The conventional control methods of variable air volume (VAV) air conditioning systems usually assume that the indoor air is well mixed, and consider each building zone as one node with homogeneous temperature distrib...The conventional control methods of variable air volume (VAV) air conditioning systems usually assume that the indoor air is well mixed, and consider each building zone as one node with homogeneous temperature distribution. The average temperature is subsequently used as the controlled parameter in the VAV cascade control process, which might cause uneven temperature distribution and unsatisfactory thermal comfort. This paper presents a coupled simulation of computational fluid dynamics (CFD) and building energy simulation (BES) for the VAV system in an office building located in Shanghai for the purpose of simulating the building, the VAV control system, and indoor thermal environment simultaneously. An external interface is developed to integrate the CFD and BES models based on quasi-dynamic coupling approach. Based upon the developed co-simulation platform, the novel VAV control method is further proposed by fusing information from multiple sensors. By adding two temperature sensors to constrain the thermal comfort of the occupied zone, the supply air temperature setpoint of the VAV terminal unit can be reset in real time. The novel control method is embedded into the co-simulation platform and compared with the conventional VAV control approach. The results illustrate that the temperature distribution under the proposed method is more uniform. At most times of the typical test day, the air diffusion performance indexes (ADPIs) for the proposed method are above 80%, while the ADPIs for the conventional control method are between 60% and 80%. Due to multi-sensor information fusion, the proposed VAV control approach has better ability to ensure the indoor thermal comfort.展开更多
Microglia,which are the resident macrophages of the central nervous system,are an important part of the inflammatory response that occurs after cerebral ischemia.Vav guanine nucleotide exchange factor 1(Vav1) is a gua...Microglia,which are the resident macrophages of the central nervous system,are an important part of the inflammatory response that occurs after cerebral ischemia.Vav guanine nucleotide exchange factor 1(Vav1) is a guanine nucleotide exchange factor that is related to microglial activation.However,how Vav1 participates in the inflammato ry response after cerebral ischemia/reperfusion inj ury remains unclea r.In this study,we subjected rats to occlusion and repe rfusion of the middle cerebral artery and subjected the BV-2 mic roglia cell line to oxygen-glucose deprivatio n/reoxygenation to mimic cerebral ischemia/repe rfusion in vivo and in vitro,respectively.We found that Vav1 levels were increased in the brain tissue of rats subjected to occlusion and reperfusion of the middle cerebral arte ry and in BV-2 cells subjected to oxygen-glucose deprivation/reoxygenation.Silencing Vav1 reduced the cerebral infarct volume and brain water content,inhibited neuronal loss and apoptosis in the ischemic penumbra,and im p roved neurological function in rats subjected to occlusion and repe rfusion of the middle cerebral artery.Further analysis showed that Vav1 was almost exclusively localized to microglia and that Vav1 downregulation inhibited microglial activation and the NOD-like receptor pyrin 3(NLRP3) inflammasome in the ischemic penumbra,as well as the expression of inflammato ry facto rs.In addition,Vov1 knoc kdown decreased the inflammatory response exhibited by BV-2 cells after oxygen-glucose deprivation/reoxyge nation.Taken together,these findings show that silencing Vav1 attenuates inflammation and neuronal apoptosis in rats subjected to cerebral ischemia/repe rfusion through inhibiting the activation of mic roglia and NLRP3 inflammasome.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.51876119)the Shanghai Pujiang Program(No.17PJD017).
文摘The conventional control methods of variable air volume (VAV) air conditioning systems usually assume that the indoor air is well mixed, and consider each building zone as one node with homogeneous temperature distribution. The average temperature is subsequently used as the controlled parameter in the VAV cascade control process, which might cause uneven temperature distribution and unsatisfactory thermal comfort. This paper presents a coupled simulation of computational fluid dynamics (CFD) and building energy simulation (BES) for the VAV system in an office building located in Shanghai for the purpose of simulating the building, the VAV control system, and indoor thermal environment simultaneously. An external interface is developed to integrate the CFD and BES models based on quasi-dynamic coupling approach. Based upon the developed co-simulation platform, the novel VAV control method is further proposed by fusing information from multiple sensors. By adding two temperature sensors to constrain the thermal comfort of the occupied zone, the supply air temperature setpoint of the VAV terminal unit can be reset in real time. The novel control method is embedded into the co-simulation platform and compared with the conventional VAV control approach. The results illustrate that the temperature distribution under the proposed method is more uniform. At most times of the typical test day, the air diffusion performance indexes (ADPIs) for the proposed method are above 80%, while the ADPIs for the conventional control method are between 60% and 80%. Due to multi-sensor information fusion, the proposed VAV control approach has better ability to ensure the indoor thermal comfort.
基金Natural Science Foundation of Liaoning Province (General Program),No.2017010825 (to JQ)。
文摘Microglia,which are the resident macrophages of the central nervous system,are an important part of the inflammatory response that occurs after cerebral ischemia.Vav guanine nucleotide exchange factor 1(Vav1) is a guanine nucleotide exchange factor that is related to microglial activation.However,how Vav1 participates in the inflammato ry response after cerebral ischemia/reperfusion inj ury remains unclea r.In this study,we subjected rats to occlusion and repe rfusion of the middle cerebral artery and subjected the BV-2 mic roglia cell line to oxygen-glucose deprivatio n/reoxygenation to mimic cerebral ischemia/repe rfusion in vivo and in vitro,respectively.We found that Vav1 levels were increased in the brain tissue of rats subjected to occlusion and reperfusion of the middle cerebral arte ry and in BV-2 cells subjected to oxygen-glucose deprivation/reoxygenation.Silencing Vav1 reduced the cerebral infarct volume and brain water content,inhibited neuronal loss and apoptosis in the ischemic penumbra,and im p roved neurological function in rats subjected to occlusion and repe rfusion of the middle cerebral artery.Further analysis showed that Vav1 was almost exclusively localized to microglia and that Vav1 downregulation inhibited microglial activation and the NOD-like receptor pyrin 3(NLRP3) inflammasome in the ischemic penumbra,as well as the expression of inflammato ry facto rs.In addition,Vov1 knoc kdown decreased the inflammatory response exhibited by BV-2 cells after oxygen-glucose deprivation/reoxyge nation.Taken together,these findings show that silencing Vav1 attenuates inflammation and neuronal apoptosis in rats subjected to cerebral ischemia/repe rfusion through inhibiting the activation of mic roglia and NLRP3 inflammasome.
