Assessment of Right Ventricular Function Using Strain and Strain Rate in Patient with Acute Anterior ST Segment Elevation Myocardial Infarction

Introduction: Anterior ST-segment elevation myocardial infarctions (STEMI) are those involving the anterior ECG leads of the heart as a result of transmural ischaemia. They can be subdivided according to their extension into anteroseptal and anterolateral infarctions. Objective: The aim of this study is assessment of right ventricular function using strain and strain rate imaging in patients with anterior ST segment elevated myocardial infarction (STEMI). Methods: This prospective study was conducted on 35 patients with anterior ST segment elevated myocardial infarction (STEMI) who were admitted to ER and CCU department in National Heart Institute from May 2018 to May 2019. Results: Comparison between groups regarding longitudinal strain showed that there is highly statistically significant difference between them in lateral wall (all segments), septum (all segments) and global LS of right ventricle. Comparison between studied groups regarding circumferential strain revealed that there is highly statistically significant difference between them in all segments of right ventricle. Conclusions:Strain and strain rate imaging are feasible and reproducible tools in assessment of right ventricular function in patients with anterior ST segment elevated myocardial infarction (STEMI).

Solution for slab forging with bulge between two parallel platens by strain rate vector inner-product integration and series expansion

A new linear integration was developed. First, effective strain rate for slab forging with bulge was expressed in terms of two-dimensional strain rate vector, and its inner-product was integrated term by term. Second, a summation process of term by term integrated results and a formula of the bulging were introduced, and an analytical solution of stress effective factor was obtained. It is proved that the expression of power by the above linear integration is the same as that of traditional immediate integration. Also, the solution was simplified by series expansion and compared by slab forging test with the others. It turns out that the calculated result of total forging pressure is basically in agreement with measured value in the actual press test.

Solution of rectangular bar forging with bulging of sides by strain rate vector inner-product

Abstract：ools. The effective strain rate for for determining the total pressure developed during forging of a rectangular bar forging with bulging was expressed in terms of four-dimensional strain rate vector. The inner-product of the vector was termwise integrated and summed. The integral mean value theorem was applied to determining the ratio of the strain rate components and the values of direction cosine of the vector and then an analytical solution of stress effective factor was obtained. The compression experiments of pure lead bar were performed to test the accuracy of the solution. The optimized results of total pressure by golden section search were compared with those of the indicator readings of the testing machine. It indicates that the optimized total pressures are 2.60%-10.14% higher than those measured. The solution is available and still an upper-bound solution.

Assessment of Regional Myocardial Function in Patients with Hypertrophic Cardiomyopathy by Tissue Strain Imaging

The value of tissue strain imaging （SI） in regional myocardial systolic and diastolic func tion assessment was studied. In 18 patients with nonobstructive hypertrophic cardiomyopathy （HCM） and 20 age-matched healthy subjects, regional myocardial longitudinal peak systolic strain in eject time （represented by εet） was measured at basal, mid and apical segments of septal, lateral and posterior walls of the left ventricle （LV） and compared between groups, εet had no significant difference between segments in control group （P〉0.05）, which displayed a decreasing trend from basal segments to apical ones. εet in the HCM group was significantly decreased （P（0. 05） as compared with that in the healthy group. In the HCM group, εet in the midseptum was significantly less than at the basal and apical septum, and was also less than at the rest LV walls in the same group （P〉0.01）. The systolic reversed εet was noticed in 35% of the hypertrophic segments in HCM group. Significantly negative correlation existed between the absolute value of εet and wall thickness in the midseptum （r= -0.83）. The post-systolic strain（PSS） segment number the and amplitudes in healthy group were significantly less than those in HCM group （P〈0.05）. Both regional myocardial systolic and diastolic functions were impaired in hypertrophic or non-hypertrophic segments in patients with the HCM, especially in hypertrophic segments. Strain imaging technique is a sensitive and accura tool in myocardial dysfunction assessment.

Inner-product of strain rate vector through direction cosine in coordinates for disk forging

A new linear integration for plastic power was proposed.The effective strain rate for disk forging with bulge was expressed in terms of two-dimensional strain rate vector,and then its direction cosines were determined by the ratio of coordinate increments.Furthermore,inner-product of the vector for plastic power was term integrated by term and summed.Thereafter,through a formula for determination of bulge an analytical solution of stress effective factor was obtained.Finally,through compression tests,the calculated results of above formula were compared with those of Avitzur’s approximate solution and total indicator readings of the testing machine.It is indicated that the calculated compression forces are basically in agreement with the measured ones if the pass reduction is less than 13.35%.However,when the reduction gets up to 25.34% and 33.12%,the corresponding errors between the calculated and measured results also get up to 6% and 13.5%,respectively.

Magnetic resonance imaging characterization of circumferential and longitudinal strain under various coronary interventions in swine

AIM:To compare the acute changes in circumferential and longitudinal strain after exposing a coronary artery to various interventions in swine.METHODS:Percutaneous balloon angioplasty catheter was guided to location aid device(LAD)under X-ray fluoroscopy to create different patterns of ischemic insults.Pigs(n=32)were equally divided into 4 groups:controls,90 min LAD occlusion/reperfusion,LAD microembolization,and combined LAD occlusion/microembolization/reperfusion.Three days after interventions,cine,tagged and viability magnetic resonance imaging(MRI)were acquired to measure and compare left and right circumferential strain,longitudinal strain and myocardial viability,respectively.Measurements were obtained using HARP and semi-automated threshold method and statistically analyzed using unpaired t-test.Myocardial and vascular damage was characterized microscopically.RESULTS:Coronary microemboli caused greater impairment in l left ventricular(LV)circumferential strain and dyssynchrony than LAD occlusion/reperfusion despite the significant difference in the extent of myocardial damage.Microemboli also caused significant decrease in peak systolic strain rate of remote myocardium and LV dyssynchrony.Cine MRI demonstrated the interaction between LV and right ventricular(RV)at 3 d after interventions.Compensatory increase in RV free wall longitudinal strain was seen in response to all interventions.Viability MRI,histochemical staining and microscopy revealed different patterns of myocardial damage and microvascular obstruction.CONCLUSION:Cine MRI revealed subtle changes in LV strain caused by various ischemic insults.It also demonstrated the interaction between the right and left ventricles after coronary interventions.Coronary microemboli with and without acute myocardial infarction(AMI)cause complex myocardial injury and ventricular dysfunction that is not replicated in solely AMI.

Quantification of Regional Left Ventricular Systolic Dysfunction in Patients With Coronary Artery Disease by Strain Rate Imaging

Objectives To detect and compare the systolic strain rate (SR) and strain in the infarct and ischemic myocardium by strain rate imaging (SRI), in order to explore the clinical value of SRI in evaluating regional left ventricular systolic dysfunction. Methods Patients with coronary artery disease were divided into angina pectoris (11 cases) and myocardial infarction (21 cases) groups. Twenty age-matched normal subjects served as the control group. Septal, lateral, anterior, inferior, anteroseptal and posterior walls of the left ventricle were respectively scanned using color tissue Doppler imaging (TDI). Then SR and strain curves were derived from TDI for basal, middle and apical segments of each wall. SRI parameters were: Systolic SR (SRsys), systolic strain (εsys) and maximum strain (εmax). Results Compared with normal segments, SRsys, εsys and εmax decreased significantly in the infarct and ischemic segments (P<0.01). Compared with ischemic segments, SRsys, εsys and εmax decreased significantly in the infarct segments (P<0.05). Conclusions SRsys, εsys and εmax measured by SRI can be used to quantitatively analyze regional left ventricular systolic dysfunction in patients with coronary artery disease, and aid in differentiating infarct from ischemic myocardium.

QUANTIFICATION OF RIGHT VENTRICULAR FUNCTION IN ATRIAL SEPTAL DEFECT USING ULTRASOUND- BASED STRAIN RATE IMAGING

Objective To study the validation of ultrasound-based strain rate imaging in the quantitative assessment of right ventricular （RV） function in atrial septal defect （ASD）. Methods Tissue Doppler images （TDI） of RV longitudinal and short axes were recorded from the apical 4-chamber view and the subcostal short-axis view in 18 normal controls, 28 children with ASD and 14 children after Amplazter closure of ASD respectively. Peak systolic velocities （ V）, peak systolic strain rates （SR）, peak systolic strains （S） at the basal segment, middle segment of RV lateral wall and the basal septum from the longitudinal axis, the middle segment of RV free waU from the short axis were quantitatively measured using QLAB^TM tissue velocity quantification software system respectively. Peak dp/ dt from the RV isovolumic contraction determined during the right cardiac catheterization in 28 ASD patients was used as the gold standard of RV contractility. Peak systolic indices were compared against max dp/dt by linear correlation, Results Peak systolic indices at the basal and middle segments of RV lateral wall from the longitudiual axis increased significantly in 28 ASD patients. Peak systolic indices at the basal septum also increased in patient group, but not significantly. Significant decreases in peak systolic indices at the basal and middle segments of RV lateral wall were observed after the Amplatzer closure in 14 ASD patients. There was no significant difference at the middle segment of RV free wall from the short axis between patient group and normal control. A strong correlation was found between max dp/dt and peak systolic indices at the basal and middle segments of RV lateral wal l （ P 〈 0. 05 ）. Conclusion Ultrasound-based strain rate imaging can assess quantitatively RVfunction in CHD. Peak systolic strains determined at the basal and middle segments of RV lateral wall are strong noninvasive indices of RV contractility.

Non-invasive assessment of hepatic fibrosis by tissue strain imaging in chronic hepatitis C patients

The development of fibrosis in hepatitis C patients is associated with increased rates of liver cancer. Assessing hepatic fibrosis during interferon treatment for chronic hepatitis C is thus an important factor in treatment planning. Complications such as bleeding may occur in association with liver biopsy and there are also some reports of sampling error [1,2]. In recent years, however, a number of studies looking at noninvasive means of assessing hepatic fibrosis have appeared in the literature [3-5]. The present study was conducted to determine whether it would be possible to apply an easily performed technique of myocardial examination to hepatic fibrosis. We have already documented our findings for strain rate imaging used to differentiate the normal condition, chronic hepatitis and cirrhosis of the liver identified by diagnostic imaging and haematology data [6]. In this study, patients identified by liver biopsy were investigated, and a comparative investigation with several fibrosis markers was carried out.

Prediction of Strain Rate of Aluminum/Silicon Carbide Using Gray Level Run-Length Matrices

The microstructural processes occurring in metals and alloys during hot deformation are： DRX （dynamic recrystallization）, superplastic deformation, dynamic recovery, wedge cracking, void formation, inter-crystalline cracking, prior particle boundary （FFB） cracking, and flow instability processes. Deformation characteristics of materials are interpreted as follows： in the low temperature （T≤0.25 of melting temperature） and high strain rate regime of 10 to 100 s-1, void formation occurs at hard particles and leads to ductile fracture. Many researchers used the currently defined statistical approaches to characterize images and extract useful information from the captured images. For more suitable of specific tasks, some researchers are introducing new texture features. HOS （higher-order statistics） estimate properties of three or more pixels occurring at specific locations relative to each other. GLRLMs （gray level run-length matrices） are popular method of HOS to extract texture features. This paper deals with texture features of GLRLM to predict strain rate values for Aluminum/Silicon Carbide.

Assessment of Right Ventricular Free Wall Longitudinal Myocardial Deformation Using Speckle Tracking Imaging in Normal Subjects

To assess fight ventficular free wall longitudinal myocardium deformation and examine the changes with normal age by speckle tracking imaging （STI）, myocardial systolic peak strain （ε）, systolic peak strain rate （SRs）, early diastolic peak strain rate （SRe）, late diastolic peak strain rate （SRa）, the ratio of SRe/SRa were measured in the basal, middle and apical segments of right ventficular free wall in 75 healthy volunteers （age range： 21-71 y） by STI from the apical 4-chamber view. RV longitudinal strain and strain rate were highest in the basal segment of the free wall. Older subjects had lower early diastolic strain rate （SRe） than younger subjects, but they had higher late diastolic strain rate （SRa）. A negative correlation between age and the ratio of SRe/SRa was found in all RV free wall segments （r=-4）.466 - -0.614, P〈0.01）. It is concluded that RV diastolic strain rate changes with age and STI can be used for the study of RV myocardial deformation.

Early Detection of Regional and Global Left Ventricular Myocardial Function Using Strain and Strain-rate Imaging in Patients with Metabolic Syndrome

Background：Strain and strain-rate imaging （SRI） have been found clinically useful in the assessment of cardiac systolic and diastolic function as well as providing new insights in deciphering cardiac physiology and mechanics in cardiomyopathies,and identifying early subclinical changes in various pathologies.The aim of this study was to evaluate the regional and global left ventricular （LV） myocardial function in metabolic syndrome （MS） with SRI so that we can provide more myocardial small lesions in patients with MS,which is robust and reliable basis for early detection of LV function.Methods：Thirty-nine adults with MS were enrolled in the study.There was a control group of 39 healthy adults.In addition to classic echocardiographic assessment of LV global functional changes,SRI was used to evaluate regional and global LV function.Including：Peak systolic strain （S）,peak systolic strain-rate （SR-s）,peak diastolic strain-rate （SR-e）.Results：There were no statistically significant differences between MS and controls in all traditional parameters of LV systolic function.On the other hand,significant differences were observed between MS and the control group in most of the parameters of S,SR-s,SR-e in regional LV function.Multiple stepwise regression analyses revealed that S and SR significantly were negatively correlated with blood pressure,waist circumference,fasting plasma glucose,uric acid,suggesting that risk factories were relevant to regional systolic dysfunction.Conclusion：In MS with normal LV ejection fraction,there was regional myocardial dysfunction,risk factors contributed to the impairment of systolic and diastolic function of the regional myocardium.Assessment of myocardial function using SRI could be more accurate in MS patient evaluation than conventional echocardiography alone.

Rolling With Simplified Stream Function Velocity and Strain Rate Vector Inner Product

The dual-stream function velocity field is reduced in order to analyze two-dimensional plate broadside roll- ing in roughing. The strain rate vector inner product and integral mean value theorem, as well as coqine vector inner product are used respectively in plastic deformation power, friction losses and shear power. A theoretical solution of roll torque and separating force for the rolling is obtained and the calculated results by the solution are compared with those measured in broadside rolling on-line. It shows that both the force and torque calculated are higher than those of measured, but the maximum relative error between them is no more than 11%.

Characteristics of myocardial postsystolic shortening in patients with coronary artery disease assessed by strain rate imaging

Background Postsystolic shortening （PSS） has been proposed as a marker of myocardial dysfunction. Strain rate imaging （SRI） is a novel ultrasonic technique, allowing reliable and noninvasive measurement of myocardial deformation. The purpose of this study was to investigate the characteristics of myocardial longitudinal PSS by SRI in ischemic and infarct myocardium in patients with coronary artery disease, and to explore its clinical applicability. Methods Eleven patients with angina pectoris, 21 patients with myocardial infarction and 20 healthy subjects were included in the study. Apical four-, three- and two-chamber views were displayed; and septal, lateral, anteroseptal, posterior, anterior and inferior walls of the left ventricle were scanned, respectively. PSS strain （εpss）, the ratio of εpss and systolic strain （εpss/εsys）, the ratio of εpss and maximum strain （εpss/εmax） and the duration of PSS （Tpss） in ischemic, infarct and normal myocardium were analyzed. Results PSS was found more frequent in the ischemic and infarct segments compared with the normal segments （39% vs 22% and 56% vs 22%, respectively; both P〈0.01）. It was even more frequent in the infarct segments than in the ischemic segments （56% vs 39%, P〈0.01 ）. The absolute magnitude of εpss, εpss/εsys, εpss/εmax were significantly larger and mpss significantly longer in the ischemic and infarct segments compared with that in the normal myocardium （P〈0.01）. εpss/εsys, εpss/εmax were even larger and Tpss even longer in the infarct than in the ischemic segments （P〈0.01）. Conclusions PSS is a common and important feature of the ischemic and infarct myocardium. εpss, εpss/εsys, εpss/εmax and mpss as measured by SRI may be promising markers for the quantitative assessment of regional myocardial dysfunction in patients with coronary artery disease. εpss/εsys, εpss/εmax and mpss may be helpful in differentiating infarct from ischemic myocardium.

心脏磁共振评价慢性肾脏病患者不同左心室构型的心肌组织特征

目的通过心脏磁共振(cardiac magnetic resonance,CMR)分析慢性肾脏病(chronic kidney disease,CKD)患者不同左心室构型的心肌应变、native T1值及T2值,研究CKD患者不同左心室构型的心肌组织特征。材料与方法前瞻性纳入CKD患者114例和年龄性别匹配的健康对照(对照组)30例。扫描序列包括心脏电影序列、T1 mapping及T2 mapping序列。根据左心室重构指数(left ventricular remodeling index,LVRI)和左心室质量指数(left ventricular mass index,LVMI)将患者分为左心室正常几何构型(n=43)、向心性重构(n=22)、向心性左心室肥厚(left ventricular hypertrophy,LVH)(n=20)和离心性LVH(n=29)共四组。利用心脏后处理软件CVI 42测量受试者的左心室心肌应变及应变率,包括周向、径向和纵向的整体应变、收缩期整体应变率、舒张期整体应变率,以及native T1值和T2值。分析不同左心室构型患者的心肌组织特征。采用单因素和多因素线性回归分析探讨左心室心肌应变参数、native T1值及T2值与生理变量的关系。结果除左心室正常构型组的整体周向应变[-18.40%(3.30%)vs.-19.71%±1.66%,P=0.063]、整体径向应变(30.63%±7.03%vs.34.07%±4.61%,P=0.324)与对照组差异无统计学意义,CKD患者的其余心肌应变参数显著低于对照组(P均<0.05)。应变分析结果显示离心性LVH组的整体径向应变(22.02%±8.31%)最低;向心性LVH组的整体周向应变(-14.42%±3.24%)和整体纵向应变(-9.55%±2.79%)最低。应变率分析结果显示离心性LVH组的收缩期整体周向应变率[(-0.84±0.25)s^(-1)]、舒张期整体周向应变率[(0.73±0.29)s^(-1)]、收缩期整体径向应变率[(1.25±0.46)s^(-1)]和舒张期整体径向应变率[(-1.18±0.50)s^(-1)]最低;向心性LVH组的收缩期整体纵向应变率[(-0.62±0.16)s^(-1)]和舒张期整体纵向应变率[(0.53±0.14)s^(-1)]最低。向心性重构组的native T1值与对照组差异无统计学意义[1285.50(85.25)ms vs.(1262.53±38.18)ms,P=0.083];离心性LVH组的native T1值最大,显著高于对照组[(1351.10±58.49)ms vs.(1262.53±38.18)ms,P<0.001]。与对照组相比,四个患者组的T2值均显著升高(P均<0.05),离心性LVH组的T2值[(54.86±8.71)ms]最大。不同组CKD患者的T2值差异无统计学意义(P均>0.05)。Native T1值的独立决定因素是血红蛋白含量(校正的R^(2)=0.216,β=-0.442,P<0.001)和血清肌酐(校正的R^(2)=0.216,β=-0.220,P=0.010)。结论CKD患者的心肌应变降低、native T1值及T2值增加,离心性LVH患者的心肌组织特征改变最明显。

锂离子电池用PET-Cu复合集流体拉伸性能研究

随着锂离子电池技术的不断发展,复合集流体因其具有显著提升电池能量密度和安全性高等优势而引起了产业界的广泛关注。而复合集流体的力学性能可靠性是保证其安全服役的前提,为此,本文针对商业用聚对苯二甲酸乙二醇酯-铜(PET-Cu)复合集流体的拉伸性能开展了系统性的研究。利用扫描电镜、激光共聚焦显微镜、X射线衍射等技术手段对复合集流体材料的表面形貌、微观结构及拉伸断裂行为进行了表征与分析。借助有限元模拟分析了不同几何形状试样在拉伸过程中的应力分布状态;通过数字图像相关技术辅助的拉伸实验研究了取样方向、应变速率及试样几何尺寸对PET-Cu复合集流体拉伸性能的影响规律,并对其应变测量进行了校正。结果表明,采用狗骨状试样并进行应变校正可以更准确地评估复合集流体的拉伸性能;PET-Cu复合集流体的拉伸性能表现出试样取样方向相关性和应变速率敏感性。此外,PET-Cu复合集流体的断裂伸长率表现出明显的试样几何尺寸效应,通过引入几何尺寸系数K可以对不同尺寸的试样拉伸性能进行合理的预测。本研究为聚合物复合集流体实际应用提供了理论依据与可靠性的论证,也为相关试验标准的建立提供了参考,有望推动高性能锂离子电池的开发。

超高性能混凝土动态压缩试验与损伤分析

为探究超高性能混凝土(ultra-high performance concrete,UHPC)在动态压缩下的损伤特性,该文利用霍普金森压杆装置研究了不同应变率(52~368 s-1)下的动态压缩力学性能,并基于数字图像相关技术对试件的破坏过程进行分析。结果表明:在冲击荷载下,UHPC试件破坏后,仍能保持完整;UHPC动态抗压强度和韧性表现出明显的应变率敏感性;随着应变率的增加,钢纤维能够更好地吸收冲击能量并抑制临界应变的增大;裂缝发展受应变率影响较大,裂缝最终宽度随应变率的增加不断增加,低应变率下裂缝最终宽度并非其最大宽度。该研究可为UHPC服役性能和损伤评估提供理论支撑。

二维斑点追踪超声心动图技术对法布雷病患者右心室功能及应变特征的评估

目的:利用二维斑点追踪超声心动图技术评估法布雷病患者的右心室功能及应变特征。方法:回顾性收集2014年8月至2023年6月在北京大学第一医院经病理或基因检查证实的法布雷病患者57例(法布雷病组)和性别、年龄(±2岁)相匹配的健康对照者57例(正常对照组),比较两组临床基线资料、常规超声心动图参数及二维斑点追踪超声心动图技术测量的右心室应变参数。另将法布雷病组根据左心室质量指数(LVMI)大小分为左心室肥厚(LVH)亚组(n=22,男性LVMI≥115 g/m^(2),女性LVMI≥95 g/m^(2))和无LVH亚组(n=35,男性LVMI<115 g/m^(2),女性LVMI<95 g/m^(2)),比较两亚组的右心室应变特征,并分析右心室应变特征与LVH的关系。结果:(1)与正常对照组比,法布雷病组心率慢、B型利钠肽水平高、估算肾小球滤过率低,左心室后壁厚度(LVPWd)、室间隔厚度(IVSd)、右心室游离壁厚度(RVWT)增加,LVMI升高(P均<0.05)。(2)与无LVH亚组比,LVH亚组年龄大、收缩压高、估算肾小球滤过率低、B型利钠肽水平高,LVMI升高,RVWT增加(P均<0.05)。(3)与正常对照组比,法布雷病组的左心室整体长轴应变(LVGLS)、右心室整体长轴应变(RVGLS)、右心室游离壁应变(RVFWS)及右心室游离壁基底段应变(bal-RVFWS)、中间段应变(mid-RVFWS)和心尖部应变(api-RVFWS)均下降(P均<0.05)。右心室应变差值(ΔRV)在法布雷病组和正常对照组间的差异无统计学意义(P>0.05)。(4)与无LVH亚组比,LVH亚组的LVGLS、RVGLS均降低,ΔRV升高(P均<0.05),RVFWS、bal-RVFWS、mid-RVFWS和api-RVFWS在两亚组间的差异均无统计学意义(P均>0.05)。结论:法布雷病患者的右心室整体和节段应变均已受到损害,其中伴LVH的患者RVGLS减低而RVFWS相对保留。

CMR特征追踪技术在帕金森病患者左心评估中的价值

目的应用心脏磁共振特征追踪(cardiac magnetic resonance feature tracking,CMR-FT)技术评估帕金森病(Parkinson’s disease,PD)患者的左心结构和功能,并探讨影响其结构和功能的因素。材料与方法前瞻性纳入2022年3月至2023年8月于四川大学华西医院就诊的PD患者(PD组)39例,同期招募年龄及性别匹配的健康对照者(对照组)34例,均完成常规心脏磁共振(cardiac magnetic resonance,CMR)检查。使用专业后处理软件CVI42分别获得左心室及左心房的常规心功能及心肌应变参数。左心室参数包括:收缩末期容积、舒张末期容积、心肌质量、射血分数、整体周向、径向及纵向应变。左心房参数包括:储备期、导管期及泵血期的射血分数、容积、应变及应变率。采用独立样本t检验或Mann-Whitney U检验分析各参数的组间差异。采用Pearson或Spearman相关系数模型分析常规心功能及应变参数与运动功能及自主神经功能的相关性。结果PD组相较于对照组,左室射血分数[(62.01±6.59)%vs.(64.84±4.70)%]及整体的纵向应变[(-17.25±1.57)%vs.(-18.28±1.99)%]均较低(P均<0.05)。PD组相较于对照组,左心室收缩末期容积(left ventricular end-systolic volume,LVESV)[(51.17±16.56)mL vs.(42.56±9.06)mL]、LVESV指数(LVESV index,LVESVi)[(30.44±8.00)mL·m^(-2)vs.(25.56±5.14)m L·m^(-2)]、左心室舒张末期容积指数(left ventricular end-diastolic volume index,LVEDVi)[(79.31±10.76)m L·m^(-2)vs.(72.97±12.51)mL·m^(-2)]及左心室心肌质量指数(left ventricular mass index,LV massi)[41.82(33.11,47.77)g·m^(-2)vs.33.71(32.27,38.78)g·m^(-2)]均较高(P<0.05)。PD组的左心房储备期、导管期及泵血期的射血分数、应变及应变率较对照组明显减低(P均<0.05)。相关性分析显示,左心房储备期应变及应变率与统一帕金森评定量表Ⅲ(Unified Parkinson’s Disease Rating ScaleⅢ,UPDRSⅢ)评分呈负相关(r=-0.409、-0.355,P<0.05)。左心房导管期射血分数、应变与UPDRSⅢ评分呈负相关(r=-0.326、-0.482,P<0.05)、应变率与UPDRSⅢ评分呈正相关(r=0.417,P=0.008)。左心房储备期应变、应变率与自主神经症状自评量表(The Scales for Outcomes in Parkinson’s Disease-Autonomic,SCOPA-AUT)评分呈负相关(r=-0.535、-0.319,P均<0.05)。左心房导管期应变与SCOPA-AUT评分呈负相关(r=-0.319,P=0.048),应变率与SCOPA-AUT评分呈正相关(r=0.359,P=0.025)。左心房泵血期应变与SCOPA-AUT呈负相关(r=-0.342,P=0.033)。结论CMR-FT获得的应变及应变率参数可早期评估PD患者的心功能受损程度。PD患者左室收缩功能及左心房储备、导管、泵功能受损;左心房储备功能及导管功能与运动功能障碍及自主神经功能障碍的严重程度相关。