Value-Based Test Case Prioritization for Regression Testing Using Genetic Algorithms

Test Case Prioritization(TCP)techniques perform better than other regression test optimization techniques including Test Suite Reduction(TSR)and Test Case Selection(TCS).Many TCP techniques are available,and their performance is usually measured through a metric Average Percentage of Fault Detection(APFD).This metric is value-neutral because it only works well when all test cases have the same cost,and all faults have the same severity.Using APFD for performance evaluation of test case orders where test cases cost or faults severity varies is prone to produce false results.Therefore,using the right metric for performance evaluation of TCP techniques is very important to get reliable and correct results.In this paper,two value-based TCP techniques have been introduced using Genetic Algorithm(GA)including Value-Cognizant Fault Detection-Based TCP(VCFDB-TCP)and Value-Cognizant Requirements Coverage-Based TCP(VCRCB-TCP).Two novel value-based performance evaluation metrics are also introduced for value-based TCP including Average Percentage of Fault Detection per value(APFDv)and Average Percentage of Requirements Coverage per value(APRCv).Two case studies are performed to validate proposed techniques and performance evaluation metrics.The proposed GA-based techniques outperformed the existing state-of-the-art TCP techniques including Original Order(OO),Reverse Order(REV-O),Random Order(RO),and Greedy algorithm.

Managing Value-Based Activity Flexibility on Integrated ERP

On the background of integrated ERP development, activity-value-flexibility management (AVFM) is defined. By using economic-value-added (EVA) and corporate value creation as the objective of AVFM, custom value deviating rate, capital cost deviating rate, cash-flow-out per purchase deviating rate and cash-flow-in per sell deviating rate are developed to be the key responding variates for AVFM, and they also decide the rational quantity range for AVFM tactics. Method for rational AVFM tactics solution could be got by means of redesigning activity information process on integrated ERP.

The Practice of Pharmacist-Driven Antimicrobial Stewardship Based on Value-Based Healthcare

Objective To evaluate the effect of pharmacist-driven antimicrobial stewardship based on value-based healthcare in a tertiary hospital in China.Methods The application of plan-do-check-action(PDCA)cycle and antimicrobial stewardship(AMS)were respectively used to improve the rational use of antimicrobial agents in prophylactic and therapeutic.Data were collected and the effect was assessed during the management period(2016-2019).Results and Conclusion From 2016(before implementation)to 2019(after implementation),the rational use of antibiotics were obviously enhanced in outpatients,inpatients,and emergency department.For instance,the utilization rate in type I incision operation was decreased from 26.42%to 14.60%(P=0.000),the daily doses of antibiotic per 100 patient-days decreased from 49.34±2.97 to 35.89±4.96(P=0.000),and the average antibiotic expenditures dropped from 948.53 yuan to 526.30 yuan(P=0.000).There was no significant change in infection rate,nosocomial mortality rate,and the length of hospital stay.After the implementation of clinical pharmacist-driven antimicrobial stewardship based on value-based healthcare,the consumption and cost of antibacterial have been greatly reduced.Therefore,the pharmacist-driven antimicrobial stewardship increases its value。

Comparison of potentials between genotype-based selection and genotypic value-based selection of quantitative traits

According to the difference of selection criteria, methods of marker-assisted selection (MAS) of quantitative traits can be divided into genotype-based selection (GS) and genotypic value-based selection (GVS). By means of computer simulation, potentials of the two methods were compared. Results showed that the two methods had similar basic laws and their efficiencies were not significantly different except that GS behaved better in the case where the number of QTLs was large and QTL effects were equal. From the application point of view, combination of GS and GVS should be the development direction of MAS research in the future.

A multi process value-based reinforcement learning environment framework for adaptive traffic signal control

Realising adaptive traffic signal control(ATSC)through reinforcement learning(RL)is an important means to easetraffic congestion.This paper finds the computing power of the central processing unit(CPU)cannot fully usedwhen Simulation of Urban MObility(SUMO)is used as an environment simulator for RL.We propose a multi-process framework under value-basedRL.First,we propose a shared memory mechanism to improve exploration efficiency.Second,we use the weight sharing mechanism to solve the problem of asynchronous multi-process agents.We also explained the reason shared memory in ATSC does not lead to early local optima of the agent.Wehave verified in experiments the sampling efficiency of the 10-process method is 8.259 times that of the single process.The sampling efficiency of the 20-process method is 13.409 times that of the single process.Moreover,the agent can also converge to the optimal solution.

Economic impact of minimally invasive lumbar surgery

Cost effectiveness has been demonstrated for traditional lumbar discectomy, lumbar laminectomy as well as for instrumented and noninstrumented arthrodesis. While emerging evidence suggests that minimally invasive spine surgery reduces morbidity, duration of hospitalization, and accelerates return to activites of daily living, data regarding cost effectiveness of these novel techniques is limited. The current study analyzes all available data on minimally invasive techniques for lumbar discectomy, decompression, short-segment fusion and deformity surgery. In general, minimallyinvasive spine procedures appear to hold promise in quicker patient recovery times and earlier return to work. Thus, minimally invasive lumbar spine surgery appears to have the potential to be a cost-effective intervention. Moreover, novel less invasive procedures are less destabilizing and may therefore be utilized in certain indications that traditionally required arthrodesis procedures. However, there is a lack of studies analyzing the economic impact of minimally invasive spine surgery. Future studies are necessary to confirm the durability and further define indications for minimally invasive lumbar spine procedures.

Patient Quality-of-Life, Providers with Incentive Payments, Real-World Evidence, and Reducing Healthcare Costs through New Innovations

Background: Value-Based Care is a program that was created by Professor Michael E. PORTER and Elizabeth O. TEISBERG which has been modified for implementation over the last seventeen years. This new program is paid by Commercial Health Insurers (Insurance Companies) and Centers for Medicare and Medicaid Services (Medicare). This program incorporates the patients, doctors, Life Sciences Companies, Insurance Companies, Holistic practice, traditional Chinese medicine, etc. with alternative traditional treatments and therapies for Real-World Evidence based and value-based treatment customized to patients’ needs and the patients benefit. Methods: The program was proposed to achieve value for patients and an improved healthcare system which is especially needed to provide treatment for patients in Serious or Life-threatening conditions or diseases. The program will accurately measure the outcomes of patients and provide a wider choice of treatments that matter to patients, also to measure the cost that successful alternative treatments provide which may lower the cost to Medicare and Insurance Companies. Conclusion: The proposed and now implemented program is to achieve value for patients. Golden Sunrise Nutraceutical (Golden Sunrise) provides a New Medical Innovation and treatment alternative to patients suffering from Serious or Life-threatening illnesses. By using Golden Sunrise Innovation and with the incorporation of Value-based Care patients will become the drivers or it could be said the patient Ambassadors of their own health. By incorporating Golden Sunrise Innovation, the doctors will have more diversity of treatments available for their patients. Payment should reflect value not volume, and the New Medical Innovation Golden Sunrise offers will help in reducing the costs to Insurance Companies accelerating the adoption of Value-Based Care.

Measurement of Economic Result in Public Organizations： A Departmental Analysis

The aim of this work is to demonstrate how public university hospital （UH） managers can improve the process of decision-making by using the measurement of economic value added to the society （EVAS） generated by these organizations. Thus, the economic values of the organization and its departments were calculated, according to the theory studied： measurement model of economic result of Slomski （1996）. It was considered the conduction of a case study in a public UH, evaluating its economic performance in a 3-year period. For the interpretation of results, the Data Envelopment Analysis （DEA） which categorized the departments of the hospital studied as efficient or inefficient was used. This study revealed that managers can improve the decision-making process by using the EVAS, since it has been established that this measurement of economic value has sensitivity to identify which of the economic value drivers should be emphasized in the management.

Sustaining Dakwah Movement： A Study of KAMMI Alumni Role in Democratic Era of Indonesia

This paper examines an empirical evidence of a frame continuation performed by KAMMI alumni, a contemporary Indonesian Islamic social movement organization. The concepts of ＂frame continuation＂ and ＂value-based identity＂ can be used as theoretical foundation to explore and explain the phenomena of dakwah movement performed by the alumni of KAMMI. Field research on KAMMI alumni role provides the primary empirical foundation for investigating frame continuation, a sustainability of the dakwah movement beyond students＇ movement organization. Discussion about KAMMI alumni＇s role provides empirical evidences about how they have strong commitment on either political or religious activities （or both） as their strategies to maintain and continue their previous identity as both political and religious activists. The main foundation for their activism is a value of dakwah （proselytizing）, in which Islamic values are believed to be a suitable vehicle for constructing a sacred society in democratic era of Indonesia. The KAMMI alumni believe their movement is a significant religious duty.

Balancing medical innovation and affordability in the new healthcare ecosystem in China:Review of pharmaceutical pricing and reimbursement policies

The China Basic Medical Insurance Program was created in 1999 with three objectives:equal accessibility,affordability,and quality.Today,it has become the biggest medical insurance program in the world,covering 95%of China's population.Since 2015,China's healthcare ecosystem has been reshaped by increasing innovation,which has in turn been driven by regulatory reform,enhancement of research and development capability,and capital market development.There has also been improved regulatory efficiency to reduce lags in launching drugs.In 2022,nearly 20%of novel active substances launched globally were from China.China has also risen to become the second biggest contributor to innovation in terms of pipelines.Using a“fast-follow”strategy,many locally developed innovative drugs can compete with products from multinational companies in their quality and pricing.However,China's pharmaceutical and biotechnology industry will continue to face challenges in pricing and reimbursement,as well as a shortened product lifecycle with rapid price erosion.The government has already accelerated the timeline for updating the drug reimbursement list and is willing to create a high-quality medical insurance program.However,some obstacles are hard to overcome,including reimbursement for advanced therapies,limited funding and an increasing burden of disease due to an aging population.This article reviews the trajectory of medical innovation in China,including the challenges.Looking forward,balancing affordability and innovation will be critical for China to continue the trajectory of growth.The article also offers some suggestions for future policy reform,including optimizing reimbursement efficiency with a focus on highquality solutions,enhancing the value assessment framework,payer repositioning from“value buyer”to“strategic buyer”,and developing alternative market access pathways for innovative drugs.

Pancreatic enucleation:a valid surgical option with encouraging quality of life

In their study“Pancreatic Enucleation Patients Share the Same Quality of Life as the General Population at Long-Term Follow-Up”,Giuliani et al.(1)assess short-and long-term outcomes including quality of life after pancreatic enucleation(PE).PE aims to preserve endocrine and exocrine function while ensuring surgical ablation of a presumed benign pancreatic tumor(neuroendocrine tumors,mucinous cystadenoma,serous cystadenoma,branch duct intraductal papillary mucinous neoplasms and solid pseudopapillary tumors).

Validity of the French version of Catquest-9SF and use of an electronic notepad for entering patient-reported outcome measures

Background:The Catquest-9SF questionnaire is a patient reported outcome measure that quantifies the visual benefits from cataract surgery.The purpose of this study was to translate and adapt the Catquest-9SF questionnaire for France,to assess its psychometric properties via Rasch analysis,and to assess its validity when completed using an electronic notepad.Methods:The Catquest-9SF questionnaire was translated following the guidelines of the International Society for Pharmacoeconomics and Outcomes Research.Catquest-9SF and clinical data were collected from patients before and after routine cataract surgery.All questionnaire data were collected via an electronic notepad.Rasch analysis was performed to assess psychometric properties,and sensitivity to change was analysed for patients with complete paired pre-and post-operative questionnaires.Results:A complete filled-in preoperative questionnaire was obtained for 848 patients.Rasch analysis showed good precision(person separation:2.32,person reliability:0.84),ordered category probability curves,no item misfit,and unidimensionality.The respondents were slightly more able than the level of item difficulty(targeting:−1.12 logits).Sensitivity was analysed on 211 paired questionnaires,and the postoperative questionnaires showed a clear ceiling effect.The effect size was 2.6.The use of an electronic notepad for completing the questionnaire worked out very well after some adjustments.Conclusions:The French version of Catquest-9SF has good psychometric properties and is suitable for use in French-speaking patients.The use of the Catquest-9SF questionnaire in an electronic format showed good validity.

Active Store Window: Enabling Far Store-Load Forwarding with Scalability and Complexity-Efficiency

Conventional dynamically scheduled processors often use fully associative structures named load/store queue （LSQ） to implement the value communication between loads and the older in-flight stores and to detect the store-load order violation. But this in-flight forwarding only occupies about 15% of all store-load communications, which makes the CAM-based micro-architecture the major bottleneck to scale store-load communication further. This paper presents a new micro-architecture named ASW （short for active store window）. It provides a new structure named speculative active store window to implement more aggressively speculative store-load forwarding than conventional LSQ. This structure could forward the data of committed stores to the executing loads without accessing to L1 data cache, which is referred to as far forwarding in this paper. At the back-end of the pipeline, it uses in-order load re-execution filtered by the tagged SSBF （short for store sequence bloom filter） to verify the correctness of the store-load forwarding. The speculative active store window and tagged store sequence bloom filter are all set-associate structures that are more efficient and scalable than fully associative structures. Experiments show that this simpler and faster design outperforms a conventional load/store queue based design and the NoSO desien on most benchmarks by 10.22% and 8.71% respectively.