目的:探讨浆液性卵巢癌中血管生成抑制蛋白-1(vasohibin-1)、结肠癌转移相关蛋白1(metastasis-associated in colon cancer-1,MACC1)和抗癌1号蛋白(KAI1)表达之间的关系及其临床意义。方法:收集124例卵巢浆液性癌(卵巢浆液性癌组)和30...目的:探讨浆液性卵巢癌中血管生成抑制蛋白-1(vasohibin-1)、结肠癌转移相关蛋白1(metastasis-associated in colon cancer-1,MACC1)和抗癌1号蛋白(KAI1)表达之间的关系及其临床意义。方法:收集124例卵巢浆液性癌(卵巢浆液性癌组)和30例卵巢浆液性囊腺瘤(卵巢浆液性囊腺瘤组)术后组织标本,采用免疫组织化学ElivisionTM法检测所有肿瘤组织中vasohibin-1,MACC1和KAI1蛋白的表达情况。结果:卵巢浆液性癌组vasohibin-1和MACC1蛋白的阳性表达率分别为48.4%和58.1%,均高于卵巢浆液性囊腺瘤组(分别为10.0%和13.3%);而卵巢浆液性癌组KAI1蛋白阳性表达率为33.9%,低于浆液性囊腺瘤组(86.7%),差异均有统计学意义(均P<0.05);3种蛋白的表达与浆液性卵巢癌的病理组织学分级、国际妇产科联盟(Federation International of Gynecology and Obstetrics,FIGO)分期以及盆腔淋巴结转移有关(均P<0.05);KAI1蛋白的表达与vasohibin-1和MACC1的表达呈负相关(r值分别为–0.500和–0.600,均P<0.01),同时,vasohibin-1与MACC1蛋白的表达呈正相关(r=0.518,P<0.01)。Kaplan-Meier生存分析表明:vasohibin-1和MACC1的过表达以及KAI1的低表达均与患者的生存率有关,vasohibin-1和MACC1表达阳性及KAI1表达阴性的患者生存率明显低于vasohibin-1和MACC1表达阴性及KAI1表达阳性的患者(均P<0.05)。多因素分析表明:FIGO分期、vasohibin-1和KAI1蛋白的表达是影响浆液性卵巢癌根治术后患者预后的独立因素(RR值分别为2.185,3.893,0.413;95% CI分别为1.263~3.779,2.190~6.921,0.251~0.681;均P<0.05)。结论:浆液性卵巢癌组织中vasohibin-1和MACC1的表达上调以及KAI1的表达下调与肿瘤的分化程度、临床分期、转移和预后等因素相关,这些指标的联合检测可作为判断浆液性卵巢癌患者肿瘤演进及生存预后的重要指标。展开更多
Ischemic and neovascular disease is one of the most difficult ocular diseases to deal with nowadays.Redundancy,poor visual acuity and decreased life quality are bothering patients and ophthalmologists for decades.Afte...Ischemic and neovascular disease is one of the most difficult ocular diseases to deal with nowadays.Redundancy,poor visual acuity and decreased life quality are bothering patients and ophthalmologists for decades.After vascular endothelial growth factor(VEGF)was found to be a primary factor in promoting retinal angiogenesis,intravitreal injection of anti-VEGF drugs has been the firstline treatment.Whereas,some patients are refractory to this therapy and problems of economic burden,local complications and adverse effects promote researches into other possible targets.The vasohibin(VASH)family is a newly-investigated factor in modulating ocular angiogenesis.The family includes VASH1 and VASH2,which show opposite effects of inhibiting and accelerating angiogenesis respectively.Positive results have been reported in cellular and animal experiments.With further researches,it can be a promising future target of treating ocular neovascular diseases.展开更多
文摘目的:探讨浆液性卵巢癌中血管生成抑制蛋白-1(vasohibin-1)、结肠癌转移相关蛋白1(metastasis-associated in colon cancer-1,MACC1)和抗癌1号蛋白(KAI1)表达之间的关系及其临床意义。方法:收集124例卵巢浆液性癌(卵巢浆液性癌组)和30例卵巢浆液性囊腺瘤(卵巢浆液性囊腺瘤组)术后组织标本,采用免疫组织化学ElivisionTM法检测所有肿瘤组织中vasohibin-1,MACC1和KAI1蛋白的表达情况。结果:卵巢浆液性癌组vasohibin-1和MACC1蛋白的阳性表达率分别为48.4%和58.1%,均高于卵巢浆液性囊腺瘤组(分别为10.0%和13.3%);而卵巢浆液性癌组KAI1蛋白阳性表达率为33.9%,低于浆液性囊腺瘤组(86.7%),差异均有统计学意义(均P<0.05);3种蛋白的表达与浆液性卵巢癌的病理组织学分级、国际妇产科联盟(Federation International of Gynecology and Obstetrics,FIGO)分期以及盆腔淋巴结转移有关(均P<0.05);KAI1蛋白的表达与vasohibin-1和MACC1的表达呈负相关(r值分别为–0.500和–0.600,均P<0.01),同时,vasohibin-1与MACC1蛋白的表达呈正相关(r=0.518,P<0.01)。Kaplan-Meier生存分析表明:vasohibin-1和MACC1的过表达以及KAI1的低表达均与患者的生存率有关,vasohibin-1和MACC1表达阳性及KAI1表达阴性的患者生存率明显低于vasohibin-1和MACC1表达阴性及KAI1表达阳性的患者(均P<0.05)。多因素分析表明:FIGO分期、vasohibin-1和KAI1蛋白的表达是影响浆液性卵巢癌根治术后患者预后的独立因素(RR值分别为2.185,3.893,0.413;95% CI分别为1.263~3.779,2.190~6.921,0.251~0.681;均P<0.05)。结论:浆液性卵巢癌组织中vasohibin-1和MACC1的表达上调以及KAI1的表达下调与肿瘤的分化程度、临床分期、转移和预后等因素相关,这些指标的联合检测可作为判断浆液性卵巢癌患者肿瘤演进及生存预后的重要指标。
基金Supported by Natural Science Fund Project in Jiangsu Province(No.BK20180380)Nanjing Health Commission(No.YKK18260)。
文摘Ischemic and neovascular disease is one of the most difficult ocular diseases to deal with nowadays.Redundancy,poor visual acuity and decreased life quality are bothering patients and ophthalmologists for decades.After vascular endothelial growth factor(VEGF)was found to be a primary factor in promoting retinal angiogenesis,intravitreal injection of anti-VEGF drugs has been the firstline treatment.Whereas,some patients are refractory to this therapy and problems of economic burden,local complications and adverse effects promote researches into other possible targets.The vasohibin(VASH)family is a newly-investigated factor in modulating ocular angiogenesis.The family includes VASH1 and VASH2,which show opposite effects of inhibiting and accelerating angiogenesis respectively.Positive results have been reported in cellular and animal experiments.With further researches,it can be a promising future target of treating ocular neovascular diseases.
