讨降钙素原(PCT)、髓系细胞表达的触发受体-1(TREM-1)联合肺部感染评分(CPIS)评分对新生儿呼吸机相关性肺炎(VAP)早期诊断的临床价值。方法以88例有创机械通气患儿作为研究对象,所有患儿均在机械通气后第1天、第3天、第7天采集外周血及肺泡灌洗液标本并进行检测,同时进行CPIS评分,根据治疗后评估,将88例患儿分为VAP组(46例)与非VAP组(42例),应用ROC曲线评价PCT、TREM-1、CPIS联合指标对VAP的早期诊断价值。结果两组的PCT(第1天:0.53±0.15ng/mL vs 0.36±0.12ng/mL;第3天:2.07±1.22ng/mL vs 0.45±0.13ng/mL;第7天:2.54±1.31ng/mL vs 0.47±0.12ng/mL)、TREM-1(第1天:4.18±1.17pg/mL vs 3.01±0.78pg/mL;第3天:3.01±0.78pg/mL vs 3.52±0.85pg/mL;第7天:9.62±1.93pg/mL vs 4.03±1.14pg/mL)、CPIS评分(第1天:4.2±1.1分vs3.4±1.2分;第3天:5.2±0.9分vs 3.3±1.1分;第7天:5.5±1.2分vs 3.6±1.4分)差异有统计学意义(PCT:t值分别为-5.369、-7.583、-9.034;TREM-1;t值分别为-4.985、-7.370、-14.834;CPIS评分:t值分别为-3.053、-8.381、-6.437;均P<0.01)。第3天指标的诊断效能最高,PCT、TREM-1、CPIS评分联合指标对诊断VAP的敏感性、特异性、阳性预测值、阴性预测值分别80.4%、100.0%、93.5%、100.0%。结论结合PCT、TREM-1、CPIS评分综合分析,可以显著提高诊断的特异性,对新生儿VAP的早期诊断有较好的实用性。展开更多
基金Education Office of Sichuan province(16ZB0230)North Sichuan medical college Project(CBY17-A-YB11).
文摘Objective:To study the relationship between VAP-1,NT-proBNP,NLRP3 protein expression and survival status of patients with COPD.Methods:130 patients with COPD admitted from February 2015 to June 2016 were followed up for 2 years and were divided into death group(28 cases)and survival group(102 cases)according to the prognosis.The levels of serum VAP-1,NT-proBNP and NLRP3 protein were detected by ELISA.Logistic regression analysis of risk factors affecting the survival of patients with COPD,Spearman correlation analysis of the relationship between serum factors,and plot the survival curve of patients.Results:The serum levels of VAP-1,NT-proBNP,and NLRP3 in the survival group were significantly lower or shorter than those in the death group,and the lung function was significantly better than the death group,mainly in the I to III grades,with significant difference(P<0.05).Serum VAP-1,NT-proBNP,NLRP3,duration of disease,and pulmonary function grading can be used as independent prognostic risk factors for survival in patients with COPD.The Spearman correlation analysis showed that the expression levels of VAP-1,NT-proBNP and NLRP3 protein were positively correlated(r values were greater than 0,P values were less than 0.05).The mortality of patients with positive VAP-1,NT-proBNP and NLRP3 protein expression levels was significantly higher than that of the negative group(P<0.05).Conclusion:Serum VAP-1,NT-proBNP and NLRP3 are independent risk factors for the survival of patients.There is a positive correlation between the expression levels of each factor.The higher the level of expression,the worse the prognosis.
文摘目的探讨降钙素原(PCT)、髓系细胞表达的触发受体-1(TREM-1)联合肺部感染评分(CPIS)评分对新生儿呼吸机相关性肺炎(VAP)早期诊断的临床价值。方法以88例有创机械通气患儿作为研究对象,所有患儿均在机械通气后第1天、第3天、第7天采集外周血及肺泡灌洗液标本并进行检测,同时进行CPIS评分,根据治疗后评估,将88例患儿分为VAP组(46例)与非VAP组(42例),应用ROC曲线评价PCT、TREM-1、CPIS联合指标对VAP的早期诊断价值。结果两组的PCT(第1天:0.53±0.15ng/mL vs 0.36±0.12ng/mL;第3天:2.07±1.22ng/mL vs 0.45±0.13ng/mL;第7天:2.54±1.31ng/mL vs 0.47±0.12ng/mL)、TREM-1(第1天:4.18±1.17pg/mL vs 3.01±0.78pg/mL;第3天:3.01±0.78pg/mL vs 3.52±0.85pg/mL;第7天:9.62±1.93pg/mL vs 4.03±1.14pg/mL)、CPIS评分(第1天:4.2±1.1分vs3.4±1.2分;第3天:5.2±0.9分vs 3.3±1.1分;第7天:5.5±1.2分vs 3.6±1.4分)差异有统计学意义(PCT:t值分别为-5.369、-7.583、-9.034;TREM-1;t值分别为-4.985、-7.370、-14.834;CPIS评分:t值分别为-3.053、-8.381、-6.437;均P<0.01)。第3天指标的诊断效能最高,PCT、TREM-1、CPIS评分联合指标对诊断VAP的敏感性、特异性、阳性预测值、阴性预测值分别80.4%、100.0%、93.5%、100.0%。结论结合PCT、TREM-1、CPIS评分综合分析,可以显著提高诊断的特异性,对新生儿VAP的早期诊断有较好的实用性。
